Frontiers in Chemistry | Medicinal and Pharmaceutical Chemistry

Original Research

Published on 25 Apr 2025

Chemical profile of Rhododendron luteum Sweet leaf supercritical CO2 extracts and their anti-inflammatory and antidiabetic potential

in Medicinal and Pharmaceutical Chemistry

Lena Łyko
Renata Nowak
Marta Olech
Urszula Gawlik
Agnieszka Krajewska
Danuta Kalemba
Andriy Prokopiv

Frontiers in Chemistry

doi 10.3389/fchem.2025.1576852

2,548 views

Mini Review

Published on 25 Apr 2025

The quinoline framework and related scaffolds in natural products with anti-Leishmania properties

in Medicinal and Pharmaceutical Chemistry

Gloria Yaluff
Leídi Herrera
Miriam Soledad Rolón
Celeste Vega
Hugo Cerecetto

Frontiers in Chemistry

doi 10.3389/fchem.2025.1571067

3,984 views
5 citations

Original Research

Published on 25 Apr 2025

Effect of freeze-pressure regulated extraction technology on the physicochemical properties and pharmacological activities of guizhi extract

in Medicinal and Pharmaceutical Chemistry

Huiling Zhang
Juanzhen Luo
Qinzhao Wan
Xuecheng Wang
Zhenfeng Wu
Ming Yang
Yaqi Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581429

1,905 views

Original Research

Published on 22 Apr 2025

Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

in Medicinal and Pharmaceutical Chemistry

Jinchao Zhu
Qingyuan Lin
Honglin Zhu
Siqi Xie
Shengdong Nie

Frontiers in Chemistry

doi 10.3389/fchem.2025.1584588

5,566 views
2 citations

Original Research

Published on 16 Apr 2025

Design, synthesis, in silico studies, and apoptotic antiproliferative activity of novel thiazole-2-acetamide derivatives as tubulin polymerization inhibitors

in Medicinal and Pharmaceutical Chemistry

Lamya H. Al-Wahaibi
Ali M. Elshamsy
Taha F. S. Ali
Bahaa G. M. Youssif
Stefan Bräse
Mohamed Abdel-Aziz
Nawal A. El-Koussi

Frontiers in Chemistry

doi 10.3389/fchem.2025.1565699

13,102 views
5 citations

Review

Published on 16 Apr 2025

Research progress on extraction, separation, structure, and biological activities of polysaccharides from jujube fruit (Ziziphus jujuba Mill.): a review

in Medicinal and Pharmaceutical Chemistry

Feilong Jia
Bo Wang
Hui Ma
Changcai Bai
Yuanyuan Zhang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1581947

3,916 views
7 citations

Original Research

Published on 16 Apr 2025

Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis

in Medicinal and Pharmaceutical Chemistry

Eva Azme
Md. Mahmudul Hasan
Md. Liakot Ali
Rashedul Alam
Neamul Hoque
Fabiha Noushin
Mohammed Fazlul Kabir
Ashraful Islam
Tanzina Sharmin Nipun
S. M. Moazzem Hossen

Frontiers in Chemistry

doi 10.3389/fchem.2025.1527008

5,488 views
9 citations

Original Research

Published on 10 Apr 2025

Antioxidant activity and selective cytotoxicity in HCT-116 and WI-38 cell lines of LC-MS/MS profiled extract from Capparis spinosa L

in Medicinal and Pharmaceutical Chemistry

Amjad Ibrahim Oraibi
Ashour H. Dawood
Ghada Trabelsi
Ousman B. Mahamat
Leila Chekir-Ghedira
Soumaya Kilani-Jaziri

Frontiers in Chemistry

doi 10.3389/fchem.2025.1540174

3,964 views
5 citations

Original Research

Published on 04 Apr 2025

Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity

in Medicinal and Pharmaceutical Chemistry

Hamada Hashem
Shadwa Abdelfattah
Hesham M. Hassan
Ahmed Al-Emam
Mohammed Alqarni
Ghallab Alotaibi
Ibrahim Taha Radwan
Kirandeep Kaur
Devendra Pratap Rao
Stefan Bräse

Frontiers in Chemistry

doi 10.3389/fchem.2025.1571646

3,952 views
1 citation

Mini Review

Published on 01 Apr 2025

4-Aminoquinoline: a comprehensive review of synthetic strategies

in Medicinal and Pharmaceutical Chemistry

Francisco Delgado
Andrés Benítez
Lourdes Gotopo
Angel H. Romero

Frontiers in Chemistry

doi 10.3389/fchem.2025.1553975

8,761 views
4 citations

Original Research

Published on 01 Apr 2025

Healing and leishmanicidal activity of Zanthoxylum rhoifolium Lam.

in Medicinal and Pharmaceutical Chemistry

Juliana Correa-Barbosa
Heliton Patrick Cordovil Brígido
Bibiana Franzen Matte
Paloma Santos De Campos
Marcelo Lazzaron Lamers
Daniele Ferreira Sodré
Pedro Henrique Costa Nascimento
Gleison Gonçalves Ferreira
Valdicley Vieira Vale
Andrey Moacir do Rosário Marinho

Frontiers in Chemistry

doi 10.3389/fchem.2025.1504998

1,848 views

Original Research

Published on 28 Mar 2025

Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

in Medicinal and Pharmaceutical Chemistry

Yongzhi He
Jiachun Lu
Yushan Luo
Rizhao Pang
Xiaoming Hu
Lijuan Ding
Hua Xiao
Yunyun Wang
Wenchun Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1568551

3,296 views
4 citations

Original Research

Published on 28 Mar 2025

Synthesis, bioactivity, and molecular docking studies: novel arylpiperazine derivatives as potential new-resistant AR antagonists

in Medicinal and Pharmaceutical Chemistry

Hua Jiang
Haowei Chen
Ya Wang
Huaxin Xu
Hong Chen

Frontiers in Chemistry

doi 10.3389/fchem.2025.1557275

3,524 views

Original Research

Published on 26 Mar 2025

Structure-based identification of bioactive phytochemicals targeting kallikrein-related peptidase 2 for prostate cancer therapy

in Medicinal and Pharmaceutical Chemistry

Deeba Shamim Jairajpuri
Afzal Hussain
Mohamed F. Alajmi
Taj Mohammad
Anas Shamsi
Md. Imtaiyaz Hassan

Frontiers in Chemistry

doi 10.3389/fchem.2025.1553987

3,671 views
3 citations

Original Research

Published on 24 Mar 2025

Chemoinformatics analysis of Mangifera indica leaves extracted phytochemicals as potential EGFR kinase modulators

in Medicinal and Pharmaceutical Chemistry

Md. Abdullah Al Mashud
Ajoy Kumer
Ismat Jahan
Md. Mehedi Hasan Somrat
Md. Enamul Kabir Talukder
Md. Mashiar Rahman
A. F. M. Shahab Uddin
Md. Harun-Or-Rashid
Md. Mizanur Rahman
Mohammad Harun-Ur-Rashid

Frontiers in Chemistry

doi 10.3389/fchem.2025.1524384

3,003 views

Original Research

Published on 21 Mar 2025

Exploring the antimicrobial potential of lactobacilli against early-stage and mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

in Medicinal and Pharmaceutical Chemistry

Niharika Singh
Rohini Devidas Gulhane
Anamika Singh
Maitri Goel
Pudke Payal Udelal
Vikas Sangwan
Manvesh Kumar Sihag
Gunjan Goel
Harsh Panwar
Anil Kumar Puniya

Frontiers in Chemistry

doi 10.3389/fchem.2025.1425666

2,774 views
5 citations

Original Research

Published on 17 Mar 2025

Composite nanoparticle-based vesicles achieve enhanced delivery effects of the natural plant extract of the root, stem, and fruit

in Medicinal and Pharmaceutical Chemistry

Xiaodong Zhuang
Ting Ma
Risheng Liu
Xingyue Fang
Liangjiu Huang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1552298

1,869 views

Original Research

Published on 12 Mar 2025

Exploring shared therapeutic targets for Alzheimer’s disease and glioblastoma using network pharmacology and protein-protein interaction approach

in Medicinal and Pharmaceutical Chemistry

Sushma Pradeep
M. R. Sai Chakith
S. R. Sindhushree
Pruthvish Reddy
Esther Sushmitha
Madhusudan N. Purohit
Divya Suresh
Nanjunda Swamy Shivananju
Ekaterina Silina
Natalia Manturova

Frontiers in Chemistry

doi 10.3389/fchem.2025.1549186

4,574 views
8 citations

Original Research

Published on 10 Mar 2025

The traditional Chinese medicine formula Zhihan Anshen Tang (ZHAST) against obstructive sleep apnea hypopnea syndrome: network pharmacology and molecular docking approach

in Medicinal and Pharmaceutical Chemistry

Cai-Li Li
Yu-Xiang Zhang
Xing-Jie Zheng
Shuo Li
Jing Feng

Frontiers in Chemistry

doi 10.3389/fchem.2025.1524087

4,838 views

Original Research

Published on 07 Mar 2025

Elicitor-driven enhancement of phenolic compounds in geranium callus cultures: phytochemical profiling via LC-MS/MS and biological activities

in Medicinal and Pharmaceutical Chemistry

Amine Elbouzidi
Mohamed Taibi
Abdellah Baraich
Mounir Haddou
Ramzi A. Mothana
Sami A. Alsufyani
Hany W. Darwish
Roland Molinié
Jean-Xavier Fontaine
Ophélie Fliniaux

Frontiers in Chemistry

doi 10.3389/fchem.2025.1537877

3,145 views
3 citations

Editorial

Published on 04 Mar 2025

Editorial: Beyond borders: exploring diverse roles of heterocyclic compounds in combatting infections and cancer

in Medicinal and Pharmaceutical Chemistry

Afzal B. Shaik
Richie R. Bhandare
M. Mukhlesur Rahman
Kamal Dua

Frontiers in Chemistry

doi 10.3389/fchem.2025.1578852

2,248 views
1 citation

Original Research

Published on 27 Feb 2025

Designing novel cabozantinib analogues as p-glycoprotein inhibitors to target cancer cell resistance using molecular docking study, ADMET screening, bioisosteric approach, and molecular dynamics simulations

in Medicinal and Pharmaceutical Chemistry

Gajendra Singh Thakur
Ajay Kumar Gupta
Dipti Pal
Yogesh Vaishnav
Neeraj Kumar
Sivakumar Annadurai
Sanmati Kumar Jain

Frontiers in Chemistry

doi 10.3389/fchem.2025.1543075

3,259 views
1 citation

Original Research

Published on 27 Feb 2025

Mechanism of salidroside promoting testosterone secretion induced by H2O2 in TM3 Leydig cells based on metabolomics and network pharmacology

in Medicinal and Pharmaceutical Chemistry

Zixu Wang
Yunlong Xu
Huazhong Xiong

Frontiers in Chemistry

doi 10.3389/fchem.2025.1544876

2,703 views
1 citation

Original Research

Published on 27 Feb 2025

Insight into loading, release, and anticancer activities of the methanol hybridized glauconite nano-sheets as a potential carrier of cisplatin: equilibrium and release kinetics

in Medicinal and Pharmaceutical Chemistry

Haifa E. Alfassam
Nourhan Nasser
Sarah I. Othman
Hanan M. Alharbi
Noof A. Alenazi
Hassan A. Rudyani
Ahmed A. Allam
Wail Al Zoubi
Mostafa R. Abukhadra

Frontiers in Chemistry

doi 10.3389/fchem.2025.1523664

1,461 views
3 citations

931 articles

articles

Chemical profile of Rhododendron luteum Sweet leaf supercritical CO2 extracts and their anti-inflammatory and antidiabetic potential

The quinoline framework and related scaffolds in natural products with anti-Leishmania properties

Effect of freeze-pressure regulated extraction technology on the physicochemical properties and pharmacological activities of guizhi extract

Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

Design, synthesis, in silico studies, and apoptotic antiproliferative activity of novel thiazole-2-acetamide derivatives as tubulin polymerization inhibitors

Research progress on extraction, separation, structure, and biological activities of polysaccharides from jujube fruit (Ziziphus jujuba Mill.): a review

Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis

Antioxidant activity and selective cytotoxicity in HCT-116 and WI-38 cell lines of LC-MS/MS profiled extract from Capparis spinosa L

Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity

4-Aminoquinoline: a comprehensive review of synthetic strategies

Healing and leishmanicidal activity of Zanthoxylum rhoifolium Lam.

Exploring the therapeutic mechanism of curcumin in spinal cord injury treatment based on network pharmacology, molecular dynamics simulation, and experimental validation

Synthesis, bioactivity, and molecular docking studies: novel arylpiperazine derivatives as potential new-resistant AR antagonists

Structure-based identification of bioactive phytochemicals targeting kallikrein-related peptidase 2 for prostate cancer therapy

Chemoinformatics analysis of Mangifera indica leaves extracted phytochemicals as potential EGFR kinase modulators

Exploring the antimicrobial potential of lactobacilli against early-stage and mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa

Composite nanoparticle-based vesicles achieve enhanced delivery effects of the natural plant extract of the root, stem, and fruit

Exploring shared therapeutic targets for Alzheimer’s disease and glioblastoma using network pharmacology and protein-protein interaction approach

The traditional Chinese medicine formula Zhihan Anshen Tang (ZHAST) against obstructive sleep apnea hypopnea syndrome: network pharmacology and molecular docking approach

Elicitor-driven enhancement of phenolic compounds in geranium callus cultures: phytochemical profiling via LC-MS/MS and biological activities

Editorial: Beyond borders: exploring diverse roles of heterocyclic compounds in combatting infections and cancer

Designing novel cabozantinib analogues as p-glycoprotein inhibitors to target cancer cell resistance using molecular docking study, ADMET screening, bioisosteric approach, and molecular dynamics simulations

Mechanism of salidroside promoting testosterone secretion induced by H2O2 in TM3 Leydig cells based on metabolomics and network pharmacology

Insight into loading, release, and anticancer activities of the methanol hybridized glauconite nano-sheets as a potential carrier of cisplatin: equilibrium and release kinetics