Frontiers in Digital Health | Health Informatics

Perspective

Published on 27 Nov 2025

UpSMART: five years of digital innovation in cancer clinical research—achievements, challenges, and recommendations

in Health Informatics

Paul O’Regan
Fouziah Butt
Louise Carter
Donna M. Graham
Anja Le Blanc
Richard Hoskins
Laura Stephenson
Akshita Patil
Muhammad Shabbir
Dilan Eken

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1708067

1,538 views

Systematic Review

Published on 27 Nov 2025

Advances in machine and deep learning for ECG beat classification: a systematic review

in Health Informatics

Allam Jaya Prakash
Abdelkader Nasreddine Belkacem
Ibrahim M. Elfadel
Herbert F. Jelinek
Mohamed Atef

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1649923

3,746 views
2 citations

Original Research

Published on 26 Nov 2025

Optimized BERT-based NLP outperforms zero-shot methods for automated symptom detection in clinical practice

in Health Informatics

Juan G. Diaz Ochoa
Natalie Layer
Jonas Mahr
Faizan E Mustafa
Christian U. Menzel
Martina Müller
Tobias Schilling
Gerald Illerhaus
Markus Knott
Alexander Krohn

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1623922

1,415 views

Original Research

Accepted on 18 Nov 2025

Assessing ChatGPT versus evidence-based online responses for polycystic ovary syndrome (PCOS) self-management and education: an international cross-sectional blinded survey of healthcare professionals

in Health Informatics

Sandro Graca
Alexander Dallaway
Folashade Alloh
Harpal S. Randeva
Chris Kite
Ioannis Kyrou

Frontiers in Digital Health

372 views

Review

Published on 18 Nov 2025

Technical and legal aspects of federated learning in bioinformatics: applications, challenges and opportunities

in Health Informatics

Daniele Malpetti
Marco Scutari
Francesco Gualdi
Jessica van Setten
Sander van der Laan
Saskia Haitjema
Aaron Mark Lee
Isabelle Hering
Francesca Mangili

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1644291

1,684 views
1 citation

Original Research

Published on 18 Nov 2025

Feasibility of predicting next-day fatigue levels using heart rate variability and activity-sleep metrics in people with post-COVID fatigue

in Health Informatics

Nana Yaw Aboagye
Maria Germann
Kenneth F. Baker
Mark R. Baker
Silvia Del Din

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1689846

2,804 views

Systematic Review

Published on 17 Nov 2025

Architectural patterns for health information systems: a systematic review

in Health Informatics

Rene Casanova
Fernan A. Villa-Garzon
John W. Branch-Bedoya

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1694839

3,486 views

Brief Research Report

Published on 17 Nov 2025

Artificial intelligence in thoracic surgery consultations: evaluating the concordance between a large language model and expert clinical decisions

in Health Informatics

Carlos Déniz
Judith Marcè
Iván Macia
Francisco Rivas
Anna Muñoz
Marina Paradela
Samuel García
Camilo Moreno
Ines Serratosa
Marta García

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1633278

1,566 views

Original Research

Published on 14 Nov 2025

Sex and age estimation from cardiac signals captured via radar using data augmentation and deep learning: a privacy concern

in Health Informatics

Daniel Foronda-Pascual
Carmen Camara
Pedro Peris-Lopez

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1616770

1,002 views

Original Research

Published on 14 Nov 2025

Open LLM-based actionable incidental finding extraction from [18F]fluorodeoxyglucose PET-CT radiology reports

in Health Informatics

Stephen H. Barlow
Sugama Chicklore
Yulan He
Sebastien Ourselin
Thomas Wagner
Anna Barnes
Gary J. R. Cook

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1702082

1,786 views

Mini Review

Published on 03 Nov 2025

Generative AI in clinical (2020–2025): a mini-review of applications, emerging trends, and clinical challenges

in Health Informatics

Nafiz Fahad
Riadul Islam Rabbi
Sumayea Benta Hasan
Fariya Sultana Prity
Rasel Ahmed
Farhana Ahmed
Md. Jakir Hossen
Tze Hui Liew
Md Shohel Sayeed
Kah Ong Michael Goh

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1653369

5,652 views

Mini Review

Published on 31 Oct 2025

Current application and future pathways of smart older adult care services in China

in Health Informatics

Jie Xue

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1656624

2,519 views

Original Research

Published on 27 Oct 2025

Decentralized digital health ecosystems: a unified architecture for AI-enhanced medical record management

in Health Informatics

Harsha Kumar A.
Preetham Venkatram C.
Saran N.
Disha Daniel
Praveen Joe I. R.

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1685628

2,904 views

Original Research

Published on 27 Oct 2025

Data protection, interoperability and governance assessment tool: results from a proof-of-concept survey

in Health Informatics

Concetta Tania Di Iorio
Elettra Ronchi
Ivan Pristas
Tamara Buble
Nicholas Nicholson
Fabrizio Carinci

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1685774

1,372 views

Review

Published on 17 Oct 2025

Increasing the inclusivity of digital health co-production: an integrative review

in Health Informatics

Ian Litchfield
Gayathri Delanerolle
Helen Juffs
Stephanie Bloxham
Sian Dunning
Lorraine Harper

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1636469

2,115 views
2 citations

Original Research

Published on 15 Oct 2025

Artificial intelligence in patient education: evaluating large language models for understanding rheumatology literature

in Health Informatics

Claudia Mendoza-Pinto
Pamela Munguía-Realpozo
Ivet Etchegaray-Morales
Edith Ramírez-Lara
Juan Carlos Solis-Poblano
Máximo Alejandro García-Flores
Jorge Ayón-Aguilar

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1623399

1,649 views
1 citation

Systematic Review

Published on 14 Oct 2025

Trends and developments in health systems modeling: a bibliometric analysis

in Health Informatics

Kudakwashe Maguraushe
Patrick Ndayizigamiye
Tebogo Bokaba

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1595310

1,996 views
1 citation

Original Research

Published on 07 Oct 2025

Comparative performance evaluation of large language models in answering esophageal cancer-related questions: a multi-model assessment study

in Health Informatics

Zijie He
Lilan Zhao
Genglin Li
Jintao Wang
Songyu Cai
Pengjie Tu
Jingbo Chen
Jianman Wu
Juan Zhang
Ruiqi Chen

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1670510

2,467 views
1 citation

Original Research

Published on 07 Oct 2025

Non-contact human identification through radar signals using convolutional neural networks across multiple physiological scenarios

in Health Informatics

Daniel Foronda-Pascual
Carmen Camara
Pedro Peris-Lopez

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1637437

1,573 views

Original Research

Published on 06 Oct 2025

Streamlining wearable data integration for EHDS: a case study on advancing healthcare interoperability using Garmin devices and FHIR

in Health Informatics

Somayeh Abedian
Eugene Yesakov
Stanislav Ostrovskiy
Rada Hussein

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1636775

4,218 views

Systematic Review

Published on 30 Sep 2025

Large language models in real-world clinical workflows: a systematic review of applications and implementation

in Health Informatics

Yaara Artsi
Vera Sorin
Benjamin S. Glicksberg
Panagiotis Korfiatis
Girish N. Nadkarni
Eyal Klang

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1659134

6,730 views
8 citations

Original Research

Published on 30 Sep 2025

MYSTETH—home-based heart monitoring

in Health Informatics

Kopal Jain
Rohit Jain
Salik Khwaja Mohammad
Swati Aggarwal

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1616334

1,819 views

Perspective

Published on 29 Sep 2025

Leveraging knowledge for explainable AI in personalized cancer treatment: challenges and future directions

in Health Informatics

Emilia Daghir-Wojtkowiak
Javier Alfaro
Michele Mastromattei
Aleksander Palkowski
Mark Stares
Ana Roca-Umbert
Andraz Krajnc
Riccardo Leoni
Anne Boland
Aria Nourbaksh

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1637195

3,692 views
1 citation

Review

Published on 23 Sep 2025

AI reshaping life sciences: intelligent transformation, application challenges, and future convergence in neuroscience, biology, and medicine

in Health Informatics

Jiahuan Gong
Zihao Zhao
Xinxin Niu
Yanan Ji
Hualin Sun
Yuntian Shen
Bingqian Chen
Bei Wu

Frontiers in Digital Health

doi 10.3389/fdgth.2025.1666415

6,477 views
2 citations

377 articles

articles

UpSMART: five years of digital innovation in cancer clinical research—achievements, challenges, and recommendations

Advances in machine and deep learning for ECG beat classification: a systematic review

Optimized BERT-based NLP outperforms zero-shot methods for automated symptom detection in clinical practice

Assessing ChatGPT versus evidence-based online responses for polycystic ovary syndrome (PCOS) self-management and education: an international cross-sectional blinded survey of healthcare professionals

Technical and legal aspects of federated learning in bioinformatics: applications, challenges and opportunities

Feasibility of predicting next-day fatigue levels using heart rate variability and activity-sleep metrics in people with post-COVID fatigue

Architectural patterns for health information systems: a systematic review

Artificial intelligence in thoracic surgery consultations: evaluating the concordance between a large language model and expert clinical decisions

Sex and age estimation from cardiac signals captured via radar using data augmentation and deep learning: a privacy concern

Open LLM-based actionable incidental finding extraction from [18F]fluorodeoxyglucose PET-CT radiology reports

Generative AI in clinical (2020–2025): a mini-review of applications, emerging trends, and clinical challenges

Current application and future pathways of smart older adult care services in China

Decentralized digital health ecosystems: a unified architecture for AI-enhanced medical record management

Data protection, interoperability and governance assessment tool: results from a proof-of-concept survey

Increasing the inclusivity of digital health co-production: an integrative review

Artificial intelligence in patient education: evaluating large language models for understanding rheumatology literature

Trends and developments in health systems modeling: a bibliometric analysis

Comparative performance evaluation of large language models in answering esophageal cancer-related questions: a multi-model assessment study

Non-contact human identification through radar signals using convolutional neural networks across multiple physiological scenarios

Streamlining wearable data integration for EHDS: a case study on advancing healthcare interoperability using Garmin devices and FHIR

Large language models in real-world clinical workflows: a systematic review of applications and implementation

MYSTETH—home-based heart monitoring

Leveraging knowledge for explainable AI in personalized cancer treatment: challenges and future directions

AI reshaping life sciences: intelligent transformation, application challenges, and future convergence in neuroscience, biology, and medicine