Frontiers in Drug Discovery | Technologies and Strategies to Enable Drug Discovery

Original Research

Accepted on 26 Dec 2025

Across pre-clinical and clinical platforms, approved and investigational psychiatric drugs share pathways and associate with similar molecular functions

in Technologies and Strategies to Enable Drug Discovery

Jennifer Wilson
Emily Su
Nico Valencia
Jarod Le
Emily Liu

Frontiers in Drug Discovery

Original Research

Accepted on 09 Dec 2025

Multivalent display of membrane proteins using HIV1-Gag VLPs

in Technologies and Strategies to Enable Drug Discovery

Neha A. Bhat
Nicholas Dunn
Xiaodi Yu
Matthew DuPrie
Supratik Dutta
Matt McLean
Micheal D. Feldkamp
Jacqueline Kratch
Mandeep K. Mann
Simin Rahighi

Frontiers in Drug Discovery

140 views

Editorial

Published on 20 Feb 2025

Editorial: Exploring drug development with single cell omics analytics and stem cell-based disease models

in Technologies and Strategies to Enable Drug Discovery

Linheng Li
Fuchou Tang
Hongkui Deng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1561985

1,532 views

Perspective

Published on 19 Feb 2025

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

in Technologies and Strategies to Enable Drug Discovery

K. Taylor
R. Ram
L. Ewart
C. Goldring
G. Russomanno
G. P. Aithal
T. Kostrzewski
C. Bauch
J. M. Wilkinson
S. Modi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1536756

5,313 views
4 citations

Original Research

Published on 03 Jan 2025

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

in Technologies and Strategies to Enable Drug Discovery

Stefanie Hoffmann
Philip Hewitt
Isabel Koscielski
Dorota Kurek
Wouter Strijker
Kinga Kosim

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459424

4,278 views
3 citations

Editorial

Published on 29 Nov 2024

Editorial: Drug discovery and development explained: introductory notes for the general public

in Technologies and Strategies to Enable Drug Discovery

Bruno O. Villoutreix
Jean-Luc Poyet
Katya Tsaioun

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1528467

2,643 views

Review

Published on 19 Nov 2024

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

in Technologies and Strategies to Enable Drug Discovery

Peng Wang
Nan Tang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1495208

2,952 views
1 citation

Review

Published on 22 Oct 2024

Single-cell multiomics: a new frontier in drug research and development

in Technologies and Strategies to Enable Drug Discovery

Jiaxiu Ma
Chao Dong
Aibin He
Haiqing Xiong

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1474331

4,561 views

Review

Published on 18 Oct 2024

Single-cell technology for drug discovery and development

in Technologies and Strategies to Enable Drug Discovery

Anzhuo Zhang
Jiawei Zou
Yue Xi
Lianchong Gao
Fulan Deng
Yujun Liu
Pengfei Gao
Henry H. Y. Tong
Lianjiang Tan
Xin Zou

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459962

7,607 views
5 citations

Brief Research Report

Published on 07 Oct 2024

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

in Technologies and Strategies to Enable Drug Discovery

Liam M. Ashander
Amanda L. Lumsden
Yuefang Ma
Alwin Chun Rong Tan
Binoy Appukuttan
Santhosh Daniel
Michael Z. Michael
Justine R. Smith

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1416728

1,398 views
1 citation

Original Research

Published on 02 Oct 2024

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

in Technologies and Strategies to Enable Drug Discovery

Matthew Elcombe
Ayesha Mathur
Stephanie Wallace
Jayne Wright
Simon Plummer

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1472522

2,493 views
1 citation

Hypothesis and Theory

Published on 15 Aug 2024

Multiparameter ranking of carbazoles for anti-trypanosome lead discovery

in Technologies and Strategies to Enable Drug Discovery

Amrita Sharma
Carlos E. Sanz-Rodriguez
Michael P. Pollastri
Andrei Purmal
Kojo Mensa-Wilmot

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1430927

1,933 views

Original Research

Published on 26 Jul 2024

Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model

in Technologies and Strategies to Enable Drug Discovery

Melanie Grotz
Lieke van Gijzel
Peter Bitsch
Stefania C. Carrara
Harald Kolmar
Sakshi Garg

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1427407

4,308 views
2 citations

Methods

Published on 22 Jul 2024

An anesthetized rat assay for evaluating the effects of organophosphate-based compounds and countermeasures on intracranial EEG and respiratory rate

in Technologies and Strategies to Enable Drug Discovery

J. S. Thinschmidt
S. W. Harden
J. D. Talton
C. J. Frazier

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1393964

1,765 views

Review

Published on 08 Apr 2024

The (misleading) role of animal models in drug development

in Technologies and Strategies to Enable Drug Discovery

Thomas Hartung

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1355044

29,535 views
48 citations

Mini Review

Published on 04 Apr 2024

Confronting the bias towards animal experimentation (animal methods bias)

in Technologies and Strategies to Enable Drug Discovery

Catharine E. Krebs
Kathrin Herrmann

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1347798

6,867 views
7 citations

Mini Review

Published on 31 Jan 2024

The case of the missing mouse—developing cystic fibrosis drugs without using animals

in Technologies and Strategies to Enable Drug Discovery

Lindsay J. Marshall
Kathleen M. Conlee

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1347246

2,917 views

Mini Review

Published on 25 Jan 2024

Identification of first active compounds in drug discovery. how to proceed?

in Technologies and Strategies to Enable Drug Discovery

Stéphane Giraud

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1342866

6,716 views
2 citations

Mini Review

Published on 30 Nov 2023

Introduction to small molecule drug discovery and preclinical development

in Technologies and Strategies to Enable Drug Discovery

Michelle W. Y. Southey
Michael Brunavs

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1314077

70,485 views
51 citations

Original Research

Published on 30 Oct 2023

An improved method for large scale generation and high-throughput functional characterization of human iPSC-derived microglia

in Technologies and Strategies to Enable Drug Discovery

Manisha Padmakumar
Steven Biesmans
Jorge S. Valadas
Jan R. Detrez
Gaëlle Gillet
Priscillia Bresler
Marie-Laure Clénet
Irena Kadiu

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1289314

4,126 views

Mini Review

Published on 05 Sep 2023

Harnessing bioluminescence for drug discovery and epigenetic research

in Technologies and Strategies to Enable Drug Discovery

Hannah J. Gleneadie
Andrew Dimond
Amanda G. Fisher

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1249507

5,026 views
5 citations

Mini Review

Published on 12 Jul 2023

FAIR data management: what does it mean for drug discovery?

in Technologies and Strategies to Enable Drug Discovery

Yojana Gadiya
Vassilios Ioannidis
David Henderson
Philip Gribbon
Philippe Rocca-Serra
Venkata Satagopam
Susanna-Assunta Sansone
Wei Gu

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1226727

3,870 views
9 citations

Mini Review

Published on 24 May 2023

Drug discovery and development: introduction to the general public and patient groups

in Technologies and Strategies to Enable Drug Discovery

Natesh Singh
Philippe Vayer
Shivalika Tanwar
Jean-Luc Poyet
Katya Tsaioun
Bruno O. Villoutreix

Frontiers in Drug Discovery

doi 10.3389/fddsv.2023.1201419

205,259 views
164 citations

Original Research

Published on 12 Jan 2023

The use of cyclic peptide antigens to generate LRP8 specific antibodies

in Technologies and Strategies to Enable Drug Discovery

Maria A. Argiriadi
Kangwen Deng
David Egan
Lei Gao
Farid Gizatullin
John Harlan
Denise Karaoglu Hanzatian
Wei Qiu
Ruth Villanueva
Andrew Goodearl

Frontiers in Drug Discovery

doi 10.3389/fddsv.2022.1093153

4,489 views
4 citations

25 articles

articles

Across pre-clinical and clinical platforms, approved and investigational psychiatric drugs share pathways and associate with similar molecular functions

Multivalent display of membrane proteins using HIV1-Gag VLPs

Editorial: Exploring drug development with single cell omics analytics and stem cell-based disease models

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

Editorial: Drug discovery and development explained: introductory notes for the general public

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

Single-cell multiomics: a new frontier in drug research and development

Single-cell technology for drug discovery and development

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

Multiparameter ranking of carbazoles for anti-trypanosome lead discovery

Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model

An anesthetized rat assay for evaluating the effects of organophosphate-based compounds and countermeasures on intracranial EEG and respiratory rate

The (misleading) role of animal models in drug development

Confronting the bias towards animal experimentation (animal methods bias)

The case of the missing mouse—developing cystic fibrosis drugs without using animals

Identification of first active compounds in drug discovery. how to proceed?

Introduction to small molecule drug discovery and preclinical development

An improved method for large scale generation and high-throughput functional characterization of human iPSC-derived microglia

Harnessing bioluminescence for drug discovery and epigenetic research

FAIR data management: what does it mean for drug discovery?

Drug discovery and development: introduction to the general public and patient groups

The use of cyclic peptide antigens to generate LRP8 specific antibodies