Frontiers in Drug Discovery | Technologies and Strategies to Enable Drug Discovery

Perspective

Accepted on 24 Jan 2025

Perspective: How complex in vitro models (CIVMs) are addressing the challenges of predicting drug induced liver injury (DILI)

in Technologies and Strategies to Enable Drug Discovery

Katy Taylor
Rebecca Ram
Lorna Ewart
Chris Goldring
Giusy Russomanno
Guruprasad Padur Aithal
Tomasz Kostrzewski
Caroline Bauch
John Malcolm Wilkinson
Stephanie Modi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1536756

Editorial

Accepted on 21 Jan 2025

Advancing Drug Discovery Using Single Cell Multiomics with Stem Cell Platform

in Technologies and Strategies to Enable Drug Discovery

Linheng Li
Fuchou Tang
HongkuiHongkui Deng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1561985

Original Research

Published on 03 Jan 2025

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

in Technologies and Strategies to Enable Drug Discovery

Stefanie Hoffmann
Philip Hewitt
Isabel Koscielski
Dorota Kurek
Wouter Strijker
Kinga Kosim

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459424

427 views

Editorial

Published on 29 Nov 2024

Editorial: Drug discovery and development explained: introductory notes for the general public

in Technologies and Strategies to Enable Drug Discovery

Bruno O. Villoutreix
Jean-Luc Poyet
Katya Tsaioun

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1528467

645 views

Review

Published on 19 Nov 2024

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

in Technologies and Strategies to Enable Drug Discovery

Peng Wang
Nan Tang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1495208

569 views

Review

Published on 22 Oct 2024

Single-cell multiomics: a new frontier in drug research and development

in Technologies and Strategies to Enable Drug Discovery

Jiaxiu Ma
Chao Dong
Aibin He
Haiqing Xiong

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1474331

1,222 views

Review

Published on 18 Oct 2024

Single-cell technology for drug discovery and development

in Technologies and Strategies to Enable Drug Discovery

Anzhuo Zhang
Jiawei Zou
Yue Xi
Lianchong Gao
Fulan Deng
Yujun Liu
Pengfei Gao
Henry H. Y. Tong
Lianjiang Tan
Xin Zou

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459962

1,768 views

Brief Research Report

Published on 07 Oct 2024

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

in Technologies and Strategies to Enable Drug Discovery

Liam M. Ashander
Amanda L. Lumsden
Yuefang Ma
Alwin Chun Rong Tan
Binoy Appukuttan
Santhosh Daniel
Michael Z. Michael
Justine R. Smith

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1416728

412 views

Original Research

Published on 02 Oct 2024

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

in Technologies and Strategies to Enable Drug Discovery

Matthew Elcombe
Ayesha Mathur
Stephanie Wallace
Jayne Wright
Simon Plummer

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1472522

825 views

Hypothesis and Theory

Published on 15 Aug 2024

Multiparameter ranking of carbazoles for anti-trypanosome lead discovery

in Technologies and Strategies to Enable Drug Discovery

Amrita Sharma
Carlos E. Sanz-Rodriguez
Michael P. Pollastri
Andrei Purmal
Kojo Mensa-Wilmot

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1430927

709 views

Original Research

Published on 26 Jul 2024

Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model

in Technologies and Strategies to Enable Drug Discovery

Melanie Grotz
Lieke van Gijzel
Peter Bitsch
Stefania C. Carrara
Harald Kolmar
Sakshi Garg

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1427407

1,772 views

Methods

Published on 22 Jul 2024

An anesthetized rat assay for evaluating the effects of organophosphate-based compounds and countermeasures on intracranial EEG and respiratory rate

in Technologies and Strategies to Enable Drug Discovery

J. S. Thinschmidt
S. W. Harden
J. D. Talton
C. J. Frazier

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1393964

647 views

Review

Published on 08 Apr 2024

The (misleading) role of animal models in drug development

in Technologies and Strategies to Enable Drug Discovery

Thomas Hartung

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1355044

7,884 views
3 citations

Mini Review

Published on 04 Apr 2024

Confronting the bias towards animal experimentation (animal methods bias)

in Technologies and Strategies to Enable Drug Discovery

Catharine E. Krebs
Kathrin Herrmann

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1347798

3,202 views

Mini Review

Published on 31 Jan 2024

The case of the missing mouse—developing cystic fibrosis drugs without using animals

in Technologies and Strategies to Enable Drug Discovery

Lindsay J. Marshall
Kathleen M. Conlee

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1347246

1,397 views

Mini Review

Published on 25 Jan 2024

Identification of first active compounds in drug discovery. how to proceed?

in Technologies and Strategies to Enable Drug Discovery

Stéphane Giraud

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1342866

2,118 views

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Articles

Perspective: How complex in vitro models (CIVMs) are addressing the challenges of predicting drug induced liver injury (DILI)

Advancing Drug Discovery Using Single Cell Multiomics with Stem Cell Platform

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

Editorial: Drug discovery and development explained: introductory notes for the general public

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

Single-cell multiomics: a new frontier in drug research and development

Single-cell technology for drug discovery and development

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

Multiparameter ranking of carbazoles for anti-trypanosome lead discovery

Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model

An anesthetized rat assay for evaluating the effects of organophosphate-based compounds and countermeasures on intracranial EEG and respiratory rate

The (misleading) role of animal models in drug development

Confronting the bias towards animal experimentation (animal methods bias)

The case of the missing mouse—developing cystic fibrosis drugs without using animals

Identification of first active compounds in drug discovery. how to proceed?