Frontiers in Endocrinology | Diabetes: Molecular Mechanisms

Original Research

Published on 01 Oct 2025

Multi-omics analysis of hepatic outcomes in T2DM-MAFLD patients treated with semaglutide: a single-centre, longitudinal, data-driven study

in Diabetes: Molecular Mechanisms

Shu Niu
Shuchun Chen
Di Wu
Chenxi Wang
Jianchao Xu
Jiantong Yin
Yubin Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1650729

454 views

Original Research

Published on 01 Oct 2025

Alterations of oral microbiota and cytokines profile in children and young adults with type 1 diabetes

in Diabetes: Molecular Mechanisms

Luana Aldegheri
Eulalia Catamo
Nunzia Zanotta
Giuseppina Campisciano
Carolina Cason
Andrea Conti
Chiara Cipullo
Milena Cadenaro
Gianluca Tornese
Chiara Navarra

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1629185

176 views

Original Research

Published on 30 Sep 2025

A systematic analysis of the global disease burden of type 2 diabetes mellitus attributable to high intake of processed meat in 204 countries (1990-2021)

in Diabetes: Molecular Mechanisms

Wangchu Ze
Rui Su
Ruiyu Huang
Yanxia Guo
Xiaofang Yang
Baolu Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1635831

661 views

Original Research

Accepted on 29 Sep 2025

GROWTH FACTOR AND HYPOXIA-INDUCIBLE FACTOR ALPHA CONTENT IN THE RETINA OF MALE WISTAR RATS IN EXPERIMENTAL DIABETIC RETINOPATHY AND THE EFFECT OF CELLULAR PROTEIN KINASE BLOCKADE

in Diabetes: Molecular Mechanisms

K.O. Usenko
Olena Strubchevska
S.O. Rykov
M.S. Babenko
Kateryna Strubchevska
Oleksandra Kozyk
S.V. Ziablitsev
Marko Kozyk

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1643445

166 views

Review

Published on 29 Sep 2025

Multi-dimensional roles of sodium-glucose cotransporter 2 inhibitors: beyond hypoglycemic and cardiorenal protection

in Diabetes: Molecular Mechanisms

Siyu Li
Yaqi Wang
Quan Gong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1641699

366 views

Original Research

Published on 25 Sep 2025

Causal relationship between gut microbiota and diabetic neuropathy: a Mendelian randomization and 16S rRNA sequencing analysis

in Diabetes: Molecular Mechanisms

Yingqing Hu
Yanqiu Liang
Youyou Lv
Panwei Mu
Ying Wang
Dingbang Huang
Dezhao Liu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1632406

734 views

Original Research

Published on 25 Sep 2025

Shared senescence-associated gene networks in PCOS and T2DM: biomarker identification and functional validation

in Diabetes: Molecular Mechanisms

Mingyue Kong
Kun Lou
Dan Liu
Ziqi Dai
Tianjiao Li
Yihan Yang
Xuesong Zhang
Xin Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1652178

822 views

Original Research

Accepted on 24 Sep 2025

Mechanistic Insights Into Modified Danggui Buxue Decoction for Diabetic Retinopathy via Integrative Analysis

in Diabetes: Molecular Mechanisms

Lee Yam Poon
Lai Kwan Lam
Li Mei Hsu
Xiaoqing Huang
Peng-Li Xu
Qiuer Liang
Peng-Cheng Xie
Shu-Yu Yang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1648831

488 views

Original Research

Accepted on 24 Sep 2025

MiR-216a-5p protects against high glucose-induced HMC injury by targeting the HMGB1/RAGE signaling pathway

in Diabetes: Molecular Mechanisms

娟张
Xiyin Zheng
Hong Zhang
Juan Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1669791

371 views

Review

Accepted on 24 Sep 2025

Treatment of T2DM-related inflammation and vascular injury by regulating cellular crosstalk in the islet microenvironment

in Diabetes: Molecular Mechanisms

A-ru Sun
Hao-Yu Yang
Jun Sun
Ling Zhou
Jinli Luo
Tingting Bao
Xiaolin Tong
Yiqun Lin
Lin Han

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1551853

126 views

Original Research

Accepted on 24 Sep 2025

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes

in Diabetes: Molecular Mechanisms

Chelsea G Johansen
Kenedee Lam
Nikki Farnsworth

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1675043

138 views

Review

Accepted on 24 Sep 2025

GLP-1 Receptor Agonists Synergistic Effects of Metabolic Reprogramming and Cardioprotection

in Diabetes: Molecular Mechanisms

暄王
Mengmeng Qi
Lili Yang
Libo Yang
Xiaoyue Wang
Fang Zhang
Yukun Cui
Dongxin Wang
Yangang Wang
Wenshan Lv

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1614726

193 views

Original Research

Accepted on 23 Sep 2025

BRI is An Independent Predictor of New-onset Kidney Stones in A Non-diabetic Population: A Retrospective Analysis

in Diabetes: Molecular Mechanisms

Xiaohong Fan
Si Yu
Jing Li
Songbai Lin
Sanxi Ai
Haiting Wu
Yunyun Fei
Yan Qin
Gang Chen
Xuemei Li

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1686183

209 views

Original Research

Accepted on 23 Sep 2025

Association of Systemic Immune-Inflammation Index with Type 2 Diabetes Mellitus and Its Prognostic Significance: A Systematic Review and Meta-Analysis

in Diabetes: Molecular Mechanisms

Ru Xu
Lele Jiang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1572089

215 views

Review

Published on 23 Sep 2025

Targeting microRNAs in diabetic retinopathy: from pathogenic mechanisms to therapeutic potentials

in Diabetes: Molecular Mechanisms

Jiajun Chen
Jingjing Zhang
Changlei Li
Ling Wang
Long Tao
Shasha Xue
Fenglei Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1664604

737 views

Review

Accepted on 22 Sep 2025

Inflammation, diabetic foot and related treatments

in Diabetes: Molecular Mechanisms

Yuqi Qin
Shan Deng

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1676621

246 views