Frontiers in Endocrinology | Diabetes: Molecular Mechanisms

Original Research

Published on 14 Oct 2025

MiR-216a-5p protects against high glucose-induced HMC injury by targeting the HMGB1/RAGE signaling pathway

in Diabetes: Molecular Mechanisms

Juan Zhang
Xiyin Zheng
Hong Zhang
Juan Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1669791

1,541 views

Review

Published on 13 Oct 2025

GLP-1 receptor agonists synergistic effects of metabolic reprogramming and cardioprotection

in Diabetes: Molecular Mechanisms

Xuan Wang
Mengmeng Qi
Lili Yang
Libo Yang
Xiaoyue Wang
Fang Zhang
Yukun Cui
Dongxin Wang
Yangang Wang
Wenshan Lv

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1614726

1,957 views

Review

Published on 13 Oct 2025

Treatment of T2DM-related inflammation and vascular injury by regulating cellular crosstalk in the islet microenvironment

in Diabetes: Molecular Mechanisms

Aru Sun
Haoyu Yang
Jun Sun
Jinli Luo
Ling Zhou
Tingting Bao
Xiaolin Tong
Yiqun Lin
Lin Han

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1551853

1,704 views

Systematic Review

Published on 13 Oct 2025

The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels

in Diabetes: Molecular Mechanisms

Yongyan Song
Youjin Zhang
Xinyu Liu
Wang Gong
Yinquan Ai
Binger Shen
Jing Li
Chuan He

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1589575

1,660 views
1 citation

Original Research

Published on 10 Oct 2025

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes

in Diabetes: Molecular Mechanisms

Chelsea G. Johansen
Kenedee Lam
Nikki L. Farnsworth

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1675043

1,143 views

Original Research

Published on 10 Oct 2025

Mechanistic insights into modified Danggui Buxue Decoction for diabetic retinopathy via integrative analysis

in Diabetes: Molecular Mechanisms

Lee Yam Poon
Li Mei Hsu
Lai Kwan Lam
Xiaoqing Huang
Pengli Xu
Qiuer Liang
Pengcheng Xie
Shuyu Yang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1648831

2,186 views

Original Research

Published on 09 Oct 2025

Development of targeted drugs for diabetic retinopathy using Mendelian randomized pharmacogenomics

in Diabetes: Molecular Mechanisms

Guodan Liu
Miao Tian
Xinge Li
Xichen Wang
Songhao Zhang
Gali Bai
Xuyang Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1632691

2,091 views

Original Research

Published on 09 Oct 2025

Association of systemic immune-inflammation index with type 2 diabetes mellitus and its prognostic significance: a systematic review and meta-analysis

in Diabetes: Molecular Mechanisms

Ru Xu
Lele Jiang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1572089

2,252 views

Original Research

Published on 09 Oct 2025

Metabolomics integrated with network pharmacology and serum-urine pharmacochemistry unveils the antidiabetic mechanism of Anemarrhenae Rhizoma

in Diabetes: Molecular Mechanisms

Xunlong Zhong
Huaidong Peng
Chang Xiao
Chunhua Xiao
Xinyu Zhu
Haixuan Liang
Ruolun Wang
Yanmei Zhong
Jingwen Feng

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1618584

1,680 views

Review

Published on 07 Oct 2025

Inflammation, diabetic foot and related treatments

in Diabetes: Molecular Mechanisms

Yuqi Qin
Shan Deng

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1676621

2,834 views

Review

Published on 07 Oct 2025

The emerging role of extracellular vesicles in diabetes and complications: mechanistic insights and translational prospects

in Diabetes: Molecular Mechanisms

Siyuan Liu
Zhicheng Pan
Xuzhuo Chen
Zhenlin Wang
Wei Zhong
Jitao Ling
Yixuan Chen
Panpan Xia
Deju Zhang
Xiao Liu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1674028

2,210 views

Original Research

Published on 07 Oct 2025

HOMA-AD, inflammation, and adipose tissue dysfunction as key drivers of immunometabolic risk in people living with HIV and type 2 diabetes

in Diabetes: Molecular Mechanisms

Elsa J. Anaya-Ambriz
Tania E. Holguín-Aguirre
Paula Catalina Méndez-Ríos
Monserrat Alvarez-Zavala
Luz A. González-Hernández
Jaime F. Andrade-Villanueva
Pedro Martínez Ayala
Rodolfo I. Cabrera-Silva
Karina Sánchez-Reyes

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1669148

1,782 views

Original Research

Published on 02 Oct 2025

Early pathological changes in the liver and kidney of non-obese diabetic (NOD) mice: involvement of iron accumulation and ferroptosis

in Diabetes: Molecular Mechanisms

Ana Stancic
Milica Markelic
Nevena Savic
Ksenija Velickovic
Vesna Martinovic
Andjelija Gudelj
Danica Velickovic
Ilijana Grigorov
Vesna Otasevic

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1673012

1,789 views

Original Research

Published on 01 Oct 2025

Multi-omics analysis of hepatic outcomes in T2DM-MAFLD patients treated with semaglutide: a single-centre, longitudinal, data-driven study

in Diabetes: Molecular Mechanisms

Shu Niu
Shuchun Chen
Di Wu
Chenxi Wang
Jianchao Xu
Jiantong Yin
Yubin Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1650729

3,268 views

Original Research

Published on 01 Oct 2025

Alterations of oral microbiota and cytokines profile in children and young adults with type 1 diabetes

in Diabetes: Molecular Mechanisms

Luana Aldegheri
Eulalia Catamo
Nunzia Zanotta
Giuseppina Campisciano
Carolina Cason
Andrea Conti
Chiara Cipullo
Milena Cadenaro
Gianluca Tornese
Chiara Navarra

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1629185

1,411 views

Original Research

Published on 30 Sep 2025

A systematic analysis of the global disease burden of type 2 diabetes mellitus attributable to high intake of processed meat in 204 countries (1990-2021)

in Diabetes: Molecular Mechanisms

Wangchu Ze
Rui Su
Ruiyu Huang
Yanxia Guo
Xiaofang Yang
Baolu Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1635831

2,023 views

Review

Published on 29 Sep 2025

Multi-dimensional roles of sodium-glucose cotransporter 2 inhibitors: beyond hypoglycemic and cardiorenal protection

in Diabetes: Molecular Mechanisms

Siyu Li
Yaqi Wang
Quan Gong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1641699

2,216 views

Original Research

Published on 25 Sep 2025

Causal relationship between gut microbiota and diabetic neuropathy: a Mendelian randomization and 16S rRNA sequencing analysis

in Diabetes: Molecular Mechanisms

Yingqing Hu
Yanqiu Liang
Youyou Lv
Panwei Mu
Ying Wang
Dingbang Huang
Dezhao Liu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1632406

2,042 views
1 citation

Original Research

Published on 25 Sep 2025

Shared senescence-associated gene networks in PCOS and T2DM: biomarker identification and functional validation

in Diabetes: Molecular Mechanisms

Mingyue Kong
Kun Lou
Dan Liu
Ziqi Dai
Tianjiao Li
Yihan Yang
Xuesong Zhang
Xin Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1652178

2,517 views

Review

Published on 23 Sep 2025

Targeting microRNAs in diabetic retinopathy: from pathogenic mechanisms to therapeutic potentials

in Diabetes: Molecular Mechanisms

Jiajun Chen
Jingjing Zhang
Changlei Li
Ling Wang
Long Tao
Shasha Xue
Fenglei Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1664604

2,120 views

Correction

Published on 22 Sep 2025

Correction: The role of protein S-acylation in vascular injury associated with metabolic disorders

in Diabetes: Molecular Mechanisms

Yayun Wang
Wenhui Zhu
Wenfan Wang
Jiayi Zhang
Dongsen Hu
Huanmeng Shao
Yingtong Zhou
Shan Wang
Linhua Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1704241

881 views

Original Research

Published on 22 Sep 2025

Ischemic postconditioning ameliorates diabetic cerebral ischemia via activating the brain-derived neurotrophic factor–tropomyosin receptor kinase B–hypoxia-inducible factor 1α–Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 pathway to induce microglial mitophagy and suppress A1 astrocyte-mediated neuroinflammation

in Diabetes: Molecular Mechanisms

Ling Zhao
Yuanyuan Han
Ying Wang
Tingyu Ke
Shiying Huang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1620004

1,931 views

Review

Published on 19 Sep 2025

Gut microbiota-derived short-chain fatty acids mediate the antifibrotic effects of traditional Chinese medicine in diabetic nephropathy

in Diabetes: Molecular Mechanisms

Haiyan Jiang
Xiaoran Wang
Wei Zhou
Zhili Huang
Wen Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1643515

3,457 views
1 citation

Review

Published on 18 Sep 2025

Gut microbiota dysbiosis in diabetic nephropathy: mechanisms and therapeutic targeting via the gut-kidney axis

in Diabetes: Molecular Mechanisms

Haiyan Jiang
Xiaoran Wang
Wei Zhou
Zhili Huang
Wen Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1661037

3,688 views

833 articles

articles

MiR-216a-5p protects against high glucose-induced HMC injury by targeting the HMGB1/RAGE signaling pathway

GLP-1 receptor agonists synergistic effects of metabolic reprogramming and cardioprotection

Treatment of T2DM-related inflammation and vascular injury by regulating cellular crosstalk in the islet microenvironment

The rs7799039 variant in the leptin gene promoter drives insulin resistance through reduced serum leptin levels

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes

Mechanistic insights into modified Danggui Buxue Decoction for diabetic retinopathy via integrative analysis

Development of targeted drugs for diabetic retinopathy using Mendelian randomized pharmacogenomics

Association of systemic immune-inflammation index with type 2 diabetes mellitus and its prognostic significance: a systematic review and meta-analysis

Metabolomics integrated with network pharmacology and serum-urine pharmacochemistry unveils the antidiabetic mechanism of Anemarrhenae Rhizoma

Inflammation, diabetic foot and related treatments

The emerging role of extracellular vesicles in diabetes and complications: mechanistic insights and translational prospects

HOMA-AD, inflammation, and adipose tissue dysfunction as key drivers of immunometabolic risk in people living with HIV and type 2 diabetes

Early pathological changes in the liver and kidney of non-obese diabetic (NOD) mice: involvement of iron accumulation and ferroptosis

Multi-omics analysis of hepatic outcomes in T2DM-MAFLD patients treated with semaglutide: a single-centre, longitudinal, data-driven study

Alterations of oral microbiota and cytokines profile in children and young adults with type 1 diabetes

A systematic analysis of the global disease burden of type 2 diabetes mellitus attributable to high intake of processed meat in 204 countries (1990-2021)

Multi-dimensional roles of sodium-glucose cotransporter 2 inhibitors: beyond hypoglycemic and cardiorenal protection

Causal relationship between gut microbiota and diabetic neuropathy: a Mendelian randomization and 16S rRNA sequencing analysis

Shared senescence-associated gene networks in PCOS and T2DM: biomarker identification and functional validation

Targeting microRNAs in diabetic retinopathy: from pathogenic mechanisms to therapeutic potentials

Correction: The role of protein S-acylation in vascular injury associated with metabolic disorders

Gut microbiota-derived short-chain fatty acids mediate the antifibrotic effects of traditional Chinese medicine in diabetic nephropathy

Gut microbiota dysbiosis in diabetic nephropathy: mechanisms and therapeutic targeting via the gut-kidney axis