Frontiers in Endocrinology | Diabetes: Molecular Mechanisms

Original Research

Published on 18 Sep 2025

Future horizons in diabetes treatment: hypoglycemic activity of [1,2,4]triazino[2,3-c]quinazoline derivatives

in Diabetes: Molecular Mechanisms

Serhii Trzhetsynskyi
Inna Nosulenko
Anna Kinichenko
Dmytro Skoryna
Halyna Berest
Volodymyr Shvets
Oleksii Voskoboinik
Serhii Kovalenko
Pavlo Petakh
Oleksandr Kamyshnyi

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1638013

2,047 views
1 citation

Original Research

Published on 16 Sep 2025

Association of MIF rs1007888 and ARAP1 rs1552224 genetic variants with the risk of gestational diabetes mellitus in a chinese population; case study and meta-analysis

in Diabetes: Molecular Mechanisms

Yuxuan Zhang
Yanying Wu
Qiaoli Zeng
Watson Ray Gyan
Sining Huang
Xiner Dai
Jia Liu
Xin Liu
Yue Wei
Runmin Guo

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1650782

2,064 views

Hypothesis and Theory

Published on 16 Sep 2025

A mathematical model of insulin action on acinar tissue linking histology and radiological imaging of the pancreas

in Diabetes: Molecular Mechanisms

John Virostko

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1676627

1,440 views

Original Research

Published on 15 Sep 2025

Adipose tissue quantity, distribution and pathology and its relationship with type-2 diabetes, insulin resistance and other clustering disease risk in South Asians: a cross-sectional study

in Diabetes: Molecular Mechanisms

Aditya Saxena
Sanjay Saran
Praveen Choudhary
Balram Sharma
Shalu Gupta
Rajendra Mandia
Ramesh C. Banshiwal
Ravinder Kumar Lamoria
Anurag Dhakad
Utkarsh Raj

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1622732

2,072 views

Original Research

Published on 11 Sep 2025

Triglycerides as a mediator in the hyperuricemia-diabetes link: insights from a hypertensive Chinese population

in Diabetes: Molecular Mechanisms

Dan Lu
Xiaowen Ou
Tingjun Wang
Guoyan Xu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1645766

1,627 views

Review

Published on 10 Sep 2025

Complementary efficacy and molecular insights of Polygonati rhizoma polysaccharide for glycemic and lipid abnormalities in type 2 diabetes mellitus: a comprehensive review

in Diabetes: Molecular Mechanisms

Shichao Ma
Lu Xu
Yadi Hou
Wenjing Zhang
Yongxia Cui
Suiqing Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1606816

2,364 views

Original Research

Published on 10 Sep 2025

Genetic and phenotypic heterogeneity of type 2 diabetes across Russian ancestry groups

in Diabetes: Molecular Mechanisms

Ekaterina E. Markelova
Irina V. Kononenko
Anatoliy Zubritskiy
Elizaveta Podshivalova
Alina Matrosova
Evgeniya Plaksina
Saleem Mansour
Pavel Ahtyamov
Elena Shagimardanova
Gulnar R. Vagapova

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1672403

1,856 views

Original Research

Published on 09 Sep 2025

Impact of per- and polyfluoroalkyl substances on diabetic kidney disease

in Diabetes: Molecular Mechanisms

Siyuan Song
Liji Huang
Xiqiao Zhou
Yuan Han
Jiangyi Yu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1594897

3,384 views

Original Research

Published on 09 Sep 2025

Protective effects of Shenkang injection against diabetic kidney disease via p38 MAPK/NFκB/MCP-1/CCR2 pathway inhibition

in Diabetes: Molecular Mechanisms

Xin Zhou
Sitong Wang
Ge Jin
Kaidong Zhou
Yanmo Cai
Zongjiang Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1596000

2,446 views
1 citation

Review

Published on 08 Sep 2025

Cardiovascular risk factors and modern therapeutic strategies in children and adolescents with type 1 diabetes to prevent future diabetic angiopathy in the era of innovative miRNAs biomarkers

in Diabetes: Molecular Mechanisms

Joanna Peczyńska
Emilia Odyjewska
Kamila Koszykowska
Milena Jamiołkowska-Sztabkowska
Artur Bossowski
Barbara Głowińska-Olszewska

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1638770

1,961 views

Review

Published on 05 Sep 2025

Single-cell RNA sequencing in studies of type 1 diabetes mellitus: modern state-of-the-art and technical peculiarities

in Diabetes: Molecular Mechanisms

Azat Vadimovich Abdullatypov
Olga Valentinovna Glushkova
Ekaterina Sergeevna Petriaikina
Viktor Pavlovich Bogdanov
Dmitry Vyacheslavovich Tabakov
Vasilii Eduardovich Akimov
Vladimir Sergeevich Yudin
Anton Arturovich Keskinov
Sergey Mikhailovich Yudin
Pavel Yuryevich Volchkov

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1663728

3,727 views
1 citation

Review

Published on 04 Sep 2025

Metabolomics uncovers the diabetes metabolic network: from pathophysiological mechanisms to clinical applications

in Diabetes: Molecular Mechanisms

Zijie Xu
Yujia Zhou
Ruijie Xie
Zhongxing Ning

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1624878

3,334 views
1 citation

Original Research

Published on 04 Sep 2025

IL17RA and IL21R polymorphisms influence type 1 diabetes predisposition and autoimmune phenotypes

in Diabetes: Molecular Mechanisms

Cintia Semzezem
Karla Fabiana Brasil Gomes
Aritania Sousa Santos
Pauline Brochet
Lindiane Gomes Crisostomo
Marcia Regina Soares Correia
Amanda Farage Frade-Barros
Luciano Abreu Brito
Maria Rita Passos-Bueno
Christophe Chevillard

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1620509

1,478 views

Review

Published on 03 Sep 2025

A new perspective on protecting the blood-retinal barrier against injury in diabetic retinopathy: mitophagy

in Diabetes: Molecular Mechanisms

Mengtian Li
Liyang Yang
Haoyu Zhai
Liping Qiao
Zhaobo Wang
Xuedong An
Jia Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1617797

3,171 views
1 citation

Review

Published on 03 Sep 2025

The role of protein S-acylation in vascular injury associated with metabolic disorders

in Diabetes: Molecular Mechanisms

Yayun Wang
Wenhui Zhu
Wenfan Wang
Jiayi Zhang
Dongsen Hu
Huanmeng Shao
Yingtong zhou
Shan Wang
Linhua Zhao

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1643008

3,132 views

Original Research

Published on 03 Sep 2025

Comprehensive bioinformatics and in vivo validation reveal key molecular drivers of diabetic nephropathy progression

in Diabetes: Molecular Mechanisms

Yakun Yang
Xingyu He
Wei Liu
Lin Mu
Shuo Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1654401

2,758 views

Original Research

Published on 03 Sep 2025

Predictors of response to anti-VEGF combined with laser therapy in severe non-proliferative diabetic retinopathy: development and validation of a nomogram model from retrospective data

in Diabetes: Molecular Mechanisms

Chunmei Cui
Yuehua Li
Qian Zhang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1648425

1,869 views

Review

Published on 03 Sep 2025

Advancements in the understanding of mechanisms of the IL-6 family in relation to metabolic-associated fatty liver disease

in Diabetes: Molecular Mechanisms

Jiale Liu
Tao Wang
Fuyuan Yang
Ciren Pubu

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1642436

3,125 views
1 citation

Original Research

Published on 02 Sep 2025

Gestational diabetes increases preterm membrane rupture risk through elevated hydroxydesmethylpiperine sulfate levels

in Diabetes: Molecular Mechanisms

Ying Li
Rong Lin
Tianshu Zhang
Tianyu Shi
Xingwang Ding
Jinqi Ma

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1631638

1,663 views
1 citation

Original Research

Published on 02 Sep 2025

Counterregulatory response to hypoglycemia during a hypoglycemic clamp in people with type 2 diabetes treated with tirzepatide

in Diabetes: Molecular Mechanisms

Thomas R. Pieber
Eva Svehlikova
Shweta Urva
Axel Haupt
Chunmei Zhou
Tamer Coskun
Vera Höller
Gabriele Fluhr
Chrisanthi A. Karanikas
Zvonko Milicevic

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1627947

3,154 views

Original Research

Published on 29 Aug 2025

Differential expression and correlation analysis of whole transcriptome for type 2 diabetes mellitus

in Diabetes: Molecular Mechanisms

Fang Liu
Aihong Peng
Xiaoli Zhu
Guangming Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1541261

2,120 views

Original Research

Published on 28 Aug 2025

African regional and national burden of diabetes mellitus and its attributable risk factors from 1990 to 2021: results from the global burden of disease study 2021

in Diabetes: Molecular Mechanisms

Qiu-Yun Wang
Emmanuel Mensah
Zhi-Chao Li
De-Guo Wang
Cui-Wei Zhang
Bruno Miezah Baako
Lei Zha
Xiang Kong

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1643999

3,823 views

Original Research

Published on 27 Aug 2025

Sancai Lianmei granules ameliorate neuron injury in diabetic ischemic stroke rats by inhibiting oxidative stress and inflammation

in Diabetes: Molecular Mechanisms

Chan Zhu
Dandan Chen
Zhehao Li
Yanmei Wang
Xuke Han
Qiu Chen

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1666597

2,272 views

Original Research

Published on 26 Aug 2025

An impact of type 2 diabetes mellitus on NKT-like cell population in humans: a new insight into impaired immune response in hyperglycemia

in Diabetes: Molecular Mechanisms

Emilia Adamska-Fita
Przemysław Wiktor Śliwka
Bartłomiej Stasiak
Małgorzata Karbownik-Lewińska
Andrzej Lewiński
Magdalena Stasiak

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1641318

1,736 views
1 citation

833 articles

articles

Future horizons in diabetes treatment: hypoglycemic activity of [1,2,4]triazino[2,3-c]quinazoline derivatives

Association of MIF rs1007888 and ARAP1 rs1552224 genetic variants with the risk of gestational diabetes mellitus in a chinese population; case study and meta-analysis

A mathematical model of insulin action on acinar tissue linking histology and radiological imaging of the pancreas

Adipose tissue quantity, distribution and pathology and its relationship with type-2 diabetes, insulin resistance and other clustering disease risk in South Asians: a cross-sectional study

Triglycerides as a mediator in the hyperuricemia-diabetes link: insights from a hypertensive Chinese population

Complementary efficacy and molecular insights of Polygonati rhizoma polysaccharide for glycemic and lipid abnormalities in type 2 diabetes mellitus: a comprehensive review

Genetic and phenotypic heterogeneity of type 2 diabetes across Russian ancestry groups

Impact of per- and polyfluoroalkyl substances on diabetic kidney disease

Protective effects of Shenkang injection against diabetic kidney disease via p38 MAPK/NFκB/MCP-1/CCR2 pathway inhibition

Cardiovascular risk factors and modern therapeutic strategies in children and adolescents with type 1 diabetes to prevent future diabetic angiopathy in the era of innovative miRNAs biomarkers

Single-cell RNA sequencing in studies of type 1 diabetes mellitus: modern state-of-the-art and technical peculiarities

Metabolomics uncovers the diabetes metabolic network: from pathophysiological mechanisms to clinical applications

IL17RA and IL21R polymorphisms influence type 1 diabetes predisposition and autoimmune phenotypes

A new perspective on protecting the blood-retinal barrier against injury in diabetic retinopathy: mitophagy

The role of protein S-acylation in vascular injury associated with metabolic disorders

Comprehensive bioinformatics and in vivo validation reveal key molecular drivers of diabetic nephropathy progression

Predictors of response to anti-VEGF combined with laser therapy in severe non-proliferative diabetic retinopathy: development and validation of a nomogram model from retrospective data

Advancements in the understanding of mechanisms of the IL-6 family in relation to metabolic-associated fatty liver disease

Gestational diabetes increases preterm membrane rupture risk through elevated hydroxydesmethylpiperine sulfate levels

Counterregulatory response to hypoglycemia during a hypoglycemic clamp in people with type 2 diabetes treated with tirzepatide

Differential expression and correlation analysis of whole transcriptome for type 2 diabetes mellitus

African regional and national burden of diabetes mellitus and its attributable risk factors from 1990 to 2021: results from the global burden of disease study 2021

Sancai Lianmei granules ameliorate neuron injury in diabetic ischemic stroke rats by inhibiting oxidative stress and inflammation

An impact of type 2 diabetes mellitus on NKT-like cell population in humans: a new insight into impaired immune response in hyperglycemia