Frontiers in Genetics

Original Research

Published on 14 Oct 2025

Identification of key genes for heart failure in dilated cardiomyopathy in different populations

in Computational Genomics

Yue Yu
Chentian Xue
Dong Ji
Wei Sheng
Xiang Gao
Xize Wu
Chengyan Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1618390

2,152 views

Review

Published on 14 Oct 2025

Gene-LLMs: a comprehensive survey of transformer-based genomic language models for regulatory and clinical genomics

in Computational Genomics

P. Balakrishnan
A. Anny Leema
V. Dhivya Shree
C. Mohammad Saad
A. Mohan Babu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634882

4,254 views

Case Report

Published on 14 Oct 2025

Ataxia, intentional tremor and hypotonia syndrome caused by a novel POU4F1 gene mutation: a case report

in Neurogenomics

Qisheng Hu
Feng Zhu
Wanfen Wang
Yihang Xu
Haiyan Ren
Yanni Zheng
Yiqing Jiang
Shaofa Ke

Frontiers in Genetics

doi 10.3389/fgene.2025.1702803

1,488 views

Correction

Published on 13 Oct 2025

Correction: DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction

in Computational Genomics

Guohua Huang
Runjuan Xiao
Chunying Peng
Jinyun Jiang
Weihong Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1704319

796 views

Original Research

Published on 13 Oct 2025

Transcriptomic profiling reveals macrophage gene signatures associated with lactylation-related pathways in chronic obstructive pulmonary disease

in Epigenomics and Epigenetics

Hui Guo
Weilin Sun
Fang Zhao
Yang Yu
Xiaoyun Zhao
Daqiang Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1653163

3,459 views

Editorial

Published on 13 Oct 2025

Editorial: The neurogenetics of brain wiring

in Behavioral and Psychiatric Genetics

Ting Feng
Wenfeng Chen
Aja McDonagh
Zhenxing Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1699487

1,875 views

Case Report

Published on 13 Oct 2025

Thoracic aortic aneurysm combined with intracranial vascular abnormalities caused by dual mutations in MYLK and FBN2: a case report

in Genetics of Common and Rare Diseases

Maorong Cai
Yang Liu
Zhaodi Liao
Yiping Wu
Jiantong Jiao

Frontiers in Genetics

doi 10.3389/fgene.2025.1672342

1,323 views

Case Report

Published on 10 Oct 2025

Case Report: Practical approach to differentiating juvenile parkinsonism of genetic cause and drug-induced parkinsonism in adolescents: a case series and literature review

in Genetics of Common and Rare Diseases

Ioana Grigore
Lăcrămioara Ionela Butnariu
Thomas Gabriel Schreiner
Vasile Valeriu Lupu
Ancuta Lupu
Ludmila Darie
Cătălin Prăzaru
Elena Țarcă
Setalia Popa
Ecaterina Grigore

Frontiers in Genetics

doi 10.3389/fgene.2025.1672445

1,585 views

Editorial

Published on 09 Oct 2025

Editorial: Application of next-generation sequencing in clinical settings

in Human and Medical Genomics

Zhi Chai
Han Mei
Quan Li
Iram Maqsood
Jingxian Cai
Marilyn M. Li
Feng Xu
Xiaonan Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1700975

3,650 views

Original Research

Published on 09 Oct 2025

The molecular characterization of seven novel GLI family zinc finger 3 (GLI3) variants in Chinese families with limb malformations

in Genetics of Common and Rare Diseases

Siyuan Tao
Xuyu Gu
Xiaodong Wang
Xiaofang Shen
Xiuli Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1650790

1,324 views

Original Research

Published on 08 Oct 2025

GTAT-GRN: a graph topology-aware attention method with multi-source feature fusion for gene regulatory network inference

in Computational Genomics

Shuran Wang
Lilian Zhang
Lutao Gao
Yao Rao
Jie Cui
Linnan Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1668773

2,205 views

Original Research

Published on 08 Oct 2025

Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease

in Neurogenomics

Xin Wang
Zelin Wu
Shaoli Wei
Xinran Zhao
Juan Lin
Fang Zhao
Xiaolei Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1676565

2,222 views

Data Report

Published on 08 Oct 2025

Catalogue of mitotic chromosome-associated small RNAs in mouse 3T3 cell line

in Human and Medical Genomics

Bishan Ye
Yicong Meng
Le Zhang
Yongzhuo Deng
Xuesong Zheng
Yihang Shen
Xinhui Li
Hua Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1559795

1,505 views

Perspective

Published on 08 Oct 2025

Ethical, legal, and policy dimensions and contentions for reanalysis and reinterpretation of clinical genetic testing results

in ELSI in Science and Genetics

Zachary T. Sentell
Ma’n H. Zawati

Frontiers in Genetics

doi 10.3389/fgene.2025.1685854

1,721 views

Review

Published on 08 Oct 2025

Epigenetic and metabolic reprogramming via nanotechnology: a synergistic approach to cancer vaccination in lung tumors

in Cancer Genetics and Oncogenomics

Min Xu
Xialin Zhang
Xinlin Yu
Cheng Ma
Xinwei Li
Gang Chen
Gang Yuan
Sheng Lin
Ran Cui

Frontiers in Genetics

doi 10.3389/fgene.2025.1666561

1,988 views
1 citation

Original Research

Published on 08 Oct 2025

Modulation of the lncRNA TCONS_00265853-miR-421-5p-CLOCK axis by Ziyin Buyang Formula in polycystic ovarian syndrome with circadian rhythm disruption: an integrated bioinformatics and experimental approach

in RNA

Haixia Huang
Ling Sun
Fan Jia
Yong Tan
Yahong Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1658812

1,952 views

Brief Research Report

Published on 08 Oct 2025

A novel splicing variant in NBAS identified by minigene assay causes infantile liver failure syndrome type 2

in Genetics of Common and Rare Diseases

Anna Hu
Jun Liang
Hongbo Liu
Jinghui Jiang
Fujing Xie
Xin Zhou
Xiaojia Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1687266

1,573 views

Review

Published on 08 Oct 2025

NanoMarine therapeutics: a new wave in drug delivery from oceanic bioresources targeting colon cancer via miRNA modulation

in RNA

Ramkumar Muthu
Rajkumar Manickam
Rajkumar Thamarai
Sivabalan Sivasamy
Karthikeyan Mahendran
Rajkumar Prabhakaran

Frontiers in Genetics

doi 10.3389/fgene.2025.1668618

3,335 views

Original Research

Published on 08 Oct 2025

Pain - related methylation driver genes affect the prognosis of pancreatic cancer patients by altering immune function and perineural infiltration

in Cancer Genetics and Oncogenomics

Chencheng Zhang
Weiwei Xu
Xudong Chen
Xingdan Wang
Xiaopeng Cui
Wenjing Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1600883

2,259 views

Editorial

Published on 08 Oct 2025

Editorial: Genetics and justice: the implications of large-scale genome sequencing initiatives in the global south

in ELSI in Science and Genetics

Michel Satya Naslavsky
Tayyaba Jiwani
Ernesto Schwartz-Marin

Frontiers in Genetics

doi 10.3389/fgene.2025.1703507

1,565 views

Correction

Published on 07 Oct 2025

Correction: FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway

in Cancer Genetics and Oncogenomics

Xiaoping Yang
Zuohui Yuan
Lingzhu Gou
Long Cheng
Zirui Wang
Pingfan Wu
Xiaochun Wang
Xueni Ma
Tiantian Ma
Yi Yu

Frontiers in Genetics

doi 10.3389/fgene.2025.1684479

1,292 views

Original Research

Published on 07 Oct 2025

Identification of shared diagnostic genes between osteoporosis and Crohn’s disease through integrated transcriptomic analysis and machine learning

in Computational Genomics

Guirong Yi
Peng Zhou
Qinxu Yang
Maosheng Zhao
Qiaoqiao Yang
Shensong Li
Chenpo Dang

Frontiers in Genetics

doi 10.3389/fgene.2025.1609915

2,170 views

Original Research

Published on 07 Oct 2025

A novel de novo IL2RG nonsense mutation in a pediatric patient with X-linked severe combined immunodeficiency

in Immunogenetics

Lin Wang
Aiyan Ren
Yuanyuan He
Lu Wang
Sixi Wang
Xin Xie
Mei Tan
Yan Chen
Pei Huang
Zuochen Du

Frontiers in Genetics

doi 10.3389/fgene.2025.1641956

3,160 views

Correction

Published on 07 Oct 2025

Correction: Multi-omics integration uncovers key transcriptional regulators in triple-negative breast cancer spatial heterogeneity

in Computational Genomics

Ning Zhang
Ye Zhang
Rui-Fei Yang
Min Tan
Hai-Qing Chu
Abdur Rehman
Lu-Yu Yang
Ya-Yu Li
Fahad M. Alshabrmi
Xin Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1701926

1,170 views

16,446 articles

articles

Identification of key genes for heart failure in dilated cardiomyopathy in different populations

Gene-LLMs: a comprehensive survey of transformer-based genomic language models for regulatory and clinical genomics

Ataxia, intentional tremor and hypotonia syndrome caused by a novel POU4F1 gene mutation: a case report

Correction: DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction

Transcriptomic profiling reveals macrophage gene signatures associated with lactylation-related pathways in chronic obstructive pulmonary disease

Editorial: The neurogenetics of brain wiring

Thoracic aortic aneurysm combined with intracranial vascular abnormalities caused by dual mutations in MYLK and FBN2: a case report

Case Report: Practical approach to differentiating juvenile parkinsonism of genetic cause and drug-induced parkinsonism in adolescents: a case series and literature review

Editorial: Application of next-generation sequencing in clinical settings

The molecular characterization of seven novel GLI family zinc finger 3 (GLI3) variants in Chinese families with limb malformations

GTAT-GRN: a graph topology-aware attention method with multi-source feature fusion for gene regulatory network inference

Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease

Catalogue of mitotic chromosome-associated small RNAs in mouse 3T3 cell line

Ethical, legal, and policy dimensions and contentions for reanalysis and reinterpretation of clinical genetic testing results

Epigenetic and metabolic reprogramming via nanotechnology: a synergistic approach to cancer vaccination in lung tumors

Modulation of the lncRNA TCONS_00265853-miR-421-5p-CLOCK axis by Ziyin Buyang Formula in polycystic ovarian syndrome with circadian rhythm disruption: an integrated bioinformatics and experimental approach

A novel splicing variant in NBAS identified by minigene assay causes infantile liver failure syndrome type 2

NanoMarine therapeutics: a new wave in drug delivery from oceanic bioresources targeting colon cancer via miRNA modulation

Pain - related methylation driver genes affect the prognosis of pancreatic cancer patients by altering immune function and perineural infiltration

Editorial: Genetics and justice: the implications of large-scale genome sequencing initiatives in the global south

Correction: FEZF1-AS1 drives autophagy-mediated progression of colon cancer and reduces chemosensitivity through inhabiting the PI3K/AKT/mTOR signaling pathway

Identification of shared diagnostic genes between osteoporosis and Crohn’s disease through integrated transcriptomic analysis and machine learning

A novel de novo IL2RG nonsense mutation in a pediatric patient with X-linked severe combined immunodeficiency

Correction: Multi-omics integration uncovers key transcriptional regulators in triple-negative breast cancer spatial heterogeneity