Frontiers in Genetics

Editorial

Published on 24 Nov 2025

Editorial: Unraveling the mysteries of aging and the brain: advancements in understanding neurodegenerative diseases and dementia

in Genetics of Aging

Victoria Campos-Peña

Frontiers in Genetics

doi 10.3389/fgene.2025.1745907

1,221 views

Mini Review

Published on 24 Nov 2025

Ecuador genetic mosaic: biological and adaptive variations across Mestizos, Native Amerindians, and Afro-Ecuadorians. Implications for public health and precision medicine

in Evolutionary and Population Genetics

Fabricio González-Andrade

Frontiers in Genetics

doi 10.3389/fgene.2025.1699402

1,861 views

Case Report

Published on 21 Nov 2025

Case Report: Mild BRIC-like cholestasis despite a gross USP53 deletion—novel findings and literature review

in Genetics of Common and Rare Diseases

Ekaterina Nuzhnaya
Tatiana Cherevatova
Ekaterina Lotnik
Aleksandra Shagiazdanova
Zhanna Markova
Ekaterina Filimonova
Olga Parshina
Anastasiia Buianova
Anastasia Bobreshova
Andrey Marakhonov

Frontiers in Genetics

doi 10.3389/fgene.2025.1670664

1,360 views

Original Research

Published on 21 Nov 2025

Transcriptome-wide m6A landscape across diverse porcine tissues revealed by nanopore direct RNA sequencing

in Livestock Genomics

Yaya Liao
Zifeng Ding
Xiaoyun Chen
Chao Yin
Bin Yang
Qiang Yang
Yuyun Xing

Frontiers in Genetics

doi 10.3389/fgene.2025.1725608

1,648 views

Original Research

Published on 20 Nov 2025

Benign mosaic chromosomal structural variants across generations: evidence for a developmental correction mechanism from clinical and computational models

in Human and Medical Genomics

Jiayu Ruan
Qinhao Song
Yue Hu
Xiaodan Liu
Suping Li
Jianjun Zhu
Li Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1710280

1,297 views
1 citation

Methods

Published on 20 Nov 2025

A network-based discovery of prognostic markers in recurrent IDH wild-type gliomas

in Computational Genomics

Yang Liu
Jason Huse
Kasthuri Kannan

Frontiers in Genetics

doi 10.3389/fgene.2025.1672015

1,481 views

Opinion

Published on 20 Nov 2025

Why all MODY variants in transcription factor genes are dominantly inherited

in Genetics of Common and Rare Diseases

Roman Zug

Frontiers in Genetics

doi 10.3389/fgene.2025.1690468

1,443 views

Review

Published on 20 Nov 2025

Bioinformatics identification of key genes and therapeutic targets for exercise intervention in polycystic ovary syndrome

in Computational Genomics

Xiaodie Yang
Hong Yang
Dongyi Shen
Qiang Zhang
Chan Zhu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634588

1,581 views

Original Research

Published on 20 Nov 2025

Five novel EP300 variants expand the genetic and phenotypic spectrum of Rubinstein–Taybi syndrome type 2 in Chinese patients

in Neurogenomics

Qiang Zhang
Qi Yang
Xunzhao Zhou
Zailong Qin
Jingsi Luo

Frontiers in Genetics

doi 10.3389/fgene.2025.1690693

1,448 views

Original Research

Published on 20 Nov 2025

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells

in Cancer Genetics and Oncogenomics

Xiaobo Guo
Gang Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1694089

1,493 views

Original Research

Published on 19 Nov 2025

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels

in Genetics of Common and Rare Diseases

Yongyan Song
Ting Wang
Mi Su
Xue Wang
Youjin Zhang
Jia Pan
Yunhan Wang
Jin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1659460

1,390 views

Original Research

Published on 19 Nov 2025

Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis

in Computational Genomics

Yinfei Lu
Zao Tang
Xiangyu Zhou
Wanting Lin
Xiao Guo

Frontiers in Genetics

doi 10.3389/fgene.2025.1655000

1,644 views

Review

Published on 19 Nov 2025

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential

in Genomic Assay Technology

Duaa Elshiekh
Nour Farchoukh
Reema El Hassan
Sara Al-Marzooqi
Waad Rashed Aldosari
Haissam Abou-Saleh
Amal Al-Haidose
Hatem Zayed
Atiyeh M. Abdallah

Frontiers in Genetics

doi 10.3389/fgene.2025.1621081

2,399 views

Case Report

Published on 18 Nov 2025

MAPT mutation-induced behavioral variant frontotemporal dementia in an Asian patient: a multimodal biomarker case report resolving diagnostic challenges with Alzheimer’s disease

in Genetics of Common and Rare Diseases

Yan Zhang
Siwei Chen
Guiying Yan
Zhifei Zhang
Amina
Ting Wang
Shuang Wang
Chen Zhang
Yong’an Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1645068

1,726 views

Original Research

Published on 18 Nov 2025

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma

in Cancer Genetics and Oncogenomics

Qiyue Zhao
Huadong Xie
Chaofu Li
Yanxiang Xiong
Yongyi Fan
Yuanbi Huang
Yi Zhan
Siping Zeng

Frontiers in Genetics

doi 10.3389/fgene.2025.1605078

1,987 views

Original Research

Published on 17 Nov 2025

Phenotype and genetic variation analysis of primary congenital lymphedema caused by FLT4 gene mutations in a fetus

in Genetics of Common and Rare Diseases

Shanshan Zhai
Limin Yuan
Jing Li
Ling Liu
Lulu Hu
Yanjie Ban
Xuewen Yang
Jie Yang
Xuezhe Ouyang
Nana Huang

Frontiers in Genetics

doi 10.3389/fgene.2025.1700635

1,279 views

Original Research

Published on 17 Nov 2025

Genetic evolution of parental populations and construction of core germplasm populations in qinghai spruce seed orchard based on SLAF-seq technology

in Evolutionary and Population Genetics

Hu Zhao
Erwen Xu
Dong Lv
Wei Li
Xingpeng Zhao
Xin Jia
Hao Yuan
Rong Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1712106

1,527 views

Original Research

Published on 17 Nov 2025

Single-cell RNA-seq combined with bulk RNA-seq explores shared gene signatures between thyroid and breast cancers

in Cancer Genetics and Oncogenomics

Zhiping Feng
Liang He
Xin Yang
Anhao Wu
Jingnan Wang
Yuanhua Song
Yongchun Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1609189

1,549 views

Original Research

Published on 17 Nov 2025

Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis

in Genetics of Common and Rare Diseases

Ying Dong
Hong-Song Ge
Rui-Xue Chang
Jing Chu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634874

2,537 views

Editorial

Published on 17 Nov 2025

Editorial: Precision trait mapping and molecular breeding in high-impact crop plants

in Genetics and Genomics of Plants and Plant-Associated Organisms

Dinesh Kumar Saini
Mamta Gupta
Alla Singh
Mehak Sethi
Veena Devi
Reyazul Rouf Mir

Frontiers in Genetics

doi 10.3389/fgene.2025.1736266

1,886 views

Original Research

Published on 17 Nov 2025

Genetic background of behavior traits in lactating sows under heat-stress conditions and their relationship with heat tolerance and maternal performance traits

in Livestock Genomics

Sharlene O. Hartman
Lorena F. Benfica
Jay S. Johnson
Jeremy N. Marchant
Hinayah R. Oliveira
Victor B. Pedrosa
Allan P. Schinckel
Yijian Huang
Leonardo S. Gloria
Hui Wen

Frontiers in Genetics

doi 10.3389/fgene.2025.1688262

1,598 views

Case Report

Published on 14 Nov 2025

Familial Xq27.1q28 duplication arising from a maternal interarm forward insertion of the X chromosome: a case report

in Genetics of Common and Rare Diseases

Xiang Li
Yuan-Mei Peng
Bo-Wen Luo
Yu-Di Luo
Yun-Rong Qin
Keng Feng
De-Rong Li
Zeng-Yu Yang
Ling-Ling Zhu
Jin-Jie Pan

Frontiers in Genetics

doi 10.3389/fgene.2025.1514856

1,567 views

Original Research

Published on 14 Nov 2025

Novel variant in PNPLA6 gene causes Oliver-McFarlane syndrome in a Chinese family: 13 years follow-up

in Genetics of Common and Rare Diseases

Panpan Xiao
Yonghua Gu
Xiaolong Qi
Ting Li
Tingting Zuo
Yule Xie
Shuang Zhang
Xunlun Sheng

Frontiers in Genetics

doi 10.3389/fgene.2025.1693876

1,190 views

Case Report

Published on 14 Nov 2025

Case Report: Identification and functional characterization of a novel heterozygous splice-donor (c.647+1G>A) site mutation in the SPTB gene that causes hereditary spherocytosis with hemolytic anemia

in Genetics of Common and Rare Diseases

Ke Cao
Xiaojuan Luo
Lianlian Liu
Xiaoning Mao
Ruping Liu
Yunsheng Chen
Santasree Banerjee

Frontiers in Genetics

doi 10.3389/fgene.2025.1626155

1,356 views

16,577 articles

articles

Editorial: Unraveling the mysteries of aging and the brain: advancements in understanding neurodegenerative diseases and dementia

Ecuador genetic mosaic: biological and adaptive variations across Mestizos, Native Amerindians, and Afro-Ecuadorians. Implications for public health and precision medicine

Case Report: Mild BRIC-like cholestasis despite a gross USP53 deletion—novel findings and literature review

Transcriptome-wide m6A landscape across diverse porcine tissues revealed by nanopore direct RNA sequencing

Benign mosaic chromosomal structural variants across generations: evidence for a developmental correction mechanism from clinical and computational models

A network-based discovery of prognostic markers in recurrent IDH wild-type gliomas

Why all MODY variants in transcription factor genes are dominantly inherited

Bioinformatics identification of key genes and therapeutic targets for exercise intervention in polycystic ovary syndrome

Five novel EP300 variants expand the genetic and phenotypic spectrum of Rubinstein–Taybi syndrome type 2 in Chinese patients

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels

Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential

MAPT mutation-induced behavioral variant frontotemporal dementia in an Asian patient: a multimodal biomarker case report resolving diagnostic challenges with Alzheimer’s disease

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma

Phenotype and genetic variation analysis of primary congenital lymphedema caused by FLT4 gene mutations in a fetus

Genetic evolution of parental populations and construction of core germplasm populations in qinghai spruce seed orchard based on SLAF-seq technology

Single-cell RNA-seq combined with bulk RNA-seq explores shared gene signatures between thyroid and breast cancers

Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis

Editorial: Precision trait mapping and molecular breeding in high-impact crop plants

Genetic background of behavior traits in lactating sows under heat-stress conditions and their relationship with heat tolerance and maternal performance traits

Familial Xq27.1q28 duplication arising from a maternal interarm forward insertion of the X chromosome: a case report

Novel variant in PNPLA6 gene causes Oliver-McFarlane syndrome in a Chinese family: 13 years follow-up

Case Report: Identification and functional characterization of a novel heterozygous splice-donor (c.647+1G>A) site mutation in the SPTB gene that causes hereditary spherocytosis with hemolytic anemia