Frontiers in Genetics

Editorial

Published on 28 Aug 2025

Editorial: Emerging relevance of molecular profiling in global cancer research and management

in Cancer Genetics and Oncogenomics

Premila Leiphrakpam
Srijan Shukla
Chandrakanth Are

Frontiers in Genetics

doi 10.3389/fgene.2025.1679501

1,499 views

Original Research

Published on 26 Aug 2025

Novel estrogen-related gene variants identified by whole-exome sequencing in pregnancy-associated intrahepatic cholestasis

in Human and Medical Genomics

Hua Lai
Siming Xin
Jinliang Zhang
Yang Hu
Wenjuan Fan
Hong Wan
Bowen Chen
Yang Zou
Xiaoming Zeng
Xianxian Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1626890

2,509 views

Original Research

Published on 26 Aug 2025

Compound heterozygous missense and intronic variants in B9D1 contribute to a recurrent Meckel syndrome pedigree

in Statistical Genetics and Methodology

Huining Jing
Bocheng Xu
Hao Wang
Shanling Liu
He Wang
Jingqun Mai
Wencong Yao
Zhu Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1663455

2,507 views

Original Research

Published on 25 Aug 2025

DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction

in Computational Genomics

Guohua Huang
Runjuan Xiao
Chunying Peng
Jinyun Jiang
Weihong Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1622899

1,755 views

Original Research

Published on 25 Aug 2025

VCAM-1 predicts poor prognosis and modulates immune infiltration in gastric cancer: a TCGA-based bioinformatics study

in Cancer Genetics and Oncogenomics

Cheng Wu
Yungeng Liu
Chuanyuan Liu
Chuanfa Fang

Frontiers in Genetics

doi 10.3389/fgene.2025.1602929

2,007 views

Original Research

Published on 25 Aug 2025

Analysis of complex chromosomal structural variants through optical genome mapping integrated with karyotyping

in Cytogenomics

Xiaoxi Zhu
Huiling Zheng
Xue Wan
Hang Duan
Ying Qi
Weijia Tang
Fan Yang
Limei Yu

Frontiers in Genetics

doi 10.3389/fgene.2025.1605461

3,709 views

Original Research

Published on 25 Aug 2025

A retrospective study for the diagnostic value of chromosomal microarray analysis in fetuses with high-risk prenatal indications

in Human and Medical Genomics

Hui Xiao
Junfang Xiao
Huan Zhang
Shuhui Huang
Qing Lu
Huizhen Yuan
Yongyi Zou
Bicheng Yang
Yanqiu Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1649253

2,123 views

Original Research

Published on 25 Aug 2025

Prevalence and penetrance of pathogenic and likely pathogenic LDLR and APOB gene variants linked to familial hypercholesterolemia and increased risk of ischemic heart disease

in Applied Genetic Epidemiology

I. K. Dzhumaniiazova
A. N. Meshkov
V.V. Daniel
M. V. Ezhov
E. A. Zelenova
U. V. Chubykina
D.A. Kashtanova
M. V. Ivanov
L. R. Matkava
O. I. Blinova

Frontiers in Genetics

doi 10.3389/fgene.2025.1589014

3,290 views

Original Research

Published on 25 Aug 2025

Comparative analysis of sex-dependent serum metabolomic patterns across the lifespan of rhesus macaques

in Genetics of Aging

Ludwig A. P. Metzler
Robinson W. Goy
Jeanette M. Metzger
Marina E. Emborg
Amita Kapoor

Frontiers in Genetics

doi 10.3389/fgene.2025.1655325

2,712 views

Original Research

Published on 25 Aug 2025

Drought adaptation index (DAI) based on BLUP as a selection approach for drought-resilient switchgrass germplasm

in Genomics of Plants and the Phytoecosystem

Shiva Om Makaju
Hari Bahadur Chhetri
Chanaka Roshan Abeyratne
Mirko Pavicic
Hari Poudel
Jazib Ali Irfan
Anita Giabardo
Katrien M. Devos
Daniel Jacobson
Ali Mekki Missaoui

Frontiers in Genetics

doi 10.3389/fgene.2025.1626083

3,283 views
1 citation

Original Research

Published on 22 Aug 2025

Genome-wide association study on dairy goat milk production traits using three models

in Livestock Genomics

Zhengang Huang
Yuanping Tang
Jianyu Zhou
Dongliang Xu
Xiaokun Lin
Ming Cheng
Jianguang Wang
Qinan Zhao
Jianning He
Xiaoxiao Gao

Frontiers in Genetics

doi 10.3389/fgene.2025.1650836

2,869 views

Original Research

Published on 22 Aug 2025

Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions

in Genetics of Aging

María Aránzazu Penedo
Héctor Cañeque-Rufo
Esther Gramage
Gonzalo Herradón

Frontiers in Genetics

doi 10.3389/fgene.2025.1634202

3,026 views

Original Research

Published on 22 Aug 2025

Multi-omic insights into mitochondrial dysfunction and prostatic disease: evidence from transcriptomics, proteomics, and methylomics

in Computational Genomics

Binbin Gong
Feixiang Yang
Ning Zhang
Zhengyang Wu
Tianrui Liu
Kun Wang
Xiangyu Zhang
Yangyang Zhang
Zhengyao Song
Chaozhao Liang

Frontiers in Genetics

doi 10.3389/fgene.2025.1609933

3,307 views

Original Research

Published on 22 Aug 2025

Japanese attitudes toward cell donation in human brain organoid research: many oppose broad consent

in ELSI in Science and Genetics

Masanori Kataoka
Mayu Koike
Tsutomu Sawai

Frontiers in Genetics

doi 10.3389/fgene.2025.1606923

3,537 views

Original Research

Published on 22 Aug 2025

Novel pathogenic splicing mutation in COL11A1 in a patient with Stickler syndrome verified by minigene splicing assay

in Genetics of Common and Rare Diseases

Jie Zhang
Yaxin Huang
Yafei Deng
Xiaochun Yang
Hong Shi
Yuecheng Yang
Tao Lv
Yuanlong Yan
Ming He
Fang Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1642604

1,829 views

Review

Published on 21 Aug 2025

A decade of research on genetic privacy: the findings of the GetPreCiSe Center at Vanderbilt University

in ELSI in Science and Genetics

Christopher Slobogin
Karli Tellis
Ellen Wright Clayton
Jay Clayton
Ayden Eilmus
Bradley A. Malin

Frontiers in Genetics

doi 10.3389/fgene.2025.1629386

3,355 views
2 citations

Original Research

Published on 21 Aug 2025

Comparative genomic insights into adaptation, selection signatures, and population dynamics in indigenous Indian sheep and foreign breeds

in Livestock Genomics

Malarmathi Muthusamy
Oludayo Michael Akinsola
Pritam Pal
Chitra Ramasamy
Saravanan Ramasamy
Abdulraheem Arome Musa
Aranganoor Kannan Thiruvenkadan

Frontiers in Genetics

doi 10.3389/fgene.2025.1621960

2,703 views
1 citation

Correction

Published on 21 Aug 2025

Correction: Analysis and validation of novel biomarkers related to palmitoylation in adenomyosis

in Computational Genomics

Hongyu Zhang
Yufeng Li
Huijuan Cao
Yiling Zhao
Hongwen Zhu
Tiansheng Qin

Frontiers in Genetics

doi 10.3389/fgene.2025.1683914

1,137 views

Case Report

Published on 21 Aug 2025

Case Report: Pathogenic PNPLA2 variants and nonsense-mediated mRNA decay result in an early-onset neutral lipid storage disease with myopathy

in Genetics of Common and Rare Diseases

Sara Missaglia
Eleonora Martegani
Corrado Angelini
Rita Horvath
Veronika Karcagi
Endre Pal
Daniela Tavian

Frontiers in Genetics

doi 10.3389/fgene.2025.1642442

1,920 views

Original Research

Published on 21 Aug 2025

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma

in RNA

Minglu Zhang
Jianbo He
Rao Fu
Guojian Bao
Yijun Lu
Zechuan Zhang
Jiawu Yan
Jialu Ding
Fei Yang
Beicheng Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1620552

2,681 views

Original Research

Published on 20 Aug 2025

Unraveling the pathogenicity role of the novel compound heterozygous mutations of MED25 gene in a Chinese patient with BVSYS

in Statistical Genetics and Methodology

Linbing Zou
Ruikang Qiu
Zhijun Dai
Yulei Li
Yunjiao Liao
Yan Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1654336

2,729 views

Original Research

Published on 20 Aug 2025

A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China

in Human and Medical Genomics

Meirong Feng
Yan Chai
Jinna Li
Qi Wang
Dekui Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1619911

3,130 views

Editorial

Published on 20 Aug 2025

Editorial: Rare diseases research and diagnosis in low- and middle-income countries

in Genetics of Common and Rare Diseases

Claudia Gonzaga-Jauregui
Ferran Casals
Vajira H. W. Dissanayake

Frontiers in Genetics

doi 10.3389/fgene.2025.1675361

1,635 views
1 citation

Editorial

Published on 19 Aug 2025

Editorial: Genome-wide identification of functional markers to enhance molecular breeding efforts in agriculturally important, underutilized, and less explored plant species

in Genomics of Plants and the Phytoecosystem

Rajni Parmar
Sapna Thakur
Ram Kumar Sharma

Frontiers in Genetics

doi 10.3389/fgene.2025.1627482

1,812 views

16,444 articles

articles

Editorial: Emerging relevance of molecular profiling in global cancer research and management

Novel estrogen-related gene variants identified by whole-exome sequencing in pregnancy-associated intrahepatic cholestasis

Compound heterozygous missense and intronic variants in B9D1 contribute to a recurrent Meckel syndrome pedigree

DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction

VCAM-1 predicts poor prognosis and modulates immune infiltration in gastric cancer: a TCGA-based bioinformatics study

Analysis of complex chromosomal structural variants through optical genome mapping integrated with karyotyping

A retrospective study for the diagnostic value of chromosomal microarray analysis in fetuses with high-risk prenatal indications

Prevalence and penetrance of pathogenic and likely pathogenic LDLR and APOB gene variants linked to familial hypercholesterolemia and increased risk of ischemic heart disease

Comparative analysis of sex-dependent serum metabolomic patterns across the lifespan of rhesus macaques

Drought adaptation index (DAI) based on BLUP as a selection approach for drought-resilient switchgrass germplasm

Genome-wide association study on dairy goat milk production traits using three models

Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions

Multi-omic insights into mitochondrial dysfunction and prostatic disease: evidence from transcriptomics, proteomics, and methylomics

Japanese attitudes toward cell donation in human brain organoid research: many oppose broad consent

Novel pathogenic splicing mutation in COL11A1 in a patient with Stickler syndrome verified by minigene splicing assay

A decade of research on genetic privacy: the findings of the GetPreCiSe Center at Vanderbilt University

Comparative genomic insights into adaptation, selection signatures, and population dynamics in indigenous Indian sheep and foreign breeds

Correction: Analysis and validation of novel biomarkers related to palmitoylation in adenomyosis

Case Report: Pathogenic PNPLA2 variants and nonsense-mediated mRNA decay result in an early-onset neutral lipid storage disease with myopathy

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma

Unraveling the pathogenicity role of the novel compound heterozygous mutations of MED25 gene in a Chinese patient with BVSYS

A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China

Editorial: Rare diseases research and diagnosis in low- and middle-income countries

Editorial: Genome-wide identification of functional markers to enhance molecular breeding efforts in agriculturally important, underutilized, and less explored plant species