Frontiers in Genetics

Original Research

Published on 21 Oct 2025

A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer

in Cancer Genetics and Oncogenomics

Xuming Hu
Ye Wei
Meiying Zhang
Chunfeng Dou
Liping Wang
Gul Zaib
Huixian Wu
Wang Guo
Xiaoyuan Wang
Shihao Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1552009

2,438 views

Original Research

Published on 21 Oct 2025

Recognition of HSPB8 as a potential therapeutic target for prostate cancer

in Cancer Genetics and Oncogenomics

Xun Fu
Yutao Wang
Hongjun Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1680674

2,028 views
1 citation

Original Research

Published on 21 Oct 2025

In vitro cell model to dilucidate the underlying molecular mechanism associated with ophthalmic manifestation of congenital disorders of glycosylation: studying an ALG2-CDG patient

in Genetics of Common and Rare Diseases

Marisa Angelica Cubilla
Ana Clara Sclausero
Mariano Bisbal
Carla Gabriela Asteggiano

Frontiers in Genetics

doi 10.3389/fgene.2025.1678103

1,934 views

Original Research

Published on 20 Oct 2025

DLL1 haploinsufficiency in prenatal brain anomalies: a retrospective analysis of 6q terminal deletions

in Cytogenomics

Tingting Ge
Xiaojuan Lin
Xinyuan Tian
Xiaoyu Song
Bingbo Zhou
Ling Hui
Xiaozhuan Wang
Zhiqiang Zhang
Chuan Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1640775

1,900 views

Case Report

Published on 17 Oct 2025

Case Report: von Hippel-Lindau (VHL) disease: a young female presenting with multiple organ tumors

in Genetics of Common and Rare Diseases

Jingyuan Li
Yun Ti
Xiao Yang
Keqiang Yan
Tongshuai Chen
Tao Guo
Qin Hu
Cheng Zhang
Peili Bu

Frontiers in Genetics

doi 10.3389/fgene.2025.1676039

2,210 views

Original Research

Published on 17 Oct 2025

Genetic and clinical landscape of Duchenne muscular dystrophy in Guatemala: insights from a national study

in Genetics of Common and Rare Diseases

M. Orozco
E. Kestler
G. Ramirez
G. Silva
J. Cabrera
S. De la Vega
A. Al Khleifat

Frontiers in Genetics

doi 10.3389/fgene.2025.1595423

2,436 views
1 citation

Original Research

Published on 17 Oct 2025

Genome-wide identification of selection signals in fat-tailed and thin-tailed sheep populations

in Livestock Genomics

Lei Gao
Yiyuan Zhang
Bin Zhang
Weifeng Peng
Yucheng Liu
Zhenliang Zhang
Jingjing Wang
Pengcheng Wan
Hua Yang
Zongsheng Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1581914

2,071 views

Original Research

Published on 17 Oct 2025

Association of APOA5 rs2075291 and CIDEB rs2144492 polymorphisms with hypertriglyceridemia in individuals with traditional Chinese medicine dampness syndrome: a case-control study

in Applied Genetic Epidemiology

Na Liu
Hongli Zeng
Xiangsheng Cai
Shuo Yang
Xinyan Chen
Guli Jiang
Jiamin Yuan
Jianxiong Cai
Hui Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1654501

1,511 views

Original Research

Published on 16 Oct 2025

A novel deletion upstream of POU3F4 in a Chinese family with X-linked deafness 2 and a literature review

in Genetics of Common and Rare Diseases

Yanting Yang
Shengwen Huang
Yao Liu
Dan Mu
Ting Bai
Xiaosha Jing
Lingling Xing
Hongqian Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1641999

1,990 views

Original Research

Published on 16 Oct 2025

A novel dinucleotide variant at 5′ splice sites in the F8 gene causes exon 19 skipping in a Chinese family with hemophilia A

in Statistical Genetics and Methodology

Xunzhao Zhou
Qi Yang
Qiuli Chen
Sheng Yi
Shengkai Wei
Jingsi Luo
Dahua Meng
Zailong Qin
Shujie Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1686184

1,777 views

Original Research

Published on 16 Oct 2025

CGSDA: inferring snoRNA-disease associations via ChebNetII and GatedGCN

in Computational Genomics

Yongfu Zou
Yusong Lu
Shanghui Lu
Zhanliang Wei
Le Li
Shuilin Liao
Ting Zeng
Yi Zhang
Rui Miao

Frontiers in Genetics

doi 10.3389/fgene.2025.1684484

1,543 views

Original Research

Published on 16 Oct 2025

Whole exome sequencing identifies concurrent LDLR and ABCG8 mutations in a Saudi family with familial hypercholesterolemia and Sitosterolaemia

in Genetics of Common and Rare Diseases

Abdulrahman Hummadi
Dhayf Alrahman Mutawwam
Babajan Banaganapalli
Fai Alsubhi
Naji J. Aljohani
Ali J. Alhagawy
Turki Algohani
Ibrahim Fallatah
Mohammed Y. Daghriry
Rawan K. Alharbi

Frontiers in Genetics

doi 10.3389/fgene.2025.1679594

2,926 views

Original Research

Published on 16 Oct 2025

Transcriptome profiling of hypothalamus-pituitary-ovary axis provides insights into egg-laying interval differences between european meat pigeons and shiqi pigeons

in Livestock Genomics

Xinlei Wang
Liyu Yang
Ruiting Li
Liheng Zhang
Zhanbing Han
Runzhi Wang
Qiang Li
Dingding Zhang
Mingjun Yang
Pengkun Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1676255

2,089 views

Original Research

Published on 16 Oct 2025

Identification and validation of selenium metabolism-related genes in lung adenocarcinoma prognosis using bioinformatics analysis

in Cancer Genetics and Oncogenomics

Yun Chen
Ping Li
Yang Wang
Shuai Shen
Ni Chen
Hao Peng
Zheyuan Xu

Frontiers in Genetics

doi 10.3389/fgene.2025.1655262

1,918 views

Brief Research Report

Published on 15 Oct 2025

A rare subtype of lynch syndrome familial with co-mutation of EpCAM c.344T>C, MSH2 c.2744A>G, PMS2 c.1408C>T and APC c.5465T>A, case report and literature review

in Cancer Genetics and Oncogenomics

Guiyu Lu
Ting Pan
Cuidong Deng
Xiaoqian Wan
Zihan Wang
Tengyue Hu
Xianshuo Cheng
Jian Dong

Frontiers in Genetics

doi 10.3389/fgene.2025.1667899

2,459 views

Original Research

Published on 15 Oct 2025

Clinical and genetic analysis of MOCOS gene-related hypouricemia

in Genetics of Common and Rare Diseases

Huifang Peng
Ping Tu
Qiaobo Ma
Jinpeng Tang
Wannv Xiao
Xinyu Hu
Yingyu Zhang
Hongwei Jiang

Frontiers in Genetics

doi 10.3389/fgene.2025.1636032

1,957 views

Original Research

Published on 15 Oct 2025

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells

in RNA

Akito Yoshida
Yuqian Song
Hotaru Takaine
Sujin Song
Nonoka Konishi
Yu-Hsien Hwang-Fu
Zachary Johnson
Kiyoe Ura
Akira Sassa

Frontiers in Genetics

doi 10.3389/fgene.2025.1663827

14,874 views
1 citation

Review

Published on 14 Oct 2025

CircZFR functions in cancer from molecular networks to precision therapy

in RNA

Jinniang Nan
Min Li
Xinru Li
Yuqing Guo
Ziye Cai
Zekang Deng
Chengyi Zhan
Jiacheng Li
Shuying Liu
Ziyi Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1694220

2,422 views
1 citation

Original Research

Published on 14 Oct 2025

Identification of key genes for heart failure in dilated cardiomyopathy in different populations

in Computational Genomics

Yue Yu
Chentian Xue
Dong Ji
Wei Sheng
Xiang Gao
Xize Wu
Chengyan Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1618390

2,881 views

Review

Published on 14 Oct 2025

Gene-LLMs: a comprehensive survey of transformer-based genomic language models for regulatory and clinical genomics

in Computational Genomics

P. Balakrishnan
A. Anny Leema
V. Dhivya Shree
C. Mohammad Saad
A. Mohan Babu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634882

6,662 views

Case Report

Published on 14 Oct 2025

Ataxia, intentional tremor and hypotonia syndrome caused by a novel POU4F1 gene mutation: a case report

in Neurogenomics

Qisheng Hu
Feng Zhu
Wanfen Wang
Yihang Xu
Haiyan Ren
Yanni Zheng
Yiqing Jiang
Shaofa Ke

Frontiers in Genetics

doi 10.3389/fgene.2025.1702803

1,858 views

Correction

Published on 13 Oct 2025

Correction: DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction

in Computational Genomics

Guohua Huang
Runjuan Xiao
Chunying Peng
Jinyun Jiang
Weihong Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1704319

937 views

Original Research

Published on 13 Oct 2025

Transcriptomic profiling reveals macrophage gene signatures associated with lactylation-related pathways in chronic obstructive pulmonary disease

in Epigenomics and Epigenetics

Hui Guo
Weilin Sun
Fang Zhao
Yang Yu
Xiaoyun Zhao
Daqiang Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1653163

4,045 views

Editorial

Published on 13 Oct 2025

Editorial: The neurogenetics of brain wiring

in Behavioral and Psychiatric Genetics

Ting Feng
Wenfeng Chen
Aja McDonagh
Zhenxing Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1699487

2,091 views

16,584 articles

articles

A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer

Recognition of HSPB8 as a potential therapeutic target for prostate cancer

In vitro cell model to dilucidate the underlying molecular mechanism associated with ophthalmic manifestation of congenital disorders of glycosylation: studying an ALG2-CDG patient

DLL1 haploinsufficiency in prenatal brain anomalies: a retrospective analysis of 6q terminal deletions

Case Report: von Hippel-Lindau (VHL) disease: a young female presenting with multiple organ tumors

Genetic and clinical landscape of Duchenne muscular dystrophy in Guatemala: insights from a national study

Genome-wide identification of selection signals in fat-tailed and thin-tailed sheep populations

Association of APOA5 rs2075291 and CIDEB rs2144492 polymorphisms with hypertriglyceridemia in individuals with traditional Chinese medicine dampness syndrome: a case-control study

A novel deletion upstream of POU3F4 in a Chinese family with X-linked deafness 2 and a literature review

A novel dinucleotide variant at 5′ splice sites in the F8 gene causes exon 19 skipping in a Chinese family with hemophilia A

CGSDA: inferring snoRNA-disease associations via ChebNetII and GatedGCN

Whole exome sequencing identifies concurrent LDLR and ABCG8 mutations in a Saudi family with familial hypercholesterolemia and Sitosterolaemia

Transcriptome profiling of hypothalamus-pituitary-ovary axis provides insights into egg-laying interval differences between european meat pigeons and shiqi pigeons

Identification and validation of selenium metabolism-related genes in lung adenocarcinoma prognosis using bioinformatics analysis

A rare subtype of lynch syndrome familial with co-mutation of EpCAM c.344T>C, MSH2 c.2744A>G, PMS2 c.1408C>T and APC c.5465T>A, case report and literature review

Clinical and genetic analysis of MOCOS gene-related hypouricemia

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells

CircZFR functions in cancer from molecular networks to precision therapy

Identification of key genes for heart failure in dilated cardiomyopathy in different populations

Gene-LLMs: a comprehensive survey of transformer-based genomic language models for regulatory and clinical genomics

Ataxia, intentional tremor and hypotonia syndrome caused by a novel POU4F1 gene mutation: a case report

Correction: DeepRNAac4C: a hybrid deep learning framework for RNA N4-acetylcytidine site prediction

Transcriptomic profiling reveals macrophage gene signatures associated with lactylation-related pathways in chronic obstructive pulmonary disease

Editorial: The neurogenetics of brain wiring