Frontiers in Genetics

Original Research

Published on 17 Sep 2025

Genetic and in silico functional characterization of a novel structural variant in the PAH gene by long-reads sequencing and structural modeling

in Computational Genomics

Viviana Gallardo
Alexis Gaete
Jonathan Maldonado
Paulina Morales
Angela Peña
Valerie Hamilton
Víctor Faundes
Lorena Santa María

Frontiers in Genetics

doi 10.3389/fgene.2025.1669007

2,479 views

Original Research

Published on 16 Sep 2025

Identification and validation of three tumor suppressors associated with the immune response of acute myeloid leukemia

in Cancer Genetics and Oncogenomics

Yueyuan Pan
Guocai Wu
Chenchen Liu
Minggui Chen
Tian Xia
Yonghua Ma
Zhigang Yang
Ruiting Wen

Frontiers in Genetics

doi 10.3389/fgene.2025.1652142

3,586 views

Original Research

Published on 16 Sep 2025

The hidden in plain sight: global, regional, and national trends in the pediatric burden of Klinefelter syndrome, 1990–2021

in Applied Genetic Epidemiology

Guoqian Ma
Yuan Li
Fan Jia

Frontiers in Genetics

doi 10.3389/fgene.2025.1639699

4,170 views

Original Research

Published on 15 Sep 2025

Characterization of the phenotype and function of PRELP+ fibroblast subtype in liver metastatic colorectal cancer

in Cancer Genetics and Oncogenomics

Yuting Dai
Xingying Huang
Min Sun
Shiyu Zhang
Weiqiang Yu
Kongwang Hu
Qiang Wu
Qingfa Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1615259

3,517 views

Original Research

Published on 15 Sep 2025

Functional characterization of MFSD3 in auditory system and zebrafish embryogenesis

in Genetics of Common and Rare Diseases

Ying Ma
Shi-Wei Qiu
Wei-Qian Wang
Hai-Feng Feng
Lu Zheng
Ge-Ge Wei
Hui-Yi Nie
Jin-Yuan Yang
Yi-Jin Chen
Pu Dai

Frontiers in Genetics

doi 10.3389/fgene.2025.1634493

2,214 views

Original Research

Published on 15 Sep 2025

Personalized skin health management and nutrition strategies: a comprehensive study based on genetic polymorphisms and dietary factors

in Genetics of Aging

Jitao Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1624960

4,636 views

Methods

Published on 15 Sep 2025

Construction of a novel prognostic model for gastric cancer based on pharmacokinetics-related genes and comprehensive prognostic analysis

in Cancer Genetics and Oncogenomics

Yu Zhang
Kai Jia
Yuntong Guo
Xiaole Ma
Tian Yao
Feng Wu
He Huang

Frontiers in Genetics

doi 10.3389/fgene.2025.1541401

2,250 views

Opinion

Published on 15 Sep 2025

The potential clinical and public health implications of presymptomatic genetic testing for transthyretin amyloidosis in African American/Black adults in the United States

in Human and Medical Genomics

Inderjeet Bharaj
Simar J. Singh
Juzer Munaim
Harneet Grewal
Sonia Sabrowsky
Andrew Boshara
Marc A. Silver
Katherine H. Brendish
Paul Underwood
Sandesh Dev

Frontiers in Genetics

doi 10.3389/fgene.2025.1658636

3,284 views
1 citation

Original Research

Published on 12 Sep 2025

Dissecting and validation the biomarker of heart failure progression in patients with atherosclerosis by single-cell sequencing, bioinformatics, and machine learning

in Computational Genomics

Lihua Ni
Huabo Li
Juan Du
Ke Zhou
Fugui Zhang
Liankai Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1587274

2,731 views

Original Research

Published on 12 Sep 2025

Whole-exome sequencing in pediatric patients with glomerulonephritis

in Genetics of Common and Rare Diseases

Marina Peric
Marija Brankovic
Natasa Stajic
Jovana Putnik
Aleksandra Paripovic
Milena Jankovic
Dejan Nikolic
Filip Milanovic
Ivana Novakovic
Vladislav Vukomanovic

Frontiers in Genetics

doi 10.3389/fgene.2025.1611340

2,083 views

Original Research

Published on 11 Sep 2025

Combined molecular characterization and dopa-responsive treatment in two patients with NR4A2-associated intellectual developmental disorder

in Genetics of Common and Rare Diseases

Na Liang
Ting Li
Yang Deng

Frontiers in Genetics

doi 10.3389/fgene.2025.1590292

2,524 views
1 citation

Case Report

Published on 11 Sep 2025

Shotgun metagenomics detects the human pegivirus complete genome in a pediatric patient with acute hepatitis of unknown etiology: a case report

in Human and Medical Genomics

Roberta Vazzana
Alessandra Mularoni
Claudia Vaiana
Andrea Cona
Giovanni Mulè
Caterina Amato
Giusy Ranucci
Pier Giulio Conaldi
Valentina Agnese
Nicola Cuscino

Frontiers in Genetics

doi 10.3389/fgene.2025.1653082

3,647 views
1 citation

Case Report

Published on 10 Sep 2025

Case Report: A novel intronic variant of NIPBL gene detected in a child with cornelia de lange syndrome

in Genetics of Common and Rare Diseases

Xiao Ting Shao
Yu Xuan Dai
Yu Fang Zhao
Yu Hang Chen
Ling Jing Ying

Frontiers in Genetics

doi 10.3389/fgene.2025.1665167

1,901 views

Original Research

Published on 10 Sep 2025

Diphenyl pyridine intervention improves S. aureus-induced pneumonia by globally regulating transcriptome profile

in Computational Genomics

Wei Duan
Qingfeng Zhu
Hai Ci
Jingang Zhang
Zhiwei Tian
Wanyu Li
Zhengfu Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1624327

1,764 views

Correction

Published on 10 Sep 2025

Correction: Identification and functional characteristics of a novel splice site variant in L1CAM caused X-linked hydrocephalus

in Genetics of Common and Rare Diseases

Shijie Zhou
Hao Zhang
Xue Li
Quan Chen
Zhihong Xu

Frontiers in Genetics

doi 10.3389/fgene.2025.1676267

1,256 views

Original Research

Published on 10 Sep 2025

Clinical utility of exome sequencing in hearing loss: a retrospective cohort study

in Genetics of Common and Rare Diseases

Chang Liu
Yanlin Huang
Anpeng Fu
Yunan Wang
Jing Wu
Yan Zhang
Li Du
Hongke Ding
Lihua Yu
Fake Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1643537

2,425 views

Original Research

Published on 10 Sep 2025

Genome-wide evolution and function analysis of ALOG gene family in cotton

in Computational Genomics

Zhen Liu
Siyu Shen
Zhijuan Cui
Tao Wang
Pengtao Li
Yangyang Wei
Renhai Peng

Frontiers in Genetics

doi 10.3389/fgene.2025.1625634

1,856 views
1 citation

Original Research

Published on 09 Sep 2025

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition

in Cancer Genetics and Oncogenomics

Gizem Onder
Ozkan Ozdemir
Fulya Taylan
Cengiz Canpolat
Koray Yalcin
Fatih Erbey
Banu Oflaz Sozmen
Fikret Asarcikli
Turan Bayhan
Yunus Murat Akcabelen

Frontiers in Genetics

doi 10.3389/fgene.2025.1624306

4,401 views

Original Research

Published on 09 Sep 2025

Prediction of NR3C1 as a methylation marker for the prevention and treatment of gastric cancer in Rhizoma Atractylodis Macrocephalae based on machine learning algorithm and bioinformatics analysis

in Epigenomics and Epigenetics

Shicong Huang
Qian Gu
Yan Chen
Xiaofang Huang
Yuhua Du
Ziying Zhou
Yi Nan
Ling Yuan

Frontiers in Genetics

doi 10.3389/fgene.2025.1584986

3,408 views

Original Research

Published on 09 Sep 2025

ZC3H18 regulates alternative splicing and related genes in cervical cancer

in Cancer Genetics and Oncogenomics

Wenjuan Chen
Chenying Liu
Siyi Li
Xingyun Xie
Dan Hu
Yaobin Lin

Frontiers in Genetics

doi 10.3389/fgene.2025.1621238

2,440 views

Original Research

Published on 08 Sep 2025

Constructing a neutrophil extracellular trap model based on machine learning to predict clinical outcomes and immune therapy responses in oral squamous cell carcinoma

in RNA

Jian Wang
Zhenzhen Li
Zhiwei Li
Zijing Yu
Wenpin Xu

Frontiers in Genetics

doi 10.3389/fgene.2025.1616868

3,821 views
1 citation

Original Research

Published on 08 Sep 2025

Comprehensive analysis and validation of angiogenesis in vascular dementia from the perspective of diagnosis, prevention, and treatment

in Human and Medical Genomics

Lijun Xu
Yujiao Wang
Daojun Xie

Frontiers in Genetics

doi 10.3389/fgene.2025.1646991

2,957 views

Original Research

Published on 08 Sep 2025

A lipid metabolism and lysosome-based risk signature for prognosis and immune response prediction in uterine corpus endometrial carcinoma

in Cancer Genetics and Oncogenomics

Yuanyuan Zhu
Pusheng Yang
Shu Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1594682

2,641 views

Review

Published on 08 Sep 2025

Mechanisms and recent advances in non-coding RNAs and RNA modifications in antiplatelet drug resistance

in RNA

Ping Ni
Kejie Chen
Jing Xiang
Haifeng Shao
Xiaoling Chen
Qiao Chen
Lingling Wang
Junli Hao
Xinyi Huang
Qing Cao

Frontiers in Genetics

doi 10.3389/fgene.2025.1618105

2,591 views

16,587 articles

articles

Genetic and in silico functional characterization of a novel structural variant in the PAH gene by long-reads sequencing and structural modeling

Identification and validation of three tumor suppressors associated with the immune response of acute myeloid leukemia

The hidden in plain sight: global, regional, and national trends in the pediatric burden of Klinefelter syndrome, 1990–2021

Characterization of the phenotype and function of PRELP+ fibroblast subtype in liver metastatic colorectal cancer

Functional characterization of MFSD3 in auditory system and zebrafish embryogenesis

Personalized skin health management and nutrition strategies: a comprehensive study based on genetic polymorphisms and dietary factors

Construction of a novel prognostic model for gastric cancer based on pharmacokinetics-related genes and comprehensive prognostic analysis

The potential clinical and public health implications of presymptomatic genetic testing for transthyretin amyloidosis in African American/Black adults in the United States

Dissecting and validation the biomarker of heart failure progression in patients with atherosclerosis by single-cell sequencing, bioinformatics, and machine learning

Whole-exome sequencing in pediatric patients with glomerulonephritis

Combined molecular characterization and dopa-responsive treatment in two patients with NR4A2-associated intellectual developmental disorder

Shotgun metagenomics detects the human pegivirus complete genome in a pediatric patient with acute hepatitis of unknown etiology: a case report

Case Report: A novel intronic variant of NIPBL gene detected in a child with cornelia de lange syndrome

Diphenyl pyridine intervention improves S. aureus-induced pneumonia by globally regulating transcriptome profile

Correction: Identification and functional characteristics of a novel splice site variant in L1CAM caused X-linked hydrocephalus

Clinical utility of exome sequencing in hearing loss: a retrospective cohort study

Genome-wide evolution and function analysis of ALOG gene family in cotton

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition

Prediction of NR3C1 as a methylation marker for the prevention and treatment of gastric cancer in Rhizoma Atractylodis Macrocephalae based on machine learning algorithm and bioinformatics analysis

ZC3H18 regulates alternative splicing and related genes in cervical cancer

Constructing a neutrophil extracellular trap model based on machine learning to predict clinical outcomes and immune therapy responses in oral squamous cell carcinoma

Comprehensive analysis and validation of angiogenesis in vascular dementia from the perspective of diagnosis, prevention, and treatment

A lipid metabolism and lysosome-based risk signature for prognosis and immune response prediction in uterine corpus endometrial carcinoma

Mechanisms and recent advances in non-coding RNAs and RNA modifications in antiplatelet drug resistance