Frontiers in Genetics

Original Research

Published on 20 Nov 2025

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells

in Cancer Genetics and Oncogenomics

Xiaobo Guo
Gang Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1694089

1,086 views

Original Research

Published on 19 Nov 2025

Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis

in Computational Genomics

Yinfei Lu
Zao Tang
Xiangyu Zhou
Wanting Lin
Xiao Guo

Frontiers in Genetics

doi 10.3389/fgene.2025.1655000

953 views

Original Research

Published on 19 Nov 2025

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels

in Genetics of Common and Rare Diseases

Yongyan Song
Ting Wang
Mi Su
Xue Wang
Youjin Zhang
Jia Pan
Yunhan Wang
Jin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1659460

1,017 views

Review

Published on 19 Nov 2025

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential

in Genomic Assay Technology

Duaa Elshiekh
Nour Farchoukh
Reema El Hassan
Sara Al-Marzooqi
Waad Rashed Aldosari
Haissam Abou-Saleh
Amal Al-Haidose
Hatem Zayed
Atiyeh M. Abdallah

Frontiers in Genetics

doi 10.3389/fgene.2025.1621081

1,665 views

Case Report

Published on 18 Nov 2025

MAPT mutation-induced behavioral variant frontotemporal dementia in an Asian patient: a multimodal biomarker case report resolving diagnostic challenges with Alzheimer’s disease

in Genetics of Common and Rare Diseases

Yan Zhang
Siwei Chen
Guiying Yan
Zhifei Zhang
Amina
Ting Wang
Shuang Wang
Chen Zhang
Yong’an Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1645068

1,100 views

Original Research

Published on 18 Nov 2025

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma

in Cancer Genetics and Oncogenomics

Qiyue Zhao
Huadong Xie
Chaofu Li
Yanxiang Xiong
Yongyi Fan
Yuanbi Huang
Yi Zhan
Siping Zeng

Frontiers in Genetics

doi 10.3389/fgene.2025.1605078

1,489 views

Original Research

Published on 17 Nov 2025

Phenotype and genetic variation analysis of primary congenital lymphedema caused by FLT4 gene mutations in a fetus

in Genetics of Common and Rare Diseases

Shanshan Zhai
Limin Yuan
Jing Li
Ling Liu
Lulu Hu
Yanjie Ban
Xuewen Yang
Jie Yang
Xuezhe Ouyang
Nana Huang

Frontiers in Genetics

doi 10.3389/fgene.2025.1700635

958 views

Original Research

Published on 17 Nov 2025

Single-cell RNA-seq combined with bulk RNA-seq explores shared gene signatures between thyroid and breast cancers

in Cancer Genetics and Oncogenomics

Zhiping Feng
Liang He
Xin Yang
Anhao Wu
Jingnan Wang
Yuanhua Song
Yongchun Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1609189

1,124 views

Original Research

Published on 17 Nov 2025

Genetic evolution of parental populations and construction of core germplasm populations in qinghai spruce seed orchard based on SLAF-seq technology

in Evolutionary and Population Genetics

Hu Zhao
Erwen Xu
Dong Lv
Wei Li
Xingpeng Zhao
Xin Jia
Hao Yuan
Rong Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1712106

957 views

Original Research

Published on 17 Nov 2025

Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis

in Genetics of Common and Rare Diseases

Ying Dong
Hong-Song Ge
Rui-Xue Chang
Jing Chu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634874

1,816 views

Original Research

Published on 17 Nov 2025

Genetic background of behavior traits in lactating sows under heat-stress conditions and their relationship with heat tolerance and maternal performance traits

in Livestock Genomics

Sharlene O. Hartman
Lorena F. Benfica
Jay S. Johnson
Jeremy N. Marchant
Hinayah R. Oliveira
Victor B. Pedrosa
Allan P. Schinckel
Yijian Huang
Leonardo S. Gloria
Hui Wen

Frontiers in Genetics

doi 10.3389/fgene.2025.1688262

1,262 views

Editorial

Published on 17 Nov 2025

Editorial: Precision trait mapping and molecular breeding in high-impact crop plants

in Genomics of Plants and the Phytoecosystem

Dinesh Kumar Saini
Mamta Gupta
Alla Singh
Mehak Sethi
Veena Devi
Reyazul Rouf Mir

Frontiers in Genetics

doi 10.3389/fgene.2025.1736266

1,649 views

Case Report

Published on 14 Nov 2025

Familial Xq27.1q28 duplication arising from a maternal interarm forward insertion of the X chromosome: a case report

in Genetics of Common and Rare Diseases

Xiang Li
Yuan-Mei Peng
Bo-Wen Luo
Yu-Di Luo
Yun-Rong Qin
Keng Feng
De-Rong Li
Zeng-Yu Yang
Ling-Ling Zhu
Jin-Jie Pan

Frontiers in Genetics

doi 10.3389/fgene.2025.1514856

1,284 views

Original Research

Published on 14 Nov 2025

Novel variant in PNPLA6 gene causes Oliver-McFarlane syndrome in a Chinese family: 13 years follow-up

in Genetics of Common and Rare Diseases

Panpan Xiao
Yonghua Gu
Xiaolong Qi
Ting Li
Tingting Zuo
Yule Xie
Shuang Zhang
Xunlun Sheng

Frontiers in Genetics

doi 10.3389/fgene.2025.1693876

868 views

Case Report

Published on 14 Nov 2025

Case Report: Identification and functional characterization of a novel heterozygous splice-donor (c.647+1G>A) site mutation in the SPTB gene that causes hereditary spherocytosis with hemolytic anemia

in Genetics of Common and Rare Diseases

Ke Cao
Xiaojuan Luo
Lianlian Liu
Xiaoning Mao
Ruping Liu
Yunsheng Chen
Santasree Banerjee

Frontiers in Genetics

doi 10.3389/fgene.2025.1626155

1,038 views

Original Research

Accepted on 13 Nov 2025

Impact of rs7528684 (-169T/C) on FCRL3, FOXP3, IL-35 Gene Expression and IgG-RF Correlation: Insights into Rheumatoid Arthritis Pathogenesis

in Immunogenetics

Asha Devi S
Mohamed Muzammil.s

Frontiers in Genetics

243 views

Review

Published on 13 Nov 2025

Emerging roles of natural killer cell ligands—HLA-E, HLA-F, HLA-G, MICA, and MICB—in in vitro fertilization outcomes

in Immunogenetics

Itta Krishna Chaaithanya
Raja Rajalingam

Frontiers in Genetics

doi 10.3389/fgene.2025.1661511

1,577 views

Original Research

Published on 13 Nov 2025

Distribution characteristics of MTHFR C677T gene polymorphism in Han nationality and women of childbearing age in 8 regions of Shaanxi province and a comparative analysis with other regions in China

in Applied Genetic Epidemiology

Ting Chen
Fei Song
Jinyao Sun
Jing Yi
Wenbing Ma

Frontiers in Genetics

doi 10.3389/fgene.2025.1693729

1,306 views

Original Research

Published on 12 Nov 2025

The genetic diversity and population structure of native horse breeds in Xinjiang, China

in Livestock Genomics

Chi Tang
Baoyu Yang
Gulibaheti Dawulietihan
Li Xue
Shuyuan Liu
Yinamujiang Yalimaimaiti
Qingzheng Wang
Na Yang
Xiaoyuan Sun
Yaru Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1439312

2,228 views

Brief Research Report

Published on 12 Nov 2025

Building capability for clinician-led genomic change: insights from use and non-use of a theory-informed model for change

in ELSI in Science and Genetics

Melissa Martyn
Amy Clarke
Trang Do
Belinda Dawson-McClaren
Clara Gaff

Frontiers in Genetics

doi 10.3389/fgene.2025.1692703

1,526 views
1 citation

Correction

Published on 12 Nov 2025

Correction: Integrative machine learning and Mendelian randomization identify causal laboratory biomarkers for coronary artery lesions in Kawasaki disease: a prospective study

in Computational Genomics

Hancao Yang
Meng Wu
Keqing Liang
Yi Li
Ran Yang
Beibei Yuan
Ming Wu
Jin Xu

Frontiers in Genetics

doi 10.3389/fgene.2025.1735649

644 views

Correction

Published on 12 Nov 2025

Correction: Drought adaptation index (DAI) based on BLUP as a selection approach for drought-resilient switchgrass germplasm

in Genomics of Plants and the Phytoecosystem

Shiva Om Makaju
Hari Bahadur Chhetri
Chanaka Roshan Abeyratne
Mirko Pavicic
Hari Poudel
Jazib Ali Irfan
Anita Giabardo
Katrien M. Devos
Daniel Jacobson
Ali Mekki Missaoui

Frontiers in Genetics

doi 10.3389/fgene.2025.1731825

604 views

Original Research

Published on 12 Nov 2025

CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation

in Cancer Genetics and Oncogenomics

Jinyu Li
Ning Wang
Jianlei Bi
Meihua Guo
Bingbing Xu
Gena Huang

Frontiers in Genetics

doi 10.3389/fgene.2025.1687066

1,430 views

Case Report

Published on 12 Nov 2025

Case Report: Compound heterozygous CEP152 c.3346-5T>C variant and chr15 deletion causing recurrent MCPH–SCKS in a Chinese pregnant woman across two consecutive pregnancies

in Genetics of Common and Rare Diseases

Tao Zhang
Hua Yuan
Xiaoliang Shi
Yao He
Haitao Pan
Yongxing Zhong
Jintang Zhang
Zhen Yang
Yunyan Ke
Yan Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1646297

1,181 views

16,451 articles

articles

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells

Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential

MAPT mutation-induced behavioral variant frontotemporal dementia in an Asian patient: a multimodal biomarker case report resolving diagnostic challenges with Alzheimer’s disease

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma

Phenotype and genetic variation analysis of primary congenital lymphedema caused by FLT4 gene mutations in a fetus

Single-cell RNA-seq combined with bulk RNA-seq explores shared gene signatures between thyroid and breast cancers

Genetic evolution of parental populations and construction of core germplasm populations in qinghai spruce seed orchard based on SLAF-seq technology

Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis

Genetic background of behavior traits in lactating sows under heat-stress conditions and their relationship with heat tolerance and maternal performance traits

Editorial: Precision trait mapping and molecular breeding in high-impact crop plants

Familial Xq27.1q28 duplication arising from a maternal interarm forward insertion of the X chromosome: a case report

Novel variant in PNPLA6 gene causes Oliver-McFarlane syndrome in a Chinese family: 13 years follow-up

Case Report: Identification and functional characterization of a novel heterozygous splice-donor (c.647+1G>A) site mutation in the SPTB gene that causes hereditary spherocytosis with hemolytic anemia

Impact of rs7528684 (-169T/C) on FCRL3, FOXP3, IL-35 Gene Expression and IgG-RF Correlation: Insights into Rheumatoid Arthritis Pathogenesis

Emerging roles of natural killer cell ligands—HLA-E, HLA-F, HLA-G, MICA, and MICB—in in vitro fertilization outcomes

Distribution characteristics of MTHFR C677T gene polymorphism in Han nationality and women of childbearing age in 8 regions of Shaanxi province and a comparative analysis with other regions in China

The genetic diversity and population structure of native horse breeds in Xinjiang, China

Building capability for clinician-led genomic change: insights from use and non-use of a theory-informed model for change

Correction: Integrative machine learning and Mendelian randomization identify causal laboratory biomarkers for coronary artery lesions in Kawasaki disease: a prospective study

Correction: Drought adaptation index (DAI) based on BLUP as a selection approach for drought-resilient switchgrass germplasm

CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation

Case Report: Compound heterozygous CEP152 c.3346-5T>C variant and chr15 deletion causing recurrent MCPH–SCKS in a Chinese pregnant woman across two consecutive pregnancies