Frontiers in Genetics

Original Research

Published on 12 Nov 2025

Computational-experimental strategy identifies Co-upregulated biomarkers linking coronary heart disease and type 2 diabetes pathogenesis

in Genetics of Common and Rare Diseases

Wei Li
Yu Cao
Chen Yu
Bingjun Che
Miao He
Dongbiao Li
Lihong Jiang
Lijing Ma

Frontiers in Genetics

doi 10.3389/fgene.2025.1673303

978 views

Review

Published on 11 Nov 2025

Ocular surface health and disease: insight from single-cell RNA sequencing

in Human and Medical Genomics

Shangkun Ou
Minqing Cai
Yuchong Feng
Sijie Lin
Xueer Zheng
Su Zhao
Hao Gu
Yiming Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1683167

1,655 views

Mini Review

Published on 11 Nov 2025

Epigenetic landscape in lysosomal storage disorders: mechanisms and modulation

in Epigenomics and Epigenetics

Andrés Felipe Leal
Harry Pachajoa
Shunji Tomatsu

Frontiers in Genetics

doi 10.3389/fgene.2025.1679497

1,555 views

Original Research

Published on 11 Nov 2025

Germline activating sequence variations in RASopathy spectrum genes: genotype–phenotype correlation in a North Indian cohort

in Genetics of Common and Rare Diseases

Shifali Gupta
Priyanka Srivastava
Roshan Daniel
Chitra Bhardwaj
Parminder Kaur
Pratibha Bawa
Anu Kumari
Ravi Pratap Singh Bhadoriya
Mrinali Peters
Anupriya Kaur

Frontiers in Genetics

doi 10.3389/fgene.2025.1677143

1,488 views

Original Research

Published on 10 Nov 2025

Genotyping strategies for single-step genomic predictions in a simulated sheep population under different scenarios of pedigree error types

in Livestock Genomics

Artur O. Rocha
Leonardo S. Gloria
Andre C. Araujo
Hui Wen
Carrie S. Wilson
Bradley A. Freking
Thomas W. Murphy
Joan M. Burke
Ronald M. Lewis
Luiz F. Brito

Frontiers in Genetics

doi 10.3389/fgene.2025.1697103

2,406 views

Original Research

Published on 10 Nov 2025

Unveiling disulfidptosis-linked lncRNA signatures: insights into the immune microenvironment and drug responsiveness in oral squamous cell carcinoma

in Cancer Genetics and Oncogenomics

Xue Meng
Lichao Cao
Yantao Liu
Sihan Wang
Weixian Liu
Guangping Zhang
Siqi Guo
Fangyu Qi
Tingting Wang
Yuhe Xia

Frontiers in Genetics

doi 10.3389/fgene.2025.1650544

1,130 views

Original Research

Published on 10 Nov 2025

Construction of a HSC activation-related lncRNA–miRNA–mRNA ceRNA regulatory network reveals potential molecules involved in liver fibrosis

in RNA

Kaiqiang Wan
Qiong Zhou
Ruirui Feng
Tao Liu
Chang Fan
Xue Pang
Zhongliang Li
Qiumei Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1640326

1,445 views

Original Research

Published on 10 Nov 2025

Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) leaves

in Genomics of Plants and the Phytoecosystem

Ting Yang
Xiaolu Lin
Rui Chen
Ruiqi Wang
Tong Li
Fulong Shen
Xiaowei Zhang
Lianghua Lai
Bing Lu
Jiliang Wei

Frontiers in Genetics

doi 10.3389/fgene.2025.1662815

1,292 views

Mini Review

Published on 10 Nov 2025

Advances in post-processing methods for multiple sequence alignment

in Computational Genomics

Yixiao Zhai
Zitong Zhang
Zhen Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1722317

1,414 views

Original Research

Published on 07 Nov 2025

KSRV: a Kernel PCA-Based framework for inferring spatial RNA velocity at single-cell resolution

in Computational Genomics

Yan He
Jian Jiang
Huahai Qiu
Ya-Zhou Shi
Ben-Gong Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1695803

1,486 views

Original Research

Published on 07 Nov 2025

Mechanistic insights into NFIX frameshift mutations in Malan syndrome: proteasomal degradation-mediated haploinsufficiency

in Genetics of Common and Rare Diseases

Yan Zhou
Linbing Zou
Yaoyao Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1648420

1,157 views

Correction

Published on 07 Nov 2025

Correction: Identification of shared diagnostic genes between osteoporosis and Crohn’s disease through integrated transcriptomic analysis and machine learning

in Computational Genomics

Guirong Yi
Peng Zhou
Qinxu Yang
Maosheng Zhao
Qiaoqiao Yang
Shensong Li
Chenpo Dang

Frontiers in Genetics

doi 10.3389/fgene.2025.1722642

707 views

Original Research

Published on 07 Nov 2025

Identifying gene-environment interactions across genome-wide, twin, and polygenic risk score approaches

in Behavioral and Psychiatric Genetics

Brad Verhulst

Frontiers in Genetics

doi 10.3389/fgene.2025.1698381

1,248 views

Original Research

Published on 07 Nov 2025

BRMS1L promotes chemotherapy sensitivity by inhibiting autophagy in breast cancer

in Cancer Genetics and Oncogenomics

Yuan Li
Dian Zhang
Junhao Zhao
Mei Yang
Yiping Wang
Peiyao Lee
Shaohua Qu

Frontiers in Genetics

doi 10.3389/fgene.2025.1670001

1,401 views

Case Report

Published on 07 Nov 2025

Case Report: Whole-exome sequencing revealed a de novo variant in SETBP1 gene in a Chinese family with developmental delay

in Genetics of Common and Rare Diseases

Junlin Pan
Yan Zhang
Jinwei Hou
Na Shi
Huiling Qu
Longhuan Jiang
Haiping Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1637931

1,289 views

Original Research

Published on 07 Nov 2025

Precision genomic profiling in Gaucher disease: insights from atypical presentations

in Genetics of Common and Rare Diseases

Armaan Saith
Noor Ul Ain
Jiapeng Ruan
Maniya Kasaiyan
Dhanpat Jain
Gary Israel
Sameet Mehta
Nigel S. Bamford
Shiny Nair
Pramod K. Mistry

Frontiers in Genetics

doi 10.3389/fgene.2025.1553036

1,420 views

Original Research

Published on 07 Nov 2025

ST8SIA6-AS1 serves as a prognostic biomarker in cancer and exhibits oncogenic properties in prostate cancer

in RNA

Yaoan Wen
Jiangbin Yang
Shuyuan Zhan
Yuanjing Huang
Guoqiang Chen
Song Zheng
Shaoxing Zhu

Frontiers in Genetics

doi 10.3389/fgene.2025.1648077

1,262 views

Correction

Published on 07 Nov 2025

Correction: A novel splicing variant in NBAS identified by minigene assay causes infantile liver failure syndrome type 2

in Genetics of Common and Rare Diseases

Anna Hu
Jun Liang
Hongbo Liu
Jinghui Jiang
Fujing Xie
Xin Zhou
Xiaojia Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1722189

701 views

Original Research

Published on 06 Nov 2025

Clarifying species boundaries between bocachico (Prochilodus magdalenae) and bocachico de Maracaibo (Prochilodus reticulatus) (characiformes: Prochilodontidae) using complete mitochondrial genomes

in Evolutionary and Population Genetics

Jonny Yepes-Blandón
Diego Almansa-Villa
María José Benítez-Galeano
Daiana Mir
Jim Hernández-Rangel
Víctor Atencio-García
Ana Estrada-Posada
Nélida Rodríguez-Osorio

Frontiers in Genetics

doi 10.3389/fgene.2025.1661527

1,392 views

Case Report

Published on 06 Nov 2025

Case Report: autosomal dominant distal motor neuropathy as a new phenotype of KIF21A-related disorders

in Genetics of Common and Rare Diseases

Dmitrii Subbotin
Eugene Tatarskiy
Anna Kuchina
Tatiana Cherevatova
Tatiana Krylova
Oksana Ryzhkova
Mikhail Skoblov
Aysylu Murtazina

Frontiers in Genetics

doi 10.3389/fgene.2025.1699834

1,041 views

Case Report

Published on 06 Nov 2025

Case Report: D-bifunctional protein deficiency caused by novel compound heterozygote HSD17B4 variants in a neonate in China

in Genetics of Common and Rare Diseases

Hui Liu
Gaojie Liu
Lianjun Gao
Hui Wang
Yizhong Wang
Hongfang Ding

Frontiers in Genetics

doi 10.3389/fgene.2025.1631767

1,092 views

Case Report

Published on 06 Nov 2025

Case Report: Co-occurring de novo SHANK3 and SRCAP variants in a patient with autoimmune encephalitis and exhibiting Phelan-McDermid syndrome features

in Neurogenomics

Li Li
Jie Zhang
Xiaoyan Shi
Yaqing Huang
Xingzhi Chang
Liya Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1699311

1,095 views

Case Report

Published on 06 Nov 2025

Case Report: Novel compound heterozygous mutations in PNPLA6 gene associated with Oliver-McFarlane syndrome

in Genetics of Common and Rare Diseases

Jia Zheng
Zhe Wang
Keqing Li
Lixia Chen
Yayin Luo
Fei Yu
Dan Wang
Guangxiang Yu

Frontiers in Genetics

doi 10.3389/fgene.2025.1660243

1,063 views

Case Report

Published on 06 Nov 2025

A rare case of de novo 20p12.3 microdeletion syndrome in a nine-year-old female: case report and literature review

in Genetics of Common and Rare Diseases

Hanan Aljedani
Yousef Faden
Manar Alghamdi
Alshaimaa Alzahrani
Aiman Shawli
Reem Albakistani

Frontiers in Genetics

doi 10.3389/fgene.2025.1669947

1,126 views

16,451 articles

articles

Computational-experimental strategy identifies Co-upregulated biomarkers linking coronary heart disease and type 2 diabetes pathogenesis

Ocular surface health and disease: insight from single-cell RNA sequencing

Epigenetic landscape in lysosomal storage disorders: mechanisms and modulation

Germline activating sequence variations in RASopathy spectrum genes: genotype–phenotype correlation in a North Indian cohort

Genotyping strategies for single-step genomic predictions in a simulated sheep population under different scenarios of pedigree error types

Unveiling disulfidptosis-linked lncRNA signatures: insights into the immune microenvironment and drug responsiveness in oral squamous cell carcinoma

Construction of a HSC activation-related lncRNA–miRNA–mRNA ceRNA regulatory network reveals potential molecules involved in liver fibrosis

Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) leaves

Advances in post-processing methods for multiple sequence alignment

KSRV: a Kernel PCA-Based framework for inferring spatial RNA velocity at single-cell resolution

Mechanistic insights into NFIX frameshift mutations in Malan syndrome: proteasomal degradation-mediated haploinsufficiency

Correction: Identification of shared diagnostic genes between osteoporosis and Crohn’s disease through integrated transcriptomic analysis and machine learning

Identifying gene-environment interactions across genome-wide, twin, and polygenic risk score approaches

BRMS1L promotes chemotherapy sensitivity by inhibiting autophagy in breast cancer

Case Report: Whole-exome sequencing revealed a de novo variant in SETBP1 gene in a Chinese family with developmental delay

Precision genomic profiling in Gaucher disease: insights from atypical presentations

ST8SIA6-AS1 serves as a prognostic biomarker in cancer and exhibits oncogenic properties in prostate cancer

Correction: A novel splicing variant in NBAS identified by minigene assay causes infantile liver failure syndrome type 2

Clarifying species boundaries between bocachico (Prochilodus magdalenae) and bocachico de Maracaibo (Prochilodus reticulatus) (characiformes: Prochilodontidae) using complete mitochondrial genomes

Case Report: autosomal dominant distal motor neuropathy as a new phenotype of KIF21A-related disorders

Case Report: D-bifunctional protein deficiency caused by novel compound heterozygote HSD17B4 variants in a neonate in China

Case Report: Co-occurring de novo SHANK3 and SRCAP variants in a patient with autoimmune encephalitis and exhibiting Phelan-McDermid syndrome features

Case Report: Novel compound heterozygous mutations in PNPLA6 gene associated with Oliver-McFarlane syndrome

A rare case of de novo 20p12.3 microdeletion syndrome in a nine-year-old female: case report and literature review