Frontiers in Genetics

Original Research

Published on 06 Nov 2025

Systems biology and experimental validation indicate DDIT4, FOXO1, and STAT3 as shared key genes linking osteoporosis and sarcopenia

in Computational Genomics

Wenjing Li
Yuechen Xing
Lihong Jiang
Jia Meng
Yue Wang
Renjie Tan
Yina Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1630705

1,387 views

Review

Published on 06 Nov 2025

Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

in RNA

Yubo Ren
Bomeng Zhao
Luo Lv
Jingyuan Yang
Xiangting Nan
Bao Li
Bin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1677797

1,911 views

Original Research

Published on 06 Nov 2025

Functional analysis of a novel variant in the COL5A1 gene in a Polish patient with the classical type of Ehlers–Danlos syndrome

in Genetics of Common and Rare Diseases

Anna Junkiert-Czarnecka
Karolina Maciak
Magdalena M. Kacprzak
Agnieszka Łobodzińska
Agnieszka Sobczyńska-Tomaszewska
Aneta Jurkiewicz
Monika Gora
Beata Burzynska
Maria Pilarska-Deltow
Olga Haus

Frontiers in Genetics

doi 10.3389/fgene.2025.1689587

1,286 views

Case Report

Published on 05 Nov 2025

Case Report: identification of a novel 9.159-kb deletion in a Chinese α-thalassemia family using single molecule real-time technology sequencing

in Genetics of Common and Rare Diseases

Shulin Wu
Zonghui Feng
Fuxiang Jiang
Min Zhao
Peng Jiang
Gang Xiao
Xian Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1669814

898 views

Original Research

Published on 05 Nov 2025

Downregulation of aquaporin 3 promotes hyperosmolarity-induced apoptosis of nucleus pulposus cells through PI3K/Akt/mTOR pathway suppression

in Genetics of Common and Rare Diseases

Yuan Sang
Huiqing Zhao
Jiajun Wu
Ting Zhang
Wenbin Xu
Kaihua Liu
Chang Liu
Ping Li
Yichun Xu
Jianying Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1665899

1,142 views

Original Research

Published on 03 Nov 2025

Family-based NGS panel testing of cardiopathies and arrhythmic syndromes

in Genetics of Common and Rare Diseases

Hana Hrazderova
Jana Petrkova
Anna Crhova
Klara Herkommerova
Kvetoslava Mahutova
Julie Nejezchlebova
Lenka Petrkova
Lubos Boucek
Arpad Boday
Spiros Tavandzis

Frontiers in Genetics

doi 10.3389/fgene.2025.1677311

1,539 views

Case Report

Published on 31 Oct 2025

“Case report”: Whole-exome sequencing reveals compound heterozygous variants in the EIF2B5 gene in a familial case of vanishing white matter

in Genetics of Common and Rare Diseases

Sofía Savy
Francisco A. Montes
Carola L. Grosso
Laura E. Laróvere
Silene M. Silvera-Ruiz
Gerardo H. Carro
Guillermo Guelbert
Adriana Becerra
David Morales
Juan P. Nicola

Frontiers in Genetics

doi 10.3389/fgene.2025.1688885

1,445 views

Original Research

Published on 30 Oct 2025

Biallelic variants in the UTRN gene cause a novel form of multiple congenital arthrogryposis

in Genetics of Common and Rare Diseases

Evgeniya Melnik
Daria Akimova
Tatiana Markova
Eugene Tatarskiy
Anna Tvorogova
Viktoria Zabnenkova
Vladimir Kenis
Olga Agranovich
Mikhail Skoblov
Elena Dadali

Frontiers in Genetics

doi 10.3389/fgene.2025.1664424

1,393 views

Original Research

Published on 30 Oct 2025

Prenatal diagnosis of Prader–Willi syndrome via maternal UPD15 with placental mosaicism: incidental discovery of fetal DMD carrier status

in Genetics of Common and Rare Diseases

Yanchou Ye
Yiman Fu
Zhechao Zhang
Haofeng Ning
Fangchao Tao
Xiaonan Wang
Qun Fang
Zheng Chen
Xiulan Hao

Frontiers in Genetics

doi 10.3389/fgene.2025.1675663

1,920 views

Original Research

Published on 29 Oct 2025

LDLRAD4 is a potential diagnostic and prognostic biomarker correlated with immune infiltration in myelodysplastic syndromes

in Cytogenomics

Mengjie Xu
Shihao Wu
Kaixiang Zhang
Lirong Nie
Qinghua Li
Jihong Zhong
Yuming Zhang
Honghua He

Frontiers in Genetics

doi 10.3389/fgene.2025.1540161

1,417 views

Original Research

Published on 28 Oct 2025

Comparative RNA-seq and functional assays identify L-arginine transporter SLC7A2 as a potential regulator of osteogenesis in maxillary sinus mucosal stem cells

in Stem Cell Research

Jing Ren
Ningbo Geng
Tianren Zhou
Shiting Mo
Chi Zhang
Wei Peng
Chunhui Liao
Songling Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1701001

1,523 views

Review

Published on 28 Oct 2025

From bench to bytes: a practical guide to RNA sequencing data analysis

in Computational Genomics

Prabin Dawadi
Bivek Pokharel
Anita Shrestha
Dikshya Niraula
Afifa Naeem
Sayaka Miura
Mishal Roy
Saroj Nepal

Frontiers in Genetics

doi 10.3389/fgene.2025.1697922

3,492 views

Review

Published on 28 Oct 2025

Computational models for pan-cancer classification based on multi-omics data

in Cancer Genetics and Oncogenomics

Jianlin Wang
Jiao Zhang
Xuebing Dai
Chaokun Yan
Caili Fang

Frontiers in Genetics

doi 10.3389/fgene.2025.1667325

2,226 views

Review

Published on 28 Oct 2025

Gene therapy for disorders of sex development: current applications and future challenges

in Genetics of Common and Rare Diseases

Wenyuan Peng
Qian Zhao
Jiali Chen
Huifang Peng
Hongwei Jiang

Frontiers in Genetics

doi 10.3389/fgene.2025.1661127

2,548 views

Data Report

Published on 28 Oct 2025

De novo assembly and functional annotation of Henbit (Lamium amplexicaule) transcriptome

in Genomics of Plants and the Phytoecosystem

Young Ji Choi
Hyojung Son
Jaewon Lim
Siyoon Jeong
Seongmin Oh
Bomi Nam
Kang-Yeol Yu
Kyung Min Choi
Myunghee Jung
Ha Yeun Song

Frontiers in Genetics

doi 10.3389/fgene.2025.1612607

2,502 views

Case Report

Published on 27 Oct 2025

Prenatal diagnosis of a de novo pathogenic HNRNPK variant in a Chinese fetus with abnormal ultrasound soft markers: a case report

in Human and Medical Genomics

Yuying Zhu
Zhen Yang
Qiumin Zhu
Ke Wu
Junying He
Hongmei Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1661743

1,549 views

Original Research

Published on 27 Oct 2025

Identification and functional analysis of a novel CSNK2A1 frameshift variant in stillbirth

in Statistical Genetics and Methodology

Nannan Zhang
Miao Han
Tong Zhao
Xinxin Tang
Zhiwei Wang
Yunqiu Du
Leilei Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1692704

1,491 views

Original Research

Published on 27 Oct 2025

Identification of druggable targets in melanoma by multi-omics Mendelian randomization integrated with transcriptomic and spatial analysis

in Applied Genetic Epidemiology

Jiahua Xing
Mingyong Yang
Muzi Chen
Ran Tao

Frontiers in Genetics

doi 10.3389/fgene.2025.1657356

1,468 views

Correction

Published on 27 Oct 2025

Correction: Effectiveness of non-invasive chromosomal screening for normal karyotype and chromosomal rearrangements

in ELSI in Science and Genetics

Bo-Lan Sun
Yong Wang
Sixi Wen
Liang Zhou
Chun-Hui Zhang
Ze-Xuan Wu
Jie Qiao
Qing-Yuan Sun
Ya-Xin Yao
Jing Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1711906

1,048 views

Case Report

Published on 24 Oct 2025

Case Report: Adenylosuccinate lyase deficiency type I caused by splicing disruption due to a novel missense variant in the ADSL gene

in Human and Medical Genomics

Artem Borovikov
Ksenia Davydenko
Aysylu Murtazina
Artem Sharkov
Ilya Kanivets
Alexandra Filatova
Mikhail Skoblov

Frontiers in Genetics

doi 10.3389/fgene.2025.1670299

1,407 views

Correction

Published on 24 Oct 2025

Correction: Genome-wide association study of drought tolerance traits in sugar beet germplasms at the seedling stage

in Genomics of Plants and the Phytoecosystem

Wangsheng Li
Ming Lin
Jiajia Li
Dali Liu
Wenbo Tan
Xilong Yin
Yan Zhai
Yuanhang Zhou
Wang Xing

Frontiers in Genetics

doi 10.3389/fgene.2025.1685028

739 views

Review

Published on 24 Oct 2025

Advances in RNA-based therapeutics: current breakthroughs, clinical translation, and future perspectives

in RNA

Sarbjeet Kaur Makkar

Frontiers in Genetics

doi 10.3389/fgene.2025.1675209

7,496 views
1 citation

Review

Published on 23 Oct 2025

Single-cell transcriptomics in metastatic breast cancer: mapping tumor evolution and therapeutic resistance

in Cancer Genetics and Oncogenomics

Xu Han
Xin Li
Ling Bai
Gangling Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1669741

3,016 views

Original Research

Published on 23 Oct 2025

Non-polar components in PM2.5 increase matrix remodeling of CRS by up-regulating CEMIP in nasal fibroblasts

in Predictive Toxicology and Exposomics

Jiayao Zhou
Ying Zhu
Huilin Hu
Ru Tang
Shiyao Zhang
Yuelong Gu
Song Mao
Shilei Pu
Hai Lin
Yue Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1672729

1,677 views

16,451 articles

articles

Systems biology and experimental validation indicate DDIT4, FOXO1, and STAT3 as shared key genes linking osteoporosis and sarcopenia

Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

Functional analysis of a novel variant in the COL5A1 gene in a Polish patient with the classical type of Ehlers–Danlos syndrome

Case Report: identification of a novel 9.159-kb deletion in a Chinese α-thalassemia family using single molecule real-time technology sequencing

Downregulation of aquaporin 3 promotes hyperosmolarity-induced apoptosis of nucleus pulposus cells through PI3K/Akt/mTOR pathway suppression

Family-based NGS panel testing of cardiopathies and arrhythmic syndromes

“Case report”: Whole-exome sequencing reveals compound heterozygous variants in the EIF2B5 gene in a familial case of vanishing white matter

Biallelic variants in the UTRN gene cause a novel form of multiple congenital arthrogryposis

Prenatal diagnosis of Prader–Willi syndrome via maternal UPD15 with placental mosaicism: incidental discovery of fetal DMD carrier status

LDLRAD4 is a potential diagnostic and prognostic biomarker correlated with immune infiltration in myelodysplastic syndromes

Comparative RNA-seq and functional assays identify L-arginine transporter SLC7A2 as a potential regulator of osteogenesis in maxillary sinus mucosal stem cells

From bench to bytes: a practical guide to RNA sequencing data analysis

Computational models for pan-cancer classification based on multi-omics data

Gene therapy for disorders of sex development: current applications and future challenges

De novo assembly and functional annotation of Henbit (Lamium amplexicaule) transcriptome

Prenatal diagnosis of a de novo pathogenic HNRNPK variant in a Chinese fetus with abnormal ultrasound soft markers: a case report

Identification and functional analysis of a novel CSNK2A1 frameshift variant in stillbirth

Identification of druggable targets in melanoma by multi-omics Mendelian randomization integrated with transcriptomic and spatial analysis

Correction: Effectiveness of non-invasive chromosomal screening for normal karyotype and chromosomal rearrangements

Case Report: Adenylosuccinate lyase deficiency type I caused by splicing disruption due to a novel missense variant in the ADSL gene

Correction: Genome-wide association study of drought tolerance traits in sugar beet germplasms at the seedling stage

Advances in RNA-based therapeutics: current breakthroughs, clinical translation, and future perspectives

Single-cell transcriptomics in metastatic breast cancer: mapping tumor evolution and therapeutic resistance

Non-polar components in PM2.5 increase matrix remodeling of CRS by up-regulating CEMIP in nasal fibroblasts