Frontiers in Genetics

Original Research

Published on 05 Jan 2026

Integration of chromosomal microarray analysis and whole-exome sequencing for prenatal diagnosis of fetuses with cardiac ultrasound anomalies

in Human and Medical Genomics

Youlan Wu
Gui Chen
Fang Yang
Xiang Liu
Yawen Qiang
Renhua Wu
Fang Liu
Weisheng Cheng
Jing Yuan

Frontiers in Genetics

doi 10.3389/fgene.2025.1668252

1,199 views

Correction

Published on 02 Jan 2026

Correction: Identification of a novel ANK1 gene variant c.1504-9G>A and its mechanism of intron retention in hereditary spherocytosis

in Genetics of Common and Rare Diseases

Ting Xiong
Zhongjin Xu
Qian Wan
Feng Chen
Yao Ye
Hong Wang
Chongjun Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1762322

864 views

Original Research

Published on 02 Jan 2026

Impacts of rs7528684 (−169T/C) on FCRL3, FOXP3, and IL-35 gene expressions and IgG-RF correlation: insights into the pathogenesis of rheumatoid arthritis

in Immunogenetics

S. Mohamed Muzammil
S. Asha Devi

Frontiers in Genetics

doi 10.3389/fgene.2025.1720056

1,235 views

Review

Published on 02 Jan 2026

The power and the promise of epigenetic drugs in oncology

in Pharmacogenetics and Pharmacogenomics

Thalita Basso Scandolara
Isabelle Vasconcelos Menegoy Siqueira
Luis Felipe Ribeiro Pinto
Sheila Coelho Soares-Lima

Frontiers in Genetics

doi 10.3389/fgene.2025.1622115

1,749 views

Review

Accepted on 29 Dec 2025

Applications and challenges of multi-omics approaches in lung cancer research and precision treatment

in Cancer Genetics and Oncogenomics

Shouyu Zhang
Jiadi Gan
Qian Zheng
Renjie Xu
Bojiang Chen
Weimin Li

Frontiers in Genetics

180 views

Original Research

Accepted on 24 Dec 2025

Prognosis of pediatric restrictive cardiomyopathy: more severe in sarcomeric variants

in Genetics of Common and Rare Diseases

CATHERINE GARDIN
PIERRE-EMMANUEL MICHELS
Elena Panaioli
ELISE DAIRE
FLAVIE ADER
SOPHIE MALEKZADEH MILANI
DAMIEN BONNET
DIALA KHRAICHE

Frontiers in Genetics

229 views

Editorial

Published on 19 Dec 2025

Editorial: Advances in circRNA research: disease associations and diagnostic innovations

in Computational Genomics

Quan Zou
Mengting Niu
Xiaoqing Ru

Frontiers in Genetics

doi 10.3389/fgene.2025.1759692

1,704 views

Methods

Published on 19 Dec 2025

fastMETA: a fast and efficient tool for multivariate meta-analysis of GWAS

in Computational Genomics

Georgios A. Manios
Dionysios Kandylas
Athanasios Kylonis
Pantelis G. Bagos
Panagiota I. Kontou

Frontiers in Genetics

doi 10.3389/fgene.2025.1718626

1,590 views

Original Research

Published on 19 Dec 2025

Early genetic events in the colorectal carcinogenic pathway of familial adenomatous polyposis and sporadic polyp: germline and somatic alterations in carcinogenesis

in Cancer Genetics and Oncogenomics

Hiroki Tanabe
Yusuke Mizukami
Yusuke Ono
Hidehiro Takei
Nobue Tamamura
Yu Kobayashi
Keitaro Takahashi
Katsuyoshi Ando
Nobuhiro Ueno
Shin Kashima

Frontiers in Genetics

doi 10.3389/fgene.2025.1668133

1,915 views

Original Research

Published on 18 Dec 2025

Copy number variants in fetuses with isolated and non-isolated increased nuchal translucency detected by chromosomal microarray analysis

in Human and Medical Genomics

Shuxian Huang
Heming Wu
Lingna She
Lina Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1712025

1,210 views

Original Research

Published on 18 Dec 2025

Integrative linkage and recombination analysis of 25 X-STRs across 7 linkage groups using pedigree-based and SNP-based strategies

in Evolutionary and Population Genetics

Jinglei Qian
Xiaoqin Qian
Qiqi Ji
Zhimin Li
Chengchen Shao
Hongmei Xu
Fan Yang
Jianhui Xie

Frontiers in Genetics

doi 10.3389/fgene.2025.1727583

1,820 views

Original Research

Published on 18 Dec 2025

Transcriptomic profiling of human endothelial cells infected with venezuelan equine encephalitis virus reveals NRF2 driven host reprogramming mediated by omaveloxolone treatment

in Immunogenetics

Mostafa Rezapour
Lorreta A. Opoku
Stephanie V. Trefry
Abbas Alili
Maame Konadu
Maria Galarza Dionisio
Metin Nafi Gurcan
Aarthi Narayanan

Frontiers in Genetics

doi 10.3389/fgene.2025.1722527

2,021 views

Case Report

Published on 18 Dec 2025

Case Report: Minigene assays reveal a novel DNAAF6 intronic variant as the key etiology for primary ciliary dyskinesia

in Human and Medical Genomics

Yupeng Long
Huixian Li
Haoyue Yu
Qian Yi
Xiong Meng
Xi Wang
Qinqin Ren
Dongyan Ding
Haidong Li
Fenglan Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1692658

1,660 views

Original Research

Published on 18 Dec 2025

rs9789446 genotype as susceptibility biomarkers for congenital hypothyroidism based on population and family validation

in Genetics of Common and Rare Diseases

Xue Zhong
Yaning Jia
Wenmiao Liu
Mengfei Qiao
Miaomiao Li
Xiaolong Yu
Shiguo Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1721264

1,069 views

Case Report

Published on 18 Dec 2025

Case Report: UMOD gene mutation and phenotypic overlap with REN in autosomal dominant tubulointerstitial kidney disease

in Genetics of Common and Rare Diseases

Jingying Xu
Enhui Chen
Wen Shi
Wenhui He
Dongrong Yu
Xianfa Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1661377

1,425 views

Original Research

Published on 18 Dec 2025

Post-translational modification gene signatures implicate FBXW7 in immune and vascular dysregulation of Moyamoya disease

in Human and Medical Genomics

Xiaofan Yu
Zicong Wang
Zhenyu Zhou
Yutong Liu
Shihao He
Yuanli Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1723233

1,543 views

Opinion

Published on 18 Dec 2025

Application of next-generation sequencing to determine mutations in candidate genes for congenital eye malformations in the Mexican indigenous population

in Genetics of Common and Rare Diseases

Iván Antonio García-Montalvo
Diana Matías-Pérez
María José Ruiz-Sanginéz
Juan Carlos Zenteno

Frontiers in Genetics

doi 10.3389/fgene.2025.1710953

1,701 views

Original Research

Published on 18 Dec 2025

Expanding the spectrum of NUS1-related progressive myoclonic epilepsy: a novel variant and exploratory use of metformin

in Genetics of Common and Rare Diseases

Cristina Sau
Sergi López-Rodríguez
Mercè Falip
Anna Esteve-Garcia
Jacint Sala-Padró
Cinthia Aguilera
Alba Navarro-Romero
Amaia Lasa-Aranzasti
Laura Rodríguez-Bel
Guillermo Hernández-Pérez

Frontiers in Genetics

doi 10.3389/fgene.2025.1665623

1,742 views

Brief Research Report

Published on 17 Dec 2025

Variance of Ks distribution corrects the bias in the divergence caused by the ancestral population size

in Computational Genomics

Mi-Jia Li
Xiao-Xue Li
Lin-Lin Xu
Bo-Wen Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1725551

1,710 views

Editorial

Published on 17 Dec 2025

Editorial: Genetics (SKINOMICS): new trends in skin aging research and clinical application

in Genetics of Aging

Rogério Saad Vaz
Israel Gomy
Katherine Athayde Teixeira de Carvalho

Frontiers in Genetics

doi 10.3389/fgene.2025.1764308

1,868 views

Original Research

Published on 17 Dec 2025

Diagnostic and prognostic value of polygene methylation detection in ascites

in Cancer Genetics and Oncogenomics

Yang Ma
Xueqing Wang
Yun Du

Frontiers in Genetics

doi 10.3389/fgene.2025.1680036

1,527 views

Original Research

Published on 17 Dec 2025

LRRC56 deficiency cause motile ciliopathies in humans and mice

in Genetics of Common and Rare Diseases

Xiao-Hui Xie
Heng Gu
Jun-Lin Yang
Zhuang-Zhuang Yuan
Ke-Le Qin
Zhi-Ping Tan

Frontiers in Genetics

doi 10.3389/fgene.2025.1658063

1,798 views

Editorial

Published on 16 Dec 2025

Editorial: A year in review: discussions in RNA

in RNA

Sybille Krauß
Nicoletta Potenza

Frontiers in Genetics

doi 10.3389/fgene.2025.1752525

1,603 views

Original Research

Published on 16 Dec 2025

A transcriptomic atlas at bulk and single-cell levels identifies novel transcriptional and splicing regulators of ECM homeostasis in osteoarthritis

in Genetics of Common and Rare Diseases

Xiguang Ye
Chunyan Zheng
Hao Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1690319

1,350 views

16,571 articles

articles

Integration of chromosomal microarray analysis and whole-exome sequencing for prenatal diagnosis of fetuses with cardiac ultrasound anomalies

Correction: Identification of a novel ANK1 gene variant c.1504-9G>A and its mechanism of intron retention in hereditary spherocytosis

Impacts of rs7528684 (−169T/C) on FCRL3, FOXP3, and IL-35 gene expressions and IgG-RF correlation: insights into the pathogenesis of rheumatoid arthritis

The power and the promise of epigenetic drugs in oncology

Applications and challenges of multi-omics approaches in lung cancer research and precision treatment

Prognosis of pediatric restrictive cardiomyopathy: more severe in sarcomeric variants

Editorial: Advances in circRNA research: disease associations and diagnostic innovations

fastMETA: a fast and efficient tool for multivariate meta-analysis of GWAS

Early genetic events in the colorectal carcinogenic pathway of familial adenomatous polyposis and sporadic polyp: germline and somatic alterations in carcinogenesis

Copy number variants in fetuses with isolated and non-isolated increased nuchal translucency detected by chromosomal microarray analysis

Integrative linkage and recombination analysis of 25 X-STRs across 7 linkage groups using pedigree-based and SNP-based strategies

Transcriptomic profiling of human endothelial cells infected with venezuelan equine encephalitis virus reveals NRF2 driven host reprogramming mediated by omaveloxolone treatment

Case Report: Minigene assays reveal a novel DNAAF6 intronic variant as the key etiology for primary ciliary dyskinesia

rs9789446 genotype as susceptibility biomarkers for congenital hypothyroidism based on population and family validation

Case Report: UMOD gene mutation and phenotypic overlap with REN in autosomal dominant tubulointerstitial kidney disease

Post-translational modification gene signatures implicate FBXW7 in immune and vascular dysregulation of Moyamoya disease

Application of next-generation sequencing to determine mutations in candidate genes for congenital eye malformations in the Mexican indigenous population

Expanding the spectrum of NUS1-related progressive myoclonic epilepsy: a novel variant and exploratory use of metformin

Variance of Ks distribution corrects the bias in the divergence caused by the ancestral population size

Editorial: Genetics (SKINOMICS): new trends in skin aging research and clinical application

Diagnostic and prognostic value of polygene methylation detection in ascites

LRRC56 deficiency cause motile ciliopathies in humans and mice

Editorial: A year in review: discussions in RNA

A transcriptomic atlas at bulk and single-cell levels identifies novel transcriptional and splicing regulators of ECM homeostasis in osteoarthritis