Frontiers in Genetics | Computational Genomics

Editorial

Published on 13 Feb 2026

Editorial: Advancements in AI for the analysis and interpretation of large-scale data by omics techniques

in Computational Genomics

Angelo Facchiano
Deborah Giordano
Dominik Heider

Frontiers in Genetics

doi 10.3389/fgene.2026.1784820

185 views

Editorial

Accepted on 12 Feb 2026

Editorial: Advancements in Sequencing Technologies for Epigenomic and Transcriptomic Analysis: From Bulk to Single-Cell Resolution

in Computational Genomics

Laura Veschetti
Massimiliano Cocca
DAGO DOUGBA NOEL
Giovanni Malerba

Frontiers in Genetics

Review

Accepted on 11 Feb 2026

Multiscale Computational Genomics in Wilson Disease: From Atomic Dynamics to Clinical Prediction

in Computational Genomics

Moujun Luan
Qingkai Xue
Yujie Cao
Gangli Cheng
Xingxing Huo

Frontiers in Genetics

Original Research

Published on 11 Feb 2026

Identification of programmed cell death and mitochondria correlated biomarkers for Kawasaki disease by integrated bioinformatics and machine-learning algorithms with RT-qPCR verification

in Computational Genomics

Tengyang Wang
Chengyi Wang
Yiwei Chen
Xiaofeng Guo

Frontiers in Genetics

doi 10.3389/fgene.2026.1677146

407 views

Methods

Published on 10 Feb 2026

DWGCN: distance-weighted graph convolutional network for robust spatial domain identification in spatial transcriptomics

in Computational Genomics

Chunfang Peng
Guobin Li
Jiamiao Wu
Qiao Fan
Xiaobo Guo

Frontiers in Genetics

doi 10.3389/fgene.2026.1779455

403 views

Original Research

Accepted on 09 Feb 2026

Identification of the PFK Gene Family in Solanum species and 1 Expression Analysis in the Fruitof Solanum lycopersicum 2

in Computational Genomics

Zepeng Wang
Zhongyu Wang
Ruiqiang Xu
Qingyuan Meng
Jintao Wang
Ning Li
Qinghui Yu

Frontiers in Genetics

Original Research

Published on 03 Feb 2026

TCN-5mC: a predictor of 5-methylcytosine sites based on multi-feature fusion and TCN-inspired block networks

in Computational Genomics

Cunwen Liu
Xuan Xiao
LongChang Wan
WeiZhong Lin

Frontiers in Genetics

doi 10.3389/fgene.2026.1739720

616 views

Original Research

Published on 02 Feb 2026

Mitophagy-related molecular signatures in ulcerative colitis revealed by machine learning and molecular dynamics

in Computational Genomics

Yanru Han
Weihua Ren
Sujuan Li
Zhenxia Zhao
Zhiqiang Lin
Fucheng Zhao

Frontiers in Genetics

doi 10.3389/fgene.2026.1760869

1,037 views

Original Research

Accepted on 31 Jan 2026

Auxiliary diagnosis model for pathological classification of cervical cancer based on biomarkers in radiomics

in Computational Genomics

Mei Wang
Yu Cao
Mengchen Zhu
Peilin Zhao
Qin Zhou
Hongxiang Lan
Jizhao Liu
Junqiang Lei

Frontiers in Genetics

128 views

Original Research

Accepted on 29 Jan 2026

Glycolysis-related gene signatures in spinal cord injury pathophysiology identification through integrative gene expression analysis

in Computational Genomics

Ai Xin
Xiaoqin Liu
Zhuang Wang
Jiating Hu
Guodong Shi

Frontiers in Genetics

326 views

Original Research

Published on 23 Jan 2026

Identifying druggable gene-related biomarkers in intervertebral disc degeneration through transcriptome sequencing and mendelian randomization analysis

in Computational Genomics

Keping Wang
Zuolong Wu
Guanghai Zhao
Shaolong Li
Yizhe Lou
Guanhong Pan
Guangyi Wang
Haihong Zhang

Frontiers in Genetics

doi 10.3389/fgene.2026.1627091

859 views

Case Report

Accepted on 21 Jan 2026

Association of a Rare Single Nucleotide Variant in the KCNH2 Gene with Drug-Induced QT Prolongation and Computationally Predicted Pathogenicity

in Computational Genomics

TIANCI WANG
Charlene Norgan Radler
Mohanakrishnan Sathyamoorthy

Frontiers in Genetics

282 views

Original Research

Published on 21 Jan 2026

DFL-MHC: MHC identification model based on dual-stage training and multi-view feature fusion

in Computational Genomics

Yanjuan Li
Yiben Lin
Dong Chen

Frontiers in Genetics

doi 10.3389/fgene.2026.1774569

624 views

Original Research

Published on 21 Jan 2026

Coronary heart disease risk prediction based on GAIN imputation and interpretable machine learning

in Computational Genomics

Shulin Zhao
Baoyun Nan
Jun Guo
Wenkai Xu
Zhen Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1752811

768 views

Brief Research Report

Published on 14 Jan 2026

Balancing speed and precision in protein folding: a comparison of AlphaFold2, ESMFold, and OmegaFold

in Computational Genomics

Anna Hýsková
Eva Maršálková
Petr Šimeček

Frontiers in Genetics

doi 10.3389/fgene.2025.1715037

1,305 views

Original Research

Published on 12 Jan 2026

FSFT6mA: a feature-synthesis fine-tuning framework for DNA 6mA site prediction

in Computational Genomics

Hong-Jin Yu
Ying Zhang
Dong-Jun Yu
Guansheng Zheng

Frontiers in Genetics

doi 10.3389/fgene.2025.1750223

739 views

Mini Review

Published on 09 Jan 2026

Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency

in Computational Genomics

Mahnoor Sajjad
Seong Gyu Kwon

Frontiers in Genetics

doi 10.3389/fgene.2025.1761810

960 views

Methods

Published on 07 Jan 2026

Resilience and evolutionary insights in PPI networks: comparative analysis of node resilience and centrality measures

in Computational Genomics

Jiarui Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1613475

775 views

Original Research

Published on 07 Jan 2026

DDA-bench: a manually curated database for benchmarking datasets and baseline performance values in predicting drug-disease associations

in Computational Genomics

Han Xing
Yongjian Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1755600

782 views

Original Research

Published on 05 Jan 2026

scVAR: integrating genomics and transcriptomics from single-cell RNA-seq —insights from leukemia case studies

in Computational Genomics

Ludovica Celli
Samuele Manessi
Matteo Barcella
Ivan Merelli

Frontiers in Genetics

doi 10.3389/fgene.2025.1604484

1,240 views

Original Research

Published on 05 Jan 2026

Lorentz-regularized interpretable VAE for multi-scale single-cell transcriptomic and epigenomic embeddings

in Computational Genomics

Zeyu Fu
Jiawei Fu
Chunlin Chen
Keyang Zhang
Song Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1713727

1,487 views

Methods

Published on 19 Dec 2025

fastMETA: a fast and efficient tool for multivariate meta-analysis of GWAS

in Computational Genomics

Georgios A. Manios
Dionysios Kandylas
Athanasios Kylonis
Pantelis G. Bagos
Panagiota I. Kontou

Frontiers in Genetics

doi 10.3389/fgene.2025.1718626

1,586 views

Editorial

Published on 19 Dec 2025

Editorial: Advances in circRNA research: disease associations and diagnostic innovations

in Computational Genomics

Quan Zou
Mengting Niu
Xiaoqing Ru

Frontiers in Genetics

doi 10.3389/fgene.2025.1759692

1,700 views

Brief Research Report

Published on 17 Dec 2025

Variance of Ks distribution corrects the bias in the divergence caused by the ancestral population size

in Computational Genomics

Mi-Jia Li
Xiao-Xue Li
Lin-Lin Xu
Bo-Wen Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1725551

1,697 views

2,653 articles

articles

Editorial: Advancements in AI for the analysis and interpretation of large-scale data by omics techniques

Editorial: Advancements in Sequencing Technologies for Epigenomic and Transcriptomic Analysis: From Bulk to Single-Cell Resolution

Multiscale Computational Genomics in Wilson Disease: From Atomic Dynamics to Clinical Prediction

Identification of programmed cell death and mitochondria correlated biomarkers for Kawasaki disease by integrated bioinformatics and machine-learning algorithms with RT-qPCR verification

DWGCN: distance-weighted graph convolutional network for robust spatial domain identification in spatial transcriptomics

Identification of the PFK Gene Family in Solanum species and 1 Expression Analysis in the Fruitof Solanum lycopersicum 2

TCN-5mC: a predictor of 5-methylcytosine sites based on multi-feature fusion and TCN-inspired block networks

Mitophagy-related molecular signatures in ulcerative colitis revealed by machine learning and molecular dynamics

Auxiliary diagnosis model for pathological classification of cervical cancer based on biomarkers in radiomics

Glycolysis-related gene signatures in spinal cord injury pathophysiology identification through integrative gene expression analysis

Identifying druggable gene-related biomarkers in intervertebral disc degeneration through transcriptome sequencing and mendelian randomization analysis

Association of a Rare Single Nucleotide Variant in the KCNH2 Gene with Drug-Induced QT Prolongation and Computationally Predicted Pathogenicity

DFL-MHC: MHC identification model based on dual-stage training and multi-view feature fusion

Coronary heart disease risk prediction based on GAIN imputation and interpretable machine learning

Balancing speed and precision in protein folding: a comparison of AlphaFold2, ESMFold, and OmegaFold

FSFT6mA: a feature-synthesis fine-tuning framework for DNA 6mA site prediction

Reconstructing developmental lineages: a retrospective approach using somatic mutations and variant allele frequency

Resilience and evolutionary insights in PPI networks: comparative analysis of node resilience and centrality measures

DDA-bench: a manually curated database for benchmarking datasets and baseline performance values in predicting drug-disease associations

scVAR: integrating genomics and transcriptomics from single-cell RNA-seq —insights from leukemia case studies

Lorentz-regularized interpretable VAE for multi-scale single-cell transcriptomic and epigenomic embeddings

fastMETA: a fast and efficient tool for multivariate meta-analysis of GWAS

Editorial: Advances in circRNA research: disease associations and diagnostic innovations

Variance of Ks distribution corrects the bias in the divergence caused by the ancestral population size