Frontiers in Genetics | Human and Medical Genomics

Original Research

Published on 31 Mar 2022

Identification of a Novel Deep Intronic Variant by Whole Genome Sequencing Combined With RNA Sequencing in a Chinese Patient With Menkes Disease

in Human and Medical Genomics

Xiufang Zhi
Qi Ai
Wenchao Sheng
Yuping Yu
Jianbo Shu
Changshun Yu
Xiaoli Yu
Dong Li
Chunquan Cai

Frontiers in Genetics

doi 10.3389/fgene.2022.852764

5,894 views
2 citations

Editorial

Published on 31 Mar 2022

Editorial: Clinical Genome Sequencing: Bioinformatics Challenges and Key Considerations

in Human and Medical Genomics

Shulan Tian
Zheng Jin Tu
Huihuang Yan
Eric W. Klee

Frontiers in Genetics

doi 10.3389/fgene.2022.896032

1,903 views

Original Research

Published on 31 Mar 2022

Comparison of Data Normalization Strategies for Array-Based MicroRNA Profiling Experiments and Identification and Validation of Circulating MicroRNAs as Endogenous Controls in Hypertension

in Human and Medical Genomics

Lakshmi Manasa S. Chekka
Taimour Langaee
Julie A. Johnson

Frontiers in Genetics

doi 10.3389/fgene.2022.836636

5,424 views
14 citations

Review

Published on 30 Mar 2022

Leveraging Optimized Transcriptomic and Personalized Stem Cell Technologies to Better Understand Syncytialization Defects in Preeclampsia

in Human and Medical Genomics

Sehee Choi
Teka Khan
R. Michael Roberts
Danny J. Schust

Frontiers in Genetics

doi 10.3389/fgene.2022.872818

4,778 views
5 citations

Mini Review

Published on 30 Mar 2022

Small Non-Coding RNAs in the Human Placenta: Regulatory Roles and Clinical Utility

in Human and Medical Genomics

Nikita Telkar
Greg L. Stewart
Michelle E. Pewarchuk
David E. Cohn
Wendy P. Robinson
Wan L. Lam

Frontiers in Genetics

doi 10.3389/fgene.2022.868598

4,314 views
11 citations

Case Report

Published on 29 Mar 2022

Case Report: Exome and RNA Sequencing Identify a Novel de novo Missense Variant in HNRNPK in a Chinese Patient With Au-Kline Syndrome

in Human and Medical Genomics

Xin Pan
Sihan Liu
Li Liu
Xu Zhang
Hong Yao
Bo Tan

Frontiers in Genetics

doi 10.3389/fgene.2022.853028

3,805 views
4 citations

Review

Published on 29 Mar 2022

Phospholipid Scramblases: Role in Cancer Progression and Anticancer Therapeutics

in Human and Medical Genomics

Himadri Gourav Behuria
Sabyasachi Dash
Santosh Kumar Sahu

Frontiers in Genetics

doi 10.3389/fgene.2022.875894

12,321 views
16 citations

Original Research

Published on 28 Mar 2022

Clinical and Genetic Characteristics of IKZF1 Mutation in Chinese Children With B-Cell Acute Lymphoblastic Leukemia

in Human and Medical Genomics

Jingying Zhang
Xiao-Jun Xu
Lixia Liu
Hua Song
Heping Shen
Weiqun Xu
Fenying Zhao
Juan Liang
Chan Liao
Yan Wang

Frontiers in Genetics

doi 10.3389/fgene.2022.822832

5,806 views
4 citations

Original Research

Published on 25 Mar 2022

Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I

in Human and Medical Genomics

Zhi-e Fang
Chunyu Wang
Ming Niu
Tingting Liu
Lutong Ren
Qiang Li
Zhiyong Li
Ziying Wei
Li Lin
Wenqing Mu

Frontiers in Genetics

doi 10.3389/fgene.2022.840961

4,566 views
12 citations

Opinion

Published on 25 Mar 2022

Esophageal Cancer Genomics in Africa: Recommendations for Future Research

in Human and Medical Genomics

Hannah Simba
Gerard Tromp
Vikash Sewram
Christopher G Mathew
Wenlong C. Chen
Helena Kuivaniemi

Frontiers in Genetics

doi 10.3389/fgene.2022.864575

4,070 views
4 citations

Perspective

Published on 25 Mar 2022

Parental Guidance Suggested: Engaging Parents as Partners in Research Studies of Genomic Screening for a Pediatric Population

in Human and Medical Genomics

Sabrina N. Powell
Grace Byfield
Ashley Bennetone
Annabelle M. Frantz
Langston K. Harrison
Erin R. James-Crook
Heather Osborne
Thomas H. Owens
Jonathan L. Shaw
Julianne O’Daniel

Frontiers in Genetics

doi 10.3389/fgene.2022.867030

4,813 views
10 citations

Editorial

Published on 25 Mar 2022

Editorial: The Genetic Causes Underlying Immune Mediated Disease: A Focus on Autoimmunity and Cancer

in Human and Medical Genomics

Silvia Jiménez-Morales
Xianwen Ren
Michael Dean

Frontiers in Genetics

doi 10.3389/fgene.2022.889160

2,378 views
1 citation

Original Research

Published on 25 Mar 2022

Feasibility of Follow-Up Studies and Reclassification in Spinocerebellar Ataxia Gene Variants of Unknown Significance

in Human and Medical Genomics

Fatemeh Ghorbani
Mohamed Z. Alimohamed
Juliana F. Vilacha
Krista K. Van Dijk
Jelkje De Boer-Bergsma
Michiel R. Fokkens
Henny Lemmink
Rolf H. Sijmons
Birgit Sikkema-Raddatz
Matthew R. Groves

Frontiers in Genetics

doi 10.3389/fgene.2022.782685

5,459 views
6 citations

Original Research

Published on 25 Mar 2022

Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke

in Human and Medical Genomics

Zongkai Wu
Wanyi Wei
Hongzhen Fan
Yongsheng Gu
Litao Li
Hebo Wang

Frontiers in Genetics

doi 10.3389/fgene.2022.833545

7,574 views
15 citations

Brief Research Report

Published on 24 Mar 2022

Identification of New Biological Pathways Involved in Skin Aging From the Analysis of French Women Genome-Wide Data

in Human and Medical Genomics

Myriam Rahmouni
Vincent Laville
Jean-Louis Spadoni
Randa Jdid
Leopold Eckhart
Florian Gruber
Taoufik Labib
Cedric Coulonges
Wassila Carpentier
Julie Latreille

Frontiers in Genetics

doi 10.3389/fgene.2022.836581

7,939 views
7 citations

Review

Published on 23 Mar 2022

The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review

in Human and Medical Genomics

Nikolai Paul Pace
Dillon Mintoff
Isabella Borg

Frontiers in Genetics

doi 10.3389/fgene.2022.861241

10,091 views
33 citations

Original Research

Published on 23 Mar 2022

Copy Number Variation Analysis of Euploid Pregnancy Loss

in Human and Medical Genomics

Chongjuan Gu
Huan Gao
Kuanrong Li
Xinyu Dai
Zhao Yang
Ru Li
Canliang Wen
Yaojuan He

Frontiers in Genetics

doi 10.3389/fgene.2022.766492

4,701 views
8 citations

Original Research

Published on 23 Mar 2022

Mxi1-0 Promotes Hypoxic Pulmonary Hypertension Via ERK/c-Myc-dependent Proliferation of Arterial Smooth Muscle Cells

in Human and Medical Genomics

Liang Dong
Xinning Liu
Bo Wu
Chengwei Li
Xiaomin Wei
Gulinuer Wumaier
Xiujuan Zhang
Jing Wang
Jingwen Xia
Yuanyuan Zhang

Frontiers in Genetics

doi 10.3389/fgene.2022.810157

5,309 views
11 citations

Mini Review

Published on 22 Mar 2022

Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions

in Human and Medical Genomics

Kagiso Laka
Lilian Makgoo
Zukile Mbita

Frontiers in Genetics

doi 10.3389/fgene.2022.841639

13,015 views
47 citations

Original Research

Published on 22 Mar 2022

An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection

in Human and Medical Genomics

Rabail Zehra Raza
Sumra Wajid Abbasi

Frontiers in Genetics

doi 10.3389/fgene.2022.859508

2,950 views
8 citations

Original Research

Published on 22 Mar 2022

Whole-Genome Sequencing of Vero E6 (VERO C1008) and Comparative Analysis of Four Vero Cell Sublines

in Human and Medical Genomics

Kazuhiro Konishi
Toshiyuki Yamaji
Chisato Sakuma
Fumio Kasai
Toshinori Endo
Arihiro Kohara
Kentaro Hanada
Naoki Osada

Frontiers in Genetics

doi 10.3389/fgene.2022.801382

20,142 views
18 citations

Original Research

Published on 18 Mar 2022

Identification of GGT5 as a Novel Prognostic Biomarker for Gastric Cancer and its Correlation With Immune Cell Infiltration

in Human and Medical Genomics

Yuli Wang
Yuan Fang
Fanchen Zhao
Jiefei Gu
Xiang Lv
Rongzhong Xu
Bo Zhang
Zhihong Fang
Yan Li

Frontiers in Genetics

doi 10.3389/fgene.2022.810292

6,963 views
20 citations

Original Research

Published on 18 Mar 2022

WGCNA, LASSO and SVM Algorithm Revealed RAC1 Correlated M0 Macrophage and the Risk Score to Predict the Survival of Hepatocellular Carcinoma Patients

in Human and Medical Genomics

Ji-An You
Yuhan Gong
Yongzhe Wu
Libo Jin
Qingjia Chi
Da Sun

Frontiers in Genetics

doi 10.3389/fgene.2021.730920

6,989 views
25 citations

Original Research

Published on 16 Mar 2022

Fine Mapping of the MAP2K5 Region Identified rs7175517 as a Causal Variant Related to BMI in China and the United Kingdom Populations

in Human and Medical Genomics

Ce Lu
Hai-Jun Wang
Jie-Yun Song
Shuo Wang
Xue-Ying Li
Tao Huang
Hui Wang

Frontiers in Genetics

doi 10.3389/fgene.2022.838685

2,996 views
5 citations

846 articles

articles

Identification of a Novel Deep Intronic Variant by Whole Genome Sequencing Combined With RNA Sequencing in a Chinese Patient With Menkes Disease

Editorial: Clinical Genome Sequencing: Bioinformatics Challenges and Key Considerations

Comparison of Data Normalization Strategies for Array-Based MicroRNA Profiling Experiments and Identification and Validation of Circulating MicroRNAs as Endogenous Controls in Hypertension

Leveraging Optimized Transcriptomic and Personalized Stem Cell Technologies to Better Understand Syncytialization Defects in Preeclampsia

Small Non-Coding RNAs in the Human Placenta: Regulatory Roles and Clinical Utility

Case Report: Exome and RNA Sequencing Identify a Novel de novo Missense Variant in HNRNPK in a Chinese Patient With Au-Kline Syndrome

Phospholipid Scramblases: Role in Cancer Progression and Anticancer Therapeutics

Clinical and Genetic Characteristics of IKZF1 Mutation in Chinese Children With B-Cell Acute Lymphoblastic Leukemia

Integration of Transcriptomic and Metabolomic Data to Compare the Hepatotoxicity of Neonatal and Adult Mice Exposed to Aristolochic Acid I

Esophageal Cancer Genomics in Africa: Recommendations for Future Research

Parental Guidance Suggested: Engaging Parents as Partners in Research Studies of Genomic Screening for a Pediatric Population

Editorial: The Genetic Causes Underlying Immune Mediated Disease: A Focus on Autoimmunity and Cancer

Feasibility of Follow-Up Studies and Reclassification in Spinocerebellar Ataxia Gene Variants of Unknown Significance

Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke

Identification of New Biological Pathways Involved in Skin Aging From the Analysis of French Women Genome-Wide Data

The Genomic Architecture of Hidradenitis Suppurativa—A Systematic Review

Copy Number Variation Analysis of Euploid Pregnancy Loss

Mxi1-0 Promotes Hypoxic Pulmonary Hypertension Via ERK/c-Myc-dependent Proliferation of Arterial Smooth Muscle Cells

Cholesterol-Lowering Phytochemicals: Targeting the Mevalonate Pathway for Anticancer Interventions

An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection

Whole-Genome Sequencing of Vero E6 (VERO C1008) and Comparative Analysis of Four Vero Cell Sublines

Identification of GGT5 as a Novel Prognostic Biomarker for Gastric Cancer and its Correlation With Immune Cell Infiltration

WGCNA, LASSO and SVM Algorithm Revealed RAC1 Correlated M0 Macrophage and the Risk Score to Predict the Survival of Hepatocellular Carcinoma Patients

Fine Mapping of the MAP2K5 Region Identified rs7175517 as a Causal Variant Related to BMI in China and the United Kingdom Populations