Frontiers in Genetics | Toxicogenomics

Original Research

Published on 28 Mar 2025

Differentially expressed and alternately spliced genes as a novel tool for genotoxicity: a computerized study in ATT-myc transgenic mice for the recognition of genotoxic and non-genotoxic chemical

in Toxicogenomics

Mansour A. Alghamdi
Eman M. El Nashar
Mahmoud Elalfy
Norah S. Al-Zahrani
Mohammed A. Alshehri
Mohammad El-Nablaway
Khulood M. Al-Khater
Rashid A. Aldahhan
Eman G. El-Hadidy
Fathy Sleem

Frontiers in Genetics

doi 10.3389/fgene.2025.1505379

171 views

Original Research

Published on 25 Mar 2025

Blood toxicogenomics reveals potential biomarkers for management of idiosyncratic drug-induced liver injury

in Toxicogenomics

Rachel J. Church
Benedict Anchang
Brian D. Bennett
Pierre R. Bushel
Paul B. Watkins

Frontiers in Genetics

doi 10.3389/fgene.2025.1524433

328 views

Original Research

Accepted on 17 Mar 2025

Checkpoint and Recombination Pathways Independently Suppress Rates of Spontaneous Homology-directed Chromosomal Translocations in Budding Yeast

in Toxicogenomics

Li Zeng
Mingzeng Sun
Michael T Fasullo

Frontiers in Genetics

doi 10.3389/fgene.2025.1479307

Original Research

Published on 07 Mar 2025

Tetrahymena thermophila glutathione-S-transferase superfamily: an eco-paralogs gene network differentially responding to various environmental abiotic stressors and an update on this gene family in ciliates

in Toxicogenomics

Ruth Ortega
Ana Martin-González
Juan-Carlos Gutiérrez

Frontiers in Genetics

doi 10.3389/fgene.2025.1538168

534 views

Correction

Published on 17 Feb 2025

Corrigendum: Zearalenone exposure enhanced the expression of tumorigenesis genes in donkey granulosa cells via the PTEN/PI3K/AKT signaling pathway

in Toxicogenomics

Guo-Liang Zhang
Jun-Lin Song
Chuan-Liang Ji
Yu-Long Feng
Jie Yu
Charles M. Nyachoti
Gong-She Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1564143

446 views

Original Research

Published on 02 Dec 2024

SOLA: dissecting dose-response patterns in multi-omics data using a semi-supervised workflow

in Toxicogenomics

Wanxin Lai
You Song
Knut Erik Tollefsen
Torgeir R. Hvidsten

Frontiers in Genetics

doi 10.3389/fgene.2024.1508521

784 views

Original Research

Published on 22 May 2024

Integrating gene expression and splicing dynamics across dose-response oxidative modulators

in Toxicogenomics

A. Rasim Barutcu
Michael B. Black
Raymond Samuel
Scott Slattery
Patrick D. McMullen
Andy Nong

Frontiers in Genetics

doi 10.3389/fgene.2024.1389095

1,710 views

Original Research

Published on 17 May 2024

Characteristics of phosgene aspiration lung injury analyzed based on transcriptomics and proteomics

in Toxicogenomics

Li-Na Wang
Yi-Ru Shao
Peng-Fei Wang
Jiang Lv
Dai-Kun He

Frontiers in Genetics

doi 10.3389/fgene.2024.1393665

1,652 views

Original Research

Published on 09 May 2024

Transcriptomic point of departure determination: a comparison of distribution-based and gene set-based approaches

in Toxicogenomics

Eduardo Costa
Kamin J. Johnson
Carl A. Walker
Jason M. O’Brien

Frontiers in Genetics

doi 10.3389/fgene.2024.1374791

2,807 views
2 citations

Brief Research Report

Published on 12 Jan 2024

Mft1, identified from a genome-wide screen of the yeast haploid mutants, mediates cell cycle arrest to counteract quinoxaline-induced toxicity

in Toxicogenomics

Abdallah Alhaj Sulaiman
Dana E. Al-Ansari
Reem Ali
Mustapha Aouida
Dindial Ramotar

Frontiers in Genetics

doi 10.3389/fgene.2023.1296383

2,177 views

Review

Published on 20 Apr 2023

Thallium-induced DNA damage, genetic, and epigenetic alterations

in Toxicogenomics

Laura Sánchez-Chapul
Abel Santamaría
Michael Aschner
Tao Ke
Alexey A. Tinkov
Isaac Túnez
Laura Osorio-Rico
Sonia Galván-Arzate
Edgar Rangel-López

Frontiers in Genetics

doi 10.3389/fgene.2023.1168713

6,756 views
21 citations

Original Research

Published on 03 Mar 2023

Hepatic gene expression profiles during fed–fasted–refed state in mice

in Toxicogenomics

Nana Ji
Liping Xiang
Bing Zhou
Yan Lu
Min Zhang

Frontiers in Genetics

doi 10.3389/fgene.2023.1145769

3,940 views
5 citations

Original Research

Published on 15 Feb 2023

Blood transcriptome responses to PFOA and GenX treatment in the marsupial biomedical model Monodelphis domestica

in Toxicogenomics

Wenqi Cao
Katharine Horzmann
Bettina Schemera
Myra Petrofski
Trisha Kendall
Jennifer Spooner
Patricia E. Rynders
John L. VandeBerg
Xu Wang

Frontiers in Genetics

doi 10.3389/fgene.2023.1073461

3,524 views
1 citation

Original Research

Published on 17 Jan 2023

Preclinical species gene expression database: Development and meta-analysis

in Toxicogenomics

Caitlin Krause
Kinga Suwada
Eric A. G. Blomme
Kenneth Kowalkowski
Michael J. Liguori
Prathap Kumar Mahalingaiah
Scott Mittelstadt
Richard Peterson
Lauren Rendino
Andy Vo

Frontiers in Genetics

doi 10.3389/fgene.2022.1078050

8,716 views
3 citations

Original Research

Published on 07 Dec 2022

Schizosaccharomyces pombe Grx4, Fep1, and Php4: In silico analysis and expression response to different iron concentrations

in Toxicogenomics

Alia Ebrahim
Manal A. Alfwuaires
Mohammad H. Abukhalil
Fawaz Alasmari
Fawad Ahmad
Rui Yao
Ying Luo
Ying Huang

Frontiers in Genetics

doi 10.3389/fgene.2022.1069068

3,211 views
1 citation

Original Research

Published on 24 Nov 2022

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice

in Toxicogenomics

Anju Sharma
Arigesavan Kaninathan
Sumedha Dahal
Susmita Kumari
Bibha Choudhary
Sathees C. Raghavan

Frontiers in Genetics

doi 10.3389/fgene.2022.1047746

4,911 views
6 citations