Frontiers in Genetics | Toxicogenomics

Original Research

Published on 20 Nov 2018

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury

in Toxicogenomics

Terezinha Souza
Panuwat Trairatphisan
Janet Piñero
Laura I. Furlong
Julio Saez-Rodriguez
Jos Kleinjans
Danyel Jennen

Frontiers in Genetics

doi 10.3389/fgene.2018.00527

4,413 views

Original Research

Published on 01 Nov 2018

Robust Co-clustering to Discover Toxicogenomic Biomarkers and Their Regulatory Doses of Chemical Compounds Using Logistic Probabilistic Hidden Variable Model

in Toxicogenomics

Mohammad Nazmol Hasan
Md. Masud Rana
Anjuman Ara Begum
Moizur Rahman
Md. Nurul Haque Mollah

Frontiers in Genetics

doi 10.3389/fgene.2018.00516

2,405 views
10 citations

Original Research

Published on 30 Oct 2018

A Comparison of the TempO-Seq S1500+ Platform to RNA-Seq and Microarray Using Rat Liver Mode of Action Samples

in Toxicogenomics

Pierre R. Bushel
Richard S. Paules
Scott S. Auerbach

Frontiers in Genetics

doi 10.3389/fgene.2018.00485

11,356 views
51 citations

Original Research

Published on 23 Oct 2018

AP-1 (bZIP) Transcription Factors as Potential Regulators of Metallothionein Gene Expression in Tetrahymena thermophila

in Toxicogenomics

Patricia de Francisco
Francisco Amaro
Ana Martín-González
Juan Carlos Gutiérrez

Frontiers in Genetics

doi 10.3389/fgene.2018.00459

5,085 views
8 citations

Original Research

Published on 22 Oct 2018

Network and Pathway Analysis of Toxicogenomics Data

in Toxicogenomics

Gal Barel
Ralf Herwig

Frontiers in Genetics

doi 10.3389/fgene.2018.00484

8,682 views
26 citations

Original Research

Published on 02 Oct 2018

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

in Toxicogenomics

Elias Zgheib
Alice Limonciel
Xiaoqi Jiang
Anja Wilmes
Steven Wink
Bob van de Water
Annette Kopp-Schneider
Frederic Y. Bois
Paul Jennings

Frontiers in Genetics

doi 10.3389/fgene.2018.00429

9,432 views
23 citations

Original Research

Published on 18 Sep 2018

Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

in Toxicogenomics

Alejandro Aguayo-Orozco
Frederic Yves Bois
Søren Brunak
Olivier Taboureau

Frontiers in Genetics

doi 10.3389/fgene.2018.00396

16,317 views
23 citations

Review

Published on 12 Sep 2018

Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation

in Toxicogenomics

Takamitsu Unoki
Masahiro Akiyama
Yoshito Kumagai
Filipe Marques Gonçalves
Marcelo Farina
João Batista Teixeira da Rocha
Michael Aschner

Frontiers in Genetics

doi 10.3389/fgene.2018.00373

9,258 views
57 citations

Original Research

Published on 31 Jul 2018

Zearalenone Exposure Enhanced the Expression of Tumorigenesis Genes in Donkey Granulosa Cells via the PTEN/PI3K/AKT Signaling Pathway

in Toxicogenomics

Guo-Liang Zhang
Jun-Lin Song
Chuan-Liang Ji
Yu-Long Feng
Jie Yu
Charles M. Nyachoti
Gong-She Yang

Frontiers in Genetics

doi 10.3389/fgene.2018.00293

3,642 views
19 citations

Original Research

Published on 27 Jul 2018

Genetic Susceptibility to Neurodegeneration in Amazon: Apolipoprotein E Genotyping in Vulnerable Populations Exposed to Mercury

in Toxicogenomics

Gabriela P. F. Arrifano
Rosa C. R. Martín-Doimeadios
María Jiménez-Moreno
Sergio Fernández-Trujillo
Marcus Augusto-Oliveira
José R. Souza-Monteiro
Barbarella M. Macchi
Jacqueline I. Alvarez-Leite
José L. M. do Nascimento
Marcos T. Amador

Frontiers in Genetics

doi 10.3389/fgene.2018.00285

5,330 views
39 citations

Editorial

Published on 19 Jun 2018

Editorial: Metal Biology Takes Flight: The Study of Metal Homeostasis and Detoxification in Insects

in Toxicogenomics

Stephanie E. Mohr
David W. Killilea

Frontiers in Genetics

doi 10.3389/fgene.2018.00221

2,254 views
4 citations

Original Research

Published on 15 Jun 2018

Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure

in Toxicogenomics

Christina R. Steadman Tyler
Jane J. W. Smoake
Elizabeth R. Solomon
Estrella Villicana
Kevin K. Caldwell
Andrea M. Allan

Frontiers in Genetics

doi 10.3389/fgene.2018.00200

4,809 views
21 citations

Review

Published on 05 Jun 2018

Sex Differences in Neurotoxicogenetics

in Toxicogenomics

Carolina Torres-Rojas
Byron C. Jones

Frontiers in Genetics

doi 10.3389/fgene.2018.00196

8,736 views
49 citations

Original Research

Published on 16 May 2018

A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data

in Toxicogenomics

Oswaldo A. Lozoya
Janine H. Santos
Richard P. Woychik

Frontiers in Genetics

doi 10.3389/fgene.2018.00176

6,853 views
14 citations

Original Research

Published on 20 Mar 2018

Transcriptional Responses Reveal Similarities Between Preclinical Rat Liver Testing Systems

in Toxicogenomics

Zhichao Liu
Brian Delavan
Ruth Roberts
Weida Tong

Frontiers in Genetics

doi 10.3389/fgene.2018.00074

4,178 views
11 citations

Review

Published on 16 Mar 2018

Sex-Dependent Effects of Developmental Lead Exposure on the Brain

in Toxicogenomics

Garima Singh
Vikrant Singh
Marissa Sobolewski
Deborah A. Cory-Slechta
Jay S. Schneider

Frontiers in Genetics

doi 10.3389/fgene.2018.00089

12,659 views
59 citations

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Articles

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury

Robust Co-clustering to Discover Toxicogenomic Biomarkers and Their Regulatory Doses of Chemical Compounds Using Logistic Probabilistic Hidden Variable Model

A Comparison of the TempO-Seq S1500+ Platform to RNA-Seq and Microarray Using Rat Liver Mode of Action Samples

AP-1 (bZIP) Transcription Factors as Potential Regulators of Metallothionein Gene Expression in Tetrahymena thermophila

Network and Pathway Analysis of Toxicogenomics Data

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases

Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity

Molecular Pathways Associated With Methylmercury-Induced Nrf2 Modulation

Zearalenone Exposure Enhanced the Expression of Tumorigenesis Genes in Donkey Granulosa Cells via the PTEN/PI3K/AKT Signaling Pathway

Genetic Susceptibility to Neurodegeneration in Amazon: Apolipoprotein E Genotyping in Vulnerable Populations Exposed to Mercury

Editorial: Metal Biology Takes Flight: The Study of Metal Homeostasis and Detoxification in Insects

Sex-Dependent Effects of the Histone Deacetylase Inhibitor, Sodium Valproate, on Reversal Learning After Developmental Arsenic Exposure

Sex Differences in Neurotoxicogenetics

A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data

Transcriptional Responses Reveal Similarities Between Preclinical Rat Liver Testing Systems

Sex-Dependent Effects of Developmental Lead Exposure on the Brain