Frontiers in Genetics

Original Research

Published on 24 Sep 2025

Identifying metabolism-related genes in liver cancer through weighted gene co-expression network analysis and machine learning

Taorui Wang
Zijun Lai
Shengjun Tang
Lehang Lin
Mingjiao Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1654459

4,297 views

Original Research

Published on 24 Sep 2025

Intrauterine phenotype, genetic analysis, and pregnancy follow-up of fetuses with the 16p12.2 microdeletion

Meiying Cai
Na Lin
Hailong Huang
Wenqiang You
Nan Guo
Liangpu Xu

Frontiers in Genetics

doi 10.3389/fgene.2025.1595399

2,073 views

Review

Published on 24 Sep 2025

Mechanisms of circular RNAs in diabetic cardiomyopathy: biological characteristics and clinical prospects

Yunfei Guan
Quancheng Han
Meng Wang
Jianguo Xu
Xiujuan Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1665571

3,565 views
2 citations

Case Report

Published on 23 Sep 2025

Case Report: a family report of hereditary pancreatitis caused by SPINK1 and PRSS1 gene mutations

Jing Xu
Ying Hu
Banghui Xiao
Juan He
Miao Zhang
Rui Wang
Nianchun Peng

Frontiers in Genetics

doi 10.3389/fgene.2025.1610108

3,351 views

Original Research

Published on 22 Sep 2025

Constructing a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in clear cell renal cell carcinoma

Jiaxuan Qin
Lijian Zhang
Bowen Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1543593

4,266 views

Hypothesis and Theory

Published on 22 Sep 2025

Slavs in the closet: computational genomic analysis reveals cryptic slavic signatures in the Avar Khaganate and their contribution to medieval Croatian population formation

Todor Chobanov
Svetoslav Stamov
for Bulgarian Academy of Science and Institute for Balkan Studies

Frontiers in Genetics

doi 10.3389/fgene.2025.1610942

10,600 views
1 citation

Original Research

Published on 22 Sep 2025

Identification of platelet function-related genes in STEMI patients

Jingjing Zhu
Shuangya Yang
Qing Guo
Yifan Yang
Bei Shi

Frontiers in Genetics

doi 10.3389/fgene.2025.1651794

1,971 views

Original Research

Published on 22 Sep 2025

Next-generation sequencing of mitochondrial DNA reveals pathogenic variants and protective haplogroup D4 in esophageal cancer

Xiucheng Jiang
Lan Shi
Mei Zhao
Cui Chen
Tao Tang
Simeng Ji
Bingbing Lv
Lihua Jia
Shuhan Duan
Jinyue Ma

Frontiers in Genetics

doi 10.3389/fgene.2025.1643229

2,505 views

Original Research

Published on 19 Sep 2025

The potential impact of GLS and PDHA1 on tumor immunity and immunotherapy response in LUSC

Tianhe Ling
Jiahui Wu
Ling Xiaohao

Frontiers in Genetics

doi 10.3389/fgene.2025.1606111

2,709 views

Original Research

Published on 19 Sep 2025

Deciphering the shared genetic structure between hip osteoarthritis and femoral neck bone mineral density

Jianguo Zhou
Junfu Na
Zongkun Jiang
Xiaoyan Dou
Shixuan Wang
Hongtao Li
Jian Kang

Frontiers in Genetics

doi 10.3389/fgene.2025.1597005

3,215 views

Original Research

Published on 19 Sep 2025

A hypergraph neural network for prioritizing Alzheimer’s disease risk genes

Meng Ma
Chao Deng
Yan Liu
Qingqing Cao
Fang Liu
Yan Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1668200

1,966 views
1 citation

Original Research

Published on 19 Sep 2025

A novel COL2A1 mutation in a Chinese family with predominantly ocular Stickler syndrome

Yanyu Lin
Xin Liu
Shuxian Lin
Jiansheng Lin

Frontiers in Genetics

doi 10.3389/fgene.2025.1646923

2,059 views

Review

Published on 19 Sep 2025

Beyond single references: pangenome graphs and the future of genomic medicine

Denis M. Nyaga
Roan E. Zaied
Olin K. Silander
Michael A. Black
Justin M. O’Sullivan

Frontiers in Genetics

doi 10.3389/fgene.2025.1679660

5,564 views
1 citation

Original Research

Published on 18 Sep 2025

Genome-wide association analysis of resistance to bacterial cold-water disease in an important rainbow trout aquaculture breeding population

Bruna Santana
Yniv Palti
Guangtu Gao
Vibha Tripathi
Kyle E. Martin
Breno O. Fragomeni

Frontiers in Genetics

doi 10.3389/fgene.2025.1582138

2,481 views

Original Research

Published on 18 Sep 2025

Identification of prognostic and cellular senescence gene E2F1 of papillary thyroid carcinoma through bioinformatics analyses and experimental verification

Bin Yu
Shu-Yan Zhao
Yun-Hua Zhu
Jun-Jie Luo
Ke Zheng
Bin-Jie Shen
Yi-Lin Shen
Huan-Xin Zhong

Frontiers in Genetics

doi 10.3389/fgene.2025.1605385

2,439 views

Original Research

Published on 17 Sep 2025

Panoramic analysis of the biological function and clinical value of SLC38A2 in human cancers: a study based on pan-cancer and single-cell analysis

Mao Liao
Yuqing Rao
Molan Li
Jiayang Guo
Kun Guo
Kaiyue Li
Rui Zheng
Yifan Liu
Qianyi Wang
Manni Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1658299

2,912 views

Original Research

Published on 17 Sep 2025

Uncovering differential gene expression between mtRNA-positive and -negative osteosarcoma cells: implications beyond mitochondrial function

Xiaoyuan Meng
Zhongcheng Han
Wuerkan Yeerken
Zhigang Wang
Le Ma
Hongbo Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1588581

2,071 views

Original Research

Published on 17 Sep 2025

Uncovering compound heterozygous DYSF variants in a Chinese family affected by limb-girdle muscular dystrophy type 2B

Jinlan Li
Jie Zhou
Chunbo Ji
Siqing Ma
Jianying Zhu
Tiejun Yang
Danyang Dong
Yang Ping

Frontiers in Genetics

doi 10.3389/fgene.2025.1664086

2,215 views

Original Research

Published on 17 Sep 2025

Genomic prediction powered by multi-omics data

Osval A. Montesinos-López
Abelardo Montesinos-López
Brandon Alejandro Mosqueda-González
Iván Delgado-Enciso
Moises Chavira-Flores
José Crossa
Susanne Dreisigacker
Jin Sun
Rodomiro Ortiz

Frontiers in Genetics

doi 10.3389/fgene.2025.1636438

4,678 views
6 citations

Original Research

Published on 17 Sep 2025

Rapid forensic ancestry inference in selected Northeast Asian populations: a Y-STR based attention-based ensemble framework for initial investigation guidance

Kyo-Chan Koo

Frontiers in Genetics

doi 10.3389/fgene.2025.1631529

3,434 views

Original Research

Published on 17 Sep 2025

Bioinformatics-based identification of differentially expressed genes in endometrial carcinoma: implications for early diagnosis and prognostic stratification

Liang Gao
Donglan Yuan
Aihua Huang
Hua Qian

Frontiers in Genetics

doi 10.3389/fgene.2025.1631060

2,020 views

Original Research

Published on 17 Sep 2025

BioSemAF-BiLSTM: a protein sequence feature extraction framework based on semantic and evolutionary information

Zihan Zhang
Yixuan Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1616880

2,140 views
2 citations

Original Research

Published on 17 Sep 2025

Genetic and in silico functional characterization of a novel structural variant in the PAH gene by long-reads sequencing and structural modeling

Viviana Gallardo
Alexis Gaete
Jonathan Maldonado
Paulina Morales
Angela Peña
Valerie Hamilton
Víctor Faundes
Lorena Santa María

Frontiers in Genetics

doi 10.3389/fgene.2025.1669007

2,479 views

Original Research

Published on 16 Sep 2025

Identification and validation of three tumor suppressors associated with the immune response of acute myeloid leukemia

Yueyuan Pan
Guocai Wu
Chenchen Liu
Minggui Chen
Tian Xia
Yonghua Ma
Zhigang Yang
Ruiting Wen

Frontiers in Genetics

doi 10.3389/fgene.2025.1652142

3,586 views

963 Publications

volumes

Identifying metabolism-related genes in liver cancer through weighted gene co-expression network analysis and machine learning

Intrauterine phenotype, genetic analysis, and pregnancy follow-up of fetuses with the 16p12.2 microdeletion

Mechanisms of circular RNAs in diabetic cardiomyopathy: biological characteristics and clinical prospects

Case Report: a family report of hereditary pancreatitis caused by SPINK1 and PRSS1 gene mutations

Constructing a novel mitochondrial-related gene signature for predicting survival and evaluating the tumor immune microenvironment in clear cell renal cell carcinoma

Slavs in the closet: computational genomic analysis reveals cryptic slavic signatures in the Avar Khaganate and their contribution to medieval Croatian population formation

Identification of platelet function-related genes in STEMI patients

Next-generation sequencing of mitochondrial DNA reveals pathogenic variants and protective haplogroup D4 in esophageal cancer

The potential impact of GLS and PDHA1 on tumor immunity and immunotherapy response in LUSC

Deciphering the shared genetic structure between hip osteoarthritis and femoral neck bone mineral density

A hypergraph neural network for prioritizing Alzheimer’s disease risk genes

A novel COL2A1 mutation in a Chinese family with predominantly ocular Stickler syndrome

Beyond single references: pangenome graphs and the future of genomic medicine

Genome-wide association analysis of resistance to bacterial cold-water disease in an important rainbow trout aquaculture breeding population

Identification of prognostic and cellular senescence gene E2F1 of papillary thyroid carcinoma through bioinformatics analyses and experimental verification

Panoramic analysis of the biological function and clinical value of SLC38A2 in human cancers: a study based on pan-cancer and single-cell analysis

Uncovering differential gene expression between mtRNA-positive and -negative osteosarcoma cells: implications beyond mitochondrial function

Uncovering compound heterozygous DYSF variants in a Chinese family affected by limb-girdle muscular dystrophy type 2B

Genomic prediction powered by multi-omics data

Rapid forensic ancestry inference in selected Northeast Asian populations: a Y-STR based attention-based ensemble framework for initial investigation guidance

Bioinformatics-based identification of differentially expressed genes in endometrial carcinoma: implications for early diagnosis and prognostic stratification

BioSemAF-BiLSTM: a protein sequence feature extraction framework based on semantic and evolutionary information

Genetic and in silico functional characterization of a novel structural variant in the PAH gene by long-reads sequencing and structural modeling

Identification and validation of three tumor suppressors associated with the immune response of acute myeloid leukemia