Frontiers in Genetics

Original Research

Published on 14 Aug 2025

The rare hemoglobin variants Hb O-Arab and Hb D-Punjab identified in population-based genetic screening throughout Guangxi, China

Chunrong Gui
Zifeng Cheng
Yongsheng Chen
Yunting Ma
Hongfei Chen
Wei Wei
Xianda Wei
Juliang Liu
Xu Zhou
Qianqian Du

Frontiers in Genetics

doi 10.3389/fgene.2025.1622391

2,883 views

Case Report

Published on 14 Aug 2025

Case Report: Hereditary neuropathy with liability to pressure palsy (HNPP): the role of genetic investigation in diagnostic assessment

Salvatore Savasta
Fabiola Serra
Lucrezia Galimberti
Francesco Fabrizio Comisi
Marcello Cossu
Alessandro Vannelli
Maddalena Masala
Sara Tanca
Stefania Murru

Frontiers in Genetics

doi 10.3389/fgene.2025.1613022

4,161 views
2 citations

Original Research

Published on 14 Aug 2025

Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration

Tao Wang
Fei Ding
Kai Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1527907

2,865 views

Original Research

Published on 14 Aug 2025

Cis-regulation analysis of RNA m6A methylation and gene expression in colorectal cancer

Zhen-Liang Lin
Pan-Pan Yu
Bei-Lei Ye

Frontiers in Genetics

doi 10.3389/fgene.2025.1622957

3,294 views
1 citation

Original Research

Published on 13 Aug 2025

High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy

Xin Sun
Yao Chen
Feifei Hu
Yumeng Qiao
He Wu
Yao Su
Yue Hu
Jie Wu
Mingli Huang

Frontiers in Genetics

doi 10.3389/fgene.2025.1636834

2,522 views

Review

Published on 13 Aug 2025

Machine learning tools for deciphering the regulatory logic of enhancers in health and disease

Spyros Foutadakis
Vasiliki Bourika
Ioanna Styliara
Panagiotis Koufargyris
Asimina Safarika
Eleni Karakike

Frontiers in Genetics

doi 10.3389/fgene.2025.1603687

3,370 views
1 citation

Original Research

Published on 13 Aug 2025

Integrative multi-omics analysis and machine learning reveal the unique role of ASCC3 in combination with various immune-related genes in rectal adenocarcinoma

Chuang Miao
Fei Qian

Frontiers in Genetics

doi 10.3389/fgene.2025.1614946

2,869 views

Case Report

Published on 13 Aug 2025

Case Report: Unmasking the role of rem sleep in modulating non-convulsive status epilepticus in ring chromosome 20 syndrome: a genetic disorder of sleep architecture?

Filippo Mandato
Maria Teresa Di Claudio
Umberto Costantino
Francesca Rovito
Orazio Palumbo
Pietro Palumbo
Angela La Neve
Maura Pugliatti
M. Castori
Massimo Carella

Frontiers in Genetics

doi 10.3389/fgene.2025.1626457

2,158 views

Original Research

Published on 13 Aug 2025

A comprehensive analysis identifies and validates NPC1 as a potential biomarker for prognosis in HCC

Xingjun Lu
Tianyao Gou
Xuxing He
Xia Chen
Daqing Yang
Xiaozhen Peng

Frontiers in Genetics

doi 10.3389/fgene.2025.1588583

2,235 views

Original Research

Published on 13 Aug 2025

Genetic analysis of non-syndromic peg lateralis using whole-exome sequencing

Junglim Choi
Sungnam Kim
Hyunsoo Ahn
Donghyo Kim
Sung-Won Cho
Sanguk Kim
Jae Hoon Lee

Frontiers in Genetics

doi 10.3389/fgene.2025.1572966

1,972 views
1 citation

Original Research

Published on 13 Aug 2025

The association between diabetes and head and neck squamous cell carcinoma: evidence from clinical cohort and bioinformatics analyses

Yurong He
Jiaming Chen
Boxuan Han
Yanming Zhao
Lizhen Hou
Jugao Fang
Meng Lian

Frontiers in Genetics

doi 10.3389/fgene.2025.1660012

2,207 views
2 citations

Editorial

Published on 12 Aug 2025

Editorial: Genetics of non-syndromic hearing loss

Caio Robledo D’ Angioli Costa Quaio
Saba Battelino

Frontiers in Genetics

doi 10.3389/fgene.2025.1665942

1,771 views

Editorial

Published on 12 Aug 2025

Editorial: Next generation sequencing and cancer: new steps towards personalized medicine

Erika Bandini
Clévia Rosset

Frontiers in Genetics

doi 10.3389/fgene.2025.1675753

2,217 views

Review

Published on 11 Aug 2025

Enhancing quality and climate resilient traits in vegetatively propagated polyploids: transgenic and genome editing advancements, challenges and future directions

Surya Krishna Sakthivel
Amaranatha Reddy Vennapusa
Kalpalatha Melmaiee

Frontiers in Genetics

doi 10.3389/fgene.2025.1599242

3,605 views
4 citations

Case Report

Published on 11 Aug 2025

Identification of a novel, pathogenic CREBBP variant in a patient with Menke-Hennekam syndrome: a Case Report

Anna Μaria Anastasiou
Constantia Aristidou
Athina Theodosiou
Ludmila Kousoulidou
Ioannis Papaevripidou
Angelos Alexandrou
Paola Evangelidou
Carolina Sismani
George A. Tanteles
Despina Sanoudou

Frontiers in Genetics

doi 10.3389/fgene.2025.1585453

3,484 views

Original Research

Published on 11 Aug 2025

Identification of epithelial-mesenchymal transition prognostic signature associated with prognosis, tumor microenvironment, and therapeutic effect in prostate cancer

Yiyuan Li
Ke Li
Hua Wang
Jianguang Qiu
Chutian Xiao

Frontiers in Genetics

doi 10.3389/fgene.2025.1539745

2,600 views
1 citation

Original Research

Published on 11 Aug 2025

Identification and experimental validation of prognostic genes related to cytochrome c in breast cancer

Huimin Yu
Shihong Li
Jian Wu
Haobin Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1627134

2,590 views

Brief Research Report

Published on 08 Aug 2025

A unique case of late-onset CIPO caused by a missense mutation in the long isoform of FLNA

Ilaria D’Amato
Enrico Ganguzza
Guido Basilisco
Alessia Strippoli
Erika Salvi
Elkadia Mehmeti
Federica Chiappori
Grazia Devigili
Maurizio Vecchi
Giuseppe Lauria

Frontiers in Genetics

doi 10.3389/fgene.2025.1611614

2,222 views

Methods

Published on 08 Aug 2025

BANSMDA: a computational model for predicting potential microbe-disease associations based on bilinear attention networks and sparse autoencoders

Xianzhi Liu
Mingmin Liang
Ge Yu
Shichang Tang
Ouxiang Wu
Bin Zeng
Lei Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1618472

1,476 views
1 citation

Original Research

Published on 08 Aug 2025

Clinical and molecular findings in actin-related inborn errors of immunity: the middle East and North Africa registry

Zahra Chavoshzadeh
Shahrzad Fallah
Vahide Zeinali
Samin Sharafian
Samaneh Delavari
Mehrnaz Mesdaghi
Reda Djidjik
Brahim Belaid
Aydan Ikinciogullari
Sule Haskologlu

Frontiers in Genetics

doi 10.3389/fgene.2025.1584681

4,950 views

Perspective

Published on 08 Aug 2025

Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?

Ryszard Maleszka

Frontiers in Genetics

doi 10.3389/fgene.2025.1633921

3,950 views
1 citation

Original Research

Published on 08 Aug 2025

Identification and splicing analysis of the first deep intronic FIG4 variant causing Yunis–Varon syndrome

Hui Tang
Qingqing Chen
Jingjing Xiang
Qin Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1624122

1,499 views

Original Research

Published on 08 Aug 2025

Winner’s curse in rare variant analysis: effect size estimation bias depends on effect direction and the association method used

David Soave
Melisa Hayalioglu
Lei Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1416673

2,561 views

Original Research

Published on 07 Aug 2025

From ownership to custodianship: rethinking human biospecimens data governance in the Chinese context

Yifan Peng
Jiyuan Li
Ruipeng Lei

Frontiers in Genetics

doi 10.3389/fgene.2025.1621739

2,226 views

16,551 Publications

volumes

Volume 16 - 2025

The rare hemoglobin variants Hb O-Arab and Hb D-Punjab identified in population-based genetic screening throughout Guangxi, China

Case Report: Hereditary neuropathy with liability to pressure palsy (HNPP): the role of genetic investigation in diagnostic assessment

Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration

Cis-regulation analysis of RNA m6A methylation and gene expression in colorectal cancer

High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy

Machine learning tools for deciphering the regulatory logic of enhancers in health and disease

Integrative multi-omics analysis and machine learning reveal the unique role of ASCC3 in combination with various immune-related genes in rectal adenocarcinoma

Case Report: Unmasking the role of rem sleep in modulating non-convulsive status epilepticus in ring chromosome 20 syndrome: a genetic disorder of sleep architecture?

A comprehensive analysis identifies and validates NPC1 as a potential biomarker for prognosis in HCC

Genetic analysis of non-syndromic peg lateralis using whole-exome sequencing

The association between diabetes and head and neck squamous cell carcinoma: evidence from clinical cohort and bioinformatics analyses

Editorial: Genetics of non-syndromic hearing loss

Editorial: Next generation sequencing and cancer: new steps towards personalized medicine

Enhancing quality and climate resilient traits in vegetatively propagated polyploids: transgenic and genome editing advancements, challenges and future directions

Identification of a novel, pathogenic CREBBP variant in a patient with Menke-Hennekam syndrome: a Case Report

Identification of epithelial-mesenchymal transition prognostic signature associated with prognosis, tumor microenvironment, and therapeutic effect in prostate cancer

Identification and experimental validation of prognostic genes related to cytochrome c in breast cancer

A unique case of late-onset CIPO caused by a missense mutation in the long isoform of FLNA

BANSMDA: a computational model for predicting potential microbe-disease associations based on bilinear attention networks and sparse autoencoders

Clinical and molecular findings in actin-related inborn errors of immunity: the middle East and North Africa registry

Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?

Identification and splicing analysis of the first deep intronic FIG4 variant causing Yunis–Varon syndrome

Winner’s curse in rare variant analysis: effect size estimation bias depends on effect direction and the association method used

From ownership to custodianship: rethinking human biospecimens data governance in the Chinese context