Frontiers in Genetics

Original Research

Published on 24 Nov 2025

Application of trio-based whole-exome sequencing in fetal ultrasound anomalies: a single-center retrospective study of 454 cases

Dongyi Yu
Dairong Feng
Jiangbo Qu
Lei Nie
Qian Liu
Lu Gao
Wenzhen An
Na Liu
Yuying Fang

Frontiers in Genetics

doi 10.3389/fgene.2025.1662801

1,025 views

Editorial

Published on 24 Nov 2025

Editorial: Responses and adaptation of plants to abiotic stress: genetics, evolution and molecular insights

Yang Tao
Xilan Yang
Zhiqiang Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1729869

1,028 views

Correction

Published on 24 Nov 2025

Correction: Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

Yubo Ren
Bomeng Zhao
Luo Lv
Jingyuan Yang
Xiangting Nan
Bao Li
Bin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1746339

685 views

Editorial

Published on 24 Nov 2025

Editorial: Unraveling the mysteries of aging and the brain: advancements in understanding neurodegenerative diseases and dementia

Victoria Campos-Peña

Frontiers in Genetics

doi 10.3389/fgene.2025.1745907

973 views

Mini Review

Published on 24 Nov 2025

Ecuador genetic mosaic: biological and adaptive variations across Mestizos, Native Amerindians, and Afro-Ecuadorians. Implications for public health and precision medicine

Fabricio González-Andrade

Frontiers in Genetics

doi 10.3389/fgene.2025.1699402

1,203 views

Case Report

Published on 21 Nov 2025

Case Report: Mild BRIC-like cholestasis despite a gross USP53 deletion—novel findings and literature review

Ekaterina Nuzhnaya
Tatiana Cherevatova
Ekaterina Lotnik
Aleksandra Shagiazdanova
Zhanna Markova
Ekaterina Filimonova
Olga Parshina
Anastasiia Buianova
Anastasia Bobreshova
Andrey Marakhonov

Frontiers in Genetics

doi 10.3389/fgene.2025.1670664

990 views

Original Research

Published on 21 Nov 2025

Transcriptome-wide m6A landscape across diverse porcine tissues revealed by nanopore direct RNA sequencing

Yaya Liao
Zifeng Ding
Xiaoyun Chen
Chao Yin
Bin Yang
Qiang Yang
Yuyun Xing

Frontiers in Genetics

doi 10.3389/fgene.2025.1725608

1,198 views

Original Research

Accepted on 20 Nov 2025

Lorentz-Regularized Interpretable VAE for Multi-Scale Single-cell Transcriptomic and Epigenomic Embeddings

Zeyu Fu
Chunlin Chen
Keyang Zhang

Frontiers in Genetics

301 views

Original Research

Published on 20 Nov 2025

Benign mosaic chromosomal structural variants across generations: evidence for a developmental correction mechanism from clinical and computational models

Jiayu Ruan
Qinhao Song
Yue Hu
Xiaodan Liu
Suping Li
Jianjun Zhu
Li Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1710280

920 views

Methods

Published on 20 Nov 2025

A network-based discovery of prognostic markers in recurrent IDH wild-type gliomas

Yang Liu
Jason Huse
Kasthuri Kannan

Frontiers in Genetics

doi 10.3389/fgene.2025.1672015

1,143 views

Original Research

Published on 20 Nov 2025

Five novel EP300 variants expand the genetic and phenotypic spectrum of Rubinstein–Taybi syndrome type 2 in Chinese patients

Qiang Zhang
Qi Yang
Xunzhao Zhou
Zailong Qin
Jingsi Luo

Frontiers in Genetics

doi 10.3389/fgene.2025.1690693

983 views

Opinion

Published on 20 Nov 2025

Why all MODY variants in transcription factor genes are dominantly inherited

Roman Zug

Frontiers in Genetics

doi 10.3389/fgene.2025.1690468

1,150 views

Review

Published on 20 Nov 2025

Bioinformatics identification of key genes and therapeutic targets for exercise intervention in polycystic ovary syndrome

Xiaodie Yang
Hong Yang
Dongyi Shen
Qiang Zhang
Chan Zhu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634588

1,148 views

Original Research

Published on 20 Nov 2025

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells

Xiaobo Guo
Gang Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1694089

1,128 views

Review

Published on 19 Nov 2025

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential

Duaa Elshiekh
Nour Farchoukh
Reema El Hassan
Sara Al-Marzooqi
Waad Rashed Aldosari
Haissam Abou-Saleh
Amal Al-Haidose
Hatem Zayed
Atiyeh M. Abdallah

Frontiers in Genetics

doi 10.3389/fgene.2025.1621081

1,716 views

Original Research

Published on 19 Nov 2025

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels

Yongyan Song
Ting Wang
Mi Su
Xue Wang
Youjin Zhang
Jia Pan
Yunhan Wang
Jin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1659460

1,042 views

Original Research

Published on 19 Nov 2025

Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis

Yinfei Lu
Zao Tang
Xiangyu Zhou
Wanting Lin
Xiao Guo

Frontiers in Genetics

doi 10.3389/fgene.2025.1655000

1,006 views

Case Report

Published on 18 Nov 2025

MAPT mutation-induced behavioral variant frontotemporal dementia in an Asian patient: a multimodal biomarker case report resolving diagnostic challenges with Alzheimer’s disease

Yan Zhang
Siwei Chen
Guiying Yan
Zhifei Zhang
Amina
Ting Wang
Shuang Wang
Chen Zhang
Yong’an Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1645068

1,157 views

Original Research

Published on 18 Nov 2025

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma

Qiyue Zhao
Huadong Xie
Chaofu Li
Yanxiang Xiong
Yongyi Fan
Yuanbi Huang
Yi Zhan
Siping Zeng

Frontiers in Genetics

doi 10.3389/fgene.2025.1605078

1,547 views

Original Research

Published on 17 Nov 2025

Phenotype and genetic variation analysis of primary congenital lymphedema caused by FLT4 gene mutations in a fetus

Shanshan Zhai
Limin Yuan
Jing Li
Ling Liu
Lulu Hu
Yanjie Ban
Xuewen Yang
Jie Yang
Xuezhe Ouyang
Nana Huang

Frontiers in Genetics

doi 10.3389/fgene.2025.1700635

972 views

Original Research

Published on 17 Nov 2025

Single-cell RNA-seq combined with bulk RNA-seq explores shared gene signatures between thyroid and breast cancers

Zhiping Feng
Liang He
Xin Yang
Anhao Wu
Jingnan Wang
Yuanhua Song
Yongchun Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1609189

1,172 views

Original Research

Published on 17 Nov 2025

Genetic evolution of parental populations and construction of core germplasm populations in qinghai spruce seed orchard based on SLAF-seq technology

Hu Zhao
Erwen Xu
Dong Lv
Wei Li
Xingpeng Zhao
Xin Jia
Hao Yuan
Rong Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1712106

980 views

Original Research

Published on 17 Nov 2025

Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis

Ying Dong
Hong-Song Ge
Rui-Xue Chang
Jing Chu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634874

1,860 views

Original Research

Published on 17 Nov 2025

Genetic background of behavior traits in lactating sows under heat-stress conditions and their relationship with heat tolerance and maternal performance traits

Sharlene O. Hartman
Lorena F. Benfica
Jay S. Johnson
Jeremy N. Marchant
Hinayah R. Oliveira
Victor B. Pedrosa
Allan P. Schinckel
Yijian Huang
Leonardo S. Gloria
Hui Wen

Frontiers in Genetics

doi 10.3389/fgene.2025.1688262

1,277 views

16,464 Publications

volumes

Volume 16 - 2025

Application of trio-based whole-exome sequencing in fetal ultrasound anomalies: a single-center retrospective study of 454 cases

Editorial: Responses and adaptation of plants to abiotic stress: genetics, evolution and molecular insights

Correction: Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

Editorial: Unraveling the mysteries of aging and the brain: advancements in understanding neurodegenerative diseases and dementia

Ecuador genetic mosaic: biological and adaptive variations across Mestizos, Native Amerindians, and Afro-Ecuadorians. Implications for public health and precision medicine

Case Report: Mild BRIC-like cholestasis despite a gross USP53 deletion—novel findings and literature review

Transcriptome-wide m6A landscape across diverse porcine tissues revealed by nanopore direct RNA sequencing

Lorentz-Regularized Interpretable VAE for Multi-Scale Single-cell Transcriptomic and Epigenomic Embeddings

Benign mosaic chromosomal structural variants across generations: evidence for a developmental correction mechanism from clinical and computational models

A network-based discovery of prognostic markers in recurrent IDH wild-type gliomas

Five novel EP300 variants expand the genetic and phenotypic spectrum of Rubinstein–Taybi syndrome type 2 in Chinese patients

Why all MODY variants in transcription factor genes are dominantly inherited

Bioinformatics identification of key genes and therapeutic targets for exercise intervention in polycystic ovary syndrome

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels

Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis

MAPT mutation-induced behavioral variant frontotemporal dementia in an Asian patient: a multimodal biomarker case report resolving diagnostic challenges with Alzheimer’s disease

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma

Phenotype and genetic variation analysis of primary congenital lymphedema caused by FLT4 gene mutations in a fetus

Single-cell RNA-seq combined with bulk RNA-seq explores shared gene signatures between thyroid and breast cancers

Genetic evolution of parental populations and construction of core germplasm populations in qinghai spruce seed orchard based on SLAF-seq technology

Potential marker genes for psoriasis revealed based on single-cell sequencing and Mendelian randomization analysis

Genetic background of behavior traits in lactating sows under heat-stress conditions and their relationship with heat tolerance and maternal performance traits