Frontiers in Immunology

Original Research

Published on 01 Jul 2025

T-cell repertoire correlates with cytokine imbalance in multiple sclerosis patients

in Multiple Sclerosis and Neuroimmunology

Lisa Weidner
Rodolphe Poupardin
Tobias Zrzavy
Sandra Laner-Plamberger
Georg Gratz
Tanja Eichhorn
Viktoria Weber
Paulus S. Rommer
Christof Jungbauer
Dirk Strunk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604452

134 views

Original Research

Published on 01 Jul 2025

Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin

in Inflammation

Irene García-Jiménez
Lídia Sans-de San Nicolàs
Sandra Díez-Ribas
Laia Curto-Barredo
Marta Bertolín-Colilla
Ana Vivancos-Melenchón
Ignasi Figueras-Nart
Montserrat Bonfill-Ortí
Anna Ryzhkova
Marta Ferran

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599892

206 views

Original Research

Published on 01 Jul 2025

Genomic and immune profiling of prognostic risk groups in IgM gammopathy reveals novel biomarkers beyond MYD88 L265P

in Cancer Immunity and Immunotherapy

David F. Moreno
Ferran Nadeu
Fara Brasó-Maristany
Sergi Vaqué
Sara Paz
Joan Mañé
Oriol Cardús
Elena Medina
Ester Lozano
Luis Gerardo Rodríguez-Lobato

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604089

232 views

Original Research

Published on 01 Jul 2025

Galectin-9 and Tim-3 in gastric cancer: a checkpoint axis driving T cell exhaustion and Treg-mediated immunosuppression independently of anti-PD-1 blockade

in Cancer Immunity and Immunotherapy

Charlotte N. Hill
Gabriela Maita
Camille Cabrolier
Constanza Aros
Ana Maria Vega-Letter
Pamela Gonzalez
Alexis M. Kalergis
Patricia Luz-Crawford
Gareth I. Owen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600792

161 views

Original Research

Published on 01 Jul 2025

Identification and validation of genes related to stem cells and telomere maintenance mechanisms as biomarkers for breast cancer

in Cancer Immunity and Immunotherapy

Shuang Zhen
Lifeng Huang
Qiannan Zhu
Rui Chen
Jue Wang
Xiaoming Zha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618193

117 views

Original Research

Published on 01 Jul 2025

Interpreting immune evasion: a novel assay for HLA loss detection

in Alloimmunity and Transplantation

Linnéa Pettersson
Sofia Westerling
Hamid Ramezanali
Francesco Vezzi
Rikard Eckerud
Dan Hauzenberger
Anders Hedrum
Jonas Mattsson
Michael Uhlin
Mehmet Uzunel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1603188

327 views

Review

Published on 01 Jul 2025

A paradigm shift in simulating affinity maturation to elicit broadly neutralizing antibodies

in B Cell Biology

Fahsai Nakarin
Kayla G. Sprenger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1627674

156 views

Original Research

Published on 01 Jul 2025

Toripalimab plus chemotherapy versus chemotherapy as first-line therapy for extensive-stage small cell lung cancer: a cost-effectiveness analysis

in Cancer Immunity and Immunotherapy

Longfeng Zhang
Hongcai Chen
Huide Zhu
Zhiwei Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591517

150 views

Original Research

Published on 01 Jul 2025

Interventional treatment combined with immunotargeted therapy in unresectable combined hepatocellular-cholangiocarcinoma: a real-world retrospective cohort study

in Cancer Immunity and Immunotherapy

Yan-Song Lin
Li-Yan Wu
Li-Hui Lin
Xia Yang
Fang-Yi Liu
Yan-Qin Wu
Zhen Ding
Yu-Jing Liang
Jing-Ping Yun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1591127

195 views

Original Research

Published on 01 Jul 2025

Chronic ethanol administration exacerbates memory loss by altering N6-methyladenosine-mediated epigenetic signaling

in Multiple Sclerosis and Neuroimmunology

Yuanhang Liao
Fu Xu
Yuqing Yan
Sicheng Zhou
Na Liu
Baomin Dou
Nivetha Srinivasan
Weizheng Wang
Xiongwei Zhu
Jianghong Ye

Frontiers in Immunology

doi 10.3389/fimmu.2025.1455994

238 views

Editorial

Published on 01 Jul 2025

Editorial: Environmental stressors and aquatic animal immune system function

in Comparative Immunology

Christopher J. Martyniuk
Erchao Li
Matthew L. Rise

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610969

158 views

Systematic Review

Published on 01 Jul 2025

Efficacy and safety of upadacitinib for patients with immune-mediated inflammatory diseases: a systematic review and meta-analysis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Rui Chai
Xiaomin Li
Wei Shen
Ziyi Jin
Genhong Yao
Xiaojun Tang
Linyu Geng
Lingyun Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1586792

194 views

Original Research

Published on 01 Jul 2025

Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer

in Cancer Immunity and Immunotherapy

Haiyang Du
Gao Si
Jiqing Si
Xuejie Song
Fuchun Si

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579184

165 views

Original Research

Published on 01 Jul 2025

Heterologous prime-boost immunization combining parenteral and mucosal routes with different adjuvants mounts long-lived CD4+ T cell responses in lungs

in Mucosal Immunity

Ranmali Kavishna
Thorunn Asta Olafsdottir
Siggeir F. Brynjólfsson
Dennis Christensen
Tobias Gustafsson-Hedberg
Peter Andersen
Manuela Terrinoni
Jan Holmgren
Ali M. Harandi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599713

227 views

Original Research

Published on 01 Jul 2025

Low nanomolar affinity to major grass pollen allergen Phl p 5 as achieved in an unmutated human antibody-lineage ancestor

in B Cell Biology

Mattias Essén
Eric Franciskovic
Céleste Sele
Magdalena Godzwon
Mats Ohlin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600778

279 views

Brief Research Report

Published on 01 Jul 2025

Retinoic acid differently modulates NOD1/NOD2-mediated inflammatory responses in human macrophage subsets

in Nutritional Immunology

Hala Ahmad
Ahmad Alatshan
Eduárd Bíró
Szilvia Benkő

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609763

202 views