Frontiers in Immunology

Review

Published on 02 Dec 2025

From metabolic alterations to chronic inflammation: mechanisms and immunoregulation of metabolic reprogramming in COPD

in Inflammation

Siyu Zeng
Yanqiu Zhang
Shiran Li
Zhimin Li
Pengfei Li
Jingxian Xie
Jiao Zhang
Liling Xie
Yong Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698832

2,266 views
1 citation

Original Research

Published on 02 Dec 2025

Gemcitabine-cisplatin chemotherapy plus anti-PD-L1 therapy reinvigorates antitumor immune response by reprogramming the intrahepatic cholangiocarcinoma microenvironment

in Cancer Immunity and Immunotherapy

Yang Song
Shao-wei Huang
Bo Shu
Ying-Xia Zhou
Wei-Dong Dai
Bao-Ye Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666393

1,931 views

Review

Published on 02 Dec 2025

Organotropic metastasis in colorectal cancer: integrating molecular pathways with therapeutic opportunities

in Cancer Immunity and Immunotherapy

Hanhui Jing
Yan Gao
Zhongsheng Sun
Ying Li
Jin Wang
Liangliang Zhang
Shanglong Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686071

1,395 views

Review

Published on 02 Dec 2025

Concerned issues and controversies in perioperative immunotherapy for resectable non-small cell lung cancer

in Cancer Immunity and Immunotherapy

Jiang Liu
Qun Ren
Yin Cai
Dadong Chen
Xiang Wu
Wenjing Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704226

1,825 views

Original Research

Published on 02 Dec 2025

SDCBP2 promotes tumor progression and is a novel ferroptosis-related prognostic biomarker in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Shaowu Sun
Zhuoyu Gu
Shuang Yuan
Kaishang Zhang
Wei Liu
Zhengpan Wei
Wenbo Fan
Zelong Wang
Tianliang Zhao
Mingbo Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692308

1,723 views

Systematic Review

Published on 02 Dec 2025

High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis

in Viral Immunology

Yangyang Liu
Defu Yuan
Yueqi Yin
Qian He
Meng Zhao
Hongfei Ma
Pingmin Wei
You Ge

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701028

1,243 views

Brief Research Report

Published on 02 Dec 2025

Latent reservoirs in memory T cell subsets are linked to poor immune recovery in people living with HIV

in Viral Immunology

Selwyn Selva Kumar
John Paul Demosthenes
Madheswaran A.
Milton P.
Inbanathan A.
Nagaraj V.
Abi Manesh
Saravanabhavan Thangavel
Luke Elizabeth Hanna
Rajesh Kannangai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684924

1,776 views

Case Report

Published on 02 Dec 2025

Complete remission of recurrent human papillomavirus-associated cervical cancer managed with camrelizumab and nanoparticle albumin-bound paclitaxel as second-line treatment: a case report

in Cancer Immunity and Immunotherapy

Liping Sun
Juan Lang
Xueya Wu
Dan Shi
Jiefeng Sang
Zhongkui Xiong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679950

1,865 views

Original Research

Published on 02 Dec 2025

Association of HLA-DQA106:01 and DPB105:01:01G alleles with susceptibility to end-stage liver disease with HBV infection in liver transplant recipients from the Zhejiang Han population, China

in Alloimmunity and Transplantation

Genjie Lu
Yanmin He
Yangfang Lu
Wei Chen
Caide Lu
Faming Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684437

1,339 views

Original Research

Published on 02 Dec 2025

Identification of MUC5B as a lymph node metastasis-associated gene in lung adenocarcinoma through integrated transcriptomic and machine learning approaches

in Cancer Immunity and Immunotherapy

Weijian Song
Qian Yang
Minjun Du
Jiacong Wei
Boxuan Zhou
Jianwei Shi
Linchuan Liang
Zixu Liu
Mei Liang
Mianyang Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1666240

1,959 views

Review

Published on 02 Dec 2025

Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications

in Systems Immunology

Fangwei Zong
Jiaxin You
Hong Wu
Xuerui Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640110

1,764 views

Review

Published on 02 Dec 2025

From bark to bench: innovations in QS-21 adjuvant characterization and manufacturing

in Molecular Innate Immunity

Priyanka Talukdar
Peter H. Winegar
Graham A. Hudson
Maria C. T. Astolfi
Jamie L. Inman
Jay D. Keasling
Harshini Mukundan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677995

2,625 views

Review

Published on 02 Dec 2025

Long non-coding RNAs as key orchestrators of the tumor microenvironment in lung cancer

in Cancer Immunity and Immunotherapy

Xuechao Li
Yifei Ren
Hanming Hao
Yi Jin
Baoer Chen
Kai Zhao
Yishuo Ji
Guanyu Chen
Zhenglin He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716180

1,877 views
1 citation

Brief Research Report

Published on 02 Dec 2025

Daratumumab combined with anti-CD20 therapy in pediatric and adult refractory idiopathic nephrotic syndrome: single-center experience

in Alloimmunity and Transplantation

Hamza Naciri Bennani
Thomas Sandaye
Quentin Charroyer
Aurelie Etangsale
Henri Vacher Coponat
Marie Julien
Vincent Mear
Olivier Dunand
Ludovic Di Ascia

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722023

1,287 views

Original Research

Published on 02 Dec 2025

Clinical outcomes and early- prognostic biomarkers of primary biliary cholangitis with ductopenia

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Wenjuan Wang
Guo Zhang
Hui Liu
Lingna Lv
Jing Chang
Zefeng Liu
Huilan Ye
Huiguo Ding
Ying Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680942

1,443 views

Original Research

Published on 02 Dec 2025

Targeting PSMB5-induced PANoptosis in bladder cancer: multi-omics insights and TCM candidate discovery

in Cancer Immunity and Immunotherapy

Zhe Chang
Jirong Wang
Jiajia Cao
Xinpeng Fan
Kunpeng Li
Chenyang Wang
Yalong Zhang
Li Wang
Jianwei Yang
Siyu Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656682

2,093 views

Original Research

Published on 02 Dec 2025

Expression characteristics, prognostic value, and immune-related analysis of PPP2R1A in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Shanshan Xiao
Yuhong Hu
Yawen Li
Xin Zhang
Zijun Xiao
Mingyou Dong
Lusheng Liao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1652629

1,404 views

Original Research

Published on 02 Dec 2025

Immunomodulatory and anti-inflammatory effects of agave fructans in atopic dermatitis: gut microbiota and short-chain fatty acid implication

in Nutritional Immunology

Marcela Rios-Carlos
Mariela Jiménez
Daniel Cervantes-García
Laura Elena Córdova-Dávalos
Lidia E. Verduzco
Francisco Javier Enríquez-Medrano
Omar Fabela-Sánchez
Luis G. Bermúdez-Humarán
Eva Salinas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700023

1,969 views
1 citation

Brief Research Report

Published on 02 Dec 2025

VEXAS syndrome in rheumatology practice: features from a multicenter cohort in north-east Italy

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Sara Bindoli
Greta Morello-Pasin
Irina Guidea
Roberto Padoan
Luca Iorio
Riccardo Bixio
Giovanni Orsolini
Federica Maiolini
Sara Lombardi
Sandra Lombardi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700737

1,548 views

Case Report

Published on 02 Dec 2025

Case Report: Pseudoprogression of pancreatic acinar cell carcinoma after PD-1 blockade integrated treatment

in Cancer Immunity and Immunotherapy

Xinyuan Bai
Di Yang
Jingjing Chen
Yaru Liu
Haochen Tang
Xiang Kong
Baorui Liu
Huizi Sha
Juan Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663514

1,239 views

Methods

Published on 02 Dec 2025

Rotavirus-specific neutralization assay enables evaluation of mucosal immune responses

in Mucosal Immunity

Maxi Harzer
Antje Rückner
Thomas W. Vahlenkamp

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677823

1,255 views

Original Research

Published on 02 Dec 2025

Serum and urine anti-PLA2R antibody correlation with albuminuria in idiopathic membranous nephropathy

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Xiaogang Liu
Yunfei Fu
Manshu Sui
Xuehua Wang
Zizhen Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670960

1,307 views

Correction

Published on 02 Dec 2025

Correction: Generation of a new Paneth cell-specific Cre-recombinase transgenic mouse line

in Microbial Immunology

Natalia Garcia-Gonzalez
Charlotte Wallaeys
Wendy Toussaint
Tino Hochepied
Sylviane Dewaele
Somara De Beul
Robin Van Loke
Jolien Vandewalle
Steven Timmermans
Richard S. Blumberg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733126

594 views

Original Research

Published on 02 Dec 2025

Predictive value of current nodal staging systems and development of machine learning nomogram for resectable pancreatic head cancer: a population-based study and multicenter validation

in Cancer Immunity and Immunotherapy

Wen-Bo Zou
Xiu-Ping Zhang
Yu-Yao Song
Shuai Xu
Bo-Yuan Liu
Zhi-Ming Zhao
Yuan-Xing Gao
Ming-Gen Hu
Gao Huang
Rong Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639186

1,702 views

49,989 articles

articles

From metabolic alterations to chronic inflammation: mechanisms and immunoregulation of metabolic reprogramming in COPD

Gemcitabine-cisplatin chemotherapy plus anti-PD-L1 therapy reinvigorates antitumor immune response by reprogramming the intrahepatic cholangiocarcinoma microenvironment

Organotropic metastasis in colorectal cancer: integrating molecular pathways with therapeutic opportunities

Concerned issues and controversies in perioperative immunotherapy for resectable non-small cell lung cancer

SDCBP2 promotes tumor progression and is a novel ferroptosis-related prognostic biomarker in lung adenocarcinoma

High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis

Latent reservoirs in memory T cell subsets are linked to poor immune recovery in people living with HIV

Complete remission of recurrent human papillomavirus-associated cervical cancer managed with camrelizumab and nanoparticle albumin-bound paclitaxel as second-line treatment: a case report

Association of HLA-DQA106:01 and DPB105:01:01G alleles with susceptibility to end-stage liver disease with HBV infection in liver transplant recipients from the Zhejiang Han population, China

Identification of MUC5B as a lymph node metastasis-associated gene in lung adenocarcinoma through integrated transcriptomic and machine learning approaches

Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications

From bark to bench: innovations in QS-21 adjuvant characterization and manufacturing

Long non-coding RNAs as key orchestrators of the tumor microenvironment in lung cancer

Daratumumab combined with anti-CD20 therapy in pediatric and adult refractory idiopathic nephrotic syndrome: single-center experience

Clinical outcomes and early- prognostic biomarkers of primary biliary cholangitis with ductopenia

Targeting PSMB5-induced PANoptosis in bladder cancer: multi-omics insights and TCM candidate discovery

Expression characteristics, prognostic value, and immune-related analysis of PPP2R1A in lung adenocarcinoma

Immunomodulatory and anti-inflammatory effects of agave fructans in atopic dermatitis: gut microbiota and short-chain fatty acid implication

VEXAS syndrome in rheumatology practice: features from a multicenter cohort in north-east Italy

Case Report: Pseudoprogression of pancreatic acinar cell carcinoma after PD-1 blockade integrated treatment

Rotavirus-specific neutralization assay enables evaluation of mucosal immune responses

Serum and urine anti-PLA2R antibody correlation with albuminuria in idiopathic membranous nephropathy

Correction: Generation of a new Paneth cell-specific Cre-recombinase transgenic mouse line

Predictive value of current nodal staging systems and development of machine learning nomogram for resectable pancreatic head cancer: a population-based study and multicenter validation

articles

From metabolic alterations to chronic inflammation: mechanisms and immunoregulation of metabolic reprogramming in COPD

Gemcitabine-cisplatin chemotherapy plus anti-PD-L1 therapy reinvigorates antitumor immune response by reprogramming the intrahepatic cholangiocarcinoma microenvironment

Organotropic metastasis in colorectal cancer: integrating molecular pathways with therapeutic opportunities

Concerned issues and controversies in perioperative immunotherapy for resectable non-small cell lung cancer

SDCBP2 promotes tumor progression and is a novel ferroptosis-related prognostic biomarker in lung adenocarcinoma

High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis

Latent reservoirs in memory T cell subsets are linked to poor immune recovery in people living with HIV

Complete remission of recurrent human papillomavirus-associated cervical cancer managed with camrelizumab and nanoparticle albumin-bound paclitaxel as second-line treatment: a case report

Association of HLA-DQA1*06:01 and DPB1*05:01:01G alleles with susceptibility to end-stage liver disease with HBV infection in liver transplant recipients from the Zhejiang Han population, China

Identification of MUC5B as a lymph node metastasis-associated gene in lung adenocarcinoma through integrated transcriptomic and machine learning approaches

Glial-mediated immune modulation in glaucomatous neurodegeneration: mechanisms and therapeutic implications

From bark to bench: innovations in QS-21 adjuvant characterization and manufacturing

Long non-coding RNAs as key orchestrators of the tumor microenvironment in lung cancer

Daratumumab combined with anti-CD20 therapy in pediatric and adult refractory idiopathic nephrotic syndrome: single-center experience

Clinical outcomes and early- prognostic biomarkers of primary biliary cholangitis with ductopenia

Targeting PSMB5-induced PANoptosis in bladder cancer: multi-omics insights and TCM candidate discovery

Expression characteristics, prognostic value, and immune-related analysis of PPP2R1A in lung adenocarcinoma

Immunomodulatory and anti-inflammatory effects of agave fructans in atopic dermatitis: gut microbiota and short-chain fatty acid implication

VEXAS syndrome in rheumatology practice: features from a multicenter cohort in north-east Italy

Case Report: Pseudoprogression of pancreatic acinar cell carcinoma after PD-1 blockade integrated treatment

Rotavirus-specific neutralization assay enables evaluation of mucosal immune responses

Serum and urine anti-PLA2R antibody correlation with albuminuria in idiopathic membranous nephropathy

Correction: Generation of a new Paneth cell-specific Cre-recombinase transgenic mouse line

Predictive value of current nodal staging systems and development of machine learning nomogram for resectable pancreatic head cancer: a population-based study and multicenter validation

Association of HLA-DQA106:01 and DPB105:01:01G alleles with susceptibility to end-stage liver disease with HBV infection in liver transplant recipients from the Zhejiang Han population, China