Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Lung epithelial and alveolar macrophage-like cell interactions significantly modify innate responses to bacterial endotoxin with the involvement of direct cellular contacts, TNF-α, ICAM1 and MCP-1

in Inflammation

Connor Wood
Shagun Khera
Minjeong Woo
Vikram Sharma
Justyna Lopatecka
Frederic Coulon
Zaheer Ahmad Nasir
Vincent Delorme
Simon Jackson
Gyorgy Fejer

Frontiers in Immunology

Review

Accepted on 15 Dec 2025

Exploring Cell Death Mechanisms in Liver Transplantation: Implications for Graft Survival

in Inflammation

Hirofumi Hirao
Takeshi Watanabe
Yoichiro Uchida
Etsuro Hatano

Frontiers in Immunology

106 views

Original Research

Accepted on 15 Dec 2025

METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification

in Inflammation

Dong He
Xiaokun Jiang
Gengyin Guo
Jinfeng Ma
Jinyan Chen
Yongfei Zhang
Jianfeng Zhuang
Ping Xie
Zhen Zhang

Frontiers in Immunology

Review

Accepted on 15 Dec 2025

Enzymatic and Microenvironmental Regulation in Adenosine Metabolism-Mediated Immunosuppression

in Cancer Immunity and Immunotherapy

CHUANG LI
Lifeng Chen
Zhihao Li
LING LIANG
Benyong Lou

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Targeting the epidermal growth factor receptor using IgM antibodies: towards next generation cancer immunotherapy

in Cancer Immunity and Immunotherapy

Kamolrat Somboon
Peter J Bond
Firdaus Samsudin

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Efficacy of Neoadjuvant Immunochemotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study with Propensity-Score Matching

in Cancer Immunity and Immunotherapy

Shifa Zhang
Anhao Hu
Jiuhe Sun
Yutao Wei
Jishan Zhang
Haibo Cai
Gongchao Wang

Frontiers in Immunology

Mini Review

Accepted on 15 Dec 2025

Hemophagocytic Lymphohistiocytosis Induced by Immune Checkpoint Inhibitors: Observations and Proposed Clinical Management

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Bianca Arianna Facchini
Benjamin Switzer
Marc S Ernstoff
Igor Puzanov
Paolo Antonio Ascierto

Frontiers in Immunology

Review

Accepted on 15 Dec 2025

Immunological mechanisms underlying fibrotic diseases via single-cell technologies

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Yuzo Koda
Nobuhiro Nakamoto
Takanori Kanai

Frontiers in Immunology

Case Report

Accepted on 15 Dec 2025

IL12RB1 deficiency in an infant with Disseminated Bacille Calmette-Guérin Disease

in Primary Immunodeficiencies

Xiao Ma
Juping Chen
Junqiao Cheng
Jingbo Wang

Frontiers in Immunology

113 views

Original Research

Accepted on 15 Dec 2025

TIMP1 as a Context-Dependent Biomarker Linking Cancer Progression and Cardiovascular Disorders: A Multi-Level and Bioinformatics Study

in Cancer Immunity and Immunotherapy

Haomin Xie
Dianhua Zhou
Sicheng Chen
Yining Dai
Ranran Zhang
Zongrong Lin
Weiyi Kong
Jianfang Luo
Zhenyang Fu

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Construction of Anti-HER2 Affibody-Directed CAR-NK and Its Synergistic Effects with Doxorubicin-loaded Nanodrug Against HER2-Positive Breast Cancer

in NK and Innate Lymphoid Cell Biology

Xuesong He
Zhaoyuan Liang
Qing Liu
Xiaofei Zhang
Hao Liang
Runqing Jia
Wang Sheng

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Lysophosphatidic Acid: A Promising Biomarker for Diagnosing Sepsis and Predicting In-Hospital Mortality

in Cytokines and Soluble Mediators in Immunity

Xiaojuan Li
Tiewei Li
Pengfei Xuan
Hongyan Wang
Jingping Yang

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes

in Inflammation

Antonia Voli
Daniela Eletto
Fatima Maria Mentucci
Chiara Centrella
Martina Pannetta
Francesco Boccellato
Alfonso Finizio
Silvana Morello
Caterina Giraulo
Amalia Porta

Frontiers in Immunology

120 views

Editorial

Accepted on 15 Dec 2025

New Frontiers in Skin Immunology

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Olga Simionescu

Frontiers in Immunology

128 views

Original Research

Accepted on 15 Dec 2025

Low Maternal Pertussis Protection and Quantified Infant Risk: Supporting Maternal Tdap Vaccination in China

in Vaccines and Molecular Therapeutics

Wen Wang
Tingting Zhang
Xiang Sun

Frontiers in Immunology

Review

Accepted on 15 Dec 2025

Immunometabolic Crosstalk Between Tumor-Associated Macrophages and Ferroptotic Cancer Cells: Mechanisms, Regulation, and Therapeutic Applications

in Cancer Immunity and Immunotherapy

Zi-xing QIAN
Wei Bai
JiaXuan Li
XianJun Rao
Guodong Huang
JiaBao Liu
Wei Wei
Zhuo Zhang

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

An Antibody Uniquely Binding Short 2'-O-Methyl RNA Oligonucleotide Duplexes: Formation and Recognition of Target Duplexes on Cell Surfaces

in Vaccines and Molecular Therapeutics

IAN Seymour DUNN
Matthew M. Lawler
Leah Fagundes
Milto Simoes Junior
April Mangold
Domenic Rinaldi
Lenora B. Rose
James T. Kurnick

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Different Fc scaffolds enhance the breadth of in vitro neutralization of the same Fab against different Rotavirus strains

in Vaccines and Molecular Therapeutics

Giacomo Vezzani
Mabel Miranda Rocio Echague
Elena Morandi
Melania Della Peruta
Mirko Scordio
Teresa Anne Clarisse Reyes
Davide Oldrini
Miren Iturriza-Gómara
Rebecca Jo Loomis
Omar Rossi

Frontiers in Immunology

107 views

Original Research

Accepted on 15 Dec 2025

Impact of Absolute Lymphocyte Count upon Admission to ICU on 28-Day Mortality in Sepsis Patients in ICU

in NK and Innate Lymphoid Cell Biology

DingJun Zhong
Ling Zhao

Frontiers in Immunology

Review

Accepted on 15 Dec 2025

PCV20 in Pediatric Pneumococcal Prevention: Expanded Coverage, Remaining Challenges

in Vaccines and Molecular Therapeutics

Nicola Principi
Alberto Argentiero
Beatrice Rita Campana
Susanna Maria Roberta Esposito

Frontiers in Immunology

103 views

Review

Accepted on 15 Dec 2025

Lactylation in Cancer: Mechanistic Insights, Tumor Microenvironment, and Therapeutic Horizons

in Cancer Immunity and Immunotherapy

Qiang Yang
Zhibo Yang
Dangbo Yu
Kai Tang
Hai Zhao

Frontiers in Immunology

109 views

Original Research

Accepted on 15 Dec 2025

Activated PI3Kδ Syndrome in Inborn Errors of Immunity: Diagnostic Strategies and Clinical Challenges

in Primary Immunodeficiencies

Selcen Bozkurt
Necmiye Ozturk Ozturk
Melek Yorgun Altunbas
Salim Can
Razin Amirov
Ramin Mahmudov
Burkay Cagan Colak
Esra Karabiber
Manuela Baronio
Vassilios Lougaris

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Upregulation of Interferon-γ Activation in Patients with Anti-Interferon-γ Autoantibodies Immunodeficiency Syndrome: Insights from Single-Cell Analysis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Si-Qiao Liang
Xue-Mei Huang
Xiao-Na Liang
Si-Yao Wu
Li-Mei Hong
Ni Chen
Zeng-Tao Luo
Yan Ning
Meng-Chan Wang
Zhiyi He

Frontiers in Immunology

100 views

Mini Review

Accepted on 15 Dec 2025

Roles of immunosuppressive myeloid states in colorectal cancer checkpoint inhibitor non-response: single-cell and spatial proteomics, and reprogramming approaches

in Cancer Immunity and Immunotherapy

Yu Dai
Xinyu Luo
Li Zhang
Jin Yan

Frontiers in Immunology

147 views

48,439 articles

articles

Lung epithelial and alveolar macrophage-like cell interactions significantly modify innate responses to bacterial endotoxin with the involvement of direct cellular contacts, TNF-α, ICAM1 and MCP-1

Exploring Cell Death Mechanisms in Liver Transplantation: Implications for Graft Survival

METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification

Enzymatic and Microenvironmental Regulation in Adenosine Metabolism-Mediated Immunosuppression

Targeting the epidermal growth factor receptor using IgM antibodies: towards next generation cancer immunotherapy

Efficacy of Neoadjuvant Immunochemotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study with Propensity-Score Matching

Hemophagocytic Lymphohistiocytosis Induced by Immune Checkpoint Inhibitors: Observations and Proposed Clinical Management

Immunological mechanisms underlying fibrotic diseases via single-cell technologies

IL12RB1 deficiency in an infant with Disseminated Bacille Calmette-Guérin Disease

TIMP1 as a Context-Dependent Biomarker Linking Cancer Progression and Cardiovascular Disorders: A Multi-Level and Bioinformatics Study

Construction of Anti-HER2 Affibody-Directed CAR-NK and Its Synergistic Effects with Doxorubicin-loaded Nanodrug Against HER2-Positive Breast Cancer

Lysophosphatidic Acid: A Promising Biomarker for Diagnosing Sepsis and Predicting In-Hospital Mortality

Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes

New Frontiers in Skin Immunology

Low Maternal Pertussis Protection and Quantified Infant Risk: Supporting Maternal Tdap Vaccination in China

Immunometabolic Crosstalk Between Tumor-Associated Macrophages and Ferroptotic Cancer Cells: Mechanisms, Regulation, and Therapeutic Applications

An Antibody Uniquely Binding Short 2'-O-Methyl RNA Oligonucleotide Duplexes: Formation and Recognition of Target Duplexes on Cell Surfaces

Different Fc scaffolds enhance the breadth of in vitro neutralization of the same Fab against different Rotavirus strains

Impact of Absolute Lymphocyte Count upon Admission to ICU on 28-Day Mortality in Sepsis Patients in ICU

PCV20 in Pediatric Pneumococcal Prevention: Expanded Coverage, Remaining Challenges

Lactylation in Cancer: Mechanistic Insights, Tumor Microenvironment, and Therapeutic Horizons

Activated PI3Kδ Syndrome in Inborn Errors of Immunity: Diagnostic Strategies and Clinical Challenges

Upregulation of Interferon-γ Activation in Patients with Anti-Interferon-γ Autoantibodies Immunodeficiency Syndrome: Insights from Single-Cell Analysis

Roles of immunosuppressive myeloid states in colorectal cancer checkpoint inhibitor non-response: single-cell and spatial proteomics, and reprogramming approaches