Frontiers in Immunology

Original Research

Published on 16 Dec 2025

Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

in Molecular Innate Immunity

David Eikrem
Vivek A. Manivel
Jacob Whittaker
Osama A. Hamad
Camilla Mohlin
Anna Adler
Claudia Dührkop
Roland Ebert
Yuji Teramura
Kristina N. Ekdahl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729532

585 views

Case Report

Published on 16 Dec 2025

Case Report: Abscopal effect of radiotherapy in a patient with metastatic duodenal adenocarcinoma and resistance to chemoimmunotherapy

in Cancer Immunity and Immunotherapy

Yongping Hao
Jin Wang
Yinling Wang
Zihui Wang
Guangwei Tian
Nan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1643197

595 views

Case Report

Published on 16 Dec 2025

Adult-onset Still’s disease presenting with aseptic meningitis: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Xiao-Fen Li
Amy Ker
Hong-Li Liao
Yuan Liu
James Cheng-Chung Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660434

435 views

Original Research

Published on 16 Dec 2025

βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism

in Inflammation

Hao Wang
Damon J. Tumes
Simon Keam
Jia Wen Lim
Quynh Anh Nguyen
Ross Vlahos
Jonathan McQualter
Adam Quek
Carly Whyte
Harshita Pant

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733060

589 views

Review

Published on 16 Dec 2025

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

in T Cell Biology

Yuehong Hu
Qihan Zhao
Haoran Dai
Yadi Wu
Xinyue Tang
Naiqian Zhang
Hanxue Jiang
Hongliang Rui
Baoli Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687755

704 views

Original Research

Published on 16 Dec 2025

Next-generation cell lines for profiling different proteasome forms and their implications in cancer

in Cancer Immunity and Immunotherapy

Alexander Burov
Anastasia Yakovleva
Georgy Linovskiy
Andrei Fedotov
Vladimir Popenko
Olga Leonova
Aleksandr Lanin
Marina Drutskaya
Vadim Karpov
Alexey Morozov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672000

772 views

Original Research

Published on 16 Dec 2025

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

in Immunological Tolerance and Regulation

Elisa Talker
Tanja Gerlza
Philippe Stas
Christina Trojacher
Tiziana Adage
Andreas J. Kungl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679409

523 views

Original Research

Published on 16 Dec 2025

Eubacterium limosum modulates gut microbiota and produces anti-inflammatory metabolites to alleviate DSS-induced colitis

in Inflammation

Yao Lu
Huijing Tang
Qianhua Fan
Ruiting Lan
Xiaoying Lin
Shuwei Zhang
Liyun Liu
Jianguo Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728808

628 views

Review

Published on 16 Dec 2025

Pathogenic mechanisms and therapeutic potential of the microbiome in premature ovarian insufficiency

in Microbial Immunology

Shuai Ma
Lianwen Zheng
Xiaohua Zhuang
Min Wang
Yinggang Zou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1734367

572 views

Perspective

Published on 16 Dec 2025

Vaccination in the post-COVID era: lessons to be learned in Latin America

in Vaccines and Molecular Therapeutics

Luis Del Carpio-Orantes
Gabriela Zambrano-Sánchez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726836

782 views

Review

Published on 16 Dec 2025

Pyroptosis-driven immune dysregulation in COPD: molecular mechanisms and therapeutic implications

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Feng-Xian Ni
Hui-Xian Wang
Jie Hu
Pei-Sheng Chen
Hua-Jing Huang
Hui-Hui Chen
Dong-Hui Huang
Ze-Bo Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686175

540 views

Systematic Review

Accepted on 15 Dec 2025

Efficacy and Safety of Cadonilimab in the Treatment of Recurrent/Metastatic and Advanced Cervical Cancer: A Systematic Review and Meta-Analysis

in Cancer Immunity and Immunotherapy

Qiuqi Zhuang
Yan Liu

Frontiers in Immunology

280 views

Original Research

Accepted on 15 Dec 2025

Unveiling the hidden cardiovascular risk of sipuleucel-T: A pharmacovigilance analysis using the FDA Adverse Event Reporting System, 2010–2025

in Cancer Immunity and Immunotherapy

Wensheng Liu
Xue Song
Linlin Wang
Jiyong Liu
Qiong Du

Frontiers in Immunology

228 views

Editorial

Accepted on 15 Dec 2025

Editorial – Research Topic Systemic Vasculitis: Advances in Pathogenesis and Therapies Volume II

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Alexandre Wagner Silva De Souza
Joshua Daniel Ooi
Jun Deng
Stefania Croci
Poh-Yi Gan
Kelly L Brown

Frontiers in Immunology

326 views

Original Research

Accepted on 15 Dec 2025

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization

in Inflammation

Ting Hong
Xinyu Liu
Zepai Chi
Guoyuan Liu
Yuanfeng Zhang
Xuanhao Lin
Peixiu Yao
Qingyun Gong
Yonghai Zhang
Xuwei Hong

Frontiers in Immunology

175 views

Original Research

Accepted on 15 Dec 2025

A Lipid Nanoparticle Encapsulated CPA-CTD mRNA Vaccine Provides Protection Against Clostridium perfringens -Driven Diseases

in Comparative Immunology

Qi Jia
Haoyu Xiang
Ting Le
Jing Wang
Jitao Chang
Fang Wang
SUN CHAO
WANBO TAI
Zhigang Jiang
Xin Yin

Frontiers in Immunology

168 views

Original Research

Accepted on 15 Dec 2025

A Multi-Omics Analysis of Pancreatitis: Bridging Familial Genetics and Disease Progression

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Fu Li
Jin-xin Huang
Wen-jie Sun
Jingqing Zeng
Ke-xin Gan
Biao Gong
Jian-mei Ji
Jian Chen
Zhaohui Deng
Dongliang Xu

Frontiers in Immunology

193 views

Review

Accepted on 15 Dec 2025

Bromodomain and Extra-Terminal Proteins in Solid Tumors: Regulators of Immune Microenvironment and Emerging Therapeutic Targets

in Cancer Immunity and Immunotherapy

Deeksha Sharma
Grace Bushnell
Alexander Kalman
Chloe Hutchens
Monika Burness

Frontiers in Immunology

154 views

Original Research

Accepted on 15 Dec 2025

Comparative Risk of Systemic Autoimmune Diseases in Juvenile Idiopathic Arthritis Treated With TNF-α or IL-6 Inhibitors: A Real-World Cohort Study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jih-Jin Tsai
Li-Teh Liu
Ping-Chang Lin
Yu-Hsun Wang
Yung-Heng Lee
James Cheng-Chung Wei

Frontiers in Immunology

148 views

Mini Review

Accepted on 15 Dec 2025

The Gut Microbiota Influences Neurodegenerative Diseases Through the Gut-Brain Axis: Molecular Mechanisms and Effects on Immune Function

in Multiple Sclerosis and Neuroimmunology

Jia Heng Yang
Xiang zhun Song
Su Yan
Qian xun Li
Wen ying Yang

Frontiers in Immunology

163 views

Original Research

Accepted on 15 Dec 2025

Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder

in Multiple Sclerosis and Neuroimmunology

Yangyi Zhang
Fei Zhang
Xingyi Shen
Maoyuan Ni
Jiayi Zhang
Shunling Zhang
Jingwen Lin
Zhaoyang Yang
Huangwei Lei

Frontiers in Immunology

181 views

Original Research

Accepted on 15 Dec 2025

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

in T Cell Biology

Emily Reed
Tatlock H. Lauten
Tamara Natour
Lauren Jane Pitts
Caroline N. Jojo
Brooke L. Griffin
Sreeram Pasupuleti
Adam J Case

Frontiers in Immunology

167 views

Brief Research Report

Accepted on 15 Dec 2025

B-cell–driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review

in Multiple Sclerosis and Neuroimmunology

Pietro Antonio Bruno
Stefania Barone
Angelo Pascarella
Pier Luigi Lanza
Emanuele Tinelli
Antonio Gambardella
Paola Valentino

Frontiers in Immunology

308 views

Correction

Accepted on 15 Dec 2025

Corrigendum: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

in T Cell Biology

Karina M Berschneider
Bernhard Wetterauer
Carsten Sticht
Christian Orlik
Beate Jahraus
Henning Kirchgeßner
Anastasiia Zuieva
Stefan Wölfl
Divya Lairikyengbam
Verena Beier

Frontiers in Immunology

302 views

48,698 articles

articles

Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

Case Report: Abscopal effect of radiotherapy in a patient with metastatic duodenal adenocarcinoma and resistance to chemoimmunotherapy

Adult-onset Still’s disease presenting with aseptic meningitis: a case report

βc receptor antagonism mitigates sarcoidosis granuloma formation by targeting inflammatory signals and aberrant lipid metabolism

Metabolic reprogramming as a therapeutic target for modulating the Th17/Treg balance in autoimmune diseases: a comprehensive review

Next-generation cell lines for profiling different proteasome forms and their implications in cancer

Immunogenicity of a CXCL8-based biopharmaceutical drug candidate in comparison to its wildtype form

Eubacterium limosum modulates gut microbiota and produces anti-inflammatory metabolites to alleviate DSS-induced colitis

Pathogenic mechanisms and therapeutic potential of the microbiome in premature ovarian insufficiency

Vaccination in the post-COVID era: lessons to be learned in Latin America

Pyroptosis-driven immune dysregulation in COPD: molecular mechanisms and therapeutic implications

Efficacy and Safety of Cadonilimab in the Treatment of Recurrent/Metastatic and Advanced Cervical Cancer: A Systematic Review and Meta-Analysis

Unveiling the hidden cardiovascular risk of sipuleucel-T: A pharmacovigilance analysis using the FDA Adverse Event Reporting System, 2010–2025

Editorial – Research Topic Systemic Vasculitis: Advances in Pathogenesis and Therapies Volume II

TENS alleviates CP/CPPS-related inflammation and pain by modulating Kir2.1-dependent macrophage polarization

A Lipid Nanoparticle Encapsulated CPA-CTD mRNA Vaccine Provides Protection Against Clostridium perfringens -Driven Diseases

A Multi-Omics Analysis of Pancreatitis: Bridging Familial Genetics and Disease Progression

Bromodomain and Extra-Terminal Proteins in Solid Tumors: Regulators of Immune Microenvironment and Emerging Therapeutic Targets

Comparative Risk of Systemic Autoimmune Diseases in Juvenile Idiopathic Arthritis Treated With TNF-α or IL-6 Inhibitors: A Real-World Cohort Study

The Gut Microbiota Influences Neurodegenerative Diseases Through the Gut-Brain Axis: Molecular Mechanisms and Effects on Immune Function

Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

B-cell–driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review

Corrigendum: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways