Frontiers in Immunology

Mini Review

Accepted on 15 Dec 2025

Hemophagocytic Lymphohistiocytosis Induced by Immune Checkpoint Inhibitors: Observations and Proposed Clinical Management

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Bianca Arianna Facchini
Benjamin Switzer
Marc S Ernstoff
Igor Puzanov
Paolo Antonio Ascierto

Frontiers in Immunology

186 views

Review

Accepted on 15 Dec 2025

Immunological mechanisms underlying fibrotic diseases via single-cell technologies

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Yuzo Koda
Nobuhiro Nakamoto
Takanori Kanai

Frontiers in Immunology

149 views

Case Report

Accepted on 15 Dec 2025

IL12RB1 deficiency in an infant with Disseminated Bacille Calmette-Guérin Disease

in Primary Immunodeficiencies

Xiao Ma
Juping Chen
Junqiao Cheng
Jingbo Wang

Frontiers in Immunology

179 views

Original Research

Accepted on 15 Dec 2025

TIMP1 as a Context-Dependent Biomarker Linking Cancer Progression and Cardiovascular Disorders: A Multi-Level and Bioinformatics Study

in Cancer Immunity and Immunotherapy

Haomin Xie
Dianhua Zhou
Sicheng Chen
Yining Dai
Ranran Zhang
Zongrong Lin
Weiyi Kong
Jianfang Luo
Zhenyang Fu

Frontiers in Immunology

131 views

Original Research

Accepted on 15 Dec 2025

Construction of Anti-HER2 Affibody-Directed CAR-NK and Its Synergistic Effects with Doxorubicin-loaded Nanodrug Against HER2-Positive Breast Cancer

in NK and Innate Lymphoid Cell Biology

Xuesong He
Zhaoyuan Liang
Qing Liu
Xiaofei Zhang
Hao Liang
Runqing Jia
Wang Sheng

Frontiers in Immunology

131 views

Original Research

Accepted on 15 Dec 2025

Lysophosphatidic Acid: A Promising Biomarker for Diagnosing Sepsis and Predicting In-Hospital Mortality

in Cytokines and Soluble Mediators in Immunity

Xiaojuan Li
Tiewei Li
Pengfei Xuan
Hongyan Wang
Jingping Yang

Frontiers in Immunology

122 views

Original Research

Accepted on 15 Dec 2025

Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes

in Inflammation

Antonia Voli
Daniela Eletto
Fatima Maria Mentucci
Chiara Centrella
Martina Pannetta
Francesco Boccellato
Alfonso Finizio
Silvana Morello
Caterina Giraulo
Amalia Porta

Frontiers in Immunology

189 views

Editorial

Accepted on 15 Dec 2025

New Frontiers in Skin Immunology

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Olga Simionescu

Frontiers in Immunology

248 views

Original Research

Accepted on 15 Dec 2025

TRIM29 Drives Ulcerative Colitis by Disrupting Lipid Metabolism via Lysosomal Dysfunction: A Multi-Omics and Experimental Study

in Inflammation

Xingzhou Guo
Luyun Zhang
Zongbiao Tan
Haodong He
Yafei Liu
Yu Baoping
Weiguo Dong

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Low Maternal Pertussis Protection and Quantified Infant Risk: Supporting Maternal Tdap Vaccination in China

in Vaccines and Molecular Therapeutics

Wen Wang
Tingting Zhang
Xiang Sun

Frontiers in Immunology

112 views

Review

Accepted on 15 Dec 2025

Immunometabolic Crosstalk Between Tumor-Associated Macrophages and Ferroptotic Cancer Cells: Mechanisms, Regulation, and Therapeutic Applications

in Cancer Immunity and Immunotherapy

Zi-xing QIAN
Wei Bai
JiaXuan Li
XianJun Rao
Guodong Huang
JiaBao Liu
Wei Wei
Zhuo Zhang

Frontiers in Immunology

107 views

Original Research

Accepted on 15 Dec 2025

An Antibody Uniquely Binding Short 2'-O-Methyl RNA Oligonucleotide Duplexes: Formation and Recognition of Target Duplexes on Cell Surfaces

in Vaccines and Molecular Therapeutics

IAN Seymour DUNN
Matthew M. Lawler
Leah Fagundes
Milto Simoes Junior
April Mangold
Domenic Rinaldi
Lenora B. Rose
James T. Kurnick

Frontiers in Immunology

132 views

Original Research

Accepted on 15 Dec 2025

Different Fc scaffolds enhance the breadth of in vitro neutralization of the same Fab against different Rotavirus strains

in Vaccines and Molecular Therapeutics

Giacomo Vezzani
Mabel Miranda Rocio Echague
Elena Morandi
Melania Della Peruta
Mirko Scordio
Teresa Anne Clarisse Reyes
Davide Oldrini
Miren Iturriza-Gómara
Rebecca Jo Loomis
Omar Rossi

Frontiers in Immunology

169 views

Original Research

Accepted on 15 Dec 2025

Impact of Absolute Lymphocyte Count upon Admission to ICU on 28-Day Mortality in Sepsis Patients in ICU

in NK and Innate Lymphoid Cell Biology

DingJun Zhong
Ling Zhao

Frontiers in Immunology

Review

Accepted on 15 Dec 2025

PCV20 in Pediatric Pneumococcal Prevention: Expanded Coverage, Remaining Challenges

in Vaccines and Molecular Therapeutics

Nicola Principi
Alberto Argentiero
Beatrice Rita Campana
Susanna Maria Roberta Esposito

Frontiers in Immunology

148 views

Review

Accepted on 15 Dec 2025

Lactylation in Cancer: Mechanistic Insights, Tumor Microenvironment, and Therapeutic Horizons

in Cancer Immunity and Immunotherapy

Qiang Yang
Zhibo Yang
Dangbo Yu
Kai Tang
Hai Zhao

Frontiers in Immunology

168 views

Original Research

Accepted on 15 Dec 2025

Activated PI3Kδ Syndrome in Inborn Errors of Immunity: Diagnostic Strategies and Clinical Challenges

in Primary Immunodeficiencies

Selcen Bozkurt
Necmiye Ozturk Ozturk
Melek Yorgun Altunbas
Salim Can
Razin Amirov
Ramin Mahmudov
Burkay Cagan Colak
Esra Karabiber
Manuela Baronio
Vassilios Lougaris

Frontiers in Immunology

197 views

Original Research

Accepted on 15 Dec 2025

PD-L1 Expression and Mismatch Repair Deficiency in Locally Advanced Head and Neck Squamous Cell Carcinoma Treated with Chemoradiotherapy: Association with Treatment Response and Survival

in Cancer Immunity and Immunotherapy

Bingyi Zhang
Dong Guo
Xinyue Wei
Yuanyuan Cai
Daqing Sun
Xiaoxiao Wang
Xiaoli Wang
Jianwen Li
Furong Hao

Frontiers in Immunology

Original Research

Accepted on 15 Dec 2025

Upregulation of Interferon-γ Activation in Patients with Anti-Interferon-γ Autoantibodies Immunodeficiency Syndrome: Insights from Single-Cell Analysis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Si-Qiao Liang
Xue-Mei Huang
Xiao-Na Liang
Si-Yao Wu
Li-Mei Hong
Ni Chen
Zeng-Tao Luo
Yan Ning
Meng-Chan Wang
Zhiyi He

Frontiers in Immunology

169 views

Mini Review

Accepted on 15 Dec 2025

Roles of immunosuppressive myeloid states in colorectal cancer checkpoint inhibitor non-response: single-cell and spatial proteomics, and reprogramming approaches

in Cancer Immunity and Immunotherapy

Yu Dai
Xinyu Luo
Li Zhang
Jin Yan

Frontiers in Immunology

235 views

Original Research

Accepted on 15 Dec 2025

Targeted degradation of MAPKAP kinase 2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MAPKAP kinase 3 and 5

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Bin Yang
Guoqiang Fang
Issac Marx
Guang Liu
Stephanie Skouras
Kirti Sharma
Dirk M. Walther
Sarah Bollinger Martinez
Cedric Hubeau
Yatao Shi

Frontiers in Immunology

266 views

Original Research

Accepted on 15 Dec 2025

Clinical Characteristics and Prognosis of Paraneoplastic Syndromes: A Single-Center Cohort Study in Northern China

in Multiple Sclerosis and Neuroimmunology

Minzhe Hu
Qianchang Wang
Yuxiu Xiao
Danqing Qin
Shougang Guo
Chunjuan Wang

Frontiers in Immunology

138 views

Correction

Accepted on 15 Dec 2025

Correction: Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

in Molecular Innate Immunity

Xiuping Liang
Li Yanhong
Ziyi Tang
Yubin Luo
Yi Liu

Frontiers in Immunology

290 views

Review

Accepted on 15 Dec 2025

Engineering Neuroimmune Regulation: Biomaterial and Nanotechnology Platforms for Neuropathology Diagnosis and Targeted Immunomodulation

in Multiple Sclerosis and Neuroimmunology

Mikayla Simone Jackson
Lauren Grace Porter
Robert Smith Oakes

Frontiers in Immunology

206 views

48,714 articles

articles

Hemophagocytic Lymphohistiocytosis Induced by Immune Checkpoint Inhibitors: Observations and Proposed Clinical Management

Immunological mechanisms underlying fibrotic diseases via single-cell technologies

IL12RB1 deficiency in an infant with Disseminated Bacille Calmette-Guérin Disease

TIMP1 as a Context-Dependent Biomarker Linking Cancer Progression and Cardiovascular Disorders: A Multi-Level and Bioinformatics Study

Construction of Anti-HER2 Affibody-Directed CAR-NK and Its Synergistic Effects with Doxorubicin-loaded Nanodrug Against HER2-Positive Breast Cancer

Lysophosphatidic Acid: A Promising Biomarker for Diagnosing Sepsis and Predicting In-Hospital Mortality

Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes

New Frontiers in Skin Immunology

TRIM29 Drives Ulcerative Colitis by Disrupting Lipid Metabolism via Lysosomal Dysfunction: A Multi-Omics and Experimental Study

Low Maternal Pertussis Protection and Quantified Infant Risk: Supporting Maternal Tdap Vaccination in China

Immunometabolic Crosstalk Between Tumor-Associated Macrophages and Ferroptotic Cancer Cells: Mechanisms, Regulation, and Therapeutic Applications

An Antibody Uniquely Binding Short 2'-O-Methyl RNA Oligonucleotide Duplexes: Formation and Recognition of Target Duplexes on Cell Surfaces

Different Fc scaffolds enhance the breadth of in vitro neutralization of the same Fab against different Rotavirus strains

Impact of Absolute Lymphocyte Count upon Admission to ICU on 28-Day Mortality in Sepsis Patients in ICU

PCV20 in Pediatric Pneumococcal Prevention: Expanded Coverage, Remaining Challenges

Lactylation in Cancer: Mechanistic Insights, Tumor Microenvironment, and Therapeutic Horizons

Activated PI3Kδ Syndrome in Inborn Errors of Immunity: Diagnostic Strategies and Clinical Challenges

PD-L1 Expression and Mismatch Repair Deficiency in Locally Advanced Head and Neck Squamous Cell Carcinoma Treated with Chemoradiotherapy: Association with Treatment Response and Survival

Upregulation of Interferon-γ Activation in Patients with Anti-Interferon-γ Autoantibodies Immunodeficiency Syndrome: Insights from Single-Cell Analysis

Roles of immunosuppressive myeloid states in colorectal cancer checkpoint inhibitor non-response: single-cell and spatial proteomics, and reprogramming approaches

Targeted degradation of MAPKAP kinase 2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MAPKAP kinase 3 and 5

Clinical Characteristics and Prognosis of Paraneoplastic Syndromes: A Single-Center Cohort Study in Northern China

Correction: Neutrophils as key drivers of pulmonary fibrosis: unveiling mechanisms and therapeutic implications

Engineering Neuroimmune Regulation: Biomaterial and Nanotechnology Platforms for Neuropathology Diagnosis and Targeted Immunomodulation