Frontiers in Immunology

Original Research

Published on 11 Dec 2025

Evaluation of programmed cell death ligand-1 expression in primary central nervous system lymphoma using whole-tumor histogram analysis of multiparametric MRI: implications for immunotherapy selection

in Cancer Immunity and Immunotherapy

Xiaofang Zhou
Xiaoli Su
Lan Yu
Feng Wang
Shujie Yu
Feifei Yu
Xiaoye Lin
Yang Song
Dairong Cao
Xingfu Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676273

515 views

Clinical Trial

Published on 11 Dec 2025

Phase 1 study of chidamide in combination with venetoclax, azacitidine, aclarubicin, cytarabine and G-CSF for refractory/relapsed acute myeloid leukemia: clinical safety, efficacy, and correlative analysis

in Cancer Immunity and Immunotherapy

Yanan Wen
Jingjing Yang
Xiawei Zhang
Qingyang Liu
Wenjing Gao
Lili Dong
Weijia Zhao
Sai Huang
Daihong Liu
Yu Jing

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698710

580 views

Review

Published on 11 Dec 2025

Targeting the TLR4 axis with microbiota-oriented interventions and innovations in diabetes therapy: a narrative review

in Nutritional Immunology

Christos G. Nikolaidis
Despoina Gyriki
Elisavet Stavropoulou
Eleni Karlafti
Triantafyllos Didangelos
Christina Tsigalou
Anastasia Thanopoulou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701504

685 views

Original Research

Published on 11 Dec 2025

Fruquintinib saddles tumor immune tolerance by curbing pro-tumoral immature myeloid cell populations

in Cancer Immunity and Immunotherapy

Lucía Suárez
María Martínez-Azcona
Irantzu Serrano-Mendioroz
Leticia Fernández-Rubio
María Esperanza Rodríguez-Ruiz
Ana Rouzaut

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699980

757 views

Brief Research Report

Published on 11 Dec 2025

Plasmodium vivax infection-driven modulation of sterol carrier protein reveals a metabolic link to reproductive physiology in Anopheles stephensi

in Vaccines and Molecular Therapeutics

Seena Kumari
Pooja Yadav
Nirmala Sankhala
Jyoti Rani
Gunjan Sharma
Charu Chauhan
Sanjay Tevatiya
Rajnikant Dixit

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703479

780 views

Original Research

Published on 11 Dec 2025

Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment

in Viral Immunology

Mauro Voi
Antonella Sangalli
Erica Ginevra Milano
Carola De Martinis
Elisa Orlandi
Stefano Tamburin
Elisa Mantovani
Angela Federico
Massimiliano Lanzafame
Emanuela Lattuada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703026

845 views

Original Research

Published on 11 Dec 2025

Macrophage activation of the TREM2-DAP12-SYK pathway shapes the adipose tissue microenvironment in obesity and unveils the therapeutic potential of natural compounds egcg and SMRR

in Immunological Tolerance and Regulation

Wang Luoying
Yi Xingcheng
Cong Donghang
Long Mengtuan
Wang Ping
Zhang Lijuan
Li Yupeng
Zhao Tianyi
Chen Hongyu
Wang Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694985

1,082 views

Review

Published on 11 Dec 2025

Experimental animal models of acute respiratory distress syndrome: one-hit and two-hit establishment application

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Yue Zhao
Xin Li
Yanhua Ou
Xiangran Cai
Weijian Huang
Shuhua He
Sisi Liang
Ning Wang
Linliang Song
Meixia Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649074

650 views

Review

Accepted on 10 Dec 2025

Autoimmune Disease-Associated Lymphomas: Research Progress and Review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Chengqian Chen
Wei Guo
Yangzhi Zhao
XINGTONG WANG
Jia Li
Ying Zhang
Zhaoxia Li
Haotian Wang
Ou Bai

Frontiers in Immunology

308 views

Original Research

Accepted on 10 Dec 2025

Cadonilimab Rechallenge in Patients with Recurrent or Metastatic Cervical Cancer Following Prior PD-1/PD-L1 Inhibitor Failure: A Retrospective Multicenter Study

in Cancer Immunity and Immunotherapy

Haijuan Yu
Jian Chen
Jie Lin
Lijun Chen
Jianping Zou
Bin Liu
Linying Liu
Ning Xie
Sufang Deng
Shengtao Zhou

Frontiers in Immunology

286 views

Original Research

Accepted on 10 Dec 2025

Contrasting Immune Responses in COVID-19: Insights from Healthcare Workers and Infected Patients on Plasmablast, pDC, and NK Cell Dynamics

in Viral Immunology

Laura Martín-Pedraza
Eulalia Rodríguez-Martín
Erick De La Torre Tarazona
Elena Moreno
Roberto Pariente Rodríguez
Paulette Esperanza Walo-Delgado
Javier García-Pérez
JORGE DIAZ ALVAREZ
Laura Luna
Mario Rodriguez Dominguez

Frontiers in Immunology

287 views

Original Research

Accepted on 10 Dec 2025

NOS2/ARG1 Axis and Immune Cell Ratios as promising prognostic and predictive Biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer

in Cancer Immunity and Immunotherapy

Djehane Houria Mataam
Assia Galleze
Sarra Benkhelifa
Ryad Trari
Wafa Khelaifia
Said Belhadef
Sabrina Bouhara
Sonia Ait-younes
Anissa Benali
Hassen Mahfouf

Frontiers in Immunology

345 views

Clinical Trial

Accepted on 10 Dec 2025

Patient-reported improvements from use of IMC-2 alone and IMC-2 and Paxlovid® in a Long COVID cohort: a case series

in Multiple Sclerosis and Neuroimmunology

William L Pridgen
David Putrino

Frontiers in Immunology

333 views

Case Report

Accepted on 10 Dec 2025

Epidermolysis bullosa acquisita following dipeptidyl peptidase-4 inhibitor therapy and complicated by immune thrombocytopenic purpura

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Hirofumi Kawamoto
Natsuko Sasaki
Yukimi Ueda
Norito Ishii
Yu Sawada

Frontiers in Immunology

169 views

Original Research

Accepted on 10 Dec 2025

Risk Factors for Cancer and the Importance of Screening in Adult Recipients of Living-Donor Kidney Transplant

in Alloimmunity and Transplantation

Takahisa Hiramitsu
Yuki Shimamoto
Tomoki Himeno
Yuki Hasegawa
Kenta Futamura
Manabu Okada
Yutaka Matsuoka
Norihiko Goto
Toshihiro Ichimori
Shunji Narumi

Frontiers in Immunology

186 views

Original Research

Accepted on 10 Dec 2025

Antigen recognition induces allosteric conformational variability in adalimumab and avelumabAntigen binding triggers long-range conformational changes in monoclonal antibodies

in Vaccines and Molecular Therapeutics

Davide Bianchi
Simona Saporiti
Wolf Palinsky
Omar Ben Mariem
Mara Rossi
Ivano Eberini
Fabio Centola

Frontiers in Immunology

231 views

Review

Accepted on 10 Dec 2025

Double, Double Toil and Trouble: Transforming Growth Factor Beta (TGF-β) in HIV Infection

in Viral Immunology

Jakob Harrison-Gleason
Kayla Lacin Yerlioglu
Ariel Wolfgang Halle
Judd Hultquist
Elena Martinelli

Frontiers in Immunology

184 views

Original Research

Accepted on 10 Dec 2025

Susceptibility of broad reactivity nanobodies to resistance mutations in the S2 domain of SARS-CoV-2 predicted by yeast display deep mutational scanning

in Vaccines and Molecular Therapeutics

Simon Evan Hufton
Christina R Ball
Walter Ramage
Ryan Mate

Frontiers in Immunology

176 views

Original Research

Accepted on 10 Dec 2025

LILRB1 and LILRB2 genomics and transcriptomics in macaque and baboon species: polymorphism, diversification, and extensive alternative splicing

in Comparative Immunology

Natasja G. De Groot
Nanine de Groot
Corrine Heijmans
Annemiek J. M. de Vos-Rouweler
Marit K. H. van der Wiel
Jesse Bruijnesteijn

Frontiers in Immunology

166 views

Original Research

Accepted on 10 Dec 2025

Serum Magnesium Predictive Value in Hepatocellular Carcinoma Patients on First-Line Immunotherapy: A Retrospective Study

in Cancer Immunity and Immunotherapy

Xi Cheng
Wei Wang
Ya-nan Xue
Hong-lin Tang
Da Li

Frontiers in Immunology

262 views

Review

Accepted on 10 Dec 2025

Metabolic Reprogramming in the Post-Metastatic Tumor Microenvironment: Multi-Omics Insights into Determinants of Immunotherapy Response

in Cancer Immunity and Immunotherapy

Mengxi Li
WANG TINGTING
Zhenwang Zhang
Yuxi Dongye

Frontiers in Immunology

186 views

Original Research

Accepted on 10 Dec 2025

Prostate-Specific Membrane Antigen Targeted Organic Semiconducting Polymer Nanoparticles for Enhanced Photothermal Therapy of Prostate Cancer

in Cancer Immunity and Immunotherapy

Zhongji Jiang
Xun Zhang
Gaohaer Kadeerhan
Jin Zhang
Jiali Jin
Weijing Hu
Wenmin Guo
Hong Guo
Dongwen Wang

Frontiers in Immunology

238 views

Original Research

Accepted on 10 Dec 2025

Characterization of T cell responses against Fusobacterium necrophorum naturally-induced foot rot in dairy cows

in Comparative Immunology

Yang Yi
Lulu Zhang
Chen Yu
Sheng Zhang
Chunmei Ye
Zhangping Yang
Zhipeng Zhang

Frontiers in Immunology

174 views

Original Research

Accepted on 10 Dec 2025

Multiplex Autoantibody Screening in Pediatric Type 1 Diabetes: POC Blot vs. ELISA for Gluten-Related Disorders

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Adugna Gudeta Negussie
Patricia Wusterhausen
Dassalegn Muleta
Demise Mulugeta
Mesfin Bekele
Torsten Matthias

Frontiers in Immunology

130 views