Frontiers in Immunology

Original Research

Published on 10 Dec 2025

CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia

in Primary Immunodeficiencies

Chi Huu Nguyen
Katarina Zmajkovicova
Angelina Sekirnik
Sarah Taplin
Myriam Defontis
Jacob R. Bledsoe
Arthur G. Taveras
Lars Karlsson
Robert Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658987

1,903 views

Case Report

Published on 10 Dec 2025

Blastic plasmacytoid dendritic cell neoplasm secondary to acute myeloid leukemia with shared mutations in TET2 and DNMT3A: a case report and literature review

in Cancer Immunity and Immunotherapy

Yao Sun
Yingjie Liu
Na Liu
Xiaohui Zhang
Wenrong Huang
Liangding Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656157

417 views

Methods

Published on 10 Dec 2025

A 41-marker 37-color full spectrum flow cytometry panel for the deep immunophenotyping of human peripheral and liver natural killer cells

in NK and Innate Lymphoid Cell Biology

Alberta Gerarda Antonia Paul
Konrad H. H. Reichel
Juan J. Garcia-Vallejo
Lara R. Heij
Maria C. Jaimes
Yacine Kharraz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609732

1,569 views

Review

Published on 10 Dec 2025

Research progress on the application of nanobodies in immunity and infectious skin diseases

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Liguo Qiu
Fengming Hu
Xiaohua Tao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705553

688 views

Original Research

Published on 10 Dec 2025

A novel prognostic signature identifies MFAP4 as a tumor suppressor linking the tumor microenvironment to PI3K/AKT signaling in triple-negative breast cancer

in Cancer Immunity and Immunotherapy

Xiaoqin Yu
Xiaofen Li
Shiping Luo
Chuangui Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709141

1,047 views

Correction

Published on 10 Dec 2025

Correction: Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

in Systems Immunology

Dan Chen
Xiyi Huang
Chun Wang
Cheng Zheng
Yunhao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746347

353 views

Review

Published on 10 Dec 2025

The immunoregulatory role of integrins in pulmonary diseases

in Inflammation

Qing Xu
Chao Yang
Wanwen Li
Weiwei Qian
Shiyin Chen
Liqing Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716118

892 views

Review

Published on 10 Dec 2025

Glycosylation as a strategic mechanism for measles virus and mumps virus immune evasion

in Vaccines and Molecular Therapeutics

Catalina Galvan
Inna G. Ovsyannikova
Richard B. Kennedy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716829

1,018 views

Systematic Review

Published on 10 Dec 2025

Survival benefits of different immunotherapies for hepatocellular carcinoma: a meta-analysis highlighting age, gender, etiology, and tumor burden

in Cancer Immunity and Immunotherapy

Ming-Cheng Guan
Na Li
Qian Ding
Di Sun
Hao Li
Mei Yang
Lei Hong
Hong Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713151

959 views

Original Research

Published on 10 Dec 2025

Maternal western-style diet alters Kupffer cell proportion leading to metabolic dysfunction-associated steatotic liver disease when challenged with western diet in adulthood

in Nutritional Immunology

Sarah J. Miller
Rachel C. Janssen
Wanke Zhao
Karen R. Jonscher
Hua Zhong
Christa I. DeVette
Jacob E. Friedman
Kurt A. Zimmerman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698609

922 views

Original Research

Published on 10 Dec 2025

Cytokine-driven glycosphingolipid metabolism modulates endoplasmic reticulum calcium homeostasis in primary human renal mesangial cells

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Mariia Stefanenko
Tessa M. Ortiz
Sandra G. Mungaray
Mykhailo Fedoriuk
Oleg Palygin
Stefano Berto
Drew Moore
Tamara K. Nowling

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688916

771 views

Review

Published on 10 Dec 2025

Metabolic reprogramming and immune regulation in acute myeloid leukemia

in Cancer Immunity and Immunotherapy

Xiaogang Hao
Chenyang Fan
Lixiang Yan
Reaila Jianati
Yifei Guo
Xinli Zhou
Gengda Zhu
Yucheng Zhang
Chengyulong Zheng
Ying Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655005

663 views

Brief Research Report

Published on 10 Dec 2025

Utility of blood DNA methylation and immune cell-type estimates to identify clinically relevant links between immunity and health conditions in a large cohort

in Inflammation

Marisol Herrera-Rivero
Jan Homann
Christina M. Lill
Matthias Nauck
Wolfgang Lieb
Jens Kuhle
Heike Minnerup
Marco Hermesdorf
Klaus Berger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1613557

427 views

Case Report

Published on 10 Dec 2025

MRI features and preliminary diagnostic assessment using large language models of cystic tumor progression mimicking radiation necrosis in brain metastasis patients treated with immunotherapy: case report

in Cancer Immunity and Immunotherapy

Guirong Tan
Mingchen Cai
Yu Lu
Amy Liu
Shimin Li
Gang Xiao
Lijuan Zhong
Lijia Li
Yichuan Hu
Qiong Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661918

746 views

Case Report

Published on 10 Dec 2025

Case Report: The case of atypical OAPS complicated by positive anti-SSA and anti-SSB antibodies

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Chunyan Huang
Daorong Hong
Xiaoqing Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631323

447 views

Perspective

Published on 10 Dec 2025

Recent progress in pig-to-human kidney xenotransplantation

in Alloimmunity and Transplantation

Pei Tao
Kaiyu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735113

870 views

Original Research

Published on 10 Dec 2025

Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Chao Yang
Miao Ma
Kangjie Yu
Yi Wang
Yuting Zhang
Yan Shen
Jun Wang
Xiaoke Wang
Lulu Luo
Ya Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665078

777 views

Case Report

Published on 10 Dec 2025

MRI-negative myelitis, especially after COVID-19: a case report and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Mitsuyoshi Tamura
Yohei Yagi
Satoki Hanayama
Satoko Yoshizaki
Kazumoto Shibuya
Hiroki Masuda
Masahiro Mori

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708018

852 views

Original Research

Published on 10 Dec 2025

Prognostic Significance of baseline systemic inflammation markers in PD-L1-negative advanced non-small cell lung cancer patients treated with the BRICS sequential regimen

in Cancer Immunity and Immunotherapy

Jianxin Chen
Ming Lin
Jian Wang
Junhui Wang
Yonghai Peng
Zongyang Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686521

592 views

Review

Published on 10 Dec 2025

MicroRNAs orchestrating host and vector-borne protozoan interactions: bridging immune modulation and cross-species communication

in Parasite Immunology

Jianyong Li
Feng Zhu
Jian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673237

506 views

Original Research

Published on 10 Dec 2025

Human macrophages release exosomes containing anti-inflammatory microRNAs after phagocytosis of Leishmania infantum

in Parasite Immunology

Cinthia L. Hudachek
Bayan Zhanbolat
Yani Chen
Mary E. Wilson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593829

961 views

Review

Published on 10 Dec 2025

Immune-mediated blood-brain barrier disruption after ischemic stroke: mechanisms and therapeutic targets

in Inflammation

Hanjing Wang
Zhang Yiqiang
Jie Cai
Jiawei Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716041

896 views

Review

Published on 10 Dec 2025

Multi-omics approach to dissect the significance of lipid metabolism in helper T cell subset

in Inflammation

Toshio Kanno
Keiko Nakano
Yukie Iwao
Yusuke Endo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708616

681 views

Systematic Review

Published on 10 Dec 2025

A bibliometric analysis of vaccine research on Chikungunya virus: contributors, trends, and emerging frontiers

in Vaccines and Molecular Therapeutics

Da Shao
Zengwei Kou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692556

938 views

48,714 articles

articles

CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia

Blastic plasmacytoid dendritic cell neoplasm secondary to acute myeloid leukemia with shared mutations in TET2 and DNMT3A: a case report and literature review

A 41-marker 37-color full spectrum flow cytometry panel for the deep immunophenotyping of human peripheral and liver natural killer cells

Research progress on the application of nanobodies in immunity and infectious skin diseases

A novel prognostic signature identifies MFAP4 as a tumor suppressor linking the tumor microenvironment to PI3K/AKT signaling in triple-negative breast cancer

Correction: Portfolio analysis of single-cell RNA-sequencing and transcriptomic data unravels immune cells and telomere-related biomarkers in sepsis

The immunoregulatory role of integrins in pulmonary diseases

Glycosylation as a strategic mechanism for measles virus and mumps virus immune evasion

Survival benefits of different immunotherapies for hepatocellular carcinoma: a meta-analysis highlighting age, gender, etiology, and tumor burden

Maternal western-style diet alters Kupffer cell proportion leading to metabolic dysfunction-associated steatotic liver disease when challenged with western diet in adulthood

Cytokine-driven glycosphingolipid metabolism modulates endoplasmic reticulum calcium homeostasis in primary human renal mesangial cells

Metabolic reprogramming and immune regulation in acute myeloid leukemia

Utility of blood DNA methylation and immune cell-type estimates to identify clinically relevant links between immunity and health conditions in a large cohort

MRI features and preliminary diagnostic assessment using large language models of cystic tumor progression mimicking radiation necrosis in brain metastasis patients treated with immunotherapy: case report

Case Report: The case of atypical OAPS complicated by positive anti-SSA and anti-SSB antibodies

Recent progress in pig-to-human kidney xenotransplantation

Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis

MRI-negative myelitis, especially after COVID-19: a case report and literature review

Prognostic Significance of baseline systemic inflammation markers in PD-L1-negative advanced non-small cell lung cancer patients treated with the BRICS sequential regimen

MicroRNAs orchestrating host and vector-borne protozoan interactions: bridging immune modulation and cross-species communication

Human macrophages release exosomes containing anti-inflammatory microRNAs after phagocytosis of Leishmania infantum

Immune-mediated blood-brain barrier disruption after ischemic stroke: mechanisms and therapeutic targets

Multi-omics approach to dissect the significance of lipid metabolism in helper T cell subset

A bibliometric analysis of vaccine research on Chikungunya virus: contributors, trends, and emerging frontiers