Frontiers in Immunology

Original Research

Published on 10 Dec 2025

PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells

in T Cell Biology

Akihiro Shimba
Satoru Munakata
Shinya Abe
Guangwei Cui
Ryoma Kato
Masaki Miyazaki
Atsuhiro Ichihara
Koichi Ikuta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1566935

699 views

Original Research

Published on 10 Dec 2025

Impact of celiac disease on patients with familial Mediterranean fever: a nationwide study based on the Türkiye database

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Rıfat Bozkuş
Serdar Can Güven
Salih Başer
Nuray Yılmaz Çakmak
Hasan Satış
Emin Gemcioğlu
Naim Ata
Şuayip Birinci

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675131

602 views

Original Research

Published on 10 Dec 2025

Circulating PD-1+ effector memory T cells predict anti-PD-1 efficacy in advanced gastric cancer

in Cancer Immunity and Immunotherapy

Kongcheng Wang
Jie Shao
Kai Xin
Lianru Zhang
Baorui Liu
Wenxiu Chen
Qin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720724

715 views

Case Report

Published on 10 Dec 2025

IgG4-related disease presenting with hypercalcemia: case report and mechanistic insights

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Yaxin Li
Xing Niu
Ling Li
Zhangxue Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720791

767 views

Original Research

Published on 10 Dec 2025

Efficacy and safety of immunotherapy rechallenge in second-line treatment after failure of first-line immune checkpoint inhibitors combined with chemotherapy in advanced gastric cancer: a retrospective study

in Cancer Immunity and Immunotherapy

Fei Li
Wenjing Gong
Miaomiao Yang
Aina Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697712

754 views

Original Research

Published on 10 Dec 2025

Insomnia and anxiety: exploring their hidden effect on natural killer cells among young female adults

in NK and Innate Lymphoid Cell Biology

Renad M. Alhamawi
Fatmah A. Halawani
Sima F. Hakeem
Hadeel A. Alslimi
Ebraheim M. Alhamawi
Ahmed M. Aljohani
Ibrahim N. Mohammed
Heba M. Zahid
Yahya A. Almutawif

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698155

3,469 views

Review

Accepted on 09 Dec 2025

THE ROLE OF IMMUNOGLOBULIN E IN NON-ATOPIC DISORDERS

in Cytokines and Soluble Mediators in Immunity

Kujtim Thaçi
Aron Gyorgypal
Robert Anthony
Michelle Conroy

Frontiers in Immunology

336 views

Original Research

Accepted on 09 Dec 2025

Neuronal autoantibodies associated with poorer neuropsychological and motor outcomes 6 months after stroke: Results from the PHYS-STROKE trial

in Multiple Sclerosis and Neuroimmunology

Charlotte Pietrock
Konrad Neumann
Kristin Rentzsch
Harald Prüss
Andreas Meisel
Matthias Endres
Alexander Heinrich Nave

Frontiers in Immunology

263 views

Systematic Review

Accepted on 09 Dec 2025

Sacituzumab Govitecan as a Therapeutic Breakthrough in the Treatment of Triple-Negative Breast Cancer: A Systematic Review of Clinical Trials

in Cancer Immunity and Immunotherapy

Julia Piekarz
Natalia Picheta
Jakub Pobideł
Katarzyna Szklener
Sławomir Mańdziuk

Frontiers in Immunology

272 views

Original Research

Accepted on 09 Dec 2025

Intratumor Heterogeneity Score Reveals Immune Landscape and Survival Stratification in Colorectal Cancer

in Cancer Immunity and Immunotherapy

Zijing Wang
Liyuan Ma
Jinzhong Cao
Xi Chen
Xin Chang
Ruxue Ma
Hengyi Lv
Zixin Zhang
Hai Li
Tao Jiang

Frontiers in Immunology

218 views

Original Research

Accepted on 09 Dec 2025

ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome

in Systems Immunology

Hyunsu Bong
Joonhong Min
Songhyeon Kim
Wootaek Lim
Dongyoung Lim
Hyunjeong Eom
Young Her
Minji Jeon

Frontiers in Immunology

266 views

Original Research

Accepted on 09 Dec 2025

Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

in Molecular Innate Immunity

Min Chu
Ding Ma
Zhan Song
Li Liang
Fengjuan Xing
Hongchu Bao

Frontiers in Immunology

146 views

Review

Accepted on 09 Dec 2025

The Multifaceted Role of Post-Translational Modifications in Macrophage Polarization: From Mechanisms to Therapeutic Targets

in Molecular Innate Immunity

Rui Guo
Feng Qi

Frontiers in Immunology

147 views

Review

Accepted on 09 Dec 2025

Molecular Mechanisms and Therapeutic Progress in Atherosclerosis: Bridging Immune Inflammation and Precision Medicine

in Inflammation

Yimin Han
Hongyi Xu
Xinlei Yao
Zhanzhan Li
Chuli Zhu
Xia Li
Bingqian Chen
Hualin Sun

Frontiers in Immunology

176 views

Original Research

Accepted on 09 Dec 2025

Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis

in Inflammation

Ying Xu
Yueyan Yang
Shihua Deng
Teng Liu
Min Yang
Xintao Zhang
Xiaobian Wang
Sunhan Zhang
Ting Zhang
Dongming Wu

Frontiers in Immunology

178 views

Original Research

Accepted on 09 Dec 2025

Deciphering Immune Cell Interaction Aberrations in Necrotizing Enterocolitis: The Regulatory Role of DHRS7

in Inflammation

Kexin Gao
Yuehua Chen
Lu Jingjing
Wenliang Ge
Qiyou Yin

Frontiers in Immunology

146 views

Original Research

Accepted on 09 Dec 2025

Identification of Immune-Related Prognostic Biomarkers in Lung Squamous Cell Carcinoma Microenvironment

in Cancer Immunity and Immunotherapy

Zhihao Wang
Zhengsheng Wu

Frontiers in Immunology

215 views

Original Research

Accepted on 09 Dec 2025

NDUFS4, a Mitochondrial Complex I Subunit, is Essential for T-Cell Metabolic Fitness and Immune Function

in T Cell Biology

Oded Shamriz
Zahala Bar-On
Omri Yosef
Leonor Cohen-Daniel
Ayelet Sheer
Or Reuven
Wajeeh Salaymeh
Amijai Saragovi
Raz Somech
Atar Lev

Frontiers in Immunology

287 views

Original Research

Accepted on 09 Dec 2025

Fc-enhanced anti-CCR6 antibody elicits Robust Therapeutic Effects Across Multiple Autoimmune Diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Md Jahangir Alam
Yu-Anne Yap
Caroline Ang
Liang Xie
Hillary L. Shane
Charles R. Mackay
Remy Robert

Frontiers in Immunology

308 views

Systematic Review

Accepted on 09 Dec 2025

Bio-Boosting Transplants: A Systematic Review on Biopolymers in Vascular Composite Allotransplantation

in Alloimmunity and Transplantation

Leonard Knoedler
Tobias Niederegger
Thomas Schaschinger
Jakob Fenske
Varun P. A. Murugan
Samuel Knoedler
Max Heiland
Adriana C. Panayi
Gabriel Hundeshagen
Alexandre G. Lellouch

Frontiers in Immunology

179 views

Original Research

Accepted on 09 Dec 2025

Strongyloides stercoralis Coinfection Impairs Immune Control of Mycobacterium tuberculosis in TB infected individuals

in Parasite Immunology

Anuradha Rajamanickam
Bindu Dasan
Arul Nancy
Saravanan Munisankar
Siva Kumar Shanmugam
Subash Babu

Frontiers in Immunology

257 views

Mini Review

Accepted on 09 Dec 2025

The emerging roles of METTL1-mediated tRNA m7G methylation in cancer development and immunotherapy

in Cancer Immunity and Immunotherapy

Qiang Wang
Xiulin Jiang
Yixiao Yuan
Chunhong Li

Frontiers in Immunology

196 views

Systematic Review

Accepted on 09 Dec 2025

Efficacy and safety of PARP inhibitors in advanced or recurrent endometrial cancer: A systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Huanhuan Zhang
Guangwei Yan
Jinxiang Yan
Xianxu Zeng

Frontiers in Immunology

135 views

Original Research

Accepted on 09 Dec 2025

Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2

in Viral Immunology

Luca Perico
Alessandra Bovio
Susanna Tomasoni
Piera Trionfini
Domenico Cerullo
Daniela Corna
Anna Pezzotta
Monica Locatelli
Marta Alberti
Ariela Benigni

Frontiers in Immunology

12,324 views

48,714 articles

articles

PRR enhances anti-tumor immunity and suppresses colitis by promoting the development and survival of naive T and iNKT cells

Impact of celiac disease on patients with familial Mediterranean fever: a nationwide study based on the Türkiye database

Circulating PD-1+ effector memory T cells predict anti-PD-1 efficacy in advanced gastric cancer

IgG4-related disease presenting with hypercalcemia: case report and mechanistic insights

Efficacy and safety of immunotherapy rechallenge in second-line treatment after failure of first-line immune checkpoint inhibitors combined with chemotherapy in advanced gastric cancer: a retrospective study

Insomnia and anxiety: exploring their hidden effect on natural killer cells among young female adults

THE ROLE OF IMMUNOGLOBULIN E IN NON-ATOPIC DISORDERS

Neuronal autoantibodies associated with poorer neuropsychological and motor outcomes 6 months after stroke: Results from the PHYS-STROKE trial

Sacituzumab Govitecan as a Therapeutic Breakthrough in the Treatment of Triple-Negative Breast Cancer: A Systematic Review of Clinical Trials

Intratumor Heterogeneity Score Reveals Immune Landscape and Survival Stratification in Colorectal Cancer

ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome

Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

The Multifaceted Role of Post-Translational Modifications in Macrophage Polarization: From Mechanisms to Therapeutic Targets

Molecular Mechanisms and Therapeutic Progress in Atherosclerosis: Bridging Immune Inflammation and Precision Medicine

Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis

Deciphering Immune Cell Interaction Aberrations in Necrotizing Enterocolitis: The Regulatory Role of DHRS7

Identification of Immune-Related Prognostic Biomarkers in Lung Squamous Cell Carcinoma Microenvironment

NDUFS4, a Mitochondrial Complex I Subunit, is Essential for T-Cell Metabolic Fitness and Immune Function

Fc-enhanced anti-CCR6 antibody elicits Robust Therapeutic Effects Across Multiple Autoimmune Diseases

Bio-Boosting Transplants: A Systematic Review on Biopolymers in Vascular Composite Allotransplantation

Strongyloides stercoralis Coinfection Impairs Immune Control of Mycobacterium tuberculosis in TB infected individuals

The emerging roles of METTL1-mediated tRNA m7G methylation in cancer development and immunotherapy

Efficacy and safety of PARP inhibitors in advanced or recurrent endometrial cancer: A systematic review and meta-analysis

Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2