Frontiers in Immunology

Original Research

Published on 13 Feb 2026

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

in Cancer Immunity and Immunotherapy

Morgane Peroz
Nicolas Roussot
Alis Ilie
David Rageot
Valentin Derangere
Caroline Truntzer
François Ghiringhelli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1750816

238 views

Original Research

Published on 13 Feb 2026

Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data

in Cancer Immunity and Immunotherapy

Yiyuan Cui
Sicong Li
Zhibin Wu
Yue Jin
Jingjie Yu
Yufan Chen
Jiayang Chen
Jinyuan Chang
Yijing Yan
Xinyu Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1685902

197 views

Original Research

Published on 13 Feb 2026

Transcriptomic and proteomic profiling of pulmonary mucormycosis reveals a failed activation of host immune response

in Microbial Immunology

Jinjin Zhong
Xiaomin Cai
Yuchen Cai
Tingting Zhao
Die Hu
Chao Sun
Yueyan Ni
Yu Gu
Xin Su

Frontiers in Immunology

doi 10.3389/fimmu.2026.1732782

387 views

Original Research

Published on 13 Feb 2026

Novel BPI3Vc-vectored surface displayed fusion and hemagglutinin-neuraminidase antigens elicit broadly neutralizing antibodies in cattle

in Vaccines and Molecular Therapeutics

Huldah Sang
Tae Kim
Rakshith Kumar
Jayden McCall
Aloysius Abraham
Tsvetoslav Koynarski
Michelle Zajac
Karim W. Abdelsalam
Daniela Hernandez Muguiro
Katherine Bauer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702440

467 views

Systematic Review

Published on 13 Feb 2026

Systematic review and meta-analysis of belatacept versus calcineurin inhibitors on risk of post-transplant diabetes mellitus in kidney transplant recipients

in Alloimmunity and Transplantation

Xuchuan Wang
Dandan Song
Shufu Hou
Aiju Liu
Jing Gao
Lei Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1615875

297 views

Original Research

Accepted on 12 Feb 2026

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway

in Cancer Immunity and Immunotherapy

Genshen Zhong
Biao Liu
Xue Gong
Qi Wang
Shuyin Zheng
Xinyu Luo
Xingya Zhang
Biliang Hu
Minna Wu
Zhiguo Chen

Frontiers in Immunology

170 views

Case Report

Accepted on 12 Feb 2026

Eosinophilic Granulomatosis with Polyangiitis Coexisting with Multiple Myeloma: Independent Entities or Coexistence? A Case Report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Longyan Qin
Yi Yin
Pengjia Wu
Aifei Zhang
Na li
Jun Liu
Ling Huang
Jun Cao
Jiashun Zeng

Frontiers in Immunology

151 views

Original Research

Accepted on 12 Feb 2026

The CNS compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity

in Multiple Sclerosis and Neuroimmunology

Sakthi Asokan
WENBO ZHOU
Anthony Fringuello
Tiffany Pointon
Ashley Kennedy
BRENDAN FREITAS
jackson Tumas French
Haiyan Zhao
Christina Coughlan
Enrique Alvarez

Frontiers in Immunology

156 views

Original Research

Accepted on 12 Feb 2026

Co-delivery of IL-12/IL-15/IL-18 Engineered DC Vaccines with Anti-IL-10R and Nanoconjugated Methotrexate in Melanoma

in Cancer Immunity and Immunotherapy

Katarzyna Węgierek-Ciura
Agnieszka Szczygieł
Anna Rudawska
Jagoda Mierzejewska
Joanna Rossowska
Bożena Szermer-Olearnik
Marta Świtalska
Tomasz Goszczynski
Elżbieta Pajtasz-Piasecka

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Precise Delivery and Controlled Release: Strategies and Advances in TLR7/8 Agonist Prodrugs for Cancer Immunotherapy

in Cancer Immunity and Immunotherapy

Xiaohua Zheng
Yutao Zou
Ting Li
Huoying Pan
Jiangle Liu
Jingxuan He
Haoyu Ju
Weiqi Wang

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

A Comprehensive Review of Mechanisms Underlying Resistance to Immune Checkpoint Inhibitors

in Cancer Immunity and Immunotherapy

Alexandre Bertucci
Khaoula Taleb
Emilien Billon
Téo Fernez
Philippe Rochigneux

Frontiers in Immunology

Case Report

Accepted on 12 Feb 2026

Case report: A case of diabetes mellitus and pneumonitis induced by envafolimab treatment in small cell lung cancer

in Cancer Immunity and Immunotherapy

Yanyan Li
Hongke Wang
Guochen Xing
Xiaodan Guo
Shanyong Yi

Frontiers in Immunology

Case Report

Accepted on 12 Feb 2026

A 28-year-old female patient presented with recurrent fevers and episodes of shock due to ZBTB24 pathogenic variant

in Primary Immunodeficiencies

Jie Gao
Xiaoling Jiang
Ye Tian
Rui Zhai
Yan Chen
Jinling Guo
Liulin Wu
Mei Hu

Frontiers in Immunology

134 views

Original Research

Accepted on 12 Feb 2026

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment

in Vaccines and Molecular Therapeutics

I Seul Park
Ji Hyung Kim
Dongyeop Kim
Ye Won Kim
Yoojin Shin
Ki Beom Kim
Haiying Zhang
TAE IL KIM
Seung Won Kim
Young-guen Kwon

Frontiers in Immunology

Correction

Accepted on 12 Feb 2026

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

in Immunological Tolerance and Regulation

Biao Lei
Zhenyang Liu
Peifang Xie
XUANXUAN LI
Zhanyu Cui
CHEN RUIHAN
Bin Liu
Shihua Chen
Yaxin Li
Min Liang

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Biologics for Eosinophilic COPD: Current Applications and Future Prospects

in Vaccines and Molecular Therapeutics

Qi Qi
Wenbei Peng
Bohan Yang
Shijie Liu
Ying Pu
Qiong Zhou

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

The murine MHC-E molecule Qa-1b is surface displayed in a peptide-free conformation in homeostasis

in Cancer Immunity and Immunotherapy

Gaby Schaap
Soroush Ghaffari
Jim Middelburg
Marjolein Sluijter
Lisa Griffioen
Tom A.W. Schoufour
Ruud H.M. Wijdeven
Jacques Neefjes
Ramon Arens
Jon Weidanz

Frontiers in Immunology

131 views

Original Research

Accepted on 12 Feb 2026

Downregulation of Cathepsin B expression alleviates periodontitis by reducing mitochondrial reactive oxygen species production and NOD-, LRR-, and pyrin domain-containing 3 -mediated pyroptosis

in Inflammation

Tianqi Wang
Xinran Liu
Jiaxin Li
Yan Ding
Yuan Yue
Jinle Li
Min Wang
Na Wei
Liang Hao

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Dynamic Changes of Immune Cells and Therapeutic Responses in Experimental Models of COPD

in Inflammation

Jingxian Xie
Pengfei Li
Jianjun Du
Shiran Li
Zhimin Li
JIAO ZHANG
Siyu Zeng
Yanqiu zhang
Yong Yang

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

TGF-β and IL-4+IL-13 induce neuroplasticity in an in vitro model of hPSC-derived sensory neurons

in Inflammation

Carli Sanna Koster
I. Sophie T. Bos
Chiara Lavitola
Mihály Balogh
Barbro N Melgert
Reinoud Gosens

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

Dual-omics analysis of key biomarkers in T cell ubiquitination of rheumatoid arthritis blood and synovial tissue, validated by two-sample Mendelian randomization and qPCR

in T Cell Biology

Danting He
Haitao ZHAO
Jinghong MENG

Frontiers in Immunology

Original Research

Accepted on 12 Feb 2026

IQDMA disrupts STAT5 nuclear transport through CDC42-PAK2 axis collapse in cutaneous T-cell lymphoma

in Cancer Immunity and Immunotherapy

Saptaswa Dey
Helena Sorger
Michaela Schlederer
Isabella Perchthaler
Martin Metzelder
Lukas Kenner
Richard Moriggl
Peter Wolf

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Current Understanding and Advances Regarding the Adipose-Immune-Metabolic Axis in Disease Tolerance During Sepsis

in Inflammation

Quanyue Du
Fanghao He
Shanchi Zhang
Xiongyan Lan
Yanqiu Pan
Jiajun Wang

Frontiers in Immunology

Systematic Review

Accepted on 12 Feb 2026

Efficacy and Safety of Neoadjuvant Immunotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma: A Network Meta-Analysis and Real-World Study

in Cancer Immunity and Immunotherapy

Mengfei Sun
Pengjie Yang
Ling Qi
Ting Yang
Weishi Wang
Yongjun Yu
Jingjing ZHANG
Benben Zhu
Yong Li

Frontiers in Immunology

49,797 articles

articles

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data

Transcriptomic and proteomic profiling of pulmonary mucormycosis reveals a failed activation of host immune response

Novel BPI3Vc-vectored surface displayed fusion and hemagglutinin-neuraminidase antigens elicit broadly neutralizing antibodies in cattle

Systematic review and meta-analysis of belatacept versus calcineurin inhibitors on risk of post-transplant diabetes mellitus in kidney transplant recipients

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway

Eosinophilic Granulomatosis with Polyangiitis Coexisting with Multiple Myeloma: Independent Entities or Coexistence? A Case Report

The CNS compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity

Co-delivery of IL-12/IL-15/IL-18 Engineered DC Vaccines with Anti-IL-10R and Nanoconjugated Methotrexate in Melanoma

Precise Delivery and Controlled Release: Strategies and Advances in TLR7/8 Agonist Prodrugs for Cancer Immunotherapy

A Comprehensive Review of Mechanisms Underlying Resistance to Immune Checkpoint Inhibitors

Case report: A case of diabetes mellitus and pneumonitis induced by envafolimab treatment in small cell lung cancer

A 28-year-old female patient presented with recurrent fevers and episodes of shock due to ZBTB24 pathogenic variant

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

Biologics for Eosinophilic COPD: Current Applications and Future Prospects

The murine MHC-E molecule Qa-1b is surface displayed in a peptide-free conformation in homeostasis

Downregulation of Cathepsin B expression alleviates periodontitis by reducing mitochondrial reactive oxygen species production and NOD-, LRR-, and pyrin domain-containing 3 -mediated pyroptosis

Dynamic Changes of Immune Cells and Therapeutic Responses in Experimental Models of COPD

TGF-β and IL-4+IL-13 induce neuroplasticity in an in vitro model of hPSC-derived sensory neurons

Dual-omics analysis of key biomarkers in T cell ubiquitination of rheumatoid arthritis blood and synovial tissue, validated by two-sample Mendelian randomization and qPCR

IQDMA disrupts STAT5 nuclear transport through CDC42-PAK2 axis collapse in cutaneous T-cell lymphoma

Current Understanding and Advances Regarding the Adipose-Immune-Metabolic Axis in Disease Tolerance During Sepsis

Efficacy and Safety of Neoadjuvant Immunotherapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma: A Network Meta-Analysis and Real-World Study