Frontiers in Immunology

Original Research

Published on 16 Jan 2026

Intranasal vaccines adjuvanted with Nexavant demonstrate robust protective efficacy by inducing both mucosal and systemic immunity in a murine model

in Vaccines and Molecular Therapeutics

Kwang Hyun Ko
Hyun Shik Bae
So Min Lee
Somin Park
Seung Hyun Han
Jun Heo
Jinil Kim
Yerim Cho
Dong-Ho Kim
Seung Bin Cha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1745319

837 views

Brief Research Report

Published on 16 Jan 2026

Dual targeting of joint and lung disease: efficacy of tofacitinib plus iguratimod combination in progressive fibrosing rheumatoid arthritis-associated interstitial lung disease

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yuan Zhu
Yingzi Ye
Wanlin Zhou
Xu Zheng
Weilin Xie
Zhiying Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624125

931 views

Original Research

Published on 16 Jan 2026

Macrophage immunometabolic reprogramming impairs tissue regeneration in type 2 diabetes zebrafish model

in Molecular Innate Immunity

Leonel Witcoski Junior
Jordana Dinorá de Lima
André Guilherme Portela de Paula
Thais Sibioni Berti Bastos
Rebeca Bosso dos Santos Luz
Israel Henrique Bini
Matheus Brandemarte Severino
Luis Eduardo Alves Damasceno
Lais Cavalieri Paredes
Amanda Girardi Somensi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698674

815 views

Original Research

Published on 16 Jan 2026

Combined therapy with the estrogen receptor ERα and IFNα-2b suppresses HBV replication by inducing GBP1 expression

in Molecular Innate Immunity

Yadi Li
Jiaojiao Gong
Guili Tan
Haiying Luo
Xiaoxia Hu
Bo Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698786

712 views

Original Research

Published on 16 Jan 2026

Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates

in Vaccines and Molecular Therapeutics

Romy Rouzeau
Hayden R. Schmidt
Cailin E. Deal
Joel D. Allen
Dawn M. Dudley
Iszac Burton
Eva G. Rakasz
Obadiah Plante
Max Crispin
Andrea Carfi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700041

797 views

Case Report

Published on 16 Jan 2026

Case Report: A multidisciplinary, protocol-driven pathway from recurrent pregnancy loss to live birth in an anti-Ro/SSA-positive primary Sjögren’s syndrome pregnancy with literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jing Zhang
Jianhong Chen
Sheng-Guang Li
Xiangyuan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702173

892 views

General Commentary

Published on 16 Jan 2026

Commentary: Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

in Molecular Innate Immunity

Jintao Cui
Bin Xu
Penghui Zhang
Songfu Han
Chaoyanng Guo
Limin Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1752400

653 views

Original Research

Published on 16 Jan 2026

Intravital imaging reveals spatiotemporal dynamics of oncolytic Salmonella YB1-induced intratumoral vascular thrombosis and tumor targeting

in Cancer Immunity and Immunotherapy

Bin Yu
Lei Shi
Weiwang Duan
Dongmei Cui
Edwin R. Manuel
Wei Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733164

724 views

Correction

Published on 16 Jan 2026

Correction: Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

in Molecular Innate Immunity

Ya-ping Li
Xin-jian Niu
Ge Zhang
On-kei Chan
Nuo Sun
Bo Hu
Zi-jian Shi
Dong-yun Ouyang
Xian-hui He
Qing-bing Zha

Frontiers in Immunology

doi 10.3389/fimmu.2026.1782391

332 views

Correction

Published on 16 Jan 2026

Correction: Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis

in Molecular Innate Immunity

Mengkui Han
Junchi Xu
Xunxun Wu
Zhiqing Hu
Xiaoyuan Hu
Xiaolong Zhu
Cailin Chen
Qinkao Xuan
Yang Li
Chuanwu Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1784456

268 views

Original Research

Published on 16 Jan 2026

Aberrant systemic acute-phase complement responses in conjunction with soluble CR1 attribute to varying grades of dengue disease severity

in Viral Immunology

Abdul R. Anshad
Shanmugam Saravanan
Amudhan Murugesan
Ravindran Vighnesh
Sivadoss Raju
Rajendran Kannan
Yean K. Yong
Marie Larsson
Esaki M. Shankar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731011

1,107 views

Review

Published on 16 Jan 2026

Lung cancer immunotherapy in 2025: where we stand and what comes next?

in Cancer Immunity and Immunotherapy

Jie Han
Zhibo Yang
Hai Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728163

1,958 views

Brief Research Report

Published on 16 Jan 2026

Immune signatures of sepsis from mild infection to critical illness - a prospective observational study

in Microbial Immunology

Timothy Arthur Chandos Snow
Francis Ryckaert
Ingrid Hass
Holly Pan
Samer Elkhodair
Mervyn Singer
David Brealey
Nishkantha Arulkumaran

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715812

673 views

Original Research

Published on 16 Jan 2026

Effects of Lactobacillus plantarum ZG-7 on the intestinal barrier and intestinal flora of Muscovy ducks infected with avian pathogenic Escherichia coli

in Microbial Immunology

Song Peng
Bilin Xie
Guiheng Mei
Yaxiong Ma
Xin Lin
Mengshi Zhao
Fengqiang Lin
Zhaolong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701722

616 views

Original Research

Published on 16 Jan 2026

Deep learning and radiomics-based system for early diagnosis of hip synovitis in juvenile idiopathic arthritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jun Kou
Chunmei Yin
Yang Gao
Daozhen Huang
Chunjiang Yang
Huan Xiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689862

588 views

Original Research

Published on 16 Jan 2026

Autoimmune encephalitis associated with antibodies against intracellular antigens in children

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Linlin Zhang
Chao Che
Xingyu Han
Aihua Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678497

538 views

Mini Review

Published on 16 Jan 2026

Immunometabolic editing of the tumor microenvironment: from reprogramming mechanisms to therapeutic vulnerabilities

in Cancer Immunity and Immunotherapy

Yixin Li
Yunmei Zhang
Yan Nie
Xueman Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678446

612 views

Review

Published on 16 Jan 2026

Metabolic reprogramming tailors T cell immunity in sepsis

in T Cell Biology

Di Xian
Feng Chen
Bing Liu
Lei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679493

885 views

Original Research

Published on 16 Jan 2026

Multiplex autoantibody screening in pediatric type 1 diabetes: POC Blot vs. ELISA for gluten-related disorders

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Adugna Negussie
Patricia Wusterhausen
Deselegn Muleta
Demise Mulugeta
Mesfin Bekele
Torsten Matthias

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648451

603 views

Original Research

Published on 16 Jan 2026

Multi-omics integration and machine learning identify NPC2 as a prognostic and treatment-responsive regulator in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Ang Li
Ping Cui
Lili Liu
Jiawei Liu
Xianlei Zhou
Wenlong Wu
Zimo Yan
Yi Guan
Hongmei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697560

650 views

Editorial

Published on 16 Jan 2026

Editorial: Decoding tumor plasticity: integrative analysis of epigenetic regulation and microenvironmental adaptation

in Cancer Immunity and Immunotherapy

Ran Wang
Haitao Wang
Jian-Guo Zhou
Guan-Jun Yang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1783659

505 views

Original Research

Published on 16 Jan 2026

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

in Immunological Tolerance and Regulation

Biao Lei
Zhenyang Liu
Peifang Xie
Xuanxuan Li
Zhanyu Cui
Ruihan Chen
Bin Liu
Shihua Chen
Yaxin Li
Min Liang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1764754

781 views

Review

Published on 16 Jan 2026

Role of exosomes in gastrointestinal physiology and pathophysiology

in Mucosal Immunity

Vivian Naa Amua Wellington
Soudamani Singh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717977

860 views

Editorial

Published on 16 Jan 2026

Editorial: Thymus biology: development, immunodeficiency and cancer progression

in Cancer Immunity and Immunotherapy

Yongfeng He
Yong Fan
Nicolai Stanislas van Oers

Frontiers in Immunology

doi 10.3389/fimmu.2026.1778439

501 views

49,574 articles

articles

Intranasal vaccines adjuvanted with Nexavant demonstrate robust protective efficacy by inducing both mucosal and systemic immunity in a murine model

Dual targeting of joint and lung disease: efficacy of tofacitinib plus iguratimod combination in progressive fibrosing rheumatoid arthritis-associated interstitial lung disease

Macrophage immunometabolic reprogramming impairs tissue regeneration in type 2 diabetes zebrafish model

Combined therapy with the estrogen receptor ERα and IFNα-2b suppresses HBV replication by inducing GBP1 expression

Harnessing mRNA for the expression of monoclonal IgG and IgA in non-human primates

Case Report: A multidisciplinary, protocol-driven pathway from recurrent pregnancy loss to live birth in an anti-Ro/SSA-positive primary Sjögren’s syndrome pregnancy with literature review

Commentary: Lactylation-related gene AKR1A1 contributes to osteoporosis via metabolic–immune regulation: evidence from multi-omics integration, single-cell transcriptomics, and in vitro validation

Intravital imaging reveals spatiotemporal dynamics of oncolytic Salmonella YB1-induced intratumoral vascular thrombosis and tumor targeting

Correction: Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

Correction: Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis

Aberrant systemic acute-phase complement responses in conjunction with soluble CR1 attribute to varying grades of dengue disease severity

Lung cancer immunotherapy in 2025: where we stand and what comes next?

Immune signatures of sepsis from mild infection to critical illness - a prospective observational study

Effects of Lactobacillus plantarum ZG-7 on the intestinal barrier and intestinal flora of Muscovy ducks infected with avian pathogenic Escherichia coli

Deep learning and radiomics-based system for early diagnosis of hip synovitis in juvenile idiopathic arthritis

Autoimmune encephalitis associated with antibodies against intracellular antigens in children

Immunometabolic editing of the tumor microenvironment: from reprogramming mechanisms to therapeutic vulnerabilities

Metabolic reprogramming tailors T cell immunity in sepsis

Multiplex autoantibody screening in pediatric type 1 diabetes: POC Blot vs. ELISA for gluten-related disorders

Multi-omics integration and machine learning identify NPC2 as a prognostic and treatment-responsive regulator in lung adenocarcinoma

Editorial: Decoding tumor plasticity: integrative analysis of epigenetic regulation and microenvironmental adaptation

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

Role of exosomes in gastrointestinal physiology and pathophysiology

Editorial: Thymus biology: development, immunodeficiency and cancer progression