Frontiers in Immunology

Original Research

Published on 14 Jan 2026

Experience in emergency management of first-episode immune thrombotic thrombocytopenic purpura over the past 21 years: a single-center retrospective study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Liqian Zhang
Wenfeng Huang
Fengtao Yang
Lingjie Cao
Maojing Shi
Weibo Gao
Yuanyuan Pei
Jihong Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645558

661 views

Original Research

Published on 14 Jan 2026

Disproportionality analysis of satralizumab in FDA adverse event reporting system and Japanese adverse drug event report: a pharmacovigilance study

in Multiple Sclerosis and Neuroimmunology

Linhai Zhang
Rong Yan
Zucai Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647306

848 views

Review

Published on 14 Jan 2026

CAR-M therapy in the era of tumor immunotherapy: current research progress and engineering strategies

in Cancer Immunity and Immunotherapy

Yi-Min Yang
Yu-Fan Ding
Yi-Yang Hu
Fan Fan
Jun-Long Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723270

1,483 views

Original Research

Published on 14 Jan 2026

A shikonin-based hydrogel dressing exhibiting synergistic anti-inflammatory, anti-angiogenic, and anti-fibrotic effects for the prevention of hypertrophic scars

in Vaccines and Molecular Therapeutics

Ziyu Wang
Yujie Zhao
Zhoujiang Qu
Hui Wang
Yuling Zhang
Yufang Liu
Chengde Li
Kun Wang
Guoqi Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736748

704 views

Original Research

Published on 14 Jan 2026

Enhancing anti-tumor immunity through co-blocking PD-L1 and TIGIT by facilitating tumor-directed responses and additional VEGF inhibition

in Cancer Immunity and Immunotherapy

Xi Zhu
Xiaopei Cui
Haijia Yu
Jingen Xu
Xiaofang Chen
Xiaochen Ren
Xiaoyue Wei
Shi Chen
Yangtin Wang
Liyang Fei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1746155

1,342 views

Review

Published on 14 Jan 2026

B cell immunity and therapeutic opportunities in brain metastases

in Cancer Immunity and Immunotherapy

Grace Jones
Alina Murphy
Catalina Lee-Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740386

1,335 views

Review

Published on 14 Jan 2026

Natural products as metabolic modulators to enhance cancer immunotherapy: reprogramming the tumor microenvironment

in Cancer Immunity and Immunotherapy

Xiaoyu Fan
Shushu Guo
Wanfang Li
Yingyin Wang
Jie Bao
Jiuming He
Hongtao Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740644

810 views

Case Report

Published on 14 Jan 2026

Lung adenocarcinoma and colorectal cancer as double primary malignancies reveal lynch syndrome: a case report of germline MLH1 mutation with response to immunotherapy and familial aggregation

in Cancer Immunity and Immunotherapy

Menglei Wang
Haoyue Xue
Jiamin Hong
Qi Liu
Keke Hu
Chang Shu
Jinghua Wang
Yu Long
Yehong Han
Xuefei Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709036

625 views

Original Research

Published on 14 Jan 2026

Inflammatory burden in dialysis patients: the role of alpha defensin

in Inflammation

Maanit Shapira
Adib Abo Aqil
Ameena Zahalka
Isis Abumouch
Naama Amsalem
Rami Abu Fanne

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718452

423 views

Original Research

Published on 14 Jan 2026

Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production

in Inflammation

Wenjing Tang
Wenjie Chen
Na Li
Wei Li
Zhigang Lei
Wenhui Sun
Xuan Xie
Yihong Jiang
Ying Chen
Lei Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684836

996 views

Original Research

Published on 14 Jan 2026

Periodontitis is associated with altered salivary anti-SARS-CoV-2 antibody patterns in vaccinated individuals

in Mucosal Immunity

Hassan Alkharaan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737920

839 views

Original Research

Published on 14 Jan 2026

SLC40A1-mediated positive feedback loop with M1 macrophages suppresses epithelial ovarian cancer progression

in Cancer Immunity and Immunotherapy

Guangyan Wang
Sisi Huang
Bo Yin
Fugen Shangguan
Jinghang Ma
Anyang Li
Zhexin Xia
Zhenzhen Xu
Yuheng Li
Honglei Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709597

1,360 views

Original Research

Published on 14 Jan 2026

A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities

in Inflammation

Wei Gao
Zhiyong Lin
Yuntao Bao
Mingjiang Liu
Guangtao Ma
Xianxiang Chen
Shuiping Yu
Yonglian Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711388

710 views

Review

Published on 14 Jan 2026

Understanding the performance of HIV-1 viral vector vaccines: adenovirus and poxvirus case studies

in Vaccines and Molecular Therapeutics

Mahdiyeh M. Manafi
Touraj Farzani
Nallely Espinoza
Al Ozonoff
Pardis C. Sabeti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720342

1,015 views

Original Research

Published on 14 Jan 2026

Dysregulation of the microbiota-gut-brain axis induced by chronic pancreatitis mediates anxiety- and depression-like behaviors in mice

in Microbial Immunology

Leheng Liu
Xi Zhang
Chuanyang Wang
Kena Zhou
Jingpiao Bao
Zhiyuan Cheng
Haoran Sun
Chengying Zhu
Ge Yu
Wenqin Xiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1753424

778 views

Original Research

Published on 14 Jan 2026

Global burden and genetic insights of RA and JIA in ages 0–19 years: GBD 2021 and MR analysis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Pingyu An
Zhiqiang Ma
Tian Tian
Shibo Zhang
Jian Wang
Zhiliang Tian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661461

876 views

Original Research

Published on 14 Jan 2026

Integrating single-cell RNA sequencing with spatial transcriptomics reveal the fibrosis-related genes in hepatocellular carcinoma

in Cancer Immunity and Immunotherapy

Wenying Qiao
Lei Li
Ronghua Jin
Caixia Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659404

1,275 views

Original Research

Published on 14 Jan 2026

Multimodal analysis of TAAD pathogenesis: SHAP-enhanced interpretable models and single-cell sequencing analysis reveal immune microenvironment alterations

in Systems Immunology

Zhong Wang
Yixian Wang
Dianjun Tang
Qingwei Gang
Shikai Shen
Hongming Wei
Dongwen Zhao
Jian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630404

791 views

Original Research

Published on 14 Jan 2026

Endocytosis and non-canonical autophagy mediate extracellular histones cytotoxicity in vascular models of sepsis

in Cytokines and Soluble Mediators in Immunity

C. Garcés
P. Tascón
Luis Diago-Domingo
A. J. Ibáñez
G. Herrera
L. R. Rodríguez
K. Salewskij
G. Jonsson
J. M. Penninger
C. Romá-Mateo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650789

911 views

Original Research

Published on 14 Jan 2026

Inflammation mediates the association between the Prognosis Nutrition Index (PNI) and mortality in acute pancreatitis: evidence from international cohorts

in Nutritional Immunology

Lingwei Huang
Dan Xiao
Lingjie Yan
Juan Liao
Meimei Yang
Fei He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693888

733 views

Original Research

Published on 14 Jan 2026

Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma

in Cancer Immunity and Immunotherapy

Xuezhong Zhang
Hui Shang
Tingting Chu
Kaihui Sha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1654036

931 views

Review

Published on 14 Jan 2026

Intratumoral microbiota: synergistic reshaping of lung cancer microenvironment via inflammation and immunity

in Microbial Immunology

Ruilin Zhang
Zhao Li
Xingfei Liu
Zhengzhou Qiu
Yongxuan Li
Chenggen Gao
Changying Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653727

825 views

Review

Published on 14 Jan 2026

The clinical characteristics, mechanism and management of immune checkpoint inhibitor-related arthritis

in Inflammation

Jian Gao
Jinlin Miao
Zhinan Chen
Ping Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1611692

754 views

Original Research

Published on 14 Jan 2026

Integrative causal inference and predictive modeling reveal the iron-related gene SLC17A4 as a key biomarker in chronic rhinosinusitis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jiajia Lv
Feifei Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645726

595 views

49,574 articles

articles

Experience in emergency management of first-episode immune thrombotic thrombocytopenic purpura over the past 21 years: a single-center retrospective study

Disproportionality analysis of satralizumab in FDA adverse event reporting system and Japanese adverse drug event report: a pharmacovigilance study

CAR-M therapy in the era of tumor immunotherapy: current research progress and engineering strategies

A shikonin-based hydrogel dressing exhibiting synergistic anti-inflammatory, anti-angiogenic, and anti-fibrotic effects for the prevention of hypertrophic scars

Enhancing anti-tumor immunity through co-blocking PD-L1 and TIGIT by facilitating tumor-directed responses and additional VEGF inhibition

B cell immunity and therapeutic opportunities in brain metastases

Natural products as metabolic modulators to enhance cancer immunotherapy: reprogramming the tumor microenvironment

Lung adenocarcinoma and colorectal cancer as double primary malignancies reveal lynch syndrome: a case report of germline MLH1 mutation with response to immunotherapy and familial aggregation

Inflammatory burden in dialysis patients: the role of alpha defensin

Macrophage TRIM21 lactylation exacerbates infection-induced orchitis through enhancing STAT1-mediated CXCL9 and CXCL10 production

Periodontitis is associated with altered salivary anti-SARS-CoV-2 antibody patterns in vaccinated individuals

SLC40A1-mediated positive feedback loop with M1 macrophages suppresses epithelial ovarian cancer progression

A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities

Understanding the performance of HIV-1 viral vector vaccines: adenovirus and poxvirus case studies

Dysregulation of the microbiota-gut-brain axis induced by chronic pancreatitis mediates anxiety- and depression-like behaviors in mice

Global burden and genetic insights of RA and JIA in ages 0–19 years: GBD 2021 and MR analysis

Integrating single-cell RNA sequencing with spatial transcriptomics reveal the fibrosis-related genes in hepatocellular carcinoma

Multimodal analysis of TAAD pathogenesis: SHAP-enhanced interpretable models and single-cell sequencing analysis reveal immune microenvironment alterations

Endocytosis and non-canonical autophagy mediate extracellular histones cytotoxicity in vascular models of sepsis

Inflammation mediates the association between the Prognosis Nutrition Index (PNI) and mortality in acute pancreatitis: evidence from international cohorts

Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of MEX3 family genes in glioma

Intratumoral microbiota: synergistic reshaping of lung cancer microenvironment via inflammation and immunity

The clinical characteristics, mechanism and management of immune checkpoint inhibitor-related arthritis

Integrative causal inference and predictive modeling reveal the iron-related gene SLC17A4 as a key biomarker in chronic rhinosinusitis