Frontiers in Immunology

Original Research

Published on 14 Jan 2026

SLC40A1-mediated positive feedback loop with M1 macrophages suppresses epithelial ovarian cancer progression

in Cancer Immunity and Immunotherapy

Guangyan Wang
Sisi Huang
Bo Yin
Fugen Shangguan
Jinghang Ma
Anyang Li
Zhexin Xia
Zhenzhen Xu
Yuheng Li
Honglei Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709597

1,363 views

Original Research

Published on 14 Jan 2026

A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities

in Inflammation

Wei Gao
Zhiyong Lin
Yuntao Bao
Mingjiang Liu
Guangtao Ma
Xianxiang Chen
Shuiping Yu
Yonglian Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711388

742 views

Original Research

Published on 14 Jan 2026

Dysregulation of the microbiota-gut-brain axis induced by chronic pancreatitis mediates anxiety- and depression-like behaviors in mice

in Microbial Immunology

Leheng Liu
Xi Zhang
Chuanyang Wang
Kena Zhou
Jingpiao Bao
Zhiyuan Cheng
Haoran Sun
Chengying Zhu
Ge Yu
Wenqin Xiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1753424

803 views

Case Report

Published on 14 Jan 2026

Exploring targeted therapy in retinal vasculopathy with cerebral leukoencephalopathy: a case report and review of literature

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Patricia Tato-Moreno
Cristina Lavilla Olleros
Héctor Balastegui Martín
María Barrientos Guerrero
Anna Mensa-Vilaro
María Esther Durán-García
Paloma Sánchez-Mateos
Elena García-Martínez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707532

1,037 views

Original Research

Published on 14 Jan 2026

Integrative causal inference and predictive modeling reveal the iron-related gene SLC17A4 as a key biomarker in chronic rhinosinusitis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jiajia Lv
Feifei Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645726

631 views

Review

Published on 14 Jan 2026

Immunometabolic crosstalk between tumor- associated macrophages and ferroptotic cancer cells: mechanisms, regulation, and therapeutic applications

in Cancer Immunity and Immunotherapy

Zixing Qian
Zhuo Zhang
Wei Bai
Jiaxuan Li
Xianjun Rao
Guodong Huang
Jiabao Liu
Wei Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628142

830 views

Original Research

Published on 14 Jan 2026

Neoadjuvant therapy–associated malignant phenotype score predicts prognosis and highlights the roles of MIF signaling and DUXAP8 in ESCC

in Cancer Immunity and Immunotherapy

Wenchao Xia
Tan Lin
Mengnan Shi
Qiuqiao Mu
Han Zhang
Yijun Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683349

802 views

Brief Research Report

Published on 14 Jan 2026

Epithelial extracellular vesicles induce inflammation and neutrophil activation in the Pseudomonas aeruginosa infected cystic fibrosis bronchial epithelium

in Inflammation

Meghan June Hirsch
Kuen-You Tsai
Luke I. Jones
Angela N. Morales
Hannah J. McIntire-Ray
Patrick H. Howze IV
Jarrod W. Barnes
Camilla Margaroli
Kristopher Genschmer
Stefanie Krick

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659951

690 views

Original Research

Published on 14 Jan 2026

Expression and clinical value of key m6A RNA modification regulators in tuberculosis

in Comparative Immunology

Hongfei Du
Hang Wang
Yan Yang
Qiao Yu
Zhongyong Jiang
Ying Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729362

778 views

Original Research

Published on 14 Jan 2026

From immunological mechanisms to targeted therapies: a bibliometric analysis of vitiligo treatment research (2005–2025)

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Longfei Luo
Xiaolei He
Ying Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733857

1,535 views

Original Research

Published on 14 Jan 2026

Quantifying maternal antibody transfer to colostrum and cord blood reveals virus-specific selectivity in dogs

in Comparative Immunology

Serena S. Teh
Lotta H. Truyen
Sarah Woodyear
Jessica Palmeri
Ana Alice Pimenta-Pereira
Alexis A. E. Peprah
Ella Lanman
Tom M. Lonergan
Abigail Reid
Soon Hon Cheong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1753521

851 views

Original Research

Published on 14 Jan 2026

Integrating cuproptosis- and ferroptosis-related gene signatures to predict prognosis, immunotherapy response, and drug sensitivity in patients with skin cutaneous melanoma

in Cancer Immunity and Immunotherapy

Hua Dong
Ying Huang
Jie Shen
Zhaofeng Ding
Wei Wang
Yaping Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1742614

845 views

Original Research

Published on 14 Jan 2026

PKCϵ-mediated phosphorylation of TRPC3 channel at S712 is essential for its inactivation during inflammatory signaling

in Molecular Innate Immunity

Javier Casas
Clara Meana
Gonzalo San-José
Jesús Balsinde
María A. Balboa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737430

986 views

Original Research

Published on 14 Jan 2026

Altered acetate metabolism and signaling in IgA nephropathy: an integrated gut microbiome and glomerular spatial transcriptome analysis

in Mucosal Immunity

Jung Hun Koh
Sehoon Park
Minji Kang
Ji In Park
Jangwook Lee
Hyunjeong Cho
Ji Eun Kim
Hoonsik Nam
Doyeon Kim
Minshu Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665585

932 views

Original Research

Published on 14 Jan 2026

Diagnostic biomarkers for differentiating AQP4-IgG- negative NMOSD from other nervous system autoimmune disorders: a retrospective study

in Multiple Sclerosis and Neuroimmunology

Wencan Jiang
Yang Jiao
Menglue Zhang
Chenxu Wang
Xiaotong Li
Kelin Chen
Yaowei Ding
Haoran Li
Lijuan Wang
Siwen Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637613

867 views

Review

Published on 14 Jan 2026

Complement-mediated HUS revisited: evolving insights into pathophysiology, diagnosis, and treatment

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Ruah Alyamany
Ann M Moyer
Maria Alice V. Willrich
Meera Sridharan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621317

1,321 views

Original Research

Published on 14 Jan 2026

Single-cell and machine learning integration reveals OS-driven CCND1 promotes an aggressive phenotype in papillary thyroid carcinoma

in Inflammation

Jiaxi Wang
Qingyi Zhu
Jingyi Bie
Yueyu Han
Hanqing Liu
Chuang Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722524

491 views

Case Report

Published on 14 Jan 2026

Exceptional response to chemo-immunotherapy in a patient with HER2-negative, TMB-high metastatic gastric mucinous adenocarcinoma: a case report and literature review

in Cancer Immunity and Immunotherapy

Caiqi Liu
Xiangxue Li
Qi Qi
Fanjing Jing
Jing Lv
Wensheng Qiu
Shasha Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713214

1,098 views

Original Research

Published on 14 Jan 2026

Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Bin Yang
Guoqiang Fang
Isaac Marx
Guang Liu
Stephanie Skouras
Kirti Sharma
Dirk M. Walther
Sarah Bollinger Martinez
Cedric Hubeau
Yatao Shi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712589

855 views

Case Report

Published on 14 Jan 2026

Case Report: Ramsay Hunt syndrome with simultaneous bilateral vestibular dysfunction as the initial manifestation in a patient with a history of breast cancer

in Viral Immunology

Shusheng Jiao
Miaomiao Li
Xiaofang Cheng
Liping Chen
Yan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709001

677 views

Original Research

Published on 14 Jan 2026

m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies

in Inflammation

Yixian Chen
Qiaozhen Wei
Yuan Gan
Ba Wei
Qingmei Huang
Shuangjing Pan
Yujun Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709677

499 views

Mini Review

Published on 14 Jan 2026

The pediatric nasal microbiome and its role in chronic ENT disorders: a narrative review

in Microbial Immunology

Adriana Elena Sîrbu
Gratiela Gradisteanu Pircalabioru
Diana Maria Deaconu
Octavian Andronic
Dan Cristian Gheorghe

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699707

1,046 views

Original Research

Accepted on 13 Jan 2026

The Role of Soluble Toll-Like Receptor-2 and 4 in Children with Pneumonia: A Combined Analysis of Saliva and Serum Samples

in Cytokines and Soluble Mediators in Immunity

Ozlem Necipoglu
Osman Oguz Demir
Kubra Aykac
Sevilay Karahan
Ali Bulent Cengiz
Malik Aydin
Yasemin Ozsurekci

Frontiers in Immunology

198 views

Original Research

Accepted on 13 Jan 2026

Epidemiological and Clinical Characteristics of Hereditary Angioedema in the Baltic States

in Primary Immunodeficiencies

Natalja Kurjane
Adine Kanepa
Signe Purina
Lasma Lapina
Krista Ress
Marget Savisaar
Ieva Bajoriuniene
Edita Gasiuniene
Kotryna Linauskiene
Anželika Chomičienė

Frontiers in Immunology

138 views

49,602 articles

articles

SLC40A1-mediated positive feedback loop with M1 macrophages suppresses epithelial ovarian cancer progression

A stage specific NETs-related signature in alcoholic steatohepatitis: from molecular subtyping to therapeutic vulnerabilities

Dysregulation of the microbiota-gut-brain axis induced by chronic pancreatitis mediates anxiety- and depression-like behaviors in mice

Exploring targeted therapy in retinal vasculopathy with cerebral leukoencephalopathy: a case report and review of literature

Integrative causal inference and predictive modeling reveal the iron-related gene SLC17A4 as a key biomarker in chronic rhinosinusitis

Immunometabolic crosstalk between tumor- associated macrophages and ferroptotic cancer cells: mechanisms, regulation, and therapeutic applications

Neoadjuvant therapy–associated malignant phenotype score predicts prognosis and highlights the roles of MIF signaling and DUXAP8 in ESCC

Epithelial extracellular vesicles induce inflammation and neutrophil activation in the Pseudomonas aeruginosa infected cystic fibrosis bronchial epithelium

Expression and clinical value of key m6A RNA modification regulators in tuberculosis

From immunological mechanisms to targeted therapies: a bibliometric analysis of vitiligo treatment research (2005–2025)

Quantifying maternal antibody transfer to colostrum and cord blood reveals virus-specific selectivity in dogs

Integrating cuproptosis- and ferroptosis-related gene signatures to predict prognosis, immunotherapy response, and drug sensitivity in patients with skin cutaneous melanoma

PKCϵ-mediated phosphorylation of TRPC3 channel at S712 is essential for its inactivation during inflammatory signaling

Altered acetate metabolism and signaling in IgA nephropathy: an integrated gut microbiome and glomerular spatial transcriptome analysis

Diagnostic biomarkers for differentiating AQP4-IgG- negative NMOSD from other nervous system autoimmune disorders: a retrospective study

Complement-mediated HUS revisited: evolving insights into pathophysiology, diagnosis, and treatment

Single-cell and machine learning integration reveals OS-driven CCND1 promotes an aggressive phenotype in papillary thyroid carcinoma

Exceptional response to chemo-immunotherapy in a patient with HER2-negative, TMB-high metastatic gastric mucinous adenocarcinoma: a case report and literature review

Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5

Case Report: Ramsay Hunt syndrome with simultaneous bilateral vestibular dysfunction as the initial manifestation in a patient with a history of breast cancer

m6A epigenetic signature in necrotizing enterocolitis: insights from murine to neonatal studies

The pediatric nasal microbiome and its role in chronic ENT disorders: a narrative review

The Role of Soluble Toll-Like Receptor-2 and 4 in Children with Pneumonia: A Combined Analysis of Saliva and Serum Samples

Epidemiological and Clinical Characteristics of Hereditary Angioedema in the Baltic States