Frontiers in Immunology

Original Research

Published on 13 Jan 2026

CD82-associated exhausted CD8+ T cells define prognosis and immunotherapy resistance in colon cancer

in Cancer Immunity and Immunotherapy

Jingfeng Zhang
Hengwei Cui
Shaoxian Wu
Hongwei Shi
Haitao Wang
Jingting Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731154

695 views

Original Research

Published on 13 Jan 2026

Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer

in Cancer Immunity and Immunotherapy

Song Li
Qian Xu
Wenbin Yu
Zimin Liu
Xiaohan Cui
Meng Wei
Duanbo Shi
Wen Zhao
Xinyu Song
Di Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1753749

781 views

Review

Published on 13 Jan 2026

From cercariae to chronic inflammation: understanding schistosome infection and host immune responses

in Microbial Immunology

Alessandra Torsello
Caterina Cattani
Christian Napoli
Andrea Cavani
Fernanda Scopelliti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729394

889 views

Original Research

Published on 13 Jan 2026

Antibody levels to variant and conserved Plasmodium falciparum antigens predict reduction in parasite burden in Malian children

in Vaccines and Molecular Therapeutics

Delesa Damena
Lauren Dang
Amadou Barry
Jonathan P. Renn
Santara Gaoussou
Almahamoudou Mahamar
Oumar Attaher
Djibrilla Issiaka
Robert D. Morrison
Santosh A. Misal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1745097

809 views

Case Report

Published on 13 Jan 2026

Anti-NMDA receptor encephalitis unmasking Sjögren’s disease: a case report and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Gabriel Dimitrov
Vanya Deneva
Stefka Mantarova-Valkova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673892

856 views

Review

Published on 13 Jan 2026

The immunobiology and therapeutic potential of regulatory T cells in autoimmune diseases and allergic diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Wen-Wen Xie
Jian-Bin Huang
Yi-Chi Zhou
Jing-Yi Yuan
Jia-Xue Feng
Xiao-Hang Shi
Li Tian
Xian-Hai Zeng
Shu-Qi Qiu
Mei-Zhen Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709915

1,277 views

Review

Published on 13 Jan 2026

Iron-fueled ferroptosis: a new axis for immunomodulation to overcome cancer drug resistance—from immune microenvironment crosstalk to therapeutic translation

in Cancer Immunity and Immunotherapy

Yimao Wu
Kaiyu Zhang
Naijun Jiang
Zichang Chen
Xiaojing Sun
Hongyu Zha
Mingjun Lin
Jingxin Li
Xiaocheng Pan
Jiadong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726210

1,060 views

Original Research

Published on 13 Jan 2026

A ligand-centered framework for γδ T cell activation in colorectal cancer revealed by single-cell and transformer-based perturbation

in Cancer Immunity and Immunotherapy

Ran Ran
Douglas K. Brubaker

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715827

974 views

Review

Published on 13 Jan 2026

Mitochondrial DAMPs as a critical driver in the development of acute graft versus host disease and emerging mitochondria targeted therapeutic strategies

in Molecular Innate Immunity

Vasantharaja Raguraman
Yogamaya Divakar Prabhu
Gopal Viswanathan Velmurugan
Gerhard C. Hildebrandt
Senthilnathan Palaniyandi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740433

1,061 views

Original Research

Published on 13 Jan 2026

MUC1 peptide-loaded dendritic cell vaccine boosts antitumor immunity in pancreatic cancer

in Antigen Presenting Cell Biology

Huiping Xie
Wenzhuo Yang
Haodong Chen
Zhilan Zhang
Zelin Zhao
Yuanyuan Jin
Shuai Fan
Zhaoyong Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1752861

805 views

Original Research

Published on 13 Jan 2026

Comparative risk of systemic autoimmune diseases in juvenile idiopathic arthritis treated with TNF-α or IL-6 inhibitors: a real-world cohort study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jih-Jin Tsai
Li-Teh Liu
Ping-Chang Lin
Yu-Hsun Wang
Yung-Heng Lee
James Cheng-Chung Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1744226

833 views

Brief Research Report

Published on 13 Jan 2026

Interleukin-36 upregulates type-I interferon responses in systemic lupus erythematosus by promoting the accumulation of self-nucleic acids

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Emma J. Welsh
Daniel McCluskey
Patrick Baum
Myles J. Lewis
Francesca Capon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727524

713 views

Editorial

Published on 13 Jan 2026

Editorial: IUIS junior community: pushing the frontiers of immunology

in Molecular Innate Immunity

Adeleye O. Adeshakin
Anne M. Hahn

Frontiers in Immunology

doi 10.3389/fimmu.2025.1768685

493 views

Original Research

Published on 13 Jan 2026

Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters

in NK and Innate Lymphoid Cell Biology

M. G. Kennedy
W. Patterson
S. T. Cox
L. Wynn
C. Stock da Cunha
M. O’Dwyer
R. Danby
D. Hernandez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1734453

1,453 views

Opinion

Published on 13 Jan 2026

Harmonisation of switched memory B cell analysis for improved CVID diagnosis and classification

in Primary Immunodeficiencies

Malicorne Buysse
Jana Neirinck
Ciel De Vriendt
Filomeen Haerynck
Martín Pérez-Andrés
Alberto Orfao
Mattias Hofmans
Carolien Bonroy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726673

813 views

Mini Review

Published on 13 Jan 2026

Lactylation and tumor immune regulation: insights from recent studies

in Cancer Immunity and Immunotherapy

Chunhong Li
Xiulin Jiang
Yixiao Yuan
Qiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699314

1,011 views

Review

Published on 13 Jan 2026

Bitter taste receptors in the gut-vascular axis: a novel target for immune and metabolic regulation of hypertension

in Molecular Innate Immunity

Xiaoyu Wei
Feifei Lyu
Fuyun Jia
Lihong Zhang
Min Zhang
Qiang Xu
Shengyu Hua

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714761

841 views

Original Research

Published on 13 Jan 2026

NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis

in Inflammation

Qingxian Tu
Xiaowei Gong
Xiaoxi Yuan
Yiyue Tang
Runze Huang
Qianfeng Jiang
Wei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712786

1,084 views

Original Research

Published on 13 Jan 2026

LOXL2 labels inflammation-associated myofibroblasts predicting kidney allograft dysfunction and fibrosis

in Alloimmunity and Transplantation

Paula Schütz
Birte Hüchtmann
Veerle Van Marck
Barbara Heitplatz
Carolin Walter
Rebecca Rixen
Hermann Pavenstädt
Stefan Reuter
Konrad Buscher

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671117

797 views

Original Research

Published on 13 Jan 2026

Deep learning-based multimodal approach for non-invasive prediction and prognostic analysis of immune and angiogenic biomarkers in extrahepatic cholangiocarcinoma

in Cancer Immunity and Immunotherapy

Jiong Liu
Zhitao Cheng
Ruidan Yang
Yinfei Fan
Yue Shu
Yong Tang
Jian Shu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658122

757 views

Systematic Review

Published on 13 Jan 2026

Comprehensive evaluation of prophylactic HPV vaccines: a systematic review and meta-analysis of efficacy, safety, and immunogenicity in males and females

in Vaccines and Molecular Therapeutics

Zhiliang Wang
Hui Zhang
Yuhang Zhu
Yuanli Jiang
Danhe Yang
Xiaofeng Zou
Yi Fang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1747082

1,257 views

Original Research

Published on 13 Jan 2026

Panel of three cytokines predicts occurrence of aGVHD after allo-HSCT: a retrospective study

in Alloimmunity and Transplantation

Lin Xia
Yue Wang
Shaping Deng
Yuqiu Qi
Zhuo Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719287

671 views

Original Research

Published on 13 Jan 2026

Deciphering reprogramming efficiency in human induced pluripotent stem cells: insights from the generation of 150 cell lines

in Alloimmunity and Transplantation

Bernd Kuebler
Silvia Selvitella
Begoña Aran
Angel Raya
Anna Veiga

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719056

921 views

Original Research

Published on 13 Jan 2026

Monitoring mitochondrial function in peripheral T cells to assess immune status and graft health after kidney transplantation

in Alloimmunity and Transplantation

Erdi Zhang
Zhengli Wan
Yuwen Ma
Yamei Li
Qixiang Zhou
Bei Cai
Yi Li
Feng Li
Binwu Ying
Lin Yan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721097

801 views

49,602 articles

articles

CD82-associated exhausted CD8+ T cells define prognosis and immunotherapy resistance in colon cancer

Survival and multi-omics analysis of immunotherapy-based conversion treatment for initially unresectable gastric cancer

From cercariae to chronic inflammation: understanding schistosome infection and host immune responses

Antibody levels to variant and conserved Plasmodium falciparum antigens predict reduction in parasite burden in Malian children

Anti-NMDA receptor encephalitis unmasking Sjögren’s disease: a case report and literature review

The immunobiology and therapeutic potential of regulatory T cells in autoimmune diseases and allergic diseases

Iron-fueled ferroptosis: a new axis for immunomodulation to overcome cancer drug resistance—from immune microenvironment crosstalk to therapeutic translation

A ligand-centered framework for γδ T cell activation in colorectal cancer revealed by single-cell and transformer-based perturbation

Mitochondrial DAMPs as a critical driver in the development of acute graft versus host disease and emerging mitochondria targeted therapeutic strategies

MUC1 peptide-loaded dendritic cell vaccine boosts antitumor immunity in pancreatic cancer

Comparative risk of systemic autoimmune diseases in juvenile idiopathic arthritis treated with TNF-α or IL-6 inhibitors: a real-world cohort study

Interleukin-36 upregulates type-I interferon responses in systemic lupus erythematosus by promoting the accumulation of self-nucleic acids

Editorial: IUIS junior community: pushing the frontiers of immunology

Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters

Harmonisation of switched memory B cell analysis for improved CVID diagnosis and classification

Lactylation and tumor immune regulation: insights from recent studies

Bitter taste receptors in the gut-vascular axis: a novel target for immune and metabolic regulation of hypertension

NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis

LOXL2 labels inflammation-associated myofibroblasts predicting kidney allograft dysfunction and fibrosis

Deep learning-based multimodal approach for non-invasive prediction and prognostic analysis of immune and angiogenic biomarkers in extrahepatic cholangiocarcinoma

Comprehensive evaluation of prophylactic HPV vaccines: a systematic review and meta-analysis of efficacy, safety, and immunogenicity in males and females

Panel of three cytokines predicts occurrence of aGVHD after allo-HSCT: a retrospective study

Deciphering reprogramming efficiency in human induced pluripotent stem cells: insights from the generation of 150 cell lines

Monitoring mitochondrial function in peripheral T cells to assess immune status and graft health after kidney transplantation