Frontiers in Immunology

Review

Published on 12 Jan 2026

Terminally exhausted CD8+ T cells in solid tumors: biology, biomarker potential and translational tools for precision oncology

in Cancer Immunity and Immunotherapy

Xuejun Guo
Shuhan Ma
Jingwen Wang
Yilin Fu
Wenxue Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709852

1,537 views

Mini Review

Published on 12 Jan 2026

Research progress on protein tyrosine phosphatase A from Mycobacterium tuberculosis

in Molecular Innate Immunity

Yifei Cai
Leiliang Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1754992

665 views

Review

Published on 12 Jan 2026

Targeting the plasticity of intestinal neutrophils: bidirectional regulation strategies by natural products

in Mucosal Immunity

Ruotong Kang
Anqi Sun
Jiayin Yang
Linyuan Chang
Wenguang Sun
Fushun Kou
Yuan Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1754107

916 views

Case Report

Published on 12 Jan 2026

A critically ill adolescent with EBV-associated hemophagocytic lymphohistiocytosis-induced hyperinflammatory shock: a case report and literature review

in Viral Immunology

Yong Chen
Ruodai Zhang
Chenghu Wang
Yi Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1749172

711 views

Mini Review

Published on 12 Jan 2026

Decoding inflammatory regulation in ovarian cancer at single-cell resolution

in Cancer Immunity and Immunotherapy

Jianghao Yu
Tingting Zhou
Shuangyu Chen
Jialin Zhu
Lu Xu
Yibo He
Wei Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719669

742 views

Original Research

Published on 12 Jan 2026

METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification

in Inflammation

Dong He
Xiaokun Jiang
Gengyin Guo
Jinfeng Ma
Jinyan Chen
Yongfei Zhang
Jianfeng Zhuang
Ping Xie
Zhen Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717319

780 views

Original Research

Published on 12 Jan 2026

Single-cell transcriptional profiling revealed the protective effects of Buddleoside in sepsis-associated acute liver injury

in Inflammation

Qingmiao Shi
Na Lou
Leiya Fu
Ying Wang
Chen Xue
Shen Shen
Li Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713180

729 views

Review

Published on 12 Jan 2026

Role and mechanism of gut microbiota in regulating interferon-mediated programmed cell death in colorectal cancer

in Molecular Innate Immunity

Qipeng Yao
Shiyin Chen
Weiwei Qian
Chao Yang
Junxian Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724908

967 views

Original Research

Published on 12 Jan 2026

TRIM29 drives ulcerative colitis by disrupting lipid metabolism via lysosomal dysfunction: a multi-omics and experimental study

in Inflammation

Xing-Zhou Guo
Lu-Yun Zhang
Zong-Biao Tan
Hao-Dong He
Ya-Fei Liu
Bao-Ping Yu
Wei-Guo Dong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728932

942 views

Original Research

Published on 12 Jan 2026

From multi-omics to functional validation: the PTMRS stratifies TME and positions PDGFRB in CRC biology

in Cancer Immunity and Immunotherapy

Yanhong Liu
Chao Lu
Luchun Hua
Hankun Hao
Qijing Zhang
Zongyou Zou
Jianbin Xiang
Yaping Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728291

778 views

Systematic Review

Published on 12 Jan 2026

Efficacy and safety of Cadonilimab in the treatment of recurrent/metastatic and advanced cervical cancer: a systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Qiuqi Zhuang
Yan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729380

971 views

Review

Published on 12 Jan 2026

The infection–microbiome–immunity axis in bladder cancer: mechanistic insights and therapeutic perspectives

in Cancer Immunity and Immunotherapy

Shen Pan
Wanlin Cui
Jiaman Lin
Zhujun Wang
Zhenhua Li
Bitian Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716230

1,010 views

Original Research

Published on 12 Jan 2026

Low IgE and absence of sensitization in non-T2 asthma: a transcriptomic and cytokine study

in B Cell Biology

Jyh-Hong Lee
Yu-Tsan Lin
Li-Chieh Wang
Hsin-Hui Yu
Ya-Chiao Hu
Yao-Hsu Yang
Bor-Luen Chiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711616

908 views

Original Research

Published on 12 Jan 2026

Integrated single-cell and bulk transcriptomic analysis reveals shared pathogenesis and prognostic biomarkers in breast and thyroid cancers

in Cancer Immunity and Immunotherapy

Bingbing Shen
Jiayi Jiang
Xinyue Zhang
Cheng Yi
Jiaye Liu
Zhihui Li
Yu Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710915

775 views

Original Research

Published on 12 Jan 2026

Identification and validation of HOXB3 hypomethylation as a novel prognostically epigenetic biomarker in acute myeloid leukemia

in Cancer Immunity and Immunotherapy

Ting-juan Zhang
Ran Chang
Fei Xie
Zi-jun Xu
Ming-qiang Chu
Xiao-chi Wu
Jun Qian
Jing-dong Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709417

926 views

Case Report

Published on 12 Jan 2026

Diabetes mellitus with anti-glomerular basement membrane disease and anti-tubular basement membrane disease: a rare case report of reversible dialysis dependence

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Junqi Hu
Yuanzi Liang
Kebing Sun
Yuefei Xiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691810

737 views

Case Report

Published on 12 Jan 2026

Potential benefits of JAK inhibitor therapy in Blau syndrome: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yu Wang
Xiao-juan Yu
Zhuoli Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665949

611 views

Original Research

Published on 12 Jan 2026

Catalogue of LPS-induced transcriptional changes across vertebrates identifies syntenically conserved human long non-coding RNAs that regulate the innate immune response

in Molecular Innate Immunity

Marina R. Hadjicharalambous
Richard R. Ryder
Peter S. Fenwick
Louise E. Donnelly
Mark A. Lindsay

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686490

740 views

Original Research

Published on 12 Jan 2026

Antigenic assessment for the β2-glycoprotein I/Platelet factor 4 complex in thrombotic patients with antiphospholipid syndrome

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Francesca Villani
Antonella Capozzi
Federica Maria Ucci
Simona Truglia
Manuela De Michele
Silvia Mancuso
Luca Rapino
Giuseppe Tripodi
Valeria Manganelli
Gloria Riitano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674181

1,035 views

Original Research

Published on 12 Jan 2026

Lipid and immune dysregulation and risk of metabolic disorders after HCV clearance in HIV/HCV-coinfected participants with cACLD: a retrospective study

in Molecular Innate Immunity

Ana Virseda-Berdices
Belen Requena
Juan Berenguer
Juan González-García
Carolina Gonzalez-Riano
Cristina Díez
Victor Hontañon
Amanda Fernández-Rodríguez
Coral Barbas
Salvador Resino

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674837

597 views

Systematic Review

Published on 12 Jan 2026

Sacituzumab govitecan as a therapeutic breakthrough in the treatment of triple-negative breast cancer: a systematic review of clinical trials

in Cancer Immunity and Immunotherapy

Julia Piekarz
Natalia Picheta
Jakub Pobideł
Katarzyna Szklener
Magdalena Skórzewska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679648

1,387 views

Study Protocol

Published on 12 Jan 2026

Personalized neoantigen DC vaccine combined with camrelizumab following definitive therapy in locally advanced unresectable esophageal squamous cell carcinoma (CHANT-241): protocol for a randomized controlled trial

in Cancer Immunity and Immunotherapy

Yueyun Chen
Yue Zheng
Huashan Shi
Wenjie Yang
Heng Xu
Yang Li
Zhenyu Ding

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658670

843 views

Original Research

Published on 12 Jan 2026

Interleukin-10 as a potential biomarker reflecting the multidimensional pathological network in patients with severe fever with thrombocytopenia syndrome: viral load, cytokine storm, organ damage, and immune suppression

in Viral Immunology

Ruihua Zhang
Jingxia Wang
Yanli Xu
Ruize Ma
Wan Peng
Zhouling Jiang
Hongxiao Wu
Chenxi Zhao
Ling Lin
Mengyuan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673091

1,425 views

Original Research

Published on 12 Jan 2026

FACS-based genome-wide CRISPR screening platform identifies modulators of CD47

in Cancer Immunity and Immunotherapy

Ling Yin
Wei He
Yifan Wang
Huimin Zhang
Min Huang
Yuelong Yan
Siting Li
Xu Feng
Francisco Saenz
Jie Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684539

971 views

49,602 articles

articles

Terminally exhausted CD8+ T cells in solid tumors: biology, biomarker potential and translational tools for precision oncology

Research progress on protein tyrosine phosphatase A from Mycobacterium tuberculosis

Targeting the plasticity of intestinal neutrophils: bidirectional regulation strategies by natural products

A critically ill adolescent with EBV-associated hemophagocytic lymphohistiocytosis-induced hyperinflammatory shock: a case report and literature review

Decoding inflammatory regulation in ovarian cancer at single-cell resolution

METTL3 inhibition alleviates neuroinflammation and apoptosis by reducing ETV4 m6A modification

Single-cell transcriptional profiling revealed the protective effects of Buddleoside in sepsis-associated acute liver injury

Role and mechanism of gut microbiota in regulating interferon-mediated programmed cell death in colorectal cancer

TRIM29 drives ulcerative colitis by disrupting lipid metabolism via lysosomal dysfunction: a multi-omics and experimental study

From multi-omics to functional validation: the PTMRS stratifies TME and positions PDGFRB in CRC biology

Efficacy and safety of Cadonilimab in the treatment of recurrent/metastatic and advanced cervical cancer: a systematic review and meta-analysis

The infection–microbiome–immunity axis in bladder cancer: mechanistic insights and therapeutic perspectives

Low IgE and absence of sensitization in non-T2 asthma: a transcriptomic and cytokine study

Integrated single-cell and bulk transcriptomic analysis reveals shared pathogenesis and prognostic biomarkers in breast and thyroid cancers

Identification and validation of HOXB3 hypomethylation as a novel prognostically epigenetic biomarker in acute myeloid leukemia

Diabetes mellitus with anti-glomerular basement membrane disease and anti-tubular basement membrane disease: a rare case report of reversible dialysis dependence

Potential benefits of JAK inhibitor therapy in Blau syndrome: a case report

Catalogue of LPS-induced transcriptional changes across vertebrates identifies syntenically conserved human long non-coding RNAs that regulate the innate immune response

Antigenic assessment for the β2-glycoprotein I/Platelet factor 4 complex in thrombotic patients with antiphospholipid syndrome

Lipid and immune dysregulation and risk of metabolic disorders after HCV clearance in HIV/HCV-coinfected participants with cACLD: a retrospective study

Sacituzumab govitecan as a therapeutic breakthrough in the treatment of triple-negative breast cancer: a systematic review of clinical trials

Personalized neoantigen DC vaccine combined with camrelizumab following definitive therapy in locally advanced unresectable esophageal squamous cell carcinoma (CHANT-241): protocol for a randomized controlled trial

Interleukin-10 as a potential biomarker reflecting the multidimensional pathological network in patients with severe fever with thrombocytopenia syndrome: viral load, cytokine storm, organ damage, and immune suppression

FACS-based genome-wide CRISPR screening platform identifies modulators of CD47