Frontiers in Immunology

Original Research

Published on 18 Dec 2025

Serum CHI3L1 levels correlate with disease activity in rheumatoid arthritis and reveal potential molecular mechanisms

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yi Deng
Dan Wang
Chao Wang
Kaiyun Guo
Ming Lei
Yanzhao Huang
Langui Tang
Ya Ding
Yan Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729989

270 views

Original Research

Published on 18 Dec 2025

Impact of inotuzumab ozogamicin as bridging therapy and tumor burden in CAR-T therapy for B-acute lymphoblastic leukemia

in Cancer Immunity and Immunotherapy

Patricia Alcalde-Mellado
Victoria Ruiz-Maldonado
Javier Delgado-Serrano
Luzalba Sanoja-Flores
Marta Reinoso-Segura
Laura Pérez-Ortega
Belén Sierro-Martínez
Estefanía García-Guerrero
Concepción Pérez de Soto
José María Pérez-Hurtado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725878

420 views

Original Research

Published on 18 Dec 2025

Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung

in Mucosal Immunity

Adrienne N Wilburn
Rabia Ülkü Korkmaz
Jaclyn W McAlees
Julie M Hargis
Schmaiel Shirdel
Imke Lingel
Miki Watanabe-Chailland
Lindsey Romick-Rosendale
Inken Schmudde
James P Bridges

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715675

480 views

Original Research

Published on 18 Dec 2025

High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

in Comparative Immunology

Myung-Chul Kim
Taeeun Gu
Hyeewon Seo
Yewon Moon
Nicholas Borcherding
Ryan Kolb
Yubin Kim
Youngmin Yun
Woo-Jin Song
Chung-Young Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680437

300 views

Review

Published on 18 Dec 2025

Lactylation: the metabolic–immune hub in autoimmune diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Qingqing Xia
Dantong Sun
Ke Wan
Chengcheng Liu
Han Shu
Miao Wang
Tongsheng Zhou
Ying Chen
Xue Yang
Xiao-Feng Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651923

287 views

Original Research

Published on 18 Dec 2025

SMAC mimetics sensitize HIV-infected cells to oncolytic virus-mediated death

in Viral Immunology

Bengisu Molyer
Yasmeen Ameeriar
Jonathan B. Angel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665811

543 views

Review

Published on 18 Dec 2025

New insights into combined immunotherapy for hepatocellular carcinoma associated with liver cirrhosis

in Cancer Immunity and Immunotherapy

Yufan Liu
Kexin Cong
Qiao Li
Dan Zhang
Jiyao Sheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1741398

199 views

Original Research

Published on 18 Dec 2025

Evaluation of warning strategies for paraneoplastic neurological syndromes associated with PD-1/PD-L1 inhibitors

in Cancer Immunity and Immunotherapy

Zhuangzhuang Ren
Yudan Liu
Jianguo Liu
Xiaokun Qi
Feng Qiu
Chenjing Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670751

199 views

Original Research

Published on 18 Dec 2025

T cell immunity to seasonal Influenza A and H5N1 viruses in laboratory workers receiving annual seasonal Influenza vaccines

in Vaccines and Molecular Therapeutics

Joel Sop
Tyler P. Beckey
Lizeth Gutierrez
Li Zhang
Kelly A. Gebo
Kellie N. Smith
Joel N. Blankson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718805

332 views

Review

Published on 18 Dec 2025

Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies

in Inflammation

Sofia Shifon
Tamara Tyrinova
Tatyana Veretelnikova
Natalia Pasman
Elena Chernykh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727183

358 views

Original Research

Published on 18 Dec 2025

Differential expression profiles of lncRNAs and a preliminary study on the mechanism of lncRNA FAM225A in triple seronegative myasthenia gravis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yuehan Hao
Chen Chen
Bo Wang
ChunHua Yang
Ying Zhu
Ruixia Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664131

280 views

Original Research

Published on 18 Dec 2025

Impact of recombinant expression in Komagataella phaffii on the allergenic properties of the peanut allergen Ara h 2

in Molecular Innate Immunity

Andrea Wangorsch
Annette Jamin
Sonja Wolfheimer
Melanie Albrecht
Stefan Vieths
Jonas Lidholm
Stephan Scheurer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713823

399 views

Original Research

Published on 18 Dec 2025

Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

in Molecular Innate Immunity

Huili Zhao
Shenao Zhang
Yinjiao Wang
Haiyan Zhang
Peng Du
Aihong Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739812

290 views

Review

Published on 18 Dec 2025

Mechanism analysis and intervention strategies of the inflammatory microenvironment in traumatic spinal cord injury

in Inflammation

Hou-yun Gu
Fei-xiang Lin
Ning Liu
Can-hua Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692346

193 views

Original Research

Accepted on 17 Dec 2025

Low IgE and Absence of Sensitization in Non-T2 Asthma: A Transcriptomic and Cytokine Study

in B Cell Biology

JYH-HONG LEE
Yu-Tsan Lin
Li-Chieh Wang
Hsin-Hui Yu
Ya-Chiao Hu
Yao-Hsu Yang
Bor-Luen Chiang

Frontiers in Immunology

208 views

Original Research

Accepted on 17 Dec 2025

Impact of Epstein–Barr virus infection on clinical outcomes and immune profiles in patients with severe fever with thrombocytopenia syndrome

in Viral Immunology

Tong Wang
Ling Xu
Hanxin Li
Zhong Zheng
Sumeng Li
Hua Wang
Yanan Liu
Xin Zheng

Frontiers in Immunology

213 views

Original Research

Accepted on 17 Dec 2025

Effect of Pretransplant Spleen Volume on the Prognosis of Acute Myeloid Leukemia Treated with Allogeneic Hematopoietic Stem Cell Transplantation

in Alloimmunity and Transplantation

WEIWEI LIU
Liu Bingjie
LIhou Pang
Lixia Zhou
Fuxu Wang
Xuejun Zhang
Ying Wang

Frontiers in Immunology

107 views

Review

Accepted on 17 Dec 2025

The Tumor Microenvironment: Adding pieces to the puzzle

in Cancer Immunity and Immunotherapy

Dolores Aguilar-Cazares
Mario Perez-Medina
Jesús Jareb Benito-Lopez
Miriam Galicia
Manuel Meneses-Flores
Angel Camarena
Jose Sullivan Lopez-Gonzalez

Frontiers in Immunology

111 views

Original Research

Accepted on 17 Dec 2025

Association of NK cells with a shift in tryptophan catabolism in patients with heart failure after a single exercise exertion

in NK and Innate Lymphoid Cell Biology

Krithika Swaminathan
Bita Astan
Sabine Kaczmarek
Kristin Lehnert
Anke Hannemann
Aycen Koc
Nele Friedrich
Kathrin Budde
Ann-Kristin Henning
Grazyna Domanska

Frontiers in Immunology

139 views

Original Research

Accepted on 17 Dec 2025

Cuproptosis-Driven Reprogramming of Fibroblast Communication by GK is associated with the Immune Microenvironment in Diabetic Foot Ulcers

in Systems Immunology

Tianbo Li
Jiangning Wang
Lei Gao

Frontiers in Immunology

Original Research

Accepted on 17 Dec 2025

Efficacy and Safety of Zuberitamab in the Treatment of Primary Membranous Nephropathy: An Observational Study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Li Zong
Sha Wang
Ke Zhao
Fangyi Lu
Shan-kui Qian
Xiangdong Yang

Frontiers in Immunology

Original Research

Accepted on 17 Dec 2025

Robust, scalable and xeno-free protocol for differentiating human induced pluripotent stem cells into functional macrophages

in Alloimmunity and Transplantation

Miquel De Homdedeu
Rubén Escribá
Kenia Rodríguez-González
Sergio Querol
Jesús Fernández-Sojo
Belen Alvarez-Palomo

Frontiers in Immunology

Original Research

Accepted on 17 Dec 2025

Deciphering Reprogramming Efficiency in human induced Pluripotent Stem Cells: Insights from the Generation of 150 Cell Lines

in Alloimmunity and Transplantation

Bernd Kuebler
Silvia Selvitella
Begoña Aran
Angel Raya
ANNA VEIGA

Frontiers in Immunology

Original Research

Accepted on 17 Dec 2025

Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters

in NK and Innate Lymphoid Cell Biology

Marguerite Kennedy
Warren Patterson
Steven Thomas Cox
Liam Anthony Wynn
Carmo Stock da Cunha
Michael O'Dwyer
Robert David Danby
Diana Hernandez

Frontiers in Immunology

201 views

48,462 articles

articles

Serum CHI3L1 levels correlate with disease activity in rheumatoid arthritis and reveal potential molecular mechanisms

Impact of inotuzumab ozogamicin as bridging therapy and tumor burden in CAR-T therapy for B-acute lymphoblastic leukemia

Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung

High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

Lactylation: the metabolic–immune hub in autoimmune diseases

SMAC mimetics sensitize HIV-infected cells to oncolytic virus-mediated death

New insights into combined immunotherapy for hepatocellular carcinoma associated with liver cirrhosis

Evaluation of warning strategies for paraneoplastic neurological syndromes associated with PD-1/PD-L1 inhibitors

T cell immunity to seasonal Influenza A and H5N1 viruses in laboratory workers receiving annual seasonal Influenza vaccines

Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies

Differential expression profiles of lncRNAs and a preliminary study on the mechanism of lncRNA FAM225A in triple seronegative myasthenia gravis

Impact of recombinant expression in Komagataella phaffii on the allergenic properties of the peanut allergen Ara h 2

Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

Mechanism analysis and intervention strategies of the inflammatory microenvironment in traumatic spinal cord injury

Low IgE and Absence of Sensitization in Non-T2 Asthma: A Transcriptomic and Cytokine Study

Impact of Epstein–Barr virus infection on clinical outcomes and immune profiles in patients with severe fever with thrombocytopenia syndrome

Effect of Pretransplant Spleen Volume on the Prognosis of Acute Myeloid Leukemia Treated with Allogeneic Hematopoietic Stem Cell Transplantation

The Tumor Microenvironment: Adding pieces to the puzzle

Association of NK cells with a shift in tryptophan catabolism in patients with heart failure after a single exercise exertion

Cuproptosis-Driven Reprogramming of Fibroblast Communication by GK is associated with the Immune Microenvironment in Diabetic Foot Ulcers

Efficacy and Safety of Zuberitamab in the Treatment of Primary Membranous Nephropathy: An Observational Study

Robust, scalable and xeno-free protocol for differentiating human induced pluripotent stem cells into functional macrophages

Deciphering Reprogramming Efficiency in human induced Pluripotent Stem Cells: Insights from the Generation of 150 Cell Lines

Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters