Frontiers in Immunology

Original Research

Published on 12 Jan 2026

Integrated multi-omic profiling reveals macrophage-driven prognostic signatures in clear cell renal cell carcinoma through machine learning optimization

in Cancer Immunity and Immunotherapy

Wei Cao
Wenyuan Zhuang
Kai Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1612262

1,227 views

Case Report

Published on 12 Jan 2026

Case Report: Transfusion-associated graft-versus-host disease in severe combined immunodeficiency

in Alloimmunity and Transplantation

Chunxue Jiang
Tingting Sun
Xuewen Xu
Wei Xu
Kai You

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708366

928 views

Systematic Review

Published on 12 Jan 2026

To substitute or not? A systematic review of immunoglobulin replacement therapy in multiple myeloma patients treated with bispecific antibodies

in Cancer Immunity and Immunotherapy

Juni Songe Paulsen
Tobias S. Slørdahl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722579

1,034 views

Review

Published on 12 Jan 2026

Integrin alpha L: structure, cellular functions, and emerging role in human diseases

in Immunological Tolerance and Regulation

Xianglin Wang
Guoya Yang
Yanpei Chen
Fang Zhu
Fuming Lian
Wenzhi Shen
Dehong Luo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707291

731 views

Original Research

Published on 12 Jan 2026

A multi-omics analysis of pancreatitis: bridging familial genetics and disease progression

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Fu Li
Jin-xin Huang
Wen-jie Sun
Jing-qing Zeng
Ke-xin Gan
Biao Gong
Jian-mei Ji
Jian Chen
Zhao-hui Deng
Dong-liang Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707821

998 views

Review

Published on 12 Jan 2026

Natural killer cell-based senotherapy: a promising strategy for healthy aging

in NK and Innate Lymphoid Cell Biology

Tsutomu Nakazawa
Ryo Yamanishi
Takayuki Morimoto
Ryosuke Matusda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737572

1,139 views

Mini Review

Published on 12 Jan 2026

The roles of the mtDNA-cGAS-STING axis in tumor immunity: from immune activation to immune evasion

in Cancer Immunity and Immunotherapy

Nan Huang
Zheng Liu
Haibo Lei
Xiang Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739559

941 views

Original Research

Published on 12 Jan 2026

Neoadjuvant serplulimab and SOX chemotherapy for locally advanced gastric cancer: pathological responses and systemic immune signatures from a phase II trial

in Cancer Immunity and Immunotherapy

Hongjie Zhan
Liang Liu
Mingzhi Cai
Weilin Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702737

971 views

Systematic Review

Published on 12 Jan 2026

Ferroptosis and immunity: a bibliometric analysis of research hotspots and frontiers (2012-2025)

in Cancer Immunity and Immunotherapy

Qi Huang
Shuhang Feng
Changhao He
Rong Xu
Yixuan Cai
Linyu Guan
Jiaqi Guan
Lei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739210

909 views

Review

Published on 12 Jan 2026

Strategies and limitations of the bat immune response to Pseudogymnoascus destructans: the causative agent of white-nose syndrome

in Comparative Immunology

Maya J. Jacewicz
Noah P. Rogozynski
Brian Dixon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736823

1,102 views

Review

Published on 12 Jan 2026

T cell assays for non-clinical immunogenicity risk assessment: best practices recommended by the European Immunogenicity Platform

in Vaccines and Molecular Therapeutics

Sophie Tourdot
Anette Christine Karle
Marc Rosenbaum
Chloé Ackaert
Pauline Le Vu
Michael Gutknecht
Maryam Ahmadi
Annelies W. Turksma
Timothy P. Hickling

Frontiers in Immunology

doi 10.3389/fimmu.2025.1723110

1,349 views

Original Research

Published on 12 Jan 2026

Dual function antibody targeting αvβ3 and PD-L1 provide a promising strategy for solid tumor therapy

in Cancer Immunity and Immunotherapy

Guixia Li
Wenlei Li
Liuli Wang
Yuxin Bi
Yibo Wang
Xuemin Zheng
Ruijia Hao
Yanchen Yin
Yan Yu
Huaibin Mu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691774

928 views

Review

Published on 12 Jan 2026

Immune cell metabolic reprogramming in hepatocellular carcinoma: mechanisms, tumor microenvironment, and future immunotherapeutic directions

in Cancer Immunity and Immunotherapy

Lichen Zhou
Wenjie Zhang
Zhuoran Liu
Yaming Xie
Kangyi Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697675

1,323 views

Correction

Published on 12 Jan 2026

Correction: Targeting c-Jun orchestrates heat stroke-induced myocardial injury and reveals its biomarker potential

in Inflammation

Yunfei Xiang
Rui Huang
Xuemei Jiang
Qingsong Chen
Can Luo
Hongxia Wang
Junyu Jiang
Jia Xie
Guangbin Huang
Menglong Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1778549

399 views

Original Research

Published on 12 Jan 2026

Plasma immune proteome-based risk score predicts survival in advanced gastric cancer treated with PD-1 inhibitors and chemotherapy

in Cancer Immunity and Immunotherapy

Zhouwei Zhan
Ruyu Lin
Yigui Chen
Sha Huang
Luping Lin
Hanchen Zheng
Xiaojie Wang
Xiaoyan Lin
Zengqing Guo
Qiaoting Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715993

776 views

Original Research

Published on 12 Jan 2026

Serum paraoxonase-1 as a marker of oxidative stress and pulmonary dysfunction in sarcoidosis: association with disease activity and prognostic potential

in Inflammation

Mine Büşra Bozkürk
Ersin Günay
Nalan Ogan
İpek Candemir
Uğurcan Eker
Alpaslan Öztürk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731991

551 views

Review

Published on 12 Jan 2026

Unlocking ferroptosis to overcome cancer stem cells-mediated treatment failure and immune evasion

in Cancer Immunity and Immunotherapy

Weicheng Jin
Jun Xia
Chuanqiang Zhang
Tongguo Shi
Yu Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708850

623 views

Review

Published on 12 Jan 2026

Breast milk–saliva interactions in shaping early mucosal immunity

in Nutritional Immunology

Seon Bin Song
Jae Young Kim

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679865

844 views

Mini Review

Published on 12 Jan 2026

The gut microbiota influences neurodegenerative diseases through the gut-brain axis: molecular mechanisms and effects on immune function

in Multiple Sclerosis and Neuroimmunology

Jiaheng Yang
Xiangzhun Song
Su Yan
Qianxun Li
Wenying Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739329

1,090 views

Original Research

Published on 12 Jan 2026

Efficacy of Pediococcus acidilactici PA53 in preventing high-fat diet-induced non-alcoholic fatty liver disease in mice

in Microbial Immunology

Yue Niu
Peng Liu
Yu Chen
Yichen Yao
Shurui Bu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1743709

848 views

Original Research

Published on 12 Jan 2026

Hepatobiliary disorders associated with TNF-α inhibitors: a pharmacovigilance analysis of FAERS and JADER

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Hongyu Chen
Shirui Jiang
Jingyu Wang
Ailin Zhang
Liqin Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739631

765 views

Original Research

Published on 12 Jan 2026

Efficacy and safety of zuberitamab in the treatment of primary membranous nephropathy: an observational study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Li Zong
Sha Wang
Ke Zhao
Fang-yi Lv
Shan-kui Qian
Xiang-dong Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1741564

694 views

Original Research

Published on 12 Jan 2026

Immune checkpoint inhibitor-related Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective analysis of 21 cases

in Cancer Immunity and Immunotherapy

Tianshu Pu
Yaru Teng
Yuezhu Zhang
Meihong Da
Fei Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1734346

653 views

Brief Research Report

Published on 12 Jan 2026

SARS-CoV-2 evolution enhances endocytic uptake while preserving TMPRSS2-dependent fusion

in Viral Immunology

Clara L. Magnus
Zeliha Hamed Jaber
Andreas Hiergeist
Lisa Arnold
Harriet Marchel
Antonia Lamprecht
Frank Hanses
Thomas Dienemann
Roland Schneckenpointner
Matthias Lubnow

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736891

904 views

49,602 articles

articles

Integrated multi-omic profiling reveals macrophage-driven prognostic signatures in clear cell renal cell carcinoma through machine learning optimization

Case Report: Transfusion-associated graft-versus-host disease in severe combined immunodeficiency

To substitute or not? A systematic review of immunoglobulin replacement therapy in multiple myeloma patients treated with bispecific antibodies

Integrin alpha L: structure, cellular functions, and emerging role in human diseases

A multi-omics analysis of pancreatitis: bridging familial genetics and disease progression

Natural killer cell-based senotherapy: a promising strategy for healthy aging

The roles of the mtDNA-cGAS-STING axis in tumor immunity: from immune activation to immune evasion

Neoadjuvant serplulimab and SOX chemotherapy for locally advanced gastric cancer: pathological responses and systemic immune signatures from a phase II trial

Ferroptosis and immunity: a bibliometric analysis of research hotspots and frontiers (2012-2025)

Strategies and limitations of the bat immune response to Pseudogymnoascus destructans: the causative agent of white-nose syndrome

T cell assays for non-clinical immunogenicity risk assessment: best practices recommended by the European Immunogenicity Platform

Dual function antibody targeting αvβ3 and PD-L1 provide a promising strategy for solid tumor therapy

Immune cell metabolic reprogramming in hepatocellular carcinoma: mechanisms, tumor microenvironment, and future immunotherapeutic directions

Correction: Targeting c-Jun orchestrates heat stroke-induced myocardial injury and reveals its biomarker potential

Plasma immune proteome-based risk score predicts survival in advanced gastric cancer treated with PD-1 inhibitors and chemotherapy

Serum paraoxonase-1 as a marker of oxidative stress and pulmonary dysfunction in sarcoidosis: association with disease activity and prognostic potential

Unlocking ferroptosis to overcome cancer stem cells-mediated treatment failure and immune evasion

Breast milk–saliva interactions in shaping early mucosal immunity

The gut microbiota influences neurodegenerative diseases through the gut-brain axis: molecular mechanisms and effects on immune function

Efficacy of Pediococcus acidilactici PA53 in preventing high-fat diet-induced non-alcoholic fatty liver disease in mice

Hepatobiliary disorders associated with TNF-α inhibitors: a pharmacovigilance analysis of FAERS and JADER

Efficacy and safety of zuberitamab in the treatment of primary membranous nephropathy: an observational study

Immune checkpoint inhibitor-related Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective analysis of 21 cases

SARS-CoV-2 evolution enhances endocytic uptake while preserving TMPRSS2-dependent fusion