Frontiers in Immunology

Original Research

Published on 12 Jan 2026

An antibody uniquely binding short 2′-O-methyl RNA oligonucleotide duplexes: formation and recognition of target duplexes on cell surfaces

in Vaccines and Molecular Therapeutics

Ian S. Dunn
Matthew M. Lawler
Leah Fagundes
Milto Simoes Junior
April Mangold
Domenic Rinaldi
Lenora B. Rose
James T. Kurnick

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699400

810 views

Original Research

Published on 12 Jan 2026

Classification of angioedema types using decision tree modeling

in Systems Immunology

Felix Aulenbacher
Annika Gutsche
Henriette Farkas
Kinga Viktória Kőhalmi
Emek Kocatürk
Emel Aygören-Pürsün
Ludovic Martin
Hilary Longhurst
Petra Staubach
Andrea Zanichelli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697143

960 views

Original Research

Published on 12 Jan 2026

Multi-omics integration identifies NK cell dysregulation and a five-gene diagnostic signature in major depressive disorder

in NK and Innate Lymphoid Cell Biology

Jia Wang
Ye Kuang
Chuanmei Peng
Yong Yuan
Yong Ji
Sulian Chen
Jinrong Tian
Yuanyuan Zhou
Xingying Chen
Jing Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700629

842 views

Original Research

Published on 12 Jan 2026

Hyperammonemia increases the release of pathological extracellular vesicles from monocytes by impairing lysosomal function and autophagy through the TNFα–cAMP–PKA–LC3 pathway

in Inflammation

Maria A. Pedrosa
Paula Izquierdo-Altarejos
Marta Llansola
Vicente Felipo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724800

792 views

Case Report

Published on 12 Jan 2026

Synergistic hyperinflammation in IgA vasculitis complicated by varicella-induced HLH: a case report

in Viral Immunology

Xiaoli He
Yu Zhou
Lina Qiao
Deyuan Li
Zhongqiang Liu
Guoyan Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675483

806 views

Original Research

Published on 12 Jan 2026

Postbiotic effects elicited by heat-inactivated Lacticaseibacillus rhamnosus GG against cow’s milk allergy in human cells

in Nutritional Immunology

Franca Oglio
Lorella Paparo
Laura Carucci
Alessia Gaeta
Samantha Armiento
Serena Coppola
Antonio Molinaro
Cristina De Castro
Antonio Masino
Vittoria Mauriello

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671729

809 views

Study Protocol

Published on 12 Jan 2026

XELOX combined with sintilimab and hyperbaric oxygen therapy for advanced or metastatic gastric/gastroesophageal junction adenocarcinoma: study protocol for a prospective, single-arm, phase Ib/II clinical trial

in Cancer Immunity and Immunotherapy

Wenke Li
Pengfei Zhang
Mo Cheng
Jing Wei
Menghui Xu
Dan Li
Sihui Song
Ming Liu
Cheng Huang
Lin Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672725

783 views

Systematic Review

Published on 12 Jan 2026

Global assessment of hepatic safety in novel immunotherapies: a systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Minyan Ye
Yinuo Dong
Xiaoyun Li
Yang Zhi
Yuping Lu
Jieting Tang
Wei Zhong
Xiaohong Lei
Yimin Mao
Sha Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677998

541 views

Original Research

Published on 12 Jan 2026

Modified EASIX score on day 7 predicts survival and non-relapse mortality in pediatric acute leukemia undergoing haploidentical stem cell transplantation

in Alloimmunity and Transplantation

Kai Cui
Senlin Zhang
Yueke Du
Qingwei Wang
Yutan Chai
Li Gao
Yixin Hu
Bohan Li
Yuanyuan Tian
Yongping Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646640

653 views

Original Research

Accepted on 09 Jan 2026

Unveiling Potential Diagnostic Biomarkers for Rheumatoid Arthritis Through Integrated Gene Expression Analysis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Feng Zhiwei
yuan fa
guo minggang
chen feng
li wei
yang chenfei

Frontiers in Immunology

930 views

Editorial

Accepted on 09 Jan 2026

Exploring Immune Memory Dynamics in Chronic Antigen Exposure and Disease Progression: Implications for Immunotherapy

in Immunological Memory

Stefano Caserta
Alejandra Pera

Frontiers in Immunology

344 views

Review

Accepted on 09 Jan 2026

OX40 signaling in cancer immunotherapy: mechanisms of action, translational applications, and therapeutic perspectives

in Cancer Immunity and Immunotherapy

Luo Yuehua
Jing Li
Le Li
Bingbing Qin
Ruisheng Zhou
Ying Tang

Frontiers in Immunology

196 views

Case Report

Accepted on 09 Jan 2026

Targeted interleukin-6 (IL-6) blockade by siltuximab for cytokine release syndrome control and infection limitation in thirteen patients treated with bi-specific T-cell engagers

in Inflammation

JEANFRANCOIS ROSSI
Thierry Cailleux
Emma Wisnewski
Julie Coussirou
Françoise de Crozals

Frontiers in Immunology

151 views

Original Research

Published on 09 Jan 2026

The role of 5-methylcytosine regulator-related genes in diagnostic and immune regulatory functions in atherosclerosis

in Systems Immunology

Hui Zhao
Ying Kong
Pengfei Ding
Luqun Yang
Ning Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1636323

927 views

Systematic Review

Published on 09 Jan 2026

Effects of exercise on angiogenesis biomarkers in cancer patients: a systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Jingyu Wang
Yuxuan He
Ziqian Wang
Zhouluo Wang
Yu Sun
Kyung-Hee Lee
Jae-Young Choi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705472

836 views

Review

Published on 09 Jan 2026

Lactylation in cancer: mechanistic insights, tumor microenvironment, and therapeutic horizons

in Cancer Immunity and Immunotherapy

Qiang Yang
Zhibo Yang
Hai Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697008

1,263 views

Original Research

Published on 09 Jan 2026

Cuproptosis-driven reprogramming of fibroblast communication by GK is associated with the immune microenvironment in diabetic foot ulcers

in Systems Immunology

Tianbo Li
Jiangning Wang
Lei Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687806

982 views

Original Research

Published on 09 Jan 2026

Different Fc scaffolds enhance the breadth of in vitro neutralization of the same Fab against different Rotavirus strains

in Vaccines and Molecular Therapeutics

Mabel Rocio Miranda-Echagüe
Giacomo Vezzani
Elena Morandi
Melania Della Peruta
Mirko Scordio
Teresa Anne Clarisse Reyes
Davide Oldrini
Miren Iturriza-Gómara
Rebecca Jo Loomis
Omar Rossi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709107

996 views

Original Research

Published on 09 Jan 2026

Strongyloides stercoralis coinfection impairs immune control of Mycobacterium tuberculosis in TB infected individuals

in Parasite Immunology

Anuradha Rajamanickam
Bindu Dasan
Arul Nancy Pandiarajan
Saravanan Munisankar
Sivakumar Shanmugam
Subash Babu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735029

811 views

Original Research

Published on 09 Jan 2026

Fc-enhanced anti-CCR6 antibody elicits robust therapeutic effects across multiple autoimmune diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Md Jahangir Alam
Yu-Anne Yap
Caroline Ang
Liang Xie
Hillary L. Shane
Charles R. Mackay
Remy Robert

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728419

1,344 views

Original Research

Published on 09 Jan 2026

C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL–RANK interaction

in Cytokines and Soluble Mediators in Immunity

Trung-Loc Ho
Kun-Tsan Lee
Yu-Hao He
Le Huynh Hoai Thuong
David Achudhan
Wei-Chien Huang
Chih-Yuan Ko
Chun-Lin Liu
Jeng-Hung Guo
Chih-Hsin Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729222

1,086 views

Correction

Published on 09 Jan 2026

Correction: New serum soluble factors predicting inflammatory and non-inflammatory disability worsening in multiple sclerosis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1774415

332 views

Review

Published on 09 Jan 2026

Engineering neuroimmune regulation: biomaterial and nanotechnology platforms for neuropathology diagnosis and targeted immunomodulation

in Multiple Sclerosis and Neuroimmunology

Mikayla S. Jackson
Lauren G. Porter
Robert S. Oakes

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677612

1,246 views

Methods

Published on 09 Jan 2026

Making deep immunophenotyping accessible: the successful application of a guided 23-parameter mouse immunophenotyping panel package provided through a shared resource

in Systems Immunology

Madison G. Isbell
Alex Wendling
Xinyan Pei
Amit Kumar
Padmanabhan Mannangatti
Bradley A. Krisanits
Stanley Cheatham
Marie Michenkova
Kirill Shumilov
Rachel G. Mendoza

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668405

1,100 views

49,602 articles

articles

An antibody uniquely binding short 2′-O-methyl RNA oligonucleotide duplexes: formation and recognition of target duplexes on cell surfaces

Classification of angioedema types using decision tree modeling

Multi-omics integration identifies NK cell dysregulation and a five-gene diagnostic signature in major depressive disorder

Hyperammonemia increases the release of pathological extracellular vesicles from monocytes by impairing lysosomal function and autophagy through the TNFα–cAMP–PKA–LC3 pathway

Synergistic hyperinflammation in IgA vasculitis complicated by varicella-induced HLH: a case report

Postbiotic effects elicited by heat-inactivated Lacticaseibacillus rhamnosus GG against cow’s milk allergy in human cells

XELOX combined with sintilimab and hyperbaric oxygen therapy for advanced or metastatic gastric/gastroesophageal junction adenocarcinoma: study protocol for a prospective, single-arm, phase Ib/II clinical trial

Global assessment of hepatic safety in novel immunotherapies: a systematic review and meta-analysis

Modified EASIX score on day 7 predicts survival and non-relapse mortality in pediatric acute leukemia undergoing haploidentical stem cell transplantation

Unveiling Potential Diagnostic Biomarkers for Rheumatoid Arthritis Through Integrated Gene Expression Analysis

Exploring Immune Memory Dynamics in Chronic Antigen Exposure and Disease Progression: Implications for Immunotherapy

OX40 signaling in cancer immunotherapy: mechanisms of action, translational applications, and therapeutic perspectives

Targeted interleukin-6 (IL-6) blockade by siltuximab for cytokine release syndrome control and infection limitation in thirteen patients treated with bi-specific T-cell engagers

The role of 5-methylcytosine regulator-related genes in diagnostic and immune regulatory functions in atherosclerosis

Effects of exercise on angiogenesis biomarkers in cancer patients: a systematic review and meta-analysis

Lactylation in cancer: mechanistic insights, tumor microenvironment, and therapeutic horizons

Cuproptosis-driven reprogramming of fibroblast communication by GK is associated with the immune microenvironment in diabetic foot ulcers

Different Fc scaffolds enhance the breadth of in vitro neutralization of the same Fab against different Rotavirus strains

Strongyloides stercoralis coinfection impairs immune control of Mycobacterium tuberculosis in TB infected individuals

Fc-enhanced anti-CCR6 antibody elicits robust therapeutic effects across multiple autoimmune diseases

C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL–RANK interaction

Correction: New serum soluble factors predicting inflammatory and non-inflammatory disability worsening in multiple sclerosis

Engineering neuroimmune regulation: biomaterial and nanotechnology platforms for neuropathology diagnosis and targeted immunomodulation

Making deep immunophenotyping accessible: the successful application of a guided 23-parameter mouse immunophenotyping panel package provided through a shared resource