Frontiers in Immunology

Original Research

Published on 09 Jan 2026

Sex-specific and socioeconomic disparities in the global burden of inflammatory bowel disease in 204 countries, 1990–2021: projections to 2050

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Qingtong Li
Yanqi Kou
Mingcheng Zhang
Chunyi Wu
Rongfo Mi
Wantong Jiang
Yufei Cheng
Lei Ge
Ke Yang
Zhe Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673212

811 views

Original Research

Published on 09 Jan 2026

The impact of metabolic dysfunction-associated steatotic liver disease on the efficacy of pegylated interferon-based therapy in patients with chronic hepatitis B

in Viral Immunology

Jiaxin Han
Lianxin Xu
Yuqin Li
Ziling Wang
Minghui Zeng
Jieru Gao
Yuqiang Mi
Wentao Kuai
Huiling Xiang
Liang Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708909

849 views

Original Research

Published on 09 Jan 2026

ULMnet: inferring physical cell-cell communication networks from scRNAseq data using univariate linear models

in Systems Immunology

Sodiq A. Hameed
Luis Fernando Iglesias-Martinez
Walter Kolch
Vadim Zhernovkov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722504

1,659 views

Review

Published on 09 Jan 2026

Death as rebirth: how efferocytosis drives tissue repair and disease treatment

in Cancer Immunity and Immunotherapy

Xinliang Duan
Sichen Han
Yifu Bian
Yao Yuan
Jiayu Shen
Yixuan Dai
Junzi Mi
Zilin Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712547

1,067 views

Original Research

Published on 09 Jan 2026

Targeting the epidermal growth factor receptor using IgM antibodies: toward next generation cancer immunotherapy

in Cancer Immunity and Immunotherapy

Kamolrat Somboon
Peter J. Bond
Firdaus Samsudin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733907

618 views

Review

Published on 09 Jan 2026

Modeling the pre-metastatic niche of gastric cancer peritoneal metastasis under spatiotemporal resolution and investigating EVs-mediated immune suppression

in Cancer Immunity and Immunotherapy

Xiang Zhang
Cheng Zhang
Zheng Zhang
Xuan Zhang
Kai Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1734244

1,470 views

Review

Published on 09 Jan 2026

Aberrant B cell responses as drivers of autoantibody generation and epitope diversification in SLE pathogenesis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Fareeha Tariq
Yathavi Charavanmuttu
Kazi Labiba
Chris Wincup

Frontiers in Immunology

doi 10.3389/fimmu.2025.1731285

2,053 views

Editorial

Published on 09 Jan 2026

Editorial: Epigenetic regulation of T cell function in type 1 diabetes

in T Cell Biology

Ubaid Ullah Kalim
Giuseppina Emanuela Grieco

Frontiers in Immunology

doi 10.3389/fimmu.2025.1773432

601 views

Original Research

Published on 09 Jan 2026

The efficacy and safety of tislelizumab combined with weekly nab-paclitaxel, carboplatin, and cetuximab as first-line treatment for recurrent or metastatic head and neck squamous cell carcinoma: a real-world study

in Cancer Immunity and Immunotherapy

Zhanyong Ouyang
Linting Zhang
Feng Wang
Meijing Chen
Boran Cheng
Fang Yang
Wenjuan Lai
Jing Gao
Shubin Wang
Gangling Tong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708410

1,014 views

Original Research

Published on 09 Jan 2026

Impact of preformed donor-specific anti-human leukocyte antigen antibodies on the clinical outcomes in pediatric liver transplantation patients: a retrospective cohort study

in Alloimmunity and Transplantation

Zhong-Yu Kang
Chun Liu
Wei Liu
Xueya Han
Daihong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703788

688 views

Review

Published on 09 Jan 2026

Fibroblast–immune crosstalk in oral squamous cell carcinoma: from tumor promotion to immune evasion

in Cancer Immunity and Immunotherapy

Xiao Liu
Dandan Wang
Xue Cheng
Yining Ma
Siya Li
Jinhai Deng
Chunyan Qiao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703277

1,055 views

Original Research

Published on 09 Jan 2026

Enhancing the tumoricidal efficacy of the nanobubbles-mediated PD-L1 inhibition and immunogenic cell death in mice

in Cancer Immunity and Immunotherapy

Yun Liu
Jiaxuan Han
Chaoqi Liu
Yezi Chen
Shiqi Yang
Yao Ma
Chang Zhou
Rong Liu
Yu Hu
Yun Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672324

853 views

Review

Published on 09 Jan 2026

PRMT3 at the crossroads of inflammation: dual roles in metabolic reprogramming and immune dysregulation in chronic diseases

in Molecular Innate Immunity

Huining Hou
Jiaojiao Meng
Yingqing Chen
Xili Zhang
Zhuqing Yang
Qianqian Wang
Min Zheng
Zebo Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663258

964 views

Original Research

Published on 09 Jan 2026

Liquid-liquid phase separation-driven molecular subtyping and prognostic modeling in colorectal cancer

in Cancer Immunity and Immunotherapy

Hui Guan
Chengzi Tian
Jiawen Lin
Lihuan Zhang
Run Shi
Wenjing Wang
Shuping Li
Yuan Sui
Yanwen Lu
Tianjiao Cui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1741979

864 views

Review

Published on 09 Jan 2026

Perspective of using in vitro models to understand immunotherapy-induced cytokine release syndrome

in Cancer Immunity and Immunotherapy

Ethan Perkins
Christopher Cooper
Emma Lund
Miriam Alb
Hannah Morgan
Birgit Fogal
Philip Hewitt
Alexander Mazein
Marek Ostaszewski
Katherina Sewald

Frontiers in Immunology

doi 10.3389/fimmu.2025.1732193

1,483 views

Review

Published on 09 Jan 2026

PANoptosis in urological diseases: molecular mechanisms, pathological roles, and emerging therapeutic opportunities

in Cancer Immunity and Immunotherapy

Xin Di
Xin Jin
Shuqiang Feng
Ranwei Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729348

920 views

Original Research

Published on 09 Jan 2026

Cadonilimab rechallenge in patients with recurrent or metastatic cervical cancer following prior PD-1/PD-L1 inhibitor failure: a retrospective multicenter study

in Cancer Immunity and Immunotherapy

Haijuan Yu
Jian Chen
Jie Lin
Lijun Chen
Jianping Zou
Bin Liu
Linying Liu
Ning Xie
Sufang Deng
Shengtao Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701319

950 views

Review

Published on 09 Jan 2026

Exploring cell death mechanisms in liver transplantation: implications for graft survival

in Inflammation

Hirofumi Hirao
Takeshi Watanabe
Yoichiro Uchida
Etsuro Hatano

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700382

957 views

Review

Published on 09 Jan 2026

Immunological mechanisms underlying fibrotic diseases via single-cell technologies

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Yuzo Koda
Nobuhiro Nakamoto
Takanori Kanai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720047

1,100 views

Review

Published on 09 Jan 2026

From arthritis to central sensitization: targeting the neuro-immune axis via microglial modulation in acupuncture treatment for Juvenile Idiopathic Arthritis–associated pain

in Multiple Sclerosis and Neuroimmunology

Hang Chen
Jixiang Xu
Xia Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684060

949 views

Original Research

Published on 09 Jan 2026

Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jiaqi Chen
Qiang Zhang
Zhenqiang Huang
Chunsheng Qu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679223

655 views

Original Research

Published on 09 Jan 2026

Risk factors for cancer and the importance of screening in adult recipients of living-donor kidney transplant

in Alloimmunity and Transplantation

Takahisa Hiramitsu
Yuki Shimamoto
Tomoki Himeno
Yuki Hasegawa
Kenta Futamura
Manabu Okada
Yutaka Matsuoka
Norihiko Goto
Toshihiro Ichimori
Shunji Narumi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1678309

766 views

Original Research

Published on 09 Jan 2026

Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation

in Molecular Innate Immunity

Min Chu
Ding Ma
Zhan Song
Li Liang
Fengjuan Xing
Hongchu Bao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671848

967 views

Original Research

Published on 09 Jan 2026

Prostate-specific membrane antigen targeted organic semiconducting polymer nanoparticles for enhanced photothermal therapy of prostate cancer

in Cancer Immunity and Immunotherapy

Zhongji Jiang
Xun Zhang
Gaohaer Kadeerhan
Jin Zhang
Jiali Jin
Weijing Hu
Wenmin Guo
Hong Guo
Dongwen Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688048

819 views