Frontiers in Immunology

Original Research

Published on 09 Jan 2026

Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jiaqi Chen
Qiang Zhang
Zhenqiang Huang
Chunsheng Qu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679223

666 views

Review

Published on 09 Jan 2026

PRMT3 at the crossroads of inflammation: dual roles in metabolic reprogramming and immune dysregulation in chronic diseases

in Molecular Innate Immunity

Huining Hou
Jiaojiao Meng
Yingqing Chen
Xili Zhang
Zhuqing Yang
Qianqian Wang
Min Zheng
Zebo Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663258

976 views

Review

Published on 09 Jan 2026

Advances in the identification of novel cell signatures in benign prostatic hyperplasia and prostate cancer using single-cell RNA sequencing

in Cancer Immunity and Immunotherapy

Yu Pan
Qingqing Song
Bingjie Lai
He Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684895

823 views

Review

Published on 09 Jan 2026

The research potential of A20 in psoriatic arthritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yixuan Wang Wan
Xiaoru Duan
Zilin Jin
Hongxiang Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1630198

857 views

Original Research

Published on 09 Jan 2026

Lung epithelial and alveolar macrophage-like cell interactions significantly modify innate responses to bacterial endotoxin with the involvement of direct cellular contacts, TNF-α, ICAM1 and MCP-1

in Inflammation

Connor Wood
Shagun Khera
Minjeong Woo
Vikram Sharma
Justyna Lopatecka
Frederic Coulon
Zaheer Nasir
Vincent Delorme
Simon K. Jackson
György Fejer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715943

1,293 views

Original Research

Published on 09 Jan 2026

Large-scale screening of HBV epitopes restricted by multiple prevalent HLA-B/C allotypes and routine detection of HBV-specific T cells in CHB patients

in Viral Immunology

Yandan Wu
Yu Zhao
Ruixue Ji
Pinqing Li
Huijuan Chen
Fangping Yue
Yi Wu
Jie Qiu
Chuanlai Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717543

598 views

Review

Published on 09 Jan 2026

Macrophage polarization in acute myocardial infarction: multidimensional regulation and emerging therapeutic opportunities

in Inflammation

Zilv Ye
Bo Wang
Zhengdong Wan
Jiawei Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710249

935 views

Original Research

Published on 09 Jan 2026

LILRB1 and LILRB2 genomics and transcriptomics in macaque and baboon species: polymorphism, diversification, and extensive alternative splicing

in Comparative Immunology

Natasja G. de Groot
Nanine de Groot
Corrine M. C. Heijmans
Annemiek J. M. de Vos-Rouweler
Marit K. H. van der Wiel
Jesse Bruijnesteijn

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706720

821 views

Original Research

Published on 09 Jan 2026

A novel non-invasive diagnostic approach based on urine and blood: a cross-sectional study combining lipoarabinomannan antigen and interferon-gamma release assay for active tuberculosis

in Microbial Immunology

Long Cai
Mingzhi Zhu
Tingting Fang
Qianqian Peng
Lingshan Dai
YanQin Shao
Libin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726930

984 views

Review

Published on 09 Jan 2026

Bromodomain and extra-terminal proteins in solid tumors: regulators of immune microenvironment and emerging therapeutic targets

in Cancer Immunity and Immunotherapy

Deeksha Sharma
Grace G. Bushnell
Alexander P. Kalman
Chloe M. Hutchens
Monika L. Burness

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727365

833 views

Review

Published on 09 Jan 2026

Viral glycoprotein-mediated entry and antibody-mediated immunity in HIV-1 and SARS-CoV-2 infection

in Viral Immunology

Michael W. Grunst
Wenwei Li
Walther Mothes

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733684

1,039 views

Review

Published on 09 Jan 2026

From innate-like to innate: the next wave of off-the-shelf CAR immunotherapies

in Cancer Immunity and Immunotherapy

Ying Feng
Zhibo Yang
Yueru Zhou
Ying Liang
Hai Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691743

1,006 views

Review

Published on 09 Jan 2026

Immunotherapy in endometrial cancer: mechanisms, clinical evidence, and future directions

in Cancer Immunity and Immunotherapy

Mengyi Lian
Chengwei Zhang
Tianye Li
Aiming Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697065

1,111 views

Review

Published on 09 Jan 2026

SLC30 (ZnT) and SLC39 (ZIP) zinc transporter families: from gatekeepers of zinc homeostasis to promoters of tumorigenesis and targets for clinical therapy

in Cancer Immunity and Immunotherapy

Yuqiao Zhou
Guangfa Huang
Mengling Liu
Minghui Zhang
Bowen Wu
Jinke Gu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1750534

1,304 views

Original Research

Accepted on 08 Jan 2026

Human Serum Influences Functional Plasticity and Transcriptomic Landscape of γδ T Cells In Vitro

in Cancer Immunity and Immunotherapy

Lorraine Pinot
Zhibek Zhumadilova
Aylin Sassor
Sagar Sagar
Jose Villacorta Hidalgo

Frontiers in Immunology

383 views

Original Research

Accepted on 08 Jan 2026

Proteomic profiling of circulating extracellular vesicles from COVID-19 patients and their impact on innate Vdelta2 T-cell response

in Viral Immunology

Raffaele Strippoli
Claudia Montaldo
Eleonora Cimini
Eleonora Tartaglia
Manuela Antonioli
Veronica Bordoni
Stefania Notari
Michela Notarangelo
Eleonora Torchia
Giulia Canarutto

Frontiers in Immunology

266 views

Original Research

Published on 08 Jan 2026

Extracellular CIRP augments inflammation in acute kidney injury via NKG2D-positive macrophages

in Inflammation

Fangming Zhang
Hui Jin
Chuyi Tan
Ping Wang
Max Brenner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703126

812 views

Original Research

Published on 08 Jan 2026

ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome

in Systems Immunology

Hyunsu Bong
Joonhong Min
Songhyeon Kim
Wootaek Lim
Dongyoung Lim
Hyunjeong Eom
Young Her
Minji Jeon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670993

1,140 views

Review

Published on 08 Jan 2026

Advances in the study of gut microecology and mechanisms of hyperuricemia and gouty arthritis

in Microbial Immunology

Youliang Zhang
Hengyu Zhang
Tianwen Miao
Xuetao Wang
Yanan Zuo
Renwei Zhang
Liangtong Zhang
Yuan Cheng
Dong Liu
Xin Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1738716

959 views

Original Research

Published on 08 Jan 2026

Integrating zinc homeostasis network and immune landscape: a five-gene prognostic framework for precision oncology in lung adenocarcinoma

in Cancer Immunity and Immunotherapy

Feng Cheng
Jinhe Xu
Wenting Zhang
Xinyu Zhang
Ying Chen
Nong Zhou
Chenxin Li
Zongyang Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691179

1,272 views

Systematic Review

Published on 08 Jan 2026

Insights into immunogenicity and therapeutic strategies to mitigate the immune response in infantile-onset Pompe disease: a comprehensive systematic literature review

in Immunological Tolerance and Regulation

Priya S. Kishnani
Johanna M. P. Van Den Hout
Andreas Hahn
David Kronn
Yin-Hsiu Chien
Mei Han
Jennifer Heuterman
Susan Sparks
Colin Glen
Nadia Daba

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690312

1,120 views
1 citation

Original Research

Published on 08 Jan 2026

Assessing the endothelium’s role in COVID-19 severity using the HUVEC model

in Inflammation

Sanzio Silva Santana
Sètondji Cocou Modeste Alexandre Yahouédéhou
Corynne Stéphanie Ahouéfa Adanho
Jéssica Rebouças Silva
Hayna Malta Santos
Cynara Gomes Barbosa
Thassila Nogueira Pitanga
Valéria Matos Borges
Vitor Fortuna
Isa Menezes Lyra

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689772

817 views

Original Research

Published on 08 Jan 2026

Antigen binding triggers long-range conformational changes in monoclonal antibodies

in Vaccines and Molecular Therapeutics

Davide Bianchi
Simona Saporiti
Wolf Palinsky
Omar Ben Mariem
Mara Rossi
Ivano Eberini
Fabio Centola

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680199

1,107 views

Perspective

Published on 08 Jan 2026

The oral-gut axis in chronic atrophic gastritis: current perspectives and integrated strategies

in Mucosal Immunity

Tianyue Zha
Yonggang Ding
Xingli Xu
Yifan Zhang
Jinwei Guo
Huinan Ge
Luzhou Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699501

1,739 views

49,602 articles

articles

Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model

PRMT3 at the crossroads of inflammation: dual roles in metabolic reprogramming and immune dysregulation in chronic diseases

Advances in the identification of novel cell signatures in benign prostatic hyperplasia and prostate cancer using single-cell RNA sequencing

The research potential of A20 in psoriatic arthritis

Lung epithelial and alveolar macrophage-like cell interactions significantly modify innate responses to bacterial endotoxin with the involvement of direct cellular contacts, TNF-α, ICAM1 and MCP-1

Large-scale screening of HBV epitopes restricted by multiple prevalent HLA-B/C allotypes and routine detection of HBV-specific T cells in CHB patients

Macrophage polarization in acute myocardial infarction: multidimensional regulation and emerging therapeutic opportunities

LILRB1 and LILRB2 genomics and transcriptomics in macaque and baboon species: polymorphism, diversification, and extensive alternative splicing

A novel non-invasive diagnostic approach based on urine and blood: a cross-sectional study combining lipoarabinomannan antigen and interferon-gamma release assay for active tuberculosis

Bromodomain and extra-terminal proteins in solid tumors: regulators of immune microenvironment and emerging therapeutic targets

Viral glycoprotein-mediated entry and antibody-mediated immunity in HIV-1 and SARS-CoV-2 infection

From innate-like to innate: the next wave of off-the-shelf CAR immunotherapies

Immunotherapy in endometrial cancer: mechanisms, clinical evidence, and future directions

SLC30 (ZnT) and SLC39 (ZIP) zinc transporter families: from gatekeepers of zinc homeostasis to promoters of tumorigenesis and targets for clinical therapy

Human Serum Influences Functional Plasticity and Transcriptomic Landscape of γδ T Cells In Vitro

Proteomic profiling of circulating extracellular vesicles from COVID-19 patients and their impact on innate Vdelta2 T-cell response

Extracellular CIRP augments inflammation in acute kidney injury via NKG2D-positive macrophages

ATOMIC: a graph attention network for atopic dermatitis prediction using human gut microbiome

Advances in the study of gut microecology and mechanisms of hyperuricemia and gouty arthritis

Integrating zinc homeostasis network and immune landscape: a five-gene prognostic framework for precision oncology in lung adenocarcinoma

Insights into immunogenicity and therapeutic strategies to mitigate the immune response in infantile-onset Pompe disease: a comprehensive systematic literature review

Assessing the endothelium’s role in COVID-19 severity using the HUVEC model

Antigen binding triggers long-range conformational changes in monoclonal antibodies

The oral-gut axis in chronic atrophic gastritis: current perspectives and integrated strategies