Frontiers in Immunology

Original Research

Published on 08 Jan 2026

Tumor mutational burden predicts neoantigen profiles and immunotherapy response in microsatellite stable tumors across different cancer types

in Cancer Immunity and Immunotherapy

Olesia Kondrateva
Tugce Bilgin Sonay
Inti Zlobec
Maria Anisimova

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582464

975 views

Original Research

Published on 08 Jan 2026

A fundamental relationship between TCR diversity, repertoire size and systemic clonal expansion: insights from 30,000 TCRβ repertoires

in Systems Immunology

H. Jabran Zahid
Damon May
Harlan Robins
Julia Greissl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707727

1,052 views

Original Research

Published on 08 Jan 2026

A lipid nanoparticle encapsulated CPA-CTD mRNA vaccine provides protection against Clostridium perfringens-driven diseases

in Comparative Immunology

Qi Jia
Haoyu Xiang
Ting Le
Jing Wang
Jitao Chang
Fang Wang
Chao Sun
Wanbo Tai
Zhigang Jiang
Xin Yin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1748171

1,038 views

Editorial

Published on 08 Jan 2026

Editorial: Crosstalk in tumor microenvironments: shaping early drug and immunotherapy strategies

in Cancer Immunity and Immunotherapy

Guendalina Froechlich
Alessandro Arcucci
Emanuele Sasso

Frontiers in Immunology

doi 10.3389/fimmu.2025.1754096

389 views

Original Research

Published on 08 Jan 2026

Octopamine modulates the innate immune response in Drosophila melanogaster

in Comparative Immunology

Karin Uliczka
Stephanie Papenmeier
Beate Höschler
Christina Wagner
Thomas Roeder
Holger Heine

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720126

776 views

Original Research

Published on 08 Jan 2026

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

in T Cell Biology

Emily C. Reed
Tatlock H. Lauten
Tamara Natour
Lauren J. Pitts
Caroline N. Jojo
Brooke L. Griffin
Sreeram Pasupuleti
Adam J. Case

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725904

838 views

Correction

Published on 08 Jan 2026

Correction: Association between statin use and immune-related adverse events in patients treated with immune checkpoint inhibitors: analysis of the FAERS database

in Cancer Immunity and Immunotherapy

Huaju Yang
Rendong Huang
Ping Zhang
Yingtong Liu
Zheran Liu
Jiagang He
Xingchen Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1768895

702 views

Original Research

Published on 08 Jan 2026

Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells

in Molecular Innate Immunity

Sadiq Umar
Huan T. Chang
Mark Maienschein-Cline
Sriram Ravindran

Frontiers in Immunology

doi 10.3389/fimmu.2025.1744393

1,062 views

Original Research

Published on 08 Jan 2026

Thyroid function and liver fibrosis: FT3 levels are inversely and independently correlated with enhanced liver fibrosis score in solid organ transplant patients with dysglycemia

in Alloimmunity and Transplantation

Claudia Leanza
Maria Ausilia Giusti
Vitale Miceli
Giovanni Zito
Rosaria Tinnirello
Gioacchin Iannolo
Antonio Galante
Fabrizio Emanuele
Marco Amato
Giovanna Lo Iacono

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726617

1,191 views

Original Research

Published on 08 Jan 2026

Pilot proteomic analysis of immune dysregulation in dengue with prior SARS-CoV-2 infection

in Viral Immunology

Elizabeth Cruz-Altamirano
Miguel Angel Mayoral-Chávez
Luis Román Ramírez-Palacios
Luz Maria Quirino-Vela
Diego Sait Cruz-Hernández
Sergio Roberto Aguilar-Ruíz
Juan Alpuche

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696179

1,015 views

Case Report

Published on 08 Jan 2026

B-cell–driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review

in Multiple Sclerosis and Neuroimmunology

Pietro Antonio Bruno
Stefania Barone
Angelo Pascarella
Pier Luigi Lanza
Emanuele Tinelli
Antonio Gambardella
Paola Valentino

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710669

1,106 views

Case Report

Published on 08 Jan 2026

Sequential anlotinib and camrelizumab combination therapy achieves exceptional survival in multi-driver mutated, TMB-low/PD-L1-low/MSS pulmonary sarcomatoid carcinoma: case report and literature review

in Cancer Immunity and Immunotherapy

Jun Zhu
Ai Zhu
Gang Li
Lidong Liu
Ziran Gao
Jiayun Liu
Yunfei Ye
Xunzhi Zhu
Yi Li
Hong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718918

890 views

Review

Published on 08 Jan 2026

Adenosine receptors on the immuno-oncology expressway: TIME, perspectives, and translation

in Cancer Immunity and Immunotherapy

Biswanath Majumder
Santanu Datta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676702

2,441 views

Review

Published on 08 Jan 2026

Recent advances in immunotherapy for gliomas: overcoming barriers and advancing precision strategies

in Cancer Immunity and Immunotherapy

Abdullah Jabri
Abdulaziz Mhannayeh
Bader Taftafa
Mohamed Alsharif
Dania Sibai
Raghad Alsharif
Tasnim Abbad
Abdulrahman Elsalti
Zara Ahmed
Jahan Salma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690464

1,355 views

Review

Published on 08 Jan 2026

Spatiotemporal dynamics of Brucella immune evasion across infection stages

in Microbial Immunology

Yu Su
Lihui Zhang
Ruihua Liu
Rina Sa
Lanbing Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707297

703 views

Clinical Trial

Published on 08 Jan 2026

Efficacy and safety of SMET12 in combination with toripalimab and chemotherapy in advanced non-small-cell lung cancer patients tested positive for EGFR protein who are treatment-naïve or harbor acquired resistance to standard therapy: a phase 2, multi-cohort clinical trial

in Cancer Immunity and Immunotherapy

Jinghui Lin
Shanshan Chen
Meifang Li
Lihong Weng
Haipeng Xu
Qiang Wang
Jing Zhang
Dong Lin
Haipo Wang
Qinying Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706961

1,502 views

Review

Accepted on 07 Jan 2026

Inflammation–Metabolism–Fibrosis Axis: Mechanisms and Therapeutic Strategies Targeting the Chronicity of Pelvic Inflammatory Disease

in Inflammation

Xiange Liu
Caixia zhu
Junjiang li
Li zhang
Wenxiang Yao

Frontiers in Immunology

206 views

Original Research

Published on 07 Jan 2026

Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation

in Inflammation

Yujing Yuan
Xinyu Zhang
Yawen Zhao
Yikang Wang
Jingyi Huang
Qingqing Wang
Xueqin Song
Jianwen Deng
Zhaoxia Wang
Yun Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706045

895 views

Review

Published on 07 Jan 2026

The cGAS-STING signaling pathway: emerging targets and challenges in breast cancer immunotherapy

in Cancer Immunity and Immunotherapy

Lei Sun
Jing Chen
Shiyan Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685931

1,331 views

Original Research

Published on 07 Jan 2026

Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2

in Viral Immunology

Luca Perico
Alessandra Bovio
Susanna Tomasoni
Piera Trionfini
Domenico Cerullo
Daniela Corna
Anna Pezzotta
Monica Locatelli
Marta Alberti
Ariela Benigni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706997

27,898 views

Original Research

Published on 07 Jan 2026

NOS2/ARG1 axis and immune cell ratios as promising prognostic and predictive biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer

in Cancer Immunity and Immunotherapy

Djehane Houria Mataam
Assia Galleze
Sarra Benkhelifa
Ryad Trari
Wafa Khelaifia
Said Belhadef
Sabrina Bouhara
Sonia Ait Younes
Anissa Benali
Hassan Mahfouf

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700487

2,013 views

Original Research

Published on 07 Jan 2026

Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma

in Cancer Immunity and Immunotherapy

Chunyan Feng
Yueyue Liu
Xinyue Zhong
Zhenzhen Wei
Hongjing Cui
Jianfeng Yi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692864

1,072 views

Review

Published on 07 Jan 2026

The role of interleukins in peripheral nerve injury and the current status of treatment

in Cytokines and Soluble Mediators in Immunity

Yue Shen
MingZhu Li
ShengBo Jin
ZiYang Yu
Qian Liu
HuiNi Yao
YuXin Jiang
JiaQing Fu
NingXin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691335

676 views

Brief Research Report

Published on 07 Jan 2026

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC

in Immunological Tolerance and Regulation

Gianpiero Lupoli
Stefano Bergamini
Jeannette Salsetta
Alessandro Mereu
Agata Cova
Elisa D’Angelo
Eriomina Shahaj
Elisabetta Vergani
Martina Stroscia
Emma Di Carlo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696460

1,181 views

49,662 articles

articles

Tumor mutational burden predicts neoantigen profiles and immunotherapy response in microsatellite stable tumors across different cancer types

A fundamental relationship between TCR diversity, repertoire size and systemic clonal expansion: insights from 30,000 TCRβ repertoires

A lipid nanoparticle encapsulated CPA-CTD mRNA vaccine provides protection against Clostridium perfringens-driven diseases

Editorial: Crosstalk in tumor microenvironments: shaping early drug and immunotherapy strategies

Octopamine modulates the innate immune response in Drosophila melanogaster

Hemoglobin alpha regulates T-lymphocyte activation and mitochondrial function

Correction: Association between statin use and immune-related adverse events in patients treated with immune checkpoint inhibitors: analysis of the FAERS database

Modulation of IRAK4 as a therapeutic strategy against monosodium urate- and xanthine-induced inflammation in macrophages and HepG2 cells

Thyroid function and liver fibrosis: FT3 levels are inversely and independently correlated with enhanced liver fibrosis score in solid organ transplant patients with dysglycemia

Pilot proteomic analysis of immune dysregulation in dengue with prior SARS-CoV-2 infection

B-cell–driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review

Sequential anlotinib and camrelizumab combination therapy achieves exceptional survival in multi-driver mutated, TMB-low/PD-L1-low/MSS pulmonary sarcomatoid carcinoma: case report and literature review

Adenosine receptors on the immuno-oncology expressway: TIME, perspectives, and translation

Recent advances in immunotherapy for gliomas: overcoming barriers and advancing precision strategies

Spatiotemporal dynamics of Brucella immune evasion across infection stages

Efficacy and safety of SMET12 in combination with toripalimab and chemotherapy in advanced non-small-cell lung cancer patients tested positive for EGFR protein who are treatment-naïve or harbor acquired resistance to standard therapy: a phase 2, multi-cohort clinical trial

Inflammation–Metabolism–Fibrosis Axis: Mechanisms and Therapeutic Strategies Targeting the Chronicity of Pelvic Inflammatory Disease

Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation

The cGAS-STING signaling pathway: emerging targets and challenges in breast cancer immunotherapy

Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2

NOS2/ARG1 axis and immune cell ratios as promising prognostic and predictive biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer

Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma

The role of interleukins in peripheral nerve injury and the current status of treatment

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC