Frontiers in Immunology

Case Report

Published on 08 Jan 2026

Sequential anlotinib and camrelizumab combination therapy achieves exceptional survival in multi-driver mutated, TMB-low/PD-L1-low/MSS pulmonary sarcomatoid carcinoma: case report and literature review

in Cancer Immunity and Immunotherapy

Jun Zhu
Ai Zhu
Gang Li
Lidong Liu
Ziran Gao
Jiayun Liu
Yunfei Ye
Xunzhi Zhu
Yi Li
Hong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718918

890 views

Review

Published on 08 Jan 2026

Adenosine receptors on the immuno-oncology expressway: TIME, perspectives, and translation

in Cancer Immunity and Immunotherapy

Biswanath Majumder
Santanu Datta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1676702

2,441 views

Review

Published on 08 Jan 2026

Recent advances in immunotherapy for gliomas: overcoming barriers and advancing precision strategies

in Cancer Immunity and Immunotherapy

Abdullah Jabri
Abdulaziz Mhannayeh
Bader Taftafa
Mohamed Alsharif
Dania Sibai
Raghad Alsharif
Tasnim Abbad
Abdulrahman Elsalti
Zara Ahmed
Jahan Salma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690464

1,355 views

Review

Published on 08 Jan 2026

Spatiotemporal dynamics of Brucella immune evasion across infection stages

in Microbial Immunology

Yu Su
Lihui Zhang
Ruihua Liu
Rina Sa
Lanbing Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707297

703 views

Clinical Trial

Published on 08 Jan 2026

Efficacy and safety of SMET12 in combination with toripalimab and chemotherapy in advanced non-small-cell lung cancer patients tested positive for EGFR protein who are treatment-naïve or harbor acquired resistance to standard therapy: a phase 2, multi-cohort clinical trial

in Cancer Immunity and Immunotherapy

Jinghui Lin
Shanshan Chen
Meifang Li
Lihong Weng
Haipeng Xu
Qiang Wang
Jing Zhang
Dong Lin
Haipo Wang
Qinying Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706961

1,502 views

Review

Accepted on 07 Jan 2026

Inflammation–Metabolism–Fibrosis Axis: Mechanisms and Therapeutic Strategies Targeting the Chronicity of Pelvic Inflammatory Disease

in Inflammation

Xiange Liu
Caixia zhu
Junjiang li
Li zhang
Wenxiang Yao

Frontiers in Immunology

206 views

Original Research

Published on 07 Jan 2026

Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation

in Inflammation

Yujing Yuan
Xinyu Zhang
Yawen Zhao
Yikang Wang
Jingyi Huang
Qingqing Wang
Xueqin Song
Jianwen Deng
Zhaoxia Wang
Yun Yuan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706045

895 views

Review

Published on 07 Jan 2026

The cGAS-STING signaling pathway: emerging targets and challenges in breast cancer immunotherapy

in Cancer Immunity and Immunotherapy

Lei Sun
Jing Chen
Shiyan Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685931

1,331 views

Original Research

Published on 07 Jan 2026

Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2

in Viral Immunology

Luca Perico
Alessandra Bovio
Susanna Tomasoni
Piera Trionfini
Domenico Cerullo
Daniela Corna
Anna Pezzotta
Monica Locatelli
Marta Alberti
Ariela Benigni

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706997

27,898 views

Original Research

Published on 07 Jan 2026

NOS2/ARG1 axis and immune cell ratios as promising prognostic and predictive biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer

in Cancer Immunity and Immunotherapy

Djehane Houria Mataam
Assia Galleze
Sarra Benkhelifa
Ryad Trari
Wafa Khelaifia
Said Belhadef
Sabrina Bouhara
Sonia Ait Younes
Anissa Benali
Hassan Mahfouf

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700487

2,013 views

Original Research

Published on 07 Jan 2026

Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma

in Cancer Immunity and Immunotherapy

Chunyan Feng
Yueyue Liu
Xinyue Zhong
Zhenzhen Wei
Hongjing Cui
Jianfeng Yi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692864

1,072 views

Review

Published on 07 Jan 2026

The role of interleukins in peripheral nerve injury and the current status of treatment

in Cytokines and Soluble Mediators in Immunity

Yue Shen
MingZhu Li
ShengBo Jin
ZiYang Yu
Qian Liu
HuiNi Yao
YuXin Jiang
JiaQing Fu
NingXin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691335

676 views

Brief Research Report

Published on 07 Jan 2026

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC

in Immunological Tolerance and Regulation

Gianpiero Lupoli
Stefano Bergamini
Jeannette Salsetta
Alessandro Mereu
Agata Cova
Elisa D’Angelo
Eriomina Shahaj
Elisabetta Vergani
Martina Stroscia
Emma Di Carlo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696460

1,181 views

Review

Published on 07 Jan 2026

Post-translational modification of NK cell receptors offers clues to antigenic specificity riddle

in Immunological Memory

Maria O. Ustiuzhanina
Elena I. Kovalenko
Dmitry M. Chudakov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671844

1,079 views

Editorial

Published on 07 Jan 2026

Editorial: Cell-mediated innate immunity in aquatic invertebrates and fish: what’s new?

in Comparative Immunology

Maria Rosaria Coscia
Rita Marino
Daniela Melillo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1749877

951 views

Review

Published on 07 Jan 2026

Enzymatic and microenvironmental regulation in adenosine metabolism-mediated immunosuppression

in Cancer Immunity and Immunotherapy

Chuang Li
Lifeng Chen
Zhihao Li
Ling Liang
Benyong Lou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739983

646 views

Review

Published on 07 Jan 2026

Double, double toil and trouble: transforming growth factor beta (TGF-β) in HIV infection

in Viral Immunology

Jakob Harrison-Gleason
Kayla L. Yerlioglu
Ariel W. Halle
Judd F. Hultquist
Elena Martinelli

Frontiers in Immunology

doi 10.3389/fimmu.2025.1738092

1,186 views

Editorial

Published on 07 Jan 2026

Editorial: Deciphering cell-cell interactions in triple-negative breast cancer

in Cancer Immunity and Immunotherapy

Xue Yang
Lvyun Zhu
Xingrui Li
Yaying Du

Frontiers in Immunology

doi 10.3389/fimmu.2025.1766856

614 views

Case Report

Published on 07 Jan 2026

Case Report: Guillain−Barré syndrome temporally associated with levofloxacin exposure and improvement following efgartigimod treatment

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Shiyuan Xie
Yueling Zhang
Feng Shen
Lining Wu
Yunxia Tang
Jun Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729694

1,083 views

Original Research

Published on 07 Jan 2026

Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis

in Inflammation

Yueyan Yang
Shihua Deng
Teng Liu
Qing Yin
Min Yang
Xintao Zhang
Zhongyong Jiang
Xiaobian Wang
Sunhan Zhang
Ting Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720843

970 views

Original Research

Published on 07 Jan 2026

The relationship of chemokine levels and the type of symptoms caused by NSAIDs or alcohol in patients with NSAIDs-exacerbated respiratory disease

in Cytokines and Soluble Mediators in Immunity

Karolina Frachowicz-Guerreiro
Adrian Gajewski
Maciej Chałubiński
Aleksandra Wardzyńska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722171

801 views

Editorial

Published on 07 Jan 2026

Editorial: Methods in primary immunodeficiencies: 2022

in Primary Immunodeficiencies

Emily S. J. Edwards

Frontiers in Immunology

doi 10.3389/fimmu.2025.1768176

592 views

Original Research

Published on 07 Jan 2026

m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis

in Cancer Immunity and Immunotherapy

Ana Belén Moreno-Castaño
Sara Fernández
Helena Brillembourg
Gontzal Iraola
David F Moreno
Helena Ventosa-Capell
Julia Martinez-Sanchez
Blanca De Moner
Patricia Molina
Alex Ramos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664788

1,220 views

Mini Review

Published on 07 Jan 2026

Molecular mechanisms of streptococcal disruption of the blood-brain barrier and their pathogenic role in bacterial meningitis

in Inflammation

Yumei Shi
Tao Liang
Chao Shi
Benhai Yao
Bo Xiong
Jun Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628503

815 views

49,699 articles

articles

Sequential anlotinib and camrelizumab combination therapy achieves exceptional survival in multi-driver mutated, TMB-low/PD-L1-low/MSS pulmonary sarcomatoid carcinoma: case report and literature review

Adenosine receptors on the immuno-oncology expressway: TIME, perspectives, and translation

Recent advances in immunotherapy for gliomas: overcoming barriers and advancing precision strategies

Spatiotemporal dynamics of Brucella immune evasion across infection stages

Efficacy and safety of SMET12 in combination with toripalimab and chemotherapy in advanced non-small-cell lung cancer patients tested positive for EGFR protein who are treatment-naïve or harbor acquired resistance to standard therapy: a phase 2, multi-cohort clinical trial

Inflammation–Metabolism–Fibrosis Axis: Mechanisms and Therapeutic Strategies Targeting the Chronicity of Pelvic Inflammatory Disease

Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation

The cGAS-STING signaling pathway: emerging targets and challenges in breast cancer immunotherapy

Acetylsalicylic acid disrupts SARS-CoV-2 spike protein glycosylation and selectively impairs binding to ACE2

NOS2/ARG1 axis and immune cell ratios as promising prognostic and predictive biomarkers for Cetuximab combined with chemotherapy in wt-KRAS human colorectal cancer

Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma

The role of interleukins in peripheral nerve injury and the current status of treatment

Pazopanib-associated remodeling of platelet-immune cell crosstalk and immune suppressive platelet-derived extracellular vesicles in metastatic RCC

Post-translational modification of NK cell receptors offers clues to antigenic specificity riddle

Editorial: Cell-mediated innate immunity in aquatic invertebrates and fish: what’s new?

Enzymatic and microenvironmental regulation in adenosine metabolism-mediated immunosuppression

Double, double toil and trouble: transforming growth factor beta (TGF-β) in HIV infection

Editorial: Deciphering cell-cell interactions in triple-negative breast cancer

Case Report: Guillain−Barré syndrome temporally associated with levofloxacin exposure and improvement following efgartigimod treatment

Farrerol inhibits ferroptosis and protects against LPS-induced acute lung injury by targeting the RUNX1/SLC7A11 axis

The relationship of chemokine levels and the type of symptoms caused by NSAIDs or alcohol in patients with NSAIDs-exacerbated respiratory disease

Editorial: Methods in primary immunodeficiencies: 2022

m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis

Molecular mechanisms of streptococcal disruption of the blood-brain barrier and their pathogenic role in bacterial meningitis