Frontiers in Immunology

Original Research

Published on 07 Jan 2026

Active LXR signaling, coupled with elevated mitochondrial and glycolytic metabolism contributes to GM-CSF–induced trained immunity

in Immunological Memory

Yuanyuan Liu
Arslan Hamid
Hannah Hardege
Qian Zhang
Helena Körner
Merle Leffers
Noelia A. Gonzalez
Gerhard Liebisch
Marcus Hoering
Hannes Findeisen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685796

1,469 views

Original Research

Published on 07 Jan 2026

Dietary antigens drive the generation of functional cytotoxic intraepithelial lymphocytes for early defense against foodborne pathogens

in Mucosal Immunity

Jisun Jung
Jaeu Yi
Kwang Soon Kim
Charles D. Surh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639120

1,099 views

Original Research

Published on 07 Jan 2026

Nuclear cell-free DNA on the loose: an early warning signal of ischemia–reperfusion injury in kidney transplantation

in Alloimmunity and Transplantation

Gabriel Strandberg
Rebecca Trattner
Myriam Martin
Carl M. Öberg
Carl Raihle
Oleg Slivca
Shahnawaz Alam
Mårten Segelmark
Anders Christensson
Bo Nilsson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704152

1,032 views

Review

Published on 07 Jan 2026

Ferroptosis-immune-metabolic axis in asthma: mechanistic crosstalk, endotype-specific regulation, and translational targeting

in Molecular Innate Immunity

Feng-Xian Ni
Jie Hu
Pei-Sheng Chen
Hui-Hui Chen
Dong-Hui Huang
Ze-Bo Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1714608

1,421 views

Case Report

Published on 07 Jan 2026

Telitacicept for systemic lupus erythematosus-associated peripheral neuropathy: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Jinhui Tan
Hai Huang
Linghua Tan
Bo Li
Ximei Wu
Ruonan She
Junjia Luo
Haitao Yang
Haoru Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715983

1,028 views

Systematic Review

Published on 07 Jan 2026

Interventional effects of mesenchymal stem cells on epithelial–mesenchymal transition in head and neck squamous cell carcinoma and underlying mechanisms: a systematic review and meta-analysis of in vitro studies

in Cancer Immunity and Immunotherapy

Youhu Wang
Yanli Liu
Wanxian Du
Jing Xue
Jianhua Ruan
Juan Yu
Bin Ma
Xun Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705852

945 views

Original Research

Published on 07 Jan 2026

Tuft cell cysteinyl leukotrienes are necessary for rhinovirus-induced mucus metaplasia, type 2 inflammation and airway hyperresponsiveness in immature mice

in Mucosal Immunity

De’Jana T. Parker
J. Kelley Bentley
Jing Lei
Baljeet Domala
Hannah L. Briggs
Shilpi Singh
Yiran Li
M. Claire Reiner
Derek A. Flores
Alex L. Sliwicki

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709008

981 views

Original Research

Published on 07 Jan 2026

Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics

in Inflammation

Martina Bartolucci
Olga Utyro
Anita Muraglia
Alessia Repetto
Vanessa Agostini
Monica Pizzonia
Silvia Ottaviani
Gino Tripodi
Gilberto Filaci
Ranieri Cancedda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695213

958 views

Original Research

Published on 07 Jan 2026

Terrible APS — a newly defined variant of severe APS

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Stanley Niznik
Tania Zaher
Soad Haj Yehia
Ronen Shavit
Shiri Weinstein
Yulia Lifshitz
Nancy Agmon-Levin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721515

741 views

Correction

Published on 07 Jan 2026

Correction: Tumor-penetrating peptide boosts bispecific T-cell engager antitumor efficacy for the pancreatic cancer

in Cancer Immunity and Immunotherapy

Lu Zou
Jingjing Chen
Xinyuan Bai
Yingxin Wang
Changchang Lu
Qiaoli Wang
Subiyinuer Tuerhong
Mengzhu Li
Qinghua Zheng
Fanyan Meng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1772783

527 views

Original Research

Published on 07 Jan 2026

NDUFS4, a mitochondrial complex I subunit, is essential for T-cell metabolic fitness and immune function

in T Cell Biology

Oded Shamriz
Zahala Bar-On
Omri Yosef
Leonor Cohen-Daniel
Ayelet Sheer
Or Reuven
Wajeeh Salaymeh
Amijai Saragovi
Raz Somech
Atar Lev

Frontiers in Immunology

doi 10.3389/fimmu.2025.1734203

1,235 views

Review

Published on 07 Jan 2026

When viral infections meet the anti-MDA5 antibody-positive dermatomyositis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Shuzi Liu
Zheng Zhao
Yabin Li
Yao Tan
Huabin Tian
Fei Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1649489

1,125 views

Systematic Review

Published on 07 Jan 2026

Efficacy and safety of PARP inhibitors in advanced or recurrent endometrial cancer: a systematic review and meta-analysis

in Cancer Immunity and Immunotherapy

Huanhuan Zhang
Guangwei Yan
Jinxiang Yan
Xianxu Zeng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659650

1,013 views

Original Research

Accepted on 06 Jan 2026

Targeting the Proline-Glycine-Proline-Protease Feed-Forward Loop Attenuates Primary Graft Dysfunction after Lung Transplantation

in Alloimmunity and Transplantation

Yasufumi Goda
Stefi Lee
Adya Chawda
XX Xu
Mohd Moin Khan
Gary Visner Do
Amit Gaggar
Antonio Coppolino
Gabriel Loor
Mudassir Banday

Frontiers in Immunology

304 views

Review

Published on 06 Jan 2026

Tumor heterogeneity assessment using single-cell RNA sequencing (scRNA-seq): applications in lung cancer for diagnosis and treatment

in Cancer Immunity and Immunotherapy

Cecilia Bica
Oana Zanoaga
Laura Pop
Cristina Ciocan
Lajos Raduly
Andreea Nuțu
Ioana Berindan-Neagoe
Andreas Bender

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693784

1,596 views

Systematic Review

Published on 06 Jan 2026

Tislelizumab efficacy and safety compared to other anti–PD-1s: a network meta-analysis of first-line therapies for unresectable, locally advanced or metastatic esophageal squamous cell carcinoma

in Cancer Immunity and Immunotherapy

Jaffer A. Ajani
Elizabeth Smyth
David Tougeron
Hyun Ae Jung
Wenxi Tang
Jason Steenkamp
Emily Prentiss
JeanPierre Coaquira Castro
Kirk Szafranski
Lin Zhan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657085

1,983 views

Original Research

Published on 06 Jan 2026

Host-membrane lipid composition controls Cryptococcus neoformans cellular targets

in Microbial Immunology

Aswathi I. Ramesh
Sumukha Hegde
Aarsh Mahendra Dabhi
Sriram Krishnamurthy
Divya Chandran
Shivakumar K. Reddy
Prakash Peralam Yegneswaran
Kavitha Saravu
P.V. Mallikarjuna
Kavitha S. Shettigar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1687068

1,707 views

Review

Published on 06 Jan 2026

The endothelial-immunothrombotic storm in viral sepsis: lessons from COVID-19

in Viral Immunology

Kaihuan Zhou
Yin Chen
Jielong Pang
Jianfeng Zhang
Junyu Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681764

1,201 views
1 citation

Correction

Published on 06 Jan 2026

Correction: High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

in Comparative Immunology

Myung-Chul Kim
Taeeun Gu
Hyeewon Seo
Yewon Moon
Nicholas Borcherding
Ryan Kolb
Yubin Kim
Youngmin Yun
Woo-Jin Song
Chung-Young Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1773404

673 views

Editorial

Published on 06 Jan 2026

Editorial: Advances in skin immunology

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Olga Simionescu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1755100

1,041 views

Mini Review

Published on 06 Jan 2026

Neurotrophin NGF/TrkA and BDNF/TrkB signaling orchestrates the immune microenvironment in osteosarcoma

in Cancer Immunity and Immunotherapy

Hongyuan Liu
Guobing Wang
Chunxue Wang
Dan Hou
Shigang Li
Yuansheng Fan
Bing Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727434

1,316 views

Review

Published on 06 Jan 2026

The role of immunoglobulin E in non-atopic disorders

in Cytokines and Soluble Mediators in Immunity

Kujtim Thaçi
Aron Gyorgypal
Robert M. Anthony
Michelle E. Conroy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728940

1,518 views

Systematic Review

Published on 06 Jan 2026

The addition of CD38 monoclonal antibody to triplet regimens improves survival in newly diagnosed multiple myeloma with high-risk cytogenetics: a systematic review and meta-analysis of randomized controlled trials

in Cancer Immunity and Immunotherapy

Bin Hu
Dan Fang
Ling Jiang
Tianqi Li
Kexia Chen
Jinxia Cao
Jun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1744165

1,208 views

Original Research

Published on 06 Jan 2026

Dysregulated Tfh/B cells and their interactions in neuromyelitis optica spectrum disorder

in Multiple Sclerosis and Neuroimmunology

Liang Wang
Lei Zhou
Zhouzhou Wang
Jingzi ZhangBao
Wenjuan Huang
Hongmei Tan
Yuxin Fan
Chuanzhen Lu
Jian Yu
Min Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704282

1,043 views

49,701 articles

articles

Active LXR signaling, coupled with elevated mitochondrial and glycolytic metabolism contributes to GM-CSF–induced trained immunity

Dietary antigens drive the generation of functional cytotoxic intraepithelial lymphocytes for early defense against foodborne pathogens

Nuclear cell-free DNA on the loose: an early warning signal of ischemia–reperfusion injury in kidney transplantation

Ferroptosis-immune-metabolic axis in asthma: mechanistic crosstalk, endotype-specific regulation, and translational targeting

Telitacicept for systemic lupus erythematosus-associated peripheral neuropathy: a case report

Interventional effects of mesenchymal stem cells on epithelial–mesenchymal transition in head and neck squamous cell carcinoma and underlying mechanisms: a systematic review and meta-analysis of in vitro studies

Tuft cell cysteinyl leukotrienes are necessary for rhinovirus-induced mucus metaplasia, type 2 inflammation and airway hyperresponsiveness in immature mice

Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics

Terrible APS — a newly defined variant of severe APS

Correction: Tumor-penetrating peptide boosts bispecific T-cell engager antitumor efficacy for the pancreatic cancer

NDUFS4, a mitochondrial complex I subunit, is essential for T-cell metabolic fitness and immune function

When viral infections meet the anti-MDA5 antibody-positive dermatomyositis

Efficacy and safety of PARP inhibitors in advanced or recurrent endometrial cancer: a systematic review and meta-analysis

Targeting the Proline-Glycine-Proline-Protease Feed-Forward Loop Attenuates Primary Graft Dysfunction after Lung Transplantation

Tumor heterogeneity assessment using single-cell RNA sequencing (scRNA-seq): applications in lung cancer for diagnosis and treatment

Tislelizumab efficacy and safety compared to other anti–PD-1s: a network meta-analysis of first-line therapies for unresectable, locally advanced or metastatic esophageal squamous cell carcinoma

Host-membrane lipid composition controls Cryptococcus neoformans cellular targets

The endothelial-immunothrombotic storm in viral sepsis: lessons from COVID-19

Correction: High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

Editorial: Advances in skin immunology

Neurotrophin NGF/TrkA and BDNF/TrkB signaling orchestrates the immune microenvironment in osteosarcoma

The role of immunoglobulin E in non-atopic disorders

The addition of CD38 monoclonal antibody to triplet regimens improves survival in newly diagnosed multiple myeloma with high-risk cytogenetics: a systematic review and meta-analysis of randomized controlled trials

Dysregulated Tfh/B cells and their interactions in neuromyelitis optica spectrum disorder