Frontiers in Immunology

Original Research

Published on 06 Jan 2026

Lysophosphatidic acid: a promising biomarker for diagnosing sepsis and predicting in-hospital mortality

in Cytokines and Soluble Mediators in Immunity

Xiaojuan Li
Tiewei Li
Pengfei Xuan
Hongyan Wang
Jingping Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725394

603 views

Review

Published on 06 Jan 2026

PCV20 in pediatric pneumococcal prevention: expanded coverage, remaining challenges

in Vaccines and Molecular Therapeutics

Nicola Principi
Alberto Argentiero
Beatrice Campana
Susanna Esposito

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707345

1,305 views

Original Research

Published on 06 Jan 2026

Efficacy of neoadjuvant immunochemotherapy in locally advanced esophageal squamous cell carcinoma: a prospective cohort study with propensity-score matching

in Cancer Immunity and Immunotherapy

Shifa Zhang
Anhao Hu
Jiuhe Sun
Yutao Wei
Jishan Zhang
Haibo Cai
Gongchao Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711095

720 views

Case Report

Published on 06 Jan 2026

Case Report: Refractory hidradenitis suppurativa complicated by IgA vasculitis with nephritis: successful long-term control with surgery and bimekizumab

in Inflammation

Ayaka Yasuda
Natsuko Sasaki
Emi Hasegawa
Yu Sawada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721038

1,108 views

Original Research

Published on 06 Jan 2026

Decoding HSP90AA1-driven inflammatory signaling in the uveal melanoma microenvironment: an integrated analysis at single-cell resolution

in Cancer Immunity and Immunotherapy

Yiya Wang
Ziqiu Hu
Min Zhou
Peng Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1730622

886 views

Mini Review

Published on 06 Jan 2026

Roles of immunosuppressive myeloid states in colorectal cancer checkpoint inhibitor non-response: single-cell and spatial proteomics, and reprogramming approaches

in Cancer Immunity and Immunotherapy

Yu Dai
Xinyu Luo
Li Zhang
Jin Yan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1742654

1,566 views

Original Research

Published on 06 Jan 2026

From hypereosinophilia to hypereosinophilic syndrome: real-world application of a two-tailed approach for HES diagnosis

in Inflammation

Stefania Nicola
Richard Borrelli
Irene Ridolfi
Luca Lo Sardo
Simone Negrini
Monica Fornero
Nicolò Rashidy
Federica Corradi
Iuliana Badiu
Eleonora Cerutti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735131

1,019 views

Review

Published on 06 Jan 2026

The pro-tumorigenic roles of granzyme B: mechanisms and therapeutic implications

in Cancer Immunity and Immunotherapy

Yubi Zhang
Han Huang
Linjun Xie
Chunhong Li
Xiangyu Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1733793

982 views

Original Research

Published on 06 Jan 2026

Dual role of ACE2 in regulating inflammation triggered by Omicron S1 and other SARS-CoV-2 Spike variants

in Molecular Innate Immunity

Annamaria Pedoto
Juan M. Lozano-Gil
María Ocaña-Esparza
Ana M. Conesa-Hernández
Sergio Candel
María L. Cayuela
Victoriano Mulero
Sylwia D. Tyrkalska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667880

1,011 views

Original Research

Published on 06 Jan 2026

Integration of single cell and bulk transcriptomic analyses identifies FAM189A2 as a key prognostic gene in lung cancer

in Cancer Immunity and Immunotherapy

Peng Guo
Mengqi Xiang
Jing Chen
Huachuan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701806

1,333 views

Correction

Published on 06 Jan 2026

Correction: Lactobacillus amplifies DHAMaR1 conversion to attenuate intestinal ischemia-reperfusion injury via decreasing pyroptosis

in Mucosal Immunity

Tong Li
Hongxing Cai
Chenghao Qiu
Jianbo Zhang
Shiji Zhou
Peng Zhu
Wenjing Xian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1769659

595 views

Editorial

Published on 06 Jan 2026

Editorial: Community series: systemic vasculitis: advances in pathogenesis and therapies, volume II

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Alexandre Wagner Silva De Souza
Joshua Daniel Ooi
Jun Deng
Stefania Croci
Poh-Yi Gan
Kelly L Brown

Frontiers in Immunology

doi 10.3389/fimmu.2025.1766442

846 views

Editorial

Published on 06 Jan 2026

Editorial: Community series in recent advances in potential biomarkers for rheumatic diseases and in cell-based therapies in the management of inflammatory rheumatic diseases, volume III

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Eric Toussirot
Katarzyna Bogunia-Kubik
Philippe Saas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1771049

397 views

Brief Research Report

Published on 06 Jan 2026

Glycolytic reprogramming of resident alveolar macrophages contributes to reduced SOCS3 secretion in non-small cell lung cancer

in Cancer Immunity and Immunotherapy

Jennifer M. Speth
Mikel D. Haggadone
Marc Peters-Golden

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708467

998 views

Original Research

Published on 06 Jan 2026

Fusobacterium nucleatum drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn’s disease

in Inflammation

Mingyuan Wang
Junjian Sun
Jiang Yu
Jiayun Wang
Chenjing Xu
Jingjing Ma
Hongjie Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712971

882 views

Original Research

Published on 06 Jan 2026

Real-world efficacy and safety of disitamab vedotin monotherapy or in combination with PD-1 inhibitors in locally advanced or metastatic upper tract urothelial carcinoma: a multicenter retrospective study

in Cancer Immunity and Immunotherapy

Shuaipeng He
Cheng Wang
Xuan Li
Can Li
Dan Li
Biao Zhang
Jianghou Wan
Zhongjin Yue
Gongjin Wu
Su Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699538

1,088 views

Original Research

Published on 06 Jan 2026

Revealing intra-group immunotherapy response heterogeneity in metastatic urothelial carcinoma through interpretable feature extraction and spectral clustering

in Cancer Immunity and Immunotherapy

Yoshiyuki Nagumo
Xiucai Ye
Tianyi Shi
Bryan J. Mathis
Tetsuya Sakurai
Hiroyuki Nishiyama

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629001

910 views

Editorial

Published on 06 Jan 2026

Editorial: Unveiling the next generation of cancer immunity & immunotherapy

in Cancer Immunity and Immunotherapy

Mohanraj Sadasivam
Nethaji Muniraj
Chellappagounder Thangavel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1769324

1,062 views

Original Research

Published on 06 Jan 2026

Gender-based differences in telomere attrition and long-term respiratory dysfunction in COVID-19 ICU survivors one year post-infection: implications for aging-associated pulmonary decline

in Cytokines and Soluble Mediators in Immunity

Raquel Behar-Lagares
Ana Virseda-Berdices
Óscar Martínez-González
Rafael Blancas
Eva Manteiga
Paula Muñoz-García
María J. Mallol Poyato
Jorge Molina del Pozo
Marcela Homez-Guzmán
María A. Alonso Fernández

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681454

1,589 views

Mini Review

Published on 06 Jan 2026

Natural killer cell exhaustion in ovarian cancer: from molecular suppression to therapeutic revival

in Cancer Immunity and Immunotherapy

Jun Ning
Lan Yao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709075

849 views

Original Research

Published on 06 Jan 2026

Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer

in Cancer Immunity and Immunotherapy

Xinyu Liu
Bingyao Liu
Yuhao Tong
Xingyu Zhu
Yaodong Sang
Feng Gao
Xiangyun Niu
Youyong Tang
Kang Xu
Hao Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1744719

833 views

Original Research

Published on 06 Jan 2026

A novel liquid-liquid phase separation related gene signature including ARL6IP4 predicts prognosis and immune landscape in colorectal cancer

in Cancer Immunity and Immunotherapy

Tao Jiang
Yuqiu Li
Ning Ma
Junnan Chen
Hu Song
Yixin Xu
Jun Song

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694377

1,069 views

Case Report

Published on 06 Jan 2026

TAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Ahmad Wael Sultan
Eva Grießhammer
Carl Hinrichs
Lars Trenkmann
Ilske Oschlies
Leif Gunnar Hanitsch
Hildrun Haibel
Thomas Schneider
Rasmus Leistner

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729525

1,080 views

Original Research

Published on 06 Jan 2026

Ulcerative colitis model triggers gut α-Synuclein aggregation without brain involvement or neuronal loss in female rats

in Microbial Immunology

Ana María Espinosa-Oliva
María Dolores Vázquez-Carretero
Rocío Ruiz
María A. Roca-Ceballos
Pablo García-Miranda
María José Peral
Manuel Sarmiento Soto
Antonio J. Herrera
José Luis Venero
Rocío M. de Pablos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637548

864 views

49,701 articles

articles

Lysophosphatidic acid: a promising biomarker for diagnosing sepsis and predicting in-hospital mortality

PCV20 in pediatric pneumococcal prevention: expanded coverage, remaining challenges

Efficacy of neoadjuvant immunochemotherapy in locally advanced esophageal squamous cell carcinoma: a prospective cohort study with propensity-score matching

Case Report: Refractory hidradenitis suppurativa complicated by IgA vasculitis with nephritis: successful long-term control with surgery and bimekizumab

Decoding HSP90AA1-driven inflammatory signaling in the uveal melanoma microenvironment: an integrated analysis at single-cell resolution

Roles of immunosuppressive myeloid states in colorectal cancer checkpoint inhibitor non-response: single-cell and spatial proteomics, and reprogramming approaches

From hypereosinophilia to hypereosinophilic syndrome: real-world application of a two-tailed approach for HES diagnosis

The pro-tumorigenic roles of granzyme B: mechanisms and therapeutic implications

Dual role of ACE2 in regulating inflammation triggered by Omicron S1 and other SARS-CoV-2 Spike variants

Integration of single cell and bulk transcriptomic analyses identifies FAM189A2 as a key prognostic gene in lung cancer

Correction: Lactobacillus amplifies DHAMaR1 conversion to attenuate intestinal ischemia-reperfusion injury via decreasing pyroptosis

Editorial: Community series: systemic vasculitis: advances in pathogenesis and therapies, volume II

Editorial: Community series in recent advances in potential biomarkers for rheumatic diseases and in cell-based therapies in the management of inflammatory rheumatic diseases, volume III

Glycolytic reprogramming of resident alveolar macrophages contributes to reduced SOCS3 secretion in non-small cell lung cancer

Fusobacterium nucleatum drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn’s disease

Real-world efficacy and safety of disitamab vedotin monotherapy or in combination with PD-1 inhibitors in locally advanced or metastatic upper tract urothelial carcinoma: a multicenter retrospective study

Revealing intra-group immunotherapy response heterogeneity in metastatic urothelial carcinoma through interpretable feature extraction and spectral clustering

Editorial: Unveiling the next generation of cancer immunity & immunotherapy

Gender-based differences in telomere attrition and long-term respiratory dysfunction in COVID-19 ICU survivors one year post-infection: implications for aging-associated pulmonary decline

Natural killer cell exhaustion in ovarian cancer: from molecular suppression to therapeutic revival

Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer

A novel liquid-liquid phase separation related gene signature including ARL6IP4 predicts prognosis and immune landscape in colorectal cancer

TAFRO syndrome requiring combined IL 6 and IL 1 inhibition: a case report

Ulcerative colitis model triggers gut α-Synuclein aggregation without brain involvement or neuronal loss in female rats