Frontiers in Immunology

Original Research

Published on 05 Jan 2026

Intratumor heterogeneity score reveals immune landscape and survival stratification in colorectal cancer

in Cancer Immunity and Immunotherapy

Zijing Wang
Liyuan Ma
Jinzhong Cao
Xi Chen
Xin Chang
Ruxue Ma
Hengyi Lv
Zixin Zhang
Hai Li
Tao Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671148

1,297 views

Original Research

Published on 05 Jan 2026

Site- and structure-specific characterization of glycoproteins of H11: potent vaccine candidates against parasitic worm Haemonchus

in Vaccines and Molecular Therapeutics

Xin Liu
Feng Liu
Hui Liu
Lisha Ye
Yao Zhang
Wenjie Peng
Nishith Gupta
Min Hu
Chunqun Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669536

1,142 views

Correction

Published on 05 Jan 2026

Correction: Antibodies and cryptographic hash functions: quantifying the specificity paradox

in Systems Immunology

Robert J. Petrella

Frontiers in Immunology

doi 10.3389/fimmu.2025.1756946

731 views

Mini Review

Published on 05 Jan 2026

Decoding the immunoregulatory functions of ALKBH5 in the tumor microenvironment

in Cancer Immunity and Immunotherapy

Chunhong Li
Xiulin Jiang
Yixiao Yuan
Qiang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709260

1,108 views

Case Report

Published on 05 Jan 2026

Case report: Epidermolysis bullosa acquisita following dipeptidyl peptidase-4 inhibitor therapy and complicated by immune thrombocytopenic purpura

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Hirofumi Kawamoto
Natsuko Sasaki
Yukimi Ueda
Norito Ishii
Yu Sawada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724412

1,337 views

Original Research

Published on 05 Jan 2026

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis

in Molecular Innate Immunity

Xingyu Rong
Hai Wang
Shintaro Muraoka
Takuya Uehata
Masanori Yoshinaga
Tsuneyasu Kaisho
Osamu Takeuchi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725702

1,471 views

Original Research

Published on 05 Jan 2026

Cbl promotes MyD88 ubiquitin-mediated degradation in macrophages via phosphorylation and calcium mobilization

in Molecular Innate Immunity

Yan Zhang
Dan Wang
Jie Huang
Zhefan Wang
Jinren Zhu
Feihan Lyu
Zhengyu Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679035

636 views

Correction

Published on 05 Jan 2026

Correction: Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL

in NK and Innate Lymphoid Cell Biology

Qirui Zhou
Ruinan Jia
Jinlin Chen
Yang Tan
Yuechan Ma
Mengfan Luan
Xue Sheng
Xiao Han
Shuying Li
Fei Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1773500

562 views

Review

Published on 05 Jan 2026

Decoding the HIF-1-driven metabolic-inflammatory-immune axis in sepsis-associated lung injury: a comprehensive overview

in Inflammation

Shuang Zhang
Beilin Hu
Yuang Fang
Mudi Liu
Qingmei Liu
Ye Chen
Jun Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658103

1,172 views

Original Research

Published on 05 Jan 2026

TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming

in Molecular Innate Immunity

Christopher Kalischer
Phani Sankar Potru
Nele Lehmann
Jannik Jahn
Nikolai Leander Rupp
Natascha Vidovic
Tamara Russ
Susanne Wiemann
Björn Spittau

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623643

1,063 views

Systematic Review

Published on 05 Jan 2026

The gut microbiota–brain–CAR T cell axis: a systematic review of gut microbiome modulation and its impact on neurological complications and treatment responses in CAR T cell therapy

in Cancer Immunity and Immunotherapy

Ashvath Arumugam Pillai
Sai K. Reddy Pasya
Gaurav Kansal
Aishwarya Jaikrishnan
Anchit Chauhan
Arghadip Das
Korat Parth Manojbhai
V. Deepak Prabu
Muhammad Mahdi Nashatizadeh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703146

1,322 views

Original Research

Published on 05 Jan 2026

Neisseria bacilliformis is a periodontal pathogen exacerbating periodontitis by inducing nitric oxide production

in Microbial Immunology

Bo-Min Kim
Yeonjin Lim
Somin Park
Jintaek Im
Cheol-Heui Yun
Kee-Yeon Kum
Ok-Jin Park
Seung Hyun Han

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735500

959 views

Brief Research Report

Published on 05 Jan 2026

Phlebotomus duboscqi gut microbiota dynamics in the context of Leishmania infection

in Microbial Immunology

Kristina Tang
Yue Zhang
Claudio Meneses
Luana A. Rogerio
Laura Willen
Eva Iniguez
Shaden Kamhawi
Jesus G. Valenzuela
Fabiano Oliveira
Pedro Cecilio

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717935

1,166 views

Original Research

Published on 05 Jan 2026

Identification of immune-related prognostic biomarkers in lung squamous cell carcinoma microenvironment

in Cancer Immunity and Immunotherapy

Zhihao Wang
Zhengsheng Wu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724319

1,379 views

Original Research

Published on 05 Jan 2026

Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel

in Inflammation

Yao Liu
Xue Han
Weijie Zhang
Qingguo Pei
Shuyu Xu
Haicheng Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712759

1,037 views

Original Research

Published on 05 Jan 2026

Identification of prognostic biomarkers and development of a prediction model for prostate cancer

in Cancer Immunity and Immunotherapy

Dake Chen
Wu Chen
Ruxian Ye
Linjin Li
Feilong Miao
Xianghui Kong
Weiqiang Ning
Jingyi Jia
Qiuli Chen
Peter Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709264

1,146 views

Case Report

Published on 05 Jan 2026

Case Report: Pathological complete response yet early brain relapse in HER2-positive breast cancer: a case-based review

in Cancer Immunity and Immunotherapy

Jing Feng
Yujun Tong
Zhen Zhang
Yuanli He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668995

1,576 views

Review

Published on 05 Jan 2026

The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets

in Molecular Innate Immunity

Rui Guo
Feng Qi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1749857

1,188 views

Case Report

Published on 05 Jan 2026

Pemphigus vegetans successfully treated with systemic corticosteroid and rituximab: a rare case report with 15-month follow-up and literature review

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Hongyan Ji
Liuqing Chen
Jinbo Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701439

826 views

Review

Published on 05 Jan 2026

The potential link between inflammatory bowel disease and male erectile dysfunction: mechanistic insights and novel therapeutic perspectives

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Shuxin Li
Hongliang Cao
Yuwei Liang
Chengsen Lv
Yutao Ma
Tong Yang
Bo Yuan
Wei Wei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701741

1,318 views

Original Research

Published on 05 Jan 2026

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes

in Molecular Innate Immunity

Emmanuelle Degeorges
Stéphane Mouret
Pauline Girard
Camille Niveau
Mélanie Cettour-Cave
Eleonora Sosa Cuevas
Florence De Fraipont
Julie Charles
Philippe Saas
Caroline Aspord

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703754

887 views

Original Research

Published on 05 Jan 2026

The role of age-related genes in idiopathic pulmonary fibrosis and molecular docking analysis of their drug targets

in Inflammation

Wei Zhang
Tingting Xia
Qian Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697013

1,452 views

Brief Research Report

Published on 05 Jan 2026

Robust neutralization of emerging JN.1 subvariants by the updated JN.1 vaccine: rationale for catch-up booster recommendations in high-risk individuals

in Vaccines and Molecular Therapeutics

Ju-yeon Choi
Su-Hwan Kim
Soyoung Park
Hye Min Jang
Young Jae Lee
Hye-Jin Kim
Dokeun Kim
Jae-Hoon Ko
Hye-Sook Jeong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696676

1,045 views

Original Research

Published on 05 Jan 2026

Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation

in Immunological Tolerance and Regulation

Julian Hölzenbein
Sabine Schramm
Falko M. Heinemann
Andreas Heinold
Anja Gäckler
Johanna Reinold
Benjamin Wilde
Yannik Busch
Nina Gruenen
Wolfgang Peter

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697839

1,353 views

49,728 articles

articles

Intratumor heterogeneity score reveals immune landscape and survival stratification in colorectal cancer

Site- and structure-specific characterization of glycoproteins of H11: potent vaccine candidates against parasitic worm Haemonchus

Correction: Antibodies and cryptographic hash functions: quantifying the specificity paradox

Decoding the immunoregulatory functions of ALKBH5 in the tumor microenvironment

Case report: Epidermolysis bullosa acquisita following dipeptidyl peptidase-4 inhibitor therapy and complicated by immune thrombocytopenic purpura

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis

Cbl promotes MyD88 ubiquitin-mediated degradation in macrophages via phosphorylation and calcium mobilization

Correction: Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL

Decoding the HIF-1-driven metabolic-inflammatory-immune axis in sepsis-associated lung injury: a comprehensive overview

TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming

The gut microbiota–brain–CAR T cell axis: a systematic review of gut microbiome modulation and its impact on neurological complications and treatment responses in CAR T cell therapy

Neisseria bacilliformis is a periodontal pathogen exacerbating periodontitis by inducing nitric oxide production

Phlebotomus duboscqi gut microbiota dynamics in the context of Leishmania infection

Identification of immune-related prognostic biomarkers in lung squamous cell carcinoma microenvironment

Low-intensity pulsed ultrasound ameliorates partial infraorbital nerve ligation-induced trigeminal neuropathic pain through inhibiting Schwann cell Pannexin 1 channel

Identification of prognostic biomarkers and development of a prediction model for prostate cancer

Case Report: Pathological complete response yet early brain relapse in HER2-positive breast cancer: a case-based review

The multifaceted role of post-translational modifications in macrophage polarization: from mechanisms to therapeutic targets

Pemphigus vegetans successfully treated with systemic corticosteroid and rituximab: a rare case report with 15-month follow-up and literature review

The potential link between inflammatory bowel disease and male erectile dysfunction: mechanistic insights and novel therapeutic perspectives

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes

The role of age-related genes in idiopathic pulmonary fibrosis and molecular docking analysis of their drug targets

Robust neutralization of emerging JN.1 subvariants by the updated JN.1 vaccine: rationale for catch-up booster recommendations in high-risk individuals

Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation