Frontiers in Immunology

Original Research

Published on 05 Jan 2026

IL-22-STAT3-CD155 axis in alveolar echinococcosis: a pivotal role in immune exhaustion and therapeutic potential

in Parasite Immunology

Liang Li
Xue Zhang
Ning Yang
Hui Liu
Junlong Xue
Jin Chu
Guodong Lv
Tuerganaili Aji
Xiaojuan Bi
Renyong Lin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1674904

808 views

Brief Research Report

Published on 05 Jan 2026

Ravulizumab in NMOSD with associated interstitial pneumonitis in a 59-year-old female patient: a case report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Andrea Neundorf
Ralf Dittrich

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671145

926 views

Original Research

Published on 05 Jan 2026

Serum visfatin in multiple sclerosis: distinct profiles in healthy controls, naive patients, and treated RRMS

in Multiple Sclerosis and Neuroimmunology

Saltanat Mert
İbrahim Acır
Hümeyra Öztürk Emre
Kübra Balcı
Edanur Demir

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641260

833 views

Original Research

Published on 05 Jan 2026

Identify GDPD3 as a key regulator of epithelial–mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study

in Cancer Immunity and Immunotherapy

Lin Hao
Xiangqiu Chen
Tao He
Tao Wu
Zhiqiang Wen
Ziliang Ji
Xichun Zheng
Qingyou Zheng
Qingchun Zhou
Chengwu He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637325

1,081 views

Editorial

Published on 05 Jan 2026

Editorial: Sentinels of the immune system: tissue-resident macrophages in the battle against infection and autoimmunity

in Molecular Innate Immunity

Lalit Batra
Shilpi Giri
Shailesh K. Shahi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1759310

553 views

Original Research

Published on 05 Jan 2026

Decidual stromal cells drive CD16+ macrophages towards an immunoregulatory phenotype via extracellular matrix-adhesion molecule interaction during early pregnancy

in Immunological Tolerance and Regulation

Hui-Li Yang
Jia-Wei Shi
Zhen-Zhen Lai
Xin Li
Chun-Jie Gu
Zi-Meng Zheng
Hong-Bo Zhao
Jiang-Feng Ye
Li Wang
Ting Peng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1747323

1,074 views

Review

Published on 05 Jan 2026

Unveiling the myxofibrosarcoma tumor microenvironment: implications for immunotherapy

in Cancer Immunity and Immunotherapy

Cecilia Profumo
Massimiliano Grassi
Valentina Rigo
Matteo Mascherini
Paola Monti
Giorgia Arcovito
Giorgia Anselmi
Laura Damele
Giorgia Timon
Danila Comandini

Frontiers in Immunology

doi 10.3389/fimmu.2025.1717541

1,196 views

Original Research

Published on 05 Jan 2026

The metabolic-immune interface of obesity in Covid-19: a role for angiotensin ii and inflammatory cytokines

in Inflammation

Cíntia Maria Rodrigues
Juliane Duarte Santos
Bruna Carolina Chaves Garcia
Marcelo Henrique Fernandes Ottoni
Karine Beatriz Costa
Marina Luiza Baêta Costa
Vívian Gonzalez Figueiredo
Daniel Macedo
Danilo Bretas de Oliveira
Etel Rocha Vieira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729494

947 views

Original Research

Published on 05 Jan 2026

Beyond tumor mutation burden: tumor neoantigen burden as a superior prognostic biomarker in resected gastric cancer

in Cancer Immunity and Immunotherapy

Tingting Lu
Jingyi Cao
Peng Liu
Xiaoxin Pan
Yiming Shen
Jian Wang
Zhida Chen
Yi Liu
Fenglin Zhang
Haiya Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1722895

1,025 views

Clinical Trial

Published on 05 Jan 2026

Patient-reported improvements from use of IMC-2 alone and IMC-2 and Paxlovid® in a Long COVID cohort: a case series

in Multiple Sclerosis and Neuroimmunology

William L. Pridgen
David Putrino

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698271

12,191 views

Original Research

Published on 05 Jan 2026

MCP-1/CCR2 axis regulates M2 macrophage polarization and immunosuppression in mycobacterium tuberculosis

in Microbial Immunology

Guizeng Zhao
Can Guo
Xiaoyang Li
Lei Tan
Xueyang Chen
Feng Tian
Lili Zhang
Xia Wang
Junwei Cui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698369

1,350 views

Original Research

Published on 05 Jan 2026

An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models

in Vaccines and Molecular Therapeutics

Zachary R. Stromberg
Elvia E. Silva
Sara C. Johnston
Dylan M. Johnson
Dominique Hall
Emmanuel F. Adjei
John A. Altin
Abisola Abisoye-Ogunniyan
Travis Gollott
Wei He

Frontiers in Immunology

doi 10.3389/fimmu.2025.1682418

1,787 views

Original Research

Accepted on 02 Jan 2026

A Single-Cell Atlas of Ulcerative Colitis Reveals Neutrophil–Stromal Circuits Linked to Biologic Therapy Resistance

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Shadi Eshghi
John Mark Gubatan
Parisa Mazrooei
Luis Quintanilla
Allen Nguyen
Amelia Au-Yeung
Derek Holman
Chikara Takahashi
Courtney Schiffman
William Edward O'Gorman

Frontiers in Immunology

650 views

Review

Accepted on 02 Jan 2026

Roles of the integrated stress response in regulation of inflammatory reactions

in Inflammation

Xiaopei Cui
Fan Jiang
Guei-Sheung Liu
Junjun Liu
Yanqiu Xing

Frontiers in Immunology

223 views

Original Research

Accepted on 02 Jan 2026

Early Rise in Nasal Secretory Antibody Associated with Shorter Duration of SARS-CoV-2 Virus Shedding in an Acute Infection Cohort

in Mucosal Immunity

Caroline Brackett
Lu Zhang
Bich T.N. Do
Saman Baral
Leigh Fisher
William O. Hahn
Alexander J. Carnacchi
Sir'Tauria Hilliard
Shuying S. Li
Premkumar Lakshmanane

Frontiers in Immunology

286 views

Systematic Review

Accepted on 02 Jan 2026

Impact of Creatine Supplementation on Inflammation: Evidence from a Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo Trials

in Nutritional Immunology

Kell Mazzini Ribeiro de Camargo
Alejandro Bruna-Mejías
Juan Valenzuela
Luana A. Gonzaga
Sandra Maria Barbalho
Alexandre L. Barroca
Andrey Porto
Rodrigo Daminello Raimundo
Luiz Carlos de Abreu
Vitor E. Valenti

Frontiers in Immunology

1,298 views

Correction

Published on 02 Jan 2026

Correction: Manganese mediates antiviral effects by driving an ATM-TBK1 phosphorylation signaling pathway

in Molecular Innate Immunity

Hongyan Sui
Rosana Wiscovitch-Russo
Silvia Cachaco
Jun Yang
Whitney Bruchey
Sylvain Laverdure
Qian Chen
Tomozumi Imamichi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1770238

907 views

Correction

Published on 02 Jan 2026

Correction: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

in T Cell Biology

Karina M. Berschneider
Bernhard Wetterauer
Carsten Sticht
Christian Orlik
Beate Jahraus
Henning Kirchgessner
Anastasiia Zuieva
Stefan Wölfl
Divya Lairikyengbam
Verena Beier

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761559

566 views

Original Research

Published on 02 Jan 2026

Cerebrospinal fluid metabolomic signatures in paediatric MOGAD and POMS

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Piera De Gaspari
Stefano Sartori
Margherita Nosadini
Anna Sartori
Sara Mariotto
Roberto Assandri
Chiara Trabatti
Paola Cogo
Manuela Simonato

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650785

1,398 views

Brief Research Report

Published on 02 Jan 2026

The timing of concurrent intrathecal chemotherapy during blinatumomab infusion influences neurotoxicity in pediatric acute lymphoblastic leukemia

in Cancer Immunity and Immunotherapy

Bingju Liu
Yunpeng Dai
Liying Liu
Qi Wang
Guotao Guan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690916

1,008 views

Review

Published on 02 Jan 2026

GSDME in cardiovascular diseases: research system and contemporary progress

in Inflammation

Zhenzhen Yang
Zilong Luo
Han Zhang
Junjie Zong
Pinyan Huang
Yuqing Niu
Cheng Zhou
Song Wang
Dan Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683116

1,412 views

Original Research

Published on 02 Jan 2026

Antibodies directed against extracellular loops of FadL orthologs disrupt outer membrane integrity and neutralize infectivity of Treponema pallidum, the syphilis spirochete

in Vaccines and Molecular Therapeutics

Kristina N. Delgado
Crystal F. Vicente
Carson J. La Vake
Everton Bettin
Melissa J. Caimano
Justin D. Radolf
Kelly L. Hawley

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724458

1,227 views

Original Research

Published on 02 Jan 2026

SPACA6-hosted miR-99b~125a~let-7e cluster shapes melanoma resistance by modulating mTOR-mediated immunosuppression

in Cancer Immunity and Immunotherapy

Viviana Vallacchi
Gianpiero Lupoli
Eriomina Shahaj
Mariachiara Aloisi
Stefano Bergamini
Simona Frigerio
Loris De Cecco
Barbara Vergani
Katia Todoerti
Cristina Banfi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719461

1,308 views

Original Research

Published on 02 Jan 2026

Bronchial epithelial cell-derived extracellular vesicles drive inflammasome activation and NTHi infection in COPD

in Inflammation

Georgia Bateman
Hong Guo-Parke
Caitlyn Harvey
Aoife Rodgers
Anna Krasnodembskaya
Dermot Linden
Rabindra Tirouvanziam
Lee A. Borthwick
Andrew J. Fisher
Judith Coppinger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713012

1,824 views

49,768 articles

articles

IL-22-STAT3-CD155 axis in alveolar echinococcosis: a pivotal role in immune exhaustion and therapeutic potential

Ravulizumab in NMOSD with associated interstitial pneumonitis in a 59-year-old female patient: a case report

Serum visfatin in multiple sclerosis: distinct profiles in healthy controls, naive patients, and treated RRMS

Identify GDPD3 as a key regulator of epithelial–mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study

Editorial: Sentinels of the immune system: tissue-resident macrophages in the battle against infection and autoimmunity

Decidual stromal cells drive CD16+ macrophages towards an immunoregulatory phenotype via extracellular matrix-adhesion molecule interaction during early pregnancy

Unveiling the myxofibrosarcoma tumor microenvironment: implications for immunotherapy

The metabolic-immune interface of obesity in Covid-19: a role for angiotensin ii and inflammatory cytokines

Beyond tumor mutation burden: tumor neoantigen burden as a superior prognostic biomarker in resected gastric cancer

Patient-reported improvements from use of IMC-2 alone and IMC-2 and Paxlovid® in a Long COVID cohort: a case series

MCP-1/CCR2 axis regulates M2 macrophage polarization and immunosuppression in mycobacterium tuberculosis

An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models

A Single-Cell Atlas of Ulcerative Colitis Reveals Neutrophil–Stromal Circuits Linked to Biologic Therapy Resistance

Roles of the integrated stress response in regulation of inflammatory reactions

Early Rise in Nasal Secretory Antibody Associated with Shorter Duration of SARS-CoV-2 Virus Shedding in an Acute Infection Cohort

Impact of Creatine Supplementation on Inflammation: Evidence from a Systematic Review and Meta-Analysis of Randomized Double-Blind Placebo Trials

Correction: Manganese mediates antiviral effects by driving an ATM-TBK1 phosphorylation signaling pathway

Correction: Distinct Arnica montana L. extracts modulate human T cell activation in different ways via differential inhibition of NFκB and NFAT pathways

Cerebrospinal fluid metabolomic signatures in paediatric MOGAD and POMS

The timing of concurrent intrathecal chemotherapy during blinatumomab infusion influences neurotoxicity in pediatric acute lymphoblastic leukemia

GSDME in cardiovascular diseases: research system and contemporary progress

Antibodies directed against extracellular loops of FadL orthologs disrupt outer membrane integrity and neutralize infectivity of Treponema pallidum, the syphilis spirochete

SPACA6-hosted miR-99b~125a~let-7e cluster shapes melanoma resistance by modulating mTOR-mediated immunosuppression

Bronchial epithelial cell-derived extracellular vesicles drive inflammasome activation and NTHi infection in COPD