Frontiers in Immunology

Original Research

Published on 02 Jan 2026

Bronchial epithelial cell-derived extracellular vesicles drive inflammasome activation and NTHi infection in COPD

in Inflammation

Georgia Bateman
Hong Guo-Parke
Caitlyn Harvey
Aoife Rodgers
Anna Krasnodembskaya
Dermot Linden
Rabindra Tirouvanziam
Lee A. Borthwick
Andrew J. Fisher
Judith Coppinger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713012

1,824 views

Review

Published on 02 Jan 2026

The application of genetic testing technology in kidney transplantation: precision matching, non-invasive monitoring and personalized management

in Alloimmunity and Transplantation

Yalong Zhang
Hao Wang
Rui Yan
Kangyu Wang
Jiangwei Man
Li Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713293

1,247 views

Original Research

Published on 02 Jan 2026

The distinct contribution of sternotomy to the systemic inflammatory response during children's heart surgery

in Cytokines and Soluble Mediators in Immunity

Joel David Bierer
Julia Paffile
Roger Stanzel
Mark Henderson
John Sapp
Pantelis Andreou
Jean Sylvia Marshall
David Horne

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617524

1,044 views

Review

Published on 02 Jan 2026

Recent advances on Hippo-YAP pathway in skin diseases

in Inflammation

Xuxia Cai
Kexin Chen
Xiahong Li
Kaoyuan Zhang
Jiaxu Gu
Changbing Shen
Bo Yu
Cong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728064

1,753 views

Perspective

Published on 02 Jan 2026

IL-7: a potential next-generation adjuvant for immune cell therapies

in Cancer Immunity and Immunotherapy

Richard S. Hotchkiss
John F. DiPersio
Cassian Yee
Russell K. Pachynski
Marcel R. M. Van Den Brink

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736931

1,795 views

Original Research

Published on 02 Jan 2026

Gut microbiome composition influences immunologic alterations in the blood and gut of HIV-positive and HIV-negative men who have sex with men

in Microbial Immunology

Charles Preston Neff
Janet Siebert
Mallory Karr
Ricky Lippincott
Rachel Kvaal
Amy T. Noe
Elena Wall
Nichole Nusbacher
Suzanne Fiorillo
Blair P. Fennimore

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707736

1,364 views

Original Research

Published on 02 Jan 2026

Intranasal BCG vaccination induces systemic and pulmonary mucosal immune responses against tuberculosis in a goat model

in Vaccines and Molecular Therapeutics

Patricia Cuenca-Lara
Miriam Blay-Benach
Zoraida Cervera
Julia Moraleda
Iker A. Sevilla
Joseba M. Garrido
Mahavir Singh
Sergio López-Soria
Enric Vidal
Mariano Domingo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740197

1,194 views
1 citation

Correction

Published on 02 Jan 2026

Correction: Case Report: Fecal microbiota transplantation via capsules ameliorated clinical outcomes in a patient with multiple sclerosis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Stefano Bibbò
Flavio De Maio
Fioravante Capone
Gianluca Quaranta
Debora Rondinella
Roberto Rosato
Mauro Minelli
Desy De Lorenzis
Maurizio Sanguinetti
Giovanni Cammarota

Frontiers in Immunology

doi 10.3389/fimmu.2025.1768227

663 views

Original Research

Published on 02 Jan 2026

Comparison of chimeric mouse-human and humanized anti-CD25 monoclonal antibodies for steroid-refractory acute graft-versus-host disease

in Cancer Immunity and Immunotherapy

Xinhui Zheng
Yunxia Zhou
Yawei Zheng
Ni Lu
Yigeng Cao
Weihua Zhai
Jialin Wei
Donglin Yang
Rongli Zhang
Aiming Pang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660452

881 views

Case Report

Published on 02 Jan 2026

Case Report: Possible C3 nephritic factor–driven complement-mediated severe hemolytic anemia and acute kidney injury in a child with Bordetella parapertussis infection

in Molecular Innate Immunity

Steffen Ullitz Thorsen
Anne Todsen Hansen
Hans Jakob Hartling
Hanne Vibeke Marquart
Line Borgwardt
Mira Marie Laustsen
Lillemor Skattum
Alex Christian Yde Nielsen
Line Thousig Sehested
Hanne Nørgaard

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715464

1,583 views

Original Research

Published on 02 Jan 2026

Immune imbalance in the human hippocampus in PTSD revealed by single-nucleus transcriptomics

in Multiple Sclerosis and Neuroimmunology

Liu Liu
Pengfei Li
Brent A. Wilkerson
Yan Wu
Meng Liu
Roger Shi
Eric D. Hamlett
Steven L. Carroll
Amanda C. LaRue
Zhewu Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697171

1,322 views

Original Research

Published on 02 Jan 2026

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

in Systems Immunology

HongLi Yu
YingLi Cao
Jiebo Wang
Xianfeng Weng
Weituan Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1695979

1,162 views

Case Report

Published on 02 Jan 2026

Case report: Spatiotemporal HER2 heterogeneity in AFP-producing gastric cancer: navigating long-term survival with molecularly-guided therapy in a refractory case

in Cancer Immunity and Immunotherapy

Yanwen Diao
Haobo Yin
Xin Sun
Qian Dong
Jingdong Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1696069

1,195 views

Mini Review

Published on 02 Jan 2026

Mast cells in the bone marrow microenvironment

in Inflammation

Domenico Ribatti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1738487

979 views

Original Research

Published on 02 Jan 2026

Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality in mice by increasing M1 macrophage polarization and cytokine production

in Viral Immunology

Cheng-Huei Hung
Yi-Ling Hsiao
Yi-Ping Tsai
Ming-Shi Chang
Ching-Chuan Liu
Li-Chiu Wang
Shun-Hua Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700154

1,098 views

Review

Published on 02 Jan 2026

Building alliances for early detection of immunodeficiencies: from primary care to hematology

in Primary Immunodeficiencies

Jacques G. Rivière
Marlène Pasquet
Eleonora Gambineri

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701384

1,140 views

Original Research

Published on 02 Jan 2026

Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxins

in Inflammation

Joel J. M. Gabrili
Ângela A. A. Megale
Giselle Pidde
Trent M. Woodruff
Denise V. Tambourgi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706235

1,317 views

Technology and Code

Published on 02 Jan 2026

Pox-AbDab: the orthopoxvirus antibody database

in Viral Immunology

Henriette L. Capel
Eric Ji Da Wang
Benjamin H. Williams
Charlotte M. Deane
Matthew I. J. Raybould

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698441

1,172 views

Original Research

Published on 02 Jan 2026

Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

in Inflammation

Danying Zhu
Guang Li
Lang Yuan
Zeyu Zeng
Na Dong
Chao Wang
Ming Chen
Lijian Xie
Guohui Ding
Libing Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606650

1,429 views

Original Research

Published on 02 Jan 2026

An integrative model of pro- and anti-inflammatory signaling pathways in macrophage differentiation: the role of NF-κB and CREB

in Systems Immunology

David Martínez-Méndez
Ilean Z. Aguilar-Elguea
Lilian S. Castelán-Pacheco
Luis Armando Jiménez-Alvarez
Alfredo Cruz-Lagunas
Joaquín Zúñiga
Carlos Villarreal
Leonor Huerta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639005

1,555 views

Original Research

Published on 02 Jan 2026

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models

in T Cell Biology

Ying Xing
Gangqiang Shi
Zhengli Li
Xiancheng Liu
Linghu Nie
Yu Zhang
Yiqin Song
Shilin Sun
Mike K. S. Chan
Michelle B. F. Wong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638585

2,101 views

Clinical Trial

Published on 02 Jan 2026

Camrelizumab plus albumin-bound paclitaxel and S-1 as first-line treatment for patients with human epidermal growth factor receptor 2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial

in Cancer Immunity and Immunotherapy

Chen Wu
Shuai Li
Xinfang Hou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634502

1,287 views

Correction

Published on 02 Jan 2026

Correction: TACE-HAIC versus HAIC combined with TKIs and ICIs for hepatocellular carcinoma with a high tumor burden—a propensity-score matching comparative study

in Cancer Immunity and Immunotherapy

Chunxue Wu
Yunlong Dong
Xinge Li
Wenbo Shao
Guangshun Wang
Huiyong Wu
Xu Chang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1769802

785 views

Original Research

Published on 02 Jan 2026

The immunomodulating effect of palmitoylethanolamide on human myeloid dendritic cells and its possible impact on Alzheimer’s disease

in Multiple Sclerosis and Neuroimmunology

Iliana Piccolino
Filomena Iannuzzi
Ludovica Lionetti
Benedetta Mazzonello
Valeria Barreca
Nerisa Banaj
Valentina Arezzini
Fabrizio Piras
Paola Bossù

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664164

1,564 views

49,768 articles

articles

Bronchial epithelial cell-derived extracellular vesicles drive inflammasome activation and NTHi infection in COPD

The application of genetic testing technology in kidney transplantation: precision matching, non-invasive monitoring and personalized management

The distinct contribution of sternotomy to the systemic inflammatory response during children's heart surgery

Recent advances on Hippo-YAP pathway in skin diseases

IL-7: a potential next-generation adjuvant for immune cell therapies

Gut microbiome composition influences immunologic alterations in the blood and gut of HIV-positive and HIV-negative men who have sex with men

Intranasal BCG vaccination induces systemic and pulmonary mucosal immune responses against tuberculosis in a goat model

Correction: Case Report: Fecal microbiota transplantation via capsules ameliorated clinical outcomes in a patient with multiple sclerosis

Comparison of chimeric mouse-human and humanized anti-CD25 monoclonal antibodies for steroid-refractory acute graft-versus-host disease

Case Report: Possible C3 nephritic factor–driven complement-mediated severe hemolytic anemia and acute kidney injury in a child with Bordetella parapertussis infection

Immune imbalance in the human hippocampus in PTSD revealed by single-nucleus transcriptomics

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

Case report: Spatiotemporal HER2 heterogeneity in AFP-producing gastric cancer: navigating long-term survival with molecularly-guided therapy in a refractory case

Mast cells in the bone marrow microenvironment

Deficiency of IL-20 receptor subunit A decreases enterovirus A71 lethality in mice by increasing M1 macrophage polarization and cytokine production

Building alliances for early detection of immunodeficiencies: from primary care to hematology

Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxins

Pox-AbDab: the orthopoxvirus antibody database

Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

An integrative model of pro- and anti-inflammatory signaling pathways in macrophage differentiation: the role of NF-κB and CREB

VHH-based CAR-T cells targeting Claudin 18.2 show high efficacy in pancreatic cancer models

Camrelizumab plus albumin-bound paclitaxel and S-1 as first-line treatment for patients with human epidermal growth factor receptor 2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial

Correction: TACE-HAIC versus HAIC combined with TKIs and ICIs for hepatocellular carcinoma with a high tumor burden—a propensity-score matching comparative study

The immunomodulating effect of palmitoylethanolamide on human myeloid dendritic cells and its possible impact on Alzheimer’s disease