Frontiers in Immunology

Editorial

Published on 22 Dec 2025

Editorial: Immune-checkpoint inhibitors and immunometabolic reprogramming in cancer immunotherapy

in Cancer Immunity and Immunotherapy

Vijay Kumar
Valentina De Falco

Frontiers in Immunology

doi 10.3389/fimmu.2025.1760910

1,487 views

Original Research

Published on 22 Dec 2025

Novel pan-cancer T cell exhaustion signature forecasts immunotherapy response and unveils BCAP31 in macrophages as a therapeutic target in neuroblastoma

in Cancer Immunity and Immunotherapy

Shan Li
Jianjun Zhu
Xiang Huang
Fengming Ji
Jinrong Li
Zhigang Yao
Haoyu Tang
Ling Liu
Bing Yan
Chenghao Zhanghuang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1709225

2,661 views

Original Research

Published on 22 Dec 2025

Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4+ T cells

in Immunological Tolerance and Regulation

Gabrielle Barran
Najib Naamane
Abdul Mannan Baru
Amy E. Anderson
Jane Falconer
Catharien M. U. Hilkens

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698413

2,216 views

Review

Accepted on 19 Dec 2025

Probiotics and human health: Biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - A comprehensive review

in Microbial Immunology

Mohamed T. El-Saadony
Ahmed M. Saad
Mahmoud Sitohy
Samar Sami Alkafaas
Mthokozisi Dladla
Soumya Ghosh
Dr. Dina Mostafa Mohammed
Essam Ibrahim
Mohamed A. Fahmy
Amr Elkelish

Frontiers in Immunology

402 views

Original Research

Published on 19 Dec 2025

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

in T Cell Biology

Valerie Plajer
Adrián Madrigal-Avilés
Maria Dzamukova
Nayar Durán-Hernández
Philippe Saikali
Vivien Holecska
Isabel Panse
Katrin Lehmann
Jinfang Zhu
Mir-Farzin Mashreghi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1716422

1,477 views

Original Research

Published on 19 Dec 2025

LST1: a novel biomarker for efferocytosis in the co-occurrence of type 2 diabetes mellitus and clear cell renal cell carcinoma

in Cancer Immunity and Immunotherapy

Yuru Yang
Tingting Chen
Zhicheng Xu
Jialing Cai
Wenli Wang
Lan Pan
Xiaotian Cheng
Andong Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737749

1,906 views

Mini Review

Published on 19 Dec 2025

Nutritional intervention alleviates T cell exhaustion and empowers anti-tumor immunity

in Cancer Immunity and Immunotherapy

Yuqi Xu
Wenhui Yuan
Ke Li
Peng Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689317

1,770 views

Original Research

Published on 19 Dec 2025

Frailty and associated risk factors in patients with Sjögren’s disease: a cross-sectional study

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Zhen Tian
Qiuju Liao
Chunxiu Wang
Leiming Wang
Jagadish K. Chhetri
Yi Zhao
Piu Chan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689685

1,570 views

Original Research

Published on 19 Dec 2025

Development and validation of an interpretable machine learning model for predicting progression-free survival after immunotherapy in patients with non-small cell lung cancer: a multicenter study

in Cancer Immunity and Immunotherapy

Ya Li
Ji Xia
Tianchu He
Yong Hu
Daobin Zhou
Dan Zou
Benlan Li
Min Zhang
Zhongjun Huang
Mi Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686260

1,867 views

Review

Published on 19 Dec 2025

The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism

in Microbial Immunology

Wang Xu
Aijing Li
Huijuan Jing
Xiaoping Zhang
Xucheng Dong
Zhiqiang Song
Nanping Wu
Shufa Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653472

2,093 views

Review

Published on 19 Dec 2025

Advances in the application of PD-1/PD-L1 immunotherapy for prostate cancer: a review

in Cancer Immunity and Immunotherapy

Guangqiang Hu
Zeng Li
Yongji Chen
Hong Liao
Shukui Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664587

2,371 views

Original Research

Published on 19 Dec 2025

Anti-VEGF immunotherapy with HEBERSaVax suppresses melanoma growth and metastasis via angiogenesis blockade and enhanced T-cell infiltration

in Cancer Immunity and Immunotherapy

Yanelys Morera-Díaz
Josune García-Sanmartín
Camila Canaán-Haden
Mónica Bequet-Romero
Isabel Gonzalez-Moya
Marta Ayala-Ávila
Srdan Tadic
Pablo Garrido
Judit Narro-Íñiguez
Dasha Fuentes-Morales

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667651

1,772 views

Mini Review

Published on 19 Dec 2025

The dual role of glucocorticoids in the breast cancer immune microenvironment: mechanisms and therapeutic implications

in Cancer Immunity and Immunotherapy

Bianping Liang
Xinglan Wang
Yunrui Fu
Mingxue Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1719277

1,621 views

Review

Published on 19 Dec 2025

The metabolism-immune axis in colorectal cancer: remodeling the tumor microenvironment through metabolite signaling

in Cancer Immunity and Immunotherapy

Shaofan Hu
Hui Heng
Fang Yang
Meng Wang
Guoxiang Liu
Yuancai Xiang
Hongming Miao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735873

3,065 views

Original Research

Published on 19 Dec 2025

SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer

in Cancer Immunity and Immunotherapy

Mei Huang
Run Shi
Cong Xu
Yihan Zhang
Xiaoyue Du
Shaodi Wen
Chunbin Wang
Feng Jiang
Guoren Zhou
Xin Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735479

1,635 views

Editorial

Published on 19 Dec 2025

Editorial: How underappreciated autoinflammatory mechanisms (innate immunity) dominate disparate autoimmune disorders

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Qiao Zhou
Yue Yang
Dennis McGonagle

Frontiers in Immunology

doi 10.3389/fimmu.2025.1762297

1,062 views

Review

Published on 19 Dec 2025

CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond

in T Cell Biology

Xiang Fang
Shixuan Yan
Long He
Changwen Deng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735763

1,921 views

Review

Published on 19 Dec 2025

The progression of TRAb-positive subacute thyroiditis and its differential diagnosis from Graves’ disease

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Saiya Yuan
Xiaolu Zhao
Fan Liu
Jinming Yao
Junyu Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727240

1,556 views

Original Research

Published on 19 Dec 2025

Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

in Molecular Innate Immunity

Ya-ping Li
Xin-jian Niu
Ge Zhang
On-kei Chan
Nuo Sun
Bo Hu
Zi-jian Shi
Dong-yun Ouyang
Xian-hui He
Qing-bing Zha

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726408

1,977 views

Mini Review

Published on 19 Dec 2025

Viral reprogramming of glial metabolism as a driver of neuroinflammation

in Inflammation

Tamara Rodrigues
Gabriel Salles Beltrão
Heloísa Girardi
Aguinaldo R. Pinto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686774

2,559 views

Review

Published on 19 Dec 2025

Precision bacterial immunotherapy: an integrated mechanistic taxonomy and translational roadmap against antimicrobial resistance

in Microbial Immunology

Hamdi Al-Azzani
Djandan Tadum Arthur Vithran
Hanane Aliouat
Wenhu Zhou
Xiaoqiang Mao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675682

1,485 views

Review

Published on 19 Dec 2025

Inflammasomes as the molecular hub of cardiovascular-metabolic-immune comorbidity networks

in Inflammation

Xingyu Qian
Jian Sun
Fei Li
Li Xu
Xingjian Hu
Nianguo Dong
Guangzhou Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690443

2,150 views

Original Research

Published on 19 Dec 2025

Hepatotoxicity associated with anti-neoplastic agents: a pharmacovigilance analysis of the Food and Drug Administration Adverse Event Reporting System database

in Cancer Immunity and Immunotherapy

Lei Shi
Yan Wang
Ying Qu
Rong Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665425

1,573 views

Original Research

Published on 19 Dec 2025

Chronic stress drives ovarian cancer progression via myeloid-derived suppressor cells infiltration and Notch signaling pathway activation

in Cancer Immunity and Immunotherapy

Yadiel A. Rivera-López
Alanis P. Torres-Rosado
Jaydiel A. Casiano-Martínez
Luinet L. Meléndez-Rodríguez
Raian Imad-Hamad
Sofía M. Hernández-Carrasquillo
Luis M. Rivera-Pérez
Melanie Ortiz-León
Orlando I. Torres-Rodríguez
Alexandra N. Aquino-Acevedo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593299

3,120 views

49,795 articles

articles

Editorial: Immune-checkpoint inhibitors and immunometabolic reprogramming in cancer immunotherapy

Novel pan-cancer T cell exhaustion signature forecasts immunotherapy response and unveils BCAP31 in macrophages as a therapeutic target in neuroblastoma

Human tolerogenic dendritic cell subtypes exert divergent effects on induction of cytotoxic CD4+ T cells

Probiotics and human health: Biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - A comprehensive review

Stable characteristics of intrapopulation heterogeneity in virus-specific Th1 cells during chronic viral challenge infection

LST1: a novel biomarker for efferocytosis in the co-occurrence of type 2 diabetes mellitus and clear cell renal cell carcinoma

Nutritional intervention alleviates T cell exhaustion and empowers anti-tumor immunity

Frailty and associated risk factors in patients with Sjögren’s disease: a cross-sectional study

Development and validation of an interpretable machine learning model for predicting progression-free survival after immunotherapy in patients with non-small cell lung cancer: a multicenter study

The role of Akkermansia muciniphila in the regulation of inflammatory bowel disease: intestinal immunity and metabolism

Advances in the application of PD-1/PD-L1 immunotherapy for prostate cancer: a review

Anti-VEGF immunotherapy with HEBERSaVax suppresses melanoma growth and metastasis via angiogenesis blockade and enhanced T-cell infiltration

The dual role of glucocorticoids in the breast cancer immune microenvironment: mechanisms and therapeutic implications

The metabolism-immune axis in colorectal cancer: remodeling the tumor microenvironment through metabolite signaling

SAA restricts T cell mediated anti-tumor immunity by limiting antigen presentation in lung cancer

Editorial: How underappreciated autoinflammatory mechanisms (innate immunity) dominate disparate autoimmune disorders

CAR-γδ T cells: a new paradigm of programmable innate immune sentinels and their systemic applications in cancer and beyond

The progression of TRAb-positive subacute thyroiditis and its differential diagnosis from Graves’ disease

Anti-alcoholism drug disulfiram inhibits PANoptosis by blocking mitochondrial permeabilization in macrophages

Viral reprogramming of glial metabolism as a driver of neuroinflammation

Precision bacterial immunotherapy: an integrated mechanistic taxonomy and translational roadmap against antimicrobial resistance

Inflammasomes as the molecular hub of cardiovascular-metabolic-immune comorbidity networks

Hepatotoxicity associated with anti-neoplastic agents: a pharmacovigilance analysis of the Food and Drug Administration Adverse Event Reporting System database

Chronic stress drives ovarian cancer progression via myeloid-derived suppressor cells infiltration and Notch signaling pathway activation