Frontiers in Immunology

Original Research

Published on 18 Dec 2025

LOX1-mediated supramolecular self-assembly nanomedicine for microsatellite-stable colorectal cancer towards reactivating anti-tumor immunity

in Cancer Immunity and Immunotherapy

Xin Wei
Yuyan Guo
Jianyuan Lei
Na Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737031

1,759 views

Brief Research Report

Published on 18 Dec 2025

Prolonged impairment of immunological memory after anti-CD20 treatment in pediatric idiopathic nephrotic syndrome: an extended follow-up

in B Cell Biology

Manuela Colucci
Martina Riganati
Federica Zotta
Antonio Gargiulo
Laura Massella
Barbara Ruggiero
Nicola Cotugno
Giulia Ricci
Paolo Palma
Francesco Emma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1736921

1,292 views

Original Research

Published on 18 Dec 2025

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations

in T Cell Biology

Maria A. Salnikova
Ksenia K. Tuchynskaya
Anastasia A. Minervina
Mikhail V. Pogorelyy
Egor V. Okhezin
Galina G. Karganova
Ilgar Z. Mamedov
Yuri B. Lebedev

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663781

1,535 views

Original Research

Published on 18 Dec 2025

Joint association between pan-immune inflammation value and physical pain with self-perception of patients in rheumatoid arthritis: a retrospective cohort study employing traditional statistics and interpretable machine learning

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yang Li
Jian Liu
Yue Sun
Yuedi Hu
Jianting Wen
Xueni Cheng
Shengfeng Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711081

1,473 views

Original Research

Published on 18 Dec 2025

Targeting highly attenuated IL-18 to PD-1 for enhanced anti-tumor activity

in Cancer Immunity and Immunotherapy

Xueyuan Zhou
Felix Klaus Geyer
Jeffrey Takimoto
Harald Kolmar
Brian Rabinovich

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718321

3,278 views

Original Research

Published on 18 Dec 2025

Unmasking inflammation in juvenile dermatomyositis: myokine profiles of patients and bioengineered human muscle

in Cytokines and Soluble Mediators in Immunity

Lauren T. Covert
George A. Truskey
Sara Kandil
Jessica Neely
Jessica L. Turnier
Kaveh Ardalan
Jeffrey A. Dvergsten

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694717

1,375 views

Original Research

Published on 18 Dec 2025

Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model

in Viral Immunology

Brian Wolfe
Saurav Pantha
Saranya Vijayakumar
Shristy Budha Magar
Tawfik Aboellail
Santosh Dhakal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699275

1,978 views
1 citation

Mini Review

Published on 18 Dec 2025

MicroRNAs as multifaceted regulators and therapeutic targets in ulcerative colitis

in Cytokines and Soluble Mediators in Immunity

Xuerui Wang
Nan Jiang
Weixiang Yin
Xiaofeng Cui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697059

2,039 views

Case Report

Published on 18 Dec 2025

Combined biologic therapy targeting B cells and eosinophils in relapsing multiple sclerosis and severe asthma: a case report of ofatumumab and mepolizumab

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Aurora Zanghì
Paola Sofia Di Filippo
Claudia Rutigliano
Carlo Avolio
Emanuele D’Amico

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634477

1,162 views

Original Research

Published on 18 Dec 2025

High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

in Comparative Immunology

Myung-Chul Kim
Taeeun Gu
Hyeewon Seo
Yewon Moon
Nicholas Borcherding
Ryan Kolb
Yubin Kim
Youngmin Yun
Woo-Jin Song
Chung-Young Lee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680437

1,945 views

Review

Published on 18 Dec 2025

Lactylation: the metabolic–immune hub in autoimmune diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Qingqing Xia
Dantong Sun
Ke Wan
Chengcheng Liu
Han Shu
Miao Wang
Tongsheng Zhou
Ying Chen
Xue Yang
Xiao-Feng Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651923

2,592 views

Original Research

Published on 18 Dec 2025

SMAC mimetics sensitize HIV-infected cells to oncolytic virus-mediated death

in Viral Immunology

Bengisu Molyer
Yasmeen Ameeriar
Jonathan B. Angel

Frontiers in Immunology

doi 10.3389/fimmu.2025.1665811

1,741 views

Original Research

Published on 18 Dec 2025

Impact of inotuzumab ozogamicin as bridging therapy and tumor burden in CAR-T therapy for B-acute lymphoblastic leukemia

in Cancer Immunity and Immunotherapy

Patricia Alcalde-Mellado
Victoria Ruiz-Maldonado
Javier Delgado-Serrano
Luzalba Sanoja-Flores
Marta Reinoso-Segura
Laura Pérez-Ortega
Belén Sierro-Martínez
Estefanía García-Guerrero
Concepción Pérez de Soto
José María Pérez-Hurtado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725878

1,633 views

Original Research

Published on 18 Dec 2025

Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung

in Mucosal Immunity

Adrienne N Wilburn
Rabia Ülkü Korkmaz
Jaclyn W McAlees
Julie M Hargis
Schmaiel Shirdel
Imke Lingel
Miki Watanabe-Chailland
Lindsey Romick-Rosendale
Inken Schmudde
James P Bridges

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715675

1,698 views

Original Research

Published on 18 Dec 2025

Serum CHI3L1 levels correlate with disease activity in rheumatoid arthritis and reveal potential molecular mechanisms

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yi Deng
Dan Wang
Chao Wang
Kaiyun Guo
Ming Lei
Yanzhao Huang
Langui Tang
Ya Ding
Yan Gao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729989

1,817 views

Original Research

Published on 18 Dec 2025

T cell immunity to seasonal Influenza A and H5N1 viruses in laboratory workers receiving annual seasonal Influenza vaccines

in Vaccines and Molecular Therapeutics

Joel Sop
Tyler P. Beckey
Lizeth Gutierrez
Li Zhang
Kelly A. Gebo
Kellie N. Smith
Joel N. Blankson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718805

1,760 views

Original Research

Published on 18 Dec 2025

Impact of recombinant expression in Komagataella phaffii on the allergenic properties of the peanut allergen Ara h 2

in Molecular Innate Immunity

Andrea Wangorsch
Annette Jamin
Sonja Wolfheimer
Melanie Albrecht
Stefan Vieths
Jonas Lidholm
Stephan Scheurer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713823

1,169 views

Review

Published on 18 Dec 2025

Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies

in Inflammation

Sofia Shifon
Tamara Tyrinova
Tatyana Veretelnikova
Natalia Pasman
Elena Chernykh

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727183

3,260 views

Original Research

Published on 18 Dec 2025

Evaluation of warning strategies for paraneoplastic neurological syndromes associated with PD-1/PD-L1 inhibitors

in Cancer Immunity and Immunotherapy

Zhuangzhuang Ren
Yudan Liu
Jianguo Liu
Xiaokun Qi
Feng Qiu
Chenjing Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1670751

1,013 views

Review

Published on 18 Dec 2025

Mechanism analysis and intervention strategies of the inflammatory microenvironment in traumatic spinal cord injury

in Inflammation

Hou-yun Gu
Fei-xiang Lin
Ning Liu
Can-hua Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692346

1,630 views

Original Research

Published on 18 Dec 2025

Differential expression profiles of lncRNAs and a preliminary study on the mechanism of lncRNA FAM225A in triple seronegative myasthenia gravis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Yuehan Hao
Chen Chen
Bo Wang
ChunHua Yang
Ying Zhu
Ruixia Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664131

1,576 views

Original Research

Published on 18 Dec 2025

Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

in Molecular Innate Immunity

Huili Zhao
Shenao Zhang
Yinjiao Wang
Haiyan Zhang
Peng Du
Aihong Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739812

1,337 views

Review

Published on 18 Dec 2025

New insights into combined immunotherapy for hepatocellular carcinoma associated with liver cirrhosis

in Cancer Immunity and Immunotherapy

Yufan Liu
Kexin Cong
Qiao Li
Dan Zhang
Jiyao Sheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1741398

1,779 views

Original Research

Accepted on 17 Dec 2025

Effect of Pretransplant Spleen Volume on the Prognosis of Acute Myeloid Leukemia Treated with Allogeneic Hematopoietic Stem Cell Transplantation

in Alloimmunity and Transplantation

WEIWEI LIU
Liu Bingjie
LIhou Pang
Lixia Zhou
Fuxu Wang
Xuejun Zhang
Ying Wang

Frontiers in Immunology

251 views

49,797 articles

articles

LOX1-mediated supramolecular self-assembly nanomedicine for microsatellite-stable colorectal cancer towards reactivating anti-tumor immunity

Prolonged impairment of immunological memory after anti-CD20 treatment in pediatric idiopathic nephrotic syndrome: an extended follow-up

Tick-borne encephalitis virus variants drive distinct TCR repertoire alterations

Joint association between pan-immune inflammation value and physical pain with self-perception of patients in rheumatoid arthritis: a retrospective cohort study employing traditional statistics and interpretable machine learning

Targeting highly attenuated IL-18 to PD-1 for enhanced anti-tumor activity

Unmasking inflammation in juvenile dermatomyositis: myokine profiles of patients and bioengineered human muscle

Females with obesity exhibit greater influenza vaccine-induced immunity and protection than males in a mouse model

MicroRNAs as multifaceted regulators and therapeutic targets in ulcerative colitis

Combined biologic therapy targeting B cells and eosinophils in relapsing multiple sclerosis and severe asthma: a case report of ofatumumab and mepolizumab

High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs

Lactylation: the metabolic–immune hub in autoimmune diseases

SMAC mimetics sensitize HIV-infected cells to oncolytic virus-mediated death

Impact of inotuzumab ozogamicin as bridging therapy and tumor burden in CAR-T therapy for B-acute lymphoblastic leukemia

Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung

Serum CHI3L1 levels correlate with disease activity in rheumatoid arthritis and reveal potential molecular mechanisms

T cell immunity to seasonal Influenza A and H5N1 viruses in laboratory workers receiving annual seasonal Influenza vaccines

Impact of recombinant expression in Komagataella phaffii on the allergenic properties of the peanut allergen Ara h 2

Endometriosis as an immune-mediated disease: pathogenetic mechanisms and therapeutic strategies

Evaluation of warning strategies for paraneoplastic neurological syndromes associated with PD-1/PD-L1 inhibitors

Mechanism analysis and intervention strategies of the inflammatory microenvironment in traumatic spinal cord injury

Differential expression profiles of lncRNAs and a preliminary study on the mechanism of lncRNA FAM225A in triple seronegative myasthenia gravis

Immuno-inflammatory signature for predicting therapeutic response and survival after stereotactic radiosurgery in NSCLC patients with brain metastases: a retrospective cohort study

New insights into combined immunotherapy for hepatocellular carcinoma associated with liver cirrhosis

Effect of Pretransplant Spleen Volume on the Prognosis of Acute Myeloid Leukemia Treated with Allogeneic Hematopoietic Stem Cell Transplantation