Frontiers in Immunology

Original Research

Published on 17 Dec 2025

Bioinformatic and experimental identification and characterization of Clostridioides difficile lipoproteins as potential vaccine candidates

in Vaccines and Molecular Therapeutics

Soumyadeep Chakraborty
Joshua Heuler
Shaohui Wang
Junling Qin
Adrit Roy
Lubem Nathanel Agbendeh
Anastasia Tomatsidou
Hyeun Bum Kim
Xingmin Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650364

280 views

Original Research

Published on 17 Dec 2025

Chronic opioid use is associated with higher antibody response to influenza vaccination in people living with HIV

in Vaccines and Molecular Therapeutics

Christine M. Dang
C. Mindy Nelson
Rajendra N. Pahwa
Hansel E. Tookes
Daniel J. Feaster
Prabhsimran Singh
Allan E. Rodriguez
David W. Forrest
Nobuyo Nakamura
Priya P. Ghanta

Frontiers in Immunology

doi 10.3389/fimmu.2025.1686103

381 views

Original Research

Published on 17 Dec 2025

COVID-19 vaccination induces cross-reactive dengue virus antibodies with altered isotype profiles and in vitro antibody-dependent enhancement

in Viral Immunology

Sebastian Reinig
Chin Kuo
Sheng-Yu Huang
Kuei-Ching Hsiung
Po-Kai Chen
Etsuro Ito
Ing-Kit Lee
Ching-Yen Tsai
Shu-Min Lin
Shin-Ru Shih

Frontiers in Immunology

doi 10.3389/fimmu.2025.1683070

1,286 views

Review

Published on 17 Dec 2025

The placental battlefield: viral strategies and immune countermeasures

in Viral Immunology

Ruby Dhar
Sunil Singh
Om Saswat Sahoo
Nilesh Chandra
Anamta Gul
Indrani Mukherjee
Shreyashi Karmakar
Mohammed Amanullah
Subhradip Karmakar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667601

328 views

Original Research

Published on 17 Dec 2025

Efficacy and safety of the neoadjuvant chemoimmunotherapy with pembrolizumab plus docetaxel and cisplatin in resectable locally advanced squamous cell carcinoma of the head and neck

in Cancer Immunity and Immunotherapy

Jing Wang
Wenqian Zhang
Dongning Huang
Zhu Liu
Wei Zhang
Zhendong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664892

226 views

Review

Published on 17 Dec 2025

Keeping it local: how CD8 TRMs regulate viral and cancer immunity

in Viral Immunology

Luiz Rodrigues Junior
Cristina Bonorino
Alisson Felipe Haubert
Marvin Paulo Lins
Gabriel Pozo Pereira
Pedro R. Torres Romao
Barry T. Rouse

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618700

315 views

Review

Published on 17 Dec 2025

The long pentraxin 3: the invisible loom weaving the warp and weft of tumor destiny

in Inflammation

Tianyi Liu
Manyu Li
Yuxi Cheng
Jialin Zou
Fengying Liu
Jie Dong
Cheng Qiu
Xuenan Peng
Deyang Kong
Zhifan Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705051

260 views

Review

Published on 17 Dec 2025

Beyond monoclonal antibodies: constraints and the case for alternative PD-1/PD-L1-targeting formats

in Cancer Immunity and Immunotherapy

Natalia O. Porozova
Natalia V. Petukhova
Maxim A. Gureev
Ivan S. Moiseev
Igor E. Eliseev
Ludmila V. Fedorova
Yuri B. Porozov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1729468

307 views

Original Research

Published on 17 Dec 2025

Dynamic genetic regulation of CD4+ T cells in obstructive sleep apnea: integrating context-specific eQTL, Mendelian randomization, single-cell sequencing, and experimental validation

in Systems Immunology

Xinyue Zhang
Lingfei Ren

Frontiers in Immunology

doi 10.3389/fimmu.2025.1691347

359 views

Original Research

Published on 17 Dec 2025

A comparative study of large-vessel and small-vessel primary angiitis of the central nervous system: insights from a Chinese single-center retrospective cohort

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Yifan Wang
Jiangyi Lyu
Fangfang Li
Jing Zhao
Yu He
Shangtian Xiang
Weizhou Zang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1724588

285 views

Original Research

Published on 17 Dec 2025

OmniNeo: a multi-omics pipeline incorporating proteomics and AI selection for neoantigen optimization in tumor immunotherapy

in Vaccines and Molecular Therapeutics

Manman Lu
Yang Liu
Linfeng Xu
Yuan Gao
Peng Liu
Zhenhao Liu
Xiaoxiu Tan
Wenzhen Li
Yong Lin
Lanming Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1727642

352 views

Original Research

Published on 17 Dec 2025

Induction of trained immunity in myeloid cells and their progenitors from thyroid cancer patients

in Cancer Immunity and Immunotherapy

Pepijn van Houten
Prashant Changoer
Liesbeth van Emst
Han J. Bonenkamp
Johannes H. W. de Wilt
Willemijn Hobo
Manita E. J. Bremmers
Mieke W. H. Roeven
Janneke E. W. Walraven
Petronella B. Ottevanger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1706496

384 views

Original Research

Published on 17 Dec 2025

A novel fully human anti-ROR1 antibody PBA-0405 optimized for ADCC, induces potent anti-tumor activity against both solid and hematological malignancies

in NK and Innate Lymphoid Cell Biology

Niina Veitonmäki
Anna Kostyn
Sonia Kołt
Aleksandra Ziemblicka
Beata Romanowska
Sabina Oleksy
Ewelina Krzywińska
Kamilla Sołtys
Łukasz Świderski
Piotr Naporowski

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711509

1,106 views

Review

Published on 17 Dec 2025

Novel regulators of hepatic macrophages in liver fibrosis

in Inflammation

Xiangjun Tang
Meiwen Bai
Xianhong Du
Hong Wang
Meifang Liu
Xiaoyan Fu
Hongxia Zhang
Shujuan Liang
Liyuan Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1705503

272 views

Review

Published on 17 Dec 2025

Research progress on recombinant NDV in cancer therapy

in Cancer Immunity and Immunotherapy

Jiating Sun
Jia Wang
Min Xiao
Liming Chen
Yi Guan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1735440

225 views

Original Research

Accepted on 16 Dec 2025

The gut microbiota composition is shaped by disease activity and individual treatment responses in patients with multiple sclerosis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Veronika Ticha
Stepan Coufal
Zuzana Jiraskova Zakostelska
Tomas Thon
Radka Roubalova
Tomas Hrncir
Miloslav Kverka
Miluse Pavelcova
Pavlina Kleinova
Jana Lizrova Preiningerova

Frontiers in Immunology

395 views

Review

Accepted on 16 Dec 2025

The Infection–Microbiome–Immunity Axis in Bladder Cancer: Mechanistic Insights and Therapeutic Perspectives

in Cancer Immunity and Immunotherapy

Shen Pan
Zhujun Wang
Wanlin Cui
Bitian Liu

Frontiers in Immunology

204 views

Original Research

Accepted on 16 Dec 2025

Enhancing Named Entity Recognition for Immunology and Immune-Mediated Disorders

in Systems Immunology

Jinshan Che
Mingming Sun
Yuhong Wang

Frontiers in Immunology

139 views

Correction

Accepted on 16 Dec 2025

Correction: Antibodies and cryptographic hash functions: quantifying the specificity paradox

in Systems Immunology

Robert Petrella

Frontiers in Immunology

174 views

Editorial

Accepted on 16 Dec 2025

Editorial: Molecular Mechanisms of the Host Immune Response to Toxoplasma gondii Infection

in Parasite Immunology

Jing Yang
Rui Fang

Frontiers in Immunology

130 views

Original Research

Accepted on 16 Dec 2025

C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL–RANK interaction

in Cytokines and Soluble Mediators in Immunity

Trung-Loc Ho
Kun-Tsan Lee
Yu-Hao He
Huynh Hoai Thuong Le
Achudhan David
Wei-Chien Huang
Chih-Yuan Ko
Chun-Lin Liu
Jeng-Hung Guo
Chih-Hsin Tang

Frontiers in Immunology

262 views

Review

Accepted on 16 Dec 2025

Death as Rebirth: How Efferocytosis Drives Tissue Repair and Disease Treatment

in Cancer Immunity and Immunotherapy

Xinliang Duan
Sichen Han
Yifu Bian
Yao Yuan
Jiayu Shen
Yixuan Dai
Junzi Mi
Zilin Wang

Frontiers in Immunology

Original Research

Accepted on 16 Dec 2025

Vancomycin is a risk factor for acute pancreatitis and increases the mortality rate in patients with severe pancreatitis

in Comparative Immunology

Wang Yongxiang
He Hongye
Zou Heng
ZhongTao Liu
Yu Wen

Frontiers in Immunology

Review

Accepted on 16 Dec 2025

Aberrant B Cell Responses as Drivers of Autoantibody Generation and Epitope Diversification in SLE Pathogenesis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Fareeha Tariq
Yathavi Charavanmuttu
Kazi Labiba
Chris Wincup

Frontiers in Immunology

133 views

48,461 articles

articles

Bioinformatic and experimental identification and characterization of Clostridioides difficile lipoproteins as potential vaccine candidates

Chronic opioid use is associated with higher antibody response to influenza vaccination in people living with HIV

COVID-19 vaccination induces cross-reactive dengue virus antibodies with altered isotype profiles and in vitro antibody-dependent enhancement

The placental battlefield: viral strategies and immune countermeasures

Efficacy and safety of the neoadjuvant chemoimmunotherapy with pembrolizumab plus docetaxel and cisplatin in resectable locally advanced squamous cell carcinoma of the head and neck

Keeping it local: how CD8 TRMs regulate viral and cancer immunity

The long pentraxin 3: the invisible loom weaving the warp and weft of tumor destiny

Beyond monoclonal antibodies: constraints and the case for alternative PD-1/PD-L1-targeting formats

Dynamic genetic regulation of CD4+ T cells in obstructive sleep apnea: integrating context-specific eQTL, Mendelian randomization, single-cell sequencing, and experimental validation

A comparative study of large-vessel and small-vessel primary angiitis of the central nervous system: insights from a Chinese single-center retrospective cohort

OmniNeo: a multi-omics pipeline incorporating proteomics and AI selection for neoantigen optimization in tumor immunotherapy

Induction of trained immunity in myeloid cells and their progenitors from thyroid cancer patients

A novel fully human anti-ROR1 antibody PBA-0405 optimized for ADCC, induces potent anti-tumor activity against both solid and hematological malignancies

Novel regulators of hepatic macrophages in liver fibrosis

Research progress on recombinant NDV in cancer therapy

The gut microbiota composition is shaped by disease activity and individual treatment responses in patients with multiple sclerosis

The Infection–Microbiome–Immunity Axis in Bladder Cancer: Mechanistic Insights and Therapeutic Perspectives

Enhancing Named Entity Recognition for Immunology and Immune-Mediated Disorders

Correction: Antibodies and cryptographic hash functions: quantifying the specificity paradox

Editorial: Molecular Mechanisms of the Host Immune Response to Toxoplasma gondii Infection

C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL–RANK interaction

Death as Rebirth: How Efferocytosis Drives Tissue Repair and Disease Treatment

Vancomycin is a risk factor for acute pancreatitis and increases the mortality rate in patients with severe pancreatitis

Aberrant B Cell Responses as Drivers of Autoantibody Generation and Epitope Diversification in SLE Pathogenesis