Frontiers in Immunology

Original Research

Published on 13 Feb 2026

The role of soluble toll-like receptor-2 and 4 in children with pneumonia: a combined analysis of saliva and serum samples

in Cytokines and Soluble Mediators in Immunity

Ozlem Necipoglu
Osman Oguz Demir
Kubra Aykac
Sevilay Karahan
Ali Bulent Cengiz
Malik Aydin
Yasemin Ozsurekci

Frontiers in Immunology

doi 10.3389/fimmu.2026.1657027

513 views

Mini Review

Published on 13 Feb 2026

From static pathology to dynamic immunity: immunological plasticity and histopathological remodeling in atopic dermatitis and psoriasis

in Inflammation

Wei Shen
Yi Yao
Ying-Ming Ma
Xiao-Lei Xie
Shun-Li Tang
Yuan Wu
Hua-Jie Zhong
Yu-Mei Li
Hui Sun

Frontiers in Immunology

doi 10.3389/fimmu.2026.1770896

443 views

Correction

Published on 13 Feb 2026

Correction: TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Kailai Panlu
Yihan Wang
Xinchao Zhu
Zhiting Lin
Ting Fang
Xinyi Yao
Zhimin Xie
Xinchang Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1804355

197 views

Case Report

Published on 13 Feb 2026

Born with two faces: sequential DLBCL, NOS and TFHL-AI with TET2 mutation – a case report

in Cancer Immunity and Immunotherapy

Qing Li
Shishuo Dai
Chenlu Yang
Weiping Liu
Yu Wu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1698958

222 views

Original Research

Published on 13 Feb 2026

Spatial transcriptomics reveals the mechanistic role of lactate metabolism in the pancreatic ductal adenocarcinoma microenvironment

in Cancer Immunity and Immunotherapy

Fan Gao
Zhe Tang
Jie Lian
Luting Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1743187

419 views

Original Research

Published on 13 Feb 2026

Carnosine protects human microglia against Aβ oligomers through a multimodal mechanism of action: inhibition of oxidative stress, rescue of cellular energy status, and enhancement of phagocytosis

in Systems Immunology

Anna Privitera
Vincenzo Cardaci
Matthew C. Zupan
Lucia Di Pietro
Giuseppe Carota
Jay Sibbitts
Renata Mangione
Andrea Graziani
Lucia Buccarello
Francesco Bellia

Frontiers in Immunology

doi 10.3389/fimmu.2026.1768094

409 views

Original Research

Published on 13 Feb 2026

Transcriptomic and proteomic profiling of pulmonary mucormycosis reveals a failed activation of host immune response

in Microbial Immunology

Jinjin Zhong
Xiaomin Cai
Yuchen Cai
Tingting Zhao
Die Hu
Chao Sun
Yueyan Ni
Yu Gu
Xin Su

Frontiers in Immunology

doi 10.3389/fimmu.2026.1732782

411 views

Correction

Published on 13 Feb 2026

Correction: Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses

in Vaccines and Molecular Therapeutics

Naomi Krickeberg
Hans-Georg Rammensee
Karin Schilbach

Frontiers in Immunology

doi 10.3389/fimmu.2026.1788957

439 views

Editorial

Published on 13 Feb 2026

Editorial: HLA-G in health and disease: comprehensive insights and future therapeutic directions

in Immunological Tolerance and Regulation

Jules Russick
Roberta Rizzo
Ashwin Ajith

Frontiers in Immunology

doi 10.3389/fimmu.2026.1786277

253 views

Systematic Review

Published on 13 Feb 2026

Systematic review and meta-analysis of belatacept versus calcineurin inhibitors on risk of post-transplant diabetes mellitus in kidney transplant recipients

in Alloimmunity and Transplantation

Xuchuan Wang
Dandan Song
Shufu Hou
Aiju Liu
Jing Gao
Lei Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1615875

308 views

Original Research

Published on 13 Feb 2026

Novel BPI3Vc-vectored surface displayed fusion and hemagglutinin-neuraminidase antigens elicit broadly neutralizing antibodies in cattle

in Vaccines and Molecular Therapeutics

Huldah Sang
Tae Kim
Rakshith Kumar
Jayden McCall
Aloysius Abraham
Tsvetoslav Koynarski
Michelle Zajac
Karim W. Abdelsalam
Daniela Hernandez Muguiro
Katherine Bauer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1702440

502 views

Original Research

Published on 13 Feb 2026

Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data

in Cancer Immunity and Immunotherapy

Yiyuan Cui
Sicong Li
Zhibin Wu
Yue Jin
Jingjie Yu
Yufan Chen
Jiayang Chen
Jinyuan Chang
Yijing Yan
Xinyu Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1685902

213 views

Original Research

Published on 13 Feb 2026

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

in Cancer Immunity and Immunotherapy

Morgane Peroz
Nicolas Roussot
Alis Ilie
David Rageot
Valentin Derangere
Caroline Truntzer
François Ghiringhelli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1750816

275 views

Original Research

Accepted on 12 Feb 2026

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway

in Cancer Immunity and Immunotherapy

Genshen Zhong
Biao Liu
Xue Gong
Qi Wang
Shuyin Zheng
Xinyu Luo
Xingya Zhang
Biliang Hu
Minna Wu
Zhiguo Chen

Frontiers in Immunology

170 views

Case Report

Accepted on 12 Feb 2026

Eosinophilic Granulomatosis with Polyangiitis Coexisting with Multiple Myeloma: Independent Entities or Coexistence? A Case Report

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Longyan Qin
Yi Yin
Pengjia Wu
Aifei Zhang
Na li
Jun Liu
Ling Huang
Jun Cao
Jiashun Zeng

Frontiers in Immunology

151 views

Original Research

Accepted on 12 Feb 2026

The CNS compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity

in Multiple Sclerosis and Neuroimmunology

Sakthi Asokan
WENBO ZHOU
Anthony Fringuello
Tiffany Pointon
Ashley Kennedy
BRENDAN FREITAS
jackson Tumas French
Haiyan Zhao
Christina Coughlan
Enrique Alvarez

Frontiers in Immunology

158 views

Original Research

Accepted on 12 Feb 2026

Co-delivery of IL-12/IL-15/IL-18 Engineered DC Vaccines with Anti-IL-10R and Nanoconjugated Methotrexate in Melanoma

in Cancer Immunity and Immunotherapy

Katarzyna Węgierek-Ciura
Agnieszka Szczygieł
Anna Rudawska
Jagoda Mierzejewska
Joanna Rossowska
Bożena Szermer-Olearnik
Marta Świtalska
Tomasz Goszczynski
Elżbieta Pajtasz-Piasecka

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Precise Delivery and Controlled Release: Strategies and Advances in TLR7/8 Agonist Prodrugs for Cancer Immunotherapy

in Cancer Immunity and Immunotherapy

Xiaohua Zheng
Yutao Zou
Ting Li
Huoying Pan
Jiangle Liu
Jingxuan He
Haoyu Ju
Weiqi Wang

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

A Comprehensive Review of Mechanisms Underlying Resistance to Immune Checkpoint Inhibitors

in Cancer Immunity and Immunotherapy

Alexandre Bertucci
Khaoula Taleb
Emilien Billon
Téo Fernez
Philippe Rochigneux

Frontiers in Immunology

Case Report

Accepted on 12 Feb 2026

Case report: A case of diabetes mellitus and pneumonitis induced by envafolimab treatment in small cell lung cancer

in Cancer Immunity and Immunotherapy

Yanyan Li
Hongke Wang
Guochen Xing
Xiaodan Guo
Shanyong Yi

Frontiers in Immunology

Case Report

Accepted on 12 Feb 2026

A 28-year-old female patient presented with recurrent fevers and episodes of shock due to ZBTB24 pathogenic variant

in Primary Immunodeficiencies

Jie Gao
Xiaoling Jiang
Ye Tian
Rui Zhai
Yan Chen
Jinling Guo
Liulin Wu
Mei Hu

Frontiers in Immunology

139 views

Original Research

Accepted on 12 Feb 2026

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment

in Vaccines and Molecular Therapeutics

I Seul Park
Ji Hyung Kim
Dongyeop Kim
Ye Won Kim
Yoojin Shin
Ki Beom Kim
Haiying Zhang
TAE IL KIM
Seung Won Kim
Young-guen Kwon

Frontiers in Immunology

Correction

Accepted on 12 Feb 2026

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

in Immunological Tolerance and Regulation

Biao Lei
Zhenyang Liu
Peifang Xie
XUANXUAN LI
Zhanyu Cui
CHEN RUIHAN
Bin Liu
Shihua Chen
Yaxin Li
Min Liang

Frontiers in Immunology

Review

Accepted on 12 Feb 2026

Biologics for Eosinophilic COPD: Current Applications and Future Prospects

in Vaccines and Molecular Therapeutics

Qi Qi
Wenbei Peng
Bohan Yang
Shijie Liu
Ying Pu
Qiong Zhou

Frontiers in Immunology

49,864 articles

articles

The role of soluble toll-like receptor-2 and 4 in children with pneumonia: a combined analysis of saliva and serum samples

From static pathology to dynamic immunity: immunological plasticity and histopathological remodeling in atopic dermatitis and psoriasis

Correction: TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases

Born with two faces: sequential DLBCL, NOS and TFHL-AI with TET2 mutation – a case report

Spatial transcriptomics reveals the mechanistic role of lactate metabolism in the pancreatic ductal adenocarcinoma microenvironment

Carnosine protects human microglia against Aβ oligomers through a multimodal mechanism of action: inhibition of oxidative stress, rescue of cellular energy status, and enhancement of phagocytosis

Transcriptomic and proteomic profiling of pulmonary mucormycosis reveals a failed activation of host immune response

Correction: Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses

Editorial: HLA-G in health and disease: comprehensive insights and future therapeutic directions

Systematic review and meta-analysis of belatacept versus calcineurin inhibitors on risk of post-transplant diabetes mellitus in kidney transplant recipients

Novel BPI3Vc-vectored surface displayed fusion and hemagglutinin-neuraminidase antigens elicit broadly neutralizing antibodies in cattle

Construction and validation of a novel diagnostic model for esophageal squamous cell carcinoma: an integrated analysis of multi-omics data

Deep learning-based assessment of PD-L1 expression in NSCLC predicts outcome for patients treated with anti-PD-1 immunotherapy

The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathway

Eosinophilic Granulomatosis with Polyangiitis Coexisting with Multiple Myeloma: Independent Entities or Coexistence? A Case Report

The CNS compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity

Co-delivery of IL-12/IL-15/IL-18 Engineered DC Vaccines with Anti-IL-10R and Nanoconjugated Methotrexate in Melanoma

Precise Delivery and Controlled Release: Strategies and Advances in TLR7/8 Agonist Prodrugs for Cancer Immunotherapy

A Comprehensive Review of Mechanisms Underlying Resistance to Immune Checkpoint Inhibitors

Case report: A case of diabetes mellitus and pneumonitis induced by envafolimab treatment in small cell lung cancer

A 28-year-old female patient presented with recurrent fevers and episodes of shock due to ZBTB24 pathogenic variant

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment

Liu Shen Wan regulates the SPHK1/S1P axis to ameliorate influenza-induced inflammation via integrated network pharmacology and lipidomics

Biologics for Eosinophilic COPD: Current Applications and Future Prospects