Frontiers in Immunology

Original Research

Published on 12 Dec 2025

TMEM106A mediates atherosclerosis progression through macrophage-centered immune responses and chemokine signaling

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Menglong Gao
Xingbang Liu
Zhen Fang
Jia Lun
Qingyun Zhang
Yunbo Zhao
Yin Huang
Zhenhua Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1681645

1,414 views

Original Research

Published on 12 Dec 2025

Single-cell and bulk transcriptomics reveal a CD8+ T-cell gene signature predicting prognosis in diffuse large B-cell lymphoma

in Cancer Immunity and Immunotherapy

Hengqi Liu
Yingfang Feng
Zhengzi Qian
Zheng Song
Ning Zhang
Jingwei Yu
Xia Liu
Lihua Qiu
Shiyong Zhou
Wenchen Gong

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685541

2,734 views

Original Research

Published on 12 Dec 2025

2B4 co-stimulation and dasatinib modulation enhance anti-CD19 CAR-NK-92 cell cytotoxicity

in NK and Innate Lymphoid Cell Biology

Matheus Henrique dos Santos
Júlia Teixeira Cottas de Azevedo
Mara Elisama da Silva Januário
Dayane de Fátima Schmidt
Mariane Cariati Tirapelle
Alison Felipe Bordini Biggi
Sima Ebrahimabadi
Renata Nacasaki Silvestre
Dimas Tadeu Covas
Rodrigo T. Calado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675877

2,321 views
1 citation

Original Research

Published on 12 Dec 2025

Deep learning, deeper relief: pipeline toward tailored analgesia for experimental animal models

in Mucosal Immunity

Luisa Barleben
Mareike Simon
Lisa Drees
Franziska Flohr
Christoph Jochum
Michela Di Virgilio
Frank Tacke
Sonja Bröer
Jana Wolf
Marina Kolesnichenko

Frontiers in Immunology

doi 10.3389/fimmu.2025.1639881

1,095 views

Review

Published on 12 Dec 2025

GPR35-mediated metabolic reprogramming promotes tumorigenesis in digestive cancers

in Cancer Immunity and Immunotherapy

Fang Wang
Xin-Xin Ding
Tao-Hong Su
Jing Cao
Feng-Qin Li
Zi-Shu Dong
Xin-Zhi Guo
Yan Zhang
Yang Chen
Dong-Hua Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668471

1,573 views

Review

Published on 12 Dec 2025

Urothelial carcinoma following kidney transplantation: a narrative review of Chinese insights and challenges from pathogenesis to precision diagnosis and treatment

in Alloimmunity and Transplantation

Lei Li
Fei Ren
Zhuo Liu
Xiaojun Tian
Hongxian Zhang
Guoliang Wang
Shudong Zhang
Lulin Ma

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668356

1,359 views

Review

Published on 12 Dec 2025

Immunomodulatory biomaterials for vascularized and innervated skeletal muscle repair

in T Cell Biology

Lauren G. Mottel
Brennagh R. Shields
Brian J. Kwee

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657015

1,814 views

Original Research

Published on 12 Dec 2025

Antibodies against polysaccharide type 3 and pneumococcal proteins demonstrate synergistic protective effect in a highly virulent type 3 invasive disease model in mice

in Vaccines and Molecular Therapeutics

Taylor C. Stevenson
Heidi Burke
Sara E. Roggensack
Anthony Pratt
Aquib Hossain
Pallab Ghosh
Gilles Besin
Yingjie Lu
Fan Zhang
Richard Malley

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707686

1,852 views

Original Research

Published on 12 Dec 2025

SCGB1A1 rs3741240 variant downregulates CC16: a molecular insight into COPD pathogenesis in Indian population

in Systems Immunology

Nasima Sultana
Himani Adhikari
Achintya Mohan Goswami
Amalesh Mondal
Indranil Ganai
Himani Biswas
Asif Iqbal
Aratrika Das
Saibal Moitra
Sanjoy Podder

Frontiers in Immunology

doi 10.3389/fimmu.2025.1689340

1,550 views

Clinical Trial

Published on 12 Dec 2025

Intratumoral delivery of PD-1/PD-L1 and CTLA-4 inhibitors for recurrent/refractory solid tumors: a proof-of-concept treatment strategy

in Cancer Immunity and Immunotherapy

Hongye Tan
Noor Ul Huda Shah
Bingjia He
Tianrun Liu
Tianheng Li
Manting Liu
Yingying Gu
Cheng Zhi
Yongqiong Ou
Junhao Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669924

1,822 views

Review

Published on 12 Dec 2025

Unpacking the anti-fibrotic arsenal: molecular mechanisms and therapeutic translation of MSC-derived exosomes in pulmonary fibrosis

in Inflammation

Yijia Xiao
Iqra Hoorain
Lin Zhang
Saverio Bellusci
Xuru Jin
Hongzhong Yang
Jin-San Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725041

2,337 views

Original Research

Published on 12 Dec 2025

Lactobacillus amplifies DHAMaR1 conversion to attenuate intestinal ischemia-reperfusion injury via decreasing pyroptosis

in Mucosal Immunity

Tong Li
Hongxing Cai
Chenghao Qiu
Jianbo Zhang
Shiji Zhou
Peng Zhu
Wenjing Xian

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712761

1,445 views

Correction

Published on 12 Dec 2025

Correction: Tumor-penetrating peptide boosts bispecific T-cell engager antitumor efficacy for the pancreatic cancer

in Cancer Immunity and Immunotherapy

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761643

618 views

Correction

Published on 12 Dec 2025

Correction: The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review

in Systems Immunology

Shuangyu Chen
Wenqian Chen
Tinghui Xu
Jiayang Li
Jianghao Yu
Yibo He
Shengliang Qiu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1761409

535 views
1 citation

Original Research

Published on 12 Dec 2025

Enhancing cDC1-mediated anti-tumor immunity limits tumor progression and potentiates anti-PD-1 therapy in intrahepatic cholangiocarcinoma

in Cancer Immunity and Immunotherapy

Dong-Ni Pei
Yang Song
Ying-Xia Zhou
Bo Shu
Shao-wei Huang
Fa-Zhao Li
Wei-Dong Dai
Bao-Ye Sun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708962

1,686 views

Review

Published on 12 Dec 2025

My cells, my model: immune-competent autologous organ-on-chip systems as a new paradigm in precision medicine

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Francesco Bisconti
Hugo Abreu
Thuy Duong Nguyen
Fabiola Stolfi
Noemi Corbezzolo
Giuseppe Gigli
Davide Raineri
Giuseppe Cappellano
Alessandro Polini
Francesca Gervaso

Frontiers in Immunology

doi 10.3389/fimmu.2025.1712796

1,845 views

Mini Review

Published on 12 Dec 2025

Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics

in Vaccines and Molecular Therapeutics

Ritika Gopalakrishnan
Kamala Kannan
Ragul Gunasekaran
Priya Ramachandran
Dhanraj Ganapathy
Pitchiah Sivaperumal

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710780

1,298 views

Original Research

Published on 12 Dec 2025

Epidemiological, clinical characteristics and prognostic factors analysis of adult patients with hemophagocytic lymphohistiocytosis in a Chinese hospital

in Primary Immunodeficiencies

Mingjun Xie
Yaman Wang
Min Wang
Jun Zhou
Hua-Guo Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684308

1,023 views

Mini Review

Published on 12 Dec 2025

Clinical updates of JAK inhibitors in cutaneous granulomatous diseases

in Inflammation

Jiaxu Gu
Xinglin He
Bingcheng Lu
Jieyi Wang
Kexin Chen
Qiaofen Wang
Xingling Jian
Cong Huang
Bo Yu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698816

2,177 views

Mini Review

Published on 12 Dec 2025

Multimodal cell death drives the immunopathogenesis of RSV infection

in Viral Immunology

Tianxiang Yang
Zhizhong Mi
Zhaolong Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1740904

1,652 views

Brief Research Report

Published on 12 Dec 2025

Case report of intracranial tumor with serum MOG-IgG positivity

in Multiple Sclerosis and Neuroimmunology

Zhuo Min
Lingru Wang
Yulai Kang
Lili Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673927

1,002 views

Original Research

Published on 12 Dec 2025

Identification and validation of ubiquitination-associated genes of senile osteoporosis based on bioinformatics analysis

in Antigen Presenting Cell Biology

Xiyue Cheng
Junchuan Liu
Yiman Guan
Boya Jing
Jing Zhao
Yan Cao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629276

1,538 views

Original Research

Published on 12 Dec 2025

Application of the Richards function to serum antibody titration

in Systems Immunology

Ágnes Kovács
Krisztián Papp
József Prechl
Tamás Pfeil

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657633

1,276 views

Original Research

Published on 12 Dec 2025

Organosilicone double-long-chain diquaternary ammonium salt acts as a biofilm scavenger to ameliorate colitis induced by dextran sulfate sodium salt

in Microbial Immunology

Shaopei Shi
Guoxing Tang
Juan Wei
Si Shen
Zhihao Ding
Qin An
Hui Tao
Fangyu Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1644433

972 views

49,797 articles

articles

TMEM106A mediates atherosclerosis progression through macrophage-centered immune responses and chemokine signaling

Single-cell and bulk transcriptomics reveal a CD8+ T-cell gene signature predicting prognosis in diffuse large B-cell lymphoma

2B4 co-stimulation and dasatinib modulation enhance anti-CD19 CAR-NK-92 cell cytotoxicity

Deep learning, deeper relief: pipeline toward tailored analgesia for experimental animal models

GPR35-mediated metabolic reprogramming promotes tumorigenesis in digestive cancers

Urothelial carcinoma following kidney transplantation: a narrative review of Chinese insights and challenges from pathogenesis to precision diagnosis and treatment

Immunomodulatory biomaterials for vascularized and innervated skeletal muscle repair

Antibodies against polysaccharide type 3 and pneumococcal proteins demonstrate synergistic protective effect in a highly virulent type 3 invasive disease model in mice

SCGB1A1 rs3741240 variant downregulates CC16: a molecular insight into COPD pathogenesis in Indian population

Intratumoral delivery of PD-1/PD-L1 and CTLA-4 inhibitors for recurrent/refractory solid tumors: a proof-of-concept treatment strategy

Unpacking the anti-fibrotic arsenal: molecular mechanisms and therapeutic translation of MSC-derived exosomes in pulmonary fibrosis

Lactobacillus amplifies DHAMaR1 conversion to attenuate intestinal ischemia-reperfusion injury via decreasing pyroptosis

Correction: Tumor-penetrating peptide boosts bispecific T-cell engager antitumor efficacy for the pancreatic cancer

Correction: The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review

Enhancing cDC1-mediated anti-tumor immunity limits tumor progression and potentiates anti-PD-1 therapy in intrahepatic cholangiocarcinoma

My cells, my model: immune-competent autologous organ-on-chip systems as a new paradigm in precision medicine

Marine-derived L-asparaginase: unlocking marine power in anti-tumor therapeutics

Epidemiological, clinical characteristics and prognostic factors analysis of adult patients with hemophagocytic lymphohistiocytosis in a Chinese hospital

Clinical updates of JAK inhibitors in cutaneous granulomatous diseases

Multimodal cell death drives the immunopathogenesis of RSV infection

Case report of intracranial tumor with serum MOG-IgG positivity

Identification and validation of ubiquitination-associated genes of senile osteoporosis based on bioinformatics analysis

Application of the Richards function to serum antibody titration

Organosilicone double-long-chain diquaternary ammonium salt acts as a biofilm scavenger to ameliorate colitis induced by dextran sulfate sodium salt